Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages E4929-E4935

  Rome, Michael E ^a   Chio, Un Seng ^a   Rao, Meera ^a   Gristick, Harry ^a   Shan, Shu Ou ^a  

^a California Institute of Technology   (United States)

Author keywords

Atpase; Fluorescence; Protein interaction cascades; Protein targeting; Tail anchored protein

Indexed keywords

CELL MEMBRANE PROTEIN; CELL RECEPTOR; GET3 PROTEIN; GUIDED ENTRY OF TAIL ANCHORED PROTEIN; MEMBRANE PROTEIN; NUCLEOTIDE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CYSTEINE; GET1 PROTEIN, S CEREVISIAE; GET2 PROTEIN, S CEREVISIAE; GET3 PROTEIN, S CEREVISIAE; GET4 PROTEIN, S CEREVISIAE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MDY2 PROTEIN, S CEREVISIAE; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN; UBIQUITIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANE; FLUORESCENCE ANALYSIS; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RECYCLING; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; METABOLISM; PROTEIN ANALYSIS; PROTEIN CONFORMATION; SPECTROFLUOROMETRY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BINDING SITES; BINDING, COMPETITIVE; CARRIER PROTEINS; CYSTEINE; ENDOPLASMIC RETICULUM; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; SACCHAROMYCES CEREVISIAE PROTEINS; SPECTROMETRY, FLUORESCENCE; UBIQUITIN;

EID: 84911930505     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411284111     Document Type: Article

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