Ordered phosphorylation governs oscillation of a three-protein circadian clock

Science

Volumn 318, Issue 5851, 2007, Pages 809-812

  Rust, Michael J ^a   Markson, Joseph S ^a   Lane, William S ^b   Fisher, Daniel S ^c   O'Shea, Erin K ^a  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN KAIA; PROTEIN KAIB; PROTEIN KAIC; UNCLASSIFIED DRUG; KAIA PROTEIN, CYANOBACTERIA; KAIB PROTEIN, CYANBACTERIA; KAIC PROTEIN, CYANOBACTERIA;

CIRCADIAN RHYTHM; CYANOBACTERIUM; NUMERICAL MODEL; PHOSPHORUS; PROTEIN;

ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CYANOBACTERIUM; FEEDBACK SYSTEM; IN VITRO STUDY; MATHEMATICAL MODEL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; PHOSPHORYLATION; PHYSIOLOGY; SYNECHOCOCCUS;

CYANOBACTERIA; KAIA;

BACTERIAL PROTEINS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; MODELS, BIOLOGICAL; PHOSPHORYLATION; SYNECHOCOCCUS;

EID: 37549018348     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1148596     Document Type: Article

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29. We thank B. Budnik, J. Neveu, and R. Robinson for assistance with mass spectrometry; T. Mori and C. Johnson for SDS-PAGE conditions for phosphoform separation; J. Ferrell for helpful discussions; and B. Stern, R. Losick, M. Ebert, S. Douglas, and T. Schmidt for comments on the manuscript. This work was supported by an NSF Graduate Research Fellowship (J.S.M.), NSF grant DMR-0229243 (D.S.F.), and the Howard Hughes Medical Institute (E.K.O.).