The pathogenesis of transthyretin tissue deposition: Lessons from transgenic mice

Amyloid

Volumn 10, Issue SUPPL. 1, 2003, Pages 2-6

  Buxbaum, Joel ^a   Tagoe, Clement ^b   Gallo, Gloria ^b   Reixach, Natalia ^a   French, David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloidosis; Transgenic models; Transthyretin

Indexed keywords

PREALBUMIN; PROTEIN PRECURSOR;

ALLELE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL COMPARTMENTALIZATION; CONFERENCE PAPER; CONTROLLED STUDY; GENE DISRUPTION; GENE INSERTION; IMMUNOHISTOCHEMISTRY; IONIC STRENGTH; MOLECULAR CLONING; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TISSUE LEVEL; TISSUE SPECIFICITY;

EID: 0242643752     PISSN: 13506129     EISSN: None     Source Type: Journal    
DOI: 10.1080/13506129.2003.12088560     Document Type: Conference Paper

References (4)

1. Teng MH, Yin JY, Vidal R, Ghiso J, Kumar A, Rabenou R, Shah A, Jacobson DR, Tagoe C and Gallo G (2001). Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis. Lab Invest 81, 385-3 96
2. Yamamura KI, Wakasugi S, Maeda S, Inomoto T, Iwanaga T, Uehira M, Araki K, Miyazaki JI and Shimada K (1987). Tissue-specific and developmental expression of human transthyretin gene in transgenic mice. Dev Genet 8, 195-205
3. Nagata Y, Tashiro F, Yi S, Murakami T, Maeda S, Takahashi K, Shimada K, Okamura H and Yamamura K (1995). A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse. J Biochem 117, 169-175
4. Kohno K, Palha JA, Miyakawa K, Saraiva MJ, Ito S, Mabuchi T, Blaner WS, Iijima H, Tsukahara S, Episkopou V, Gottesman ME, Shimada K, Takahashi K, Yamamura K and Maeda S (1997). Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy. Am J Pathol 150, 1497-1508