The ups and downs of modelling mood disorders in rodents

ILAR Journal

Volumn 55, Issue 2, 2014, Pages 297-309

  Slattery, David A ^a   Cryan, John F ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Animal model; Bipolar disorder; Cognition; Depression; Stress

Indexed keywords

ANIMALIA; RODENTIA;

AGE; ANIMAL; COGNITION; DISEASE MODEL; ESCAPE BEHAVIOR; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; LEARNED HELPLESSNESS; MALE; MOOD DISORDER; MOUSE; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; RAT; SEXUAL DEVELOPMENT; SPECIES DIFFERENCE; TRANSLATIONAL RESEARCH; TRENDS;

AGE FACTORS; ANIMALS; COGNITION; DISEASE MODELS, ANIMAL; ESCAPE REACTION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HELPLESSNESS, LEARNED; HUMANS; MALE; MICE; MOOD DISORDERS; RATS; SEX CHARACTERISTICS; SPECIES SPECIFICITY; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84911492685     PISSN: 10842020     EISSN: 19306180     Source Type: Journal    
DOI: 10.1093/ilar/ilu026     Document Type: Article

References (145)

1. Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. 2007. Highspeed imaging reveals neurophysiological links to behavior in an animal model of depression. Science 317:819-823.
2. Alonso J, Petukhova M, Vilagut G, Chatterji S, Heeringa S, Ustun TB, Alhamzawi AO, Viana MC, Angermeyer M, Bromet E, et al. 2011. Days out of role due to common physical and mental conditions: Results from the WHO World Mental Health surveys. Mol Psychiatry 16:1234-1246.
3. Atkinson HC, Waddell BJ. 1997. Circadian variation in basal plasma corticosterone and adrenocorticotropin in the rat: Sexual dimorphism and changes across the estrous cycle. Endocrinology 138:3842-3848.
4. Bale TL, Dorsa DM, Johnston CA. 1995. Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle. J Neurosci 15:5058-5064.
5. Bartlang MS, Neumann ID, Slattery DA, Uschold-Schmidt N, Kraus D, Helfrich-Forster C, Reber SO. 2012. Time matters: Pathological effects of repeated psychosocial stress during the active, but not inactive, phase of male mice. J Endocrinol 215:425-437.
6. Belzung C. 2014. Innovative drugs to treat depression: did animal models fail to be predictive or did clinical trials fail to detect effects? Neuropsychopharmacology 39:1041-1051.
7. Berton O, Hahn CG, Thase ME. 2012. Are we getting closer to valid translational models for major depression? Science 338:75-79.
8. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, et al. 2006. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868.
9. Beurel E, Song L, Jope RS. 2011. Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. Mol Psychiatry 16:1068-1070.
10. Bisgaard CF, Bak S, Christensen T, Jensen ON, Enghild JJ,Wiborg O. 2012. Vesicular signalling and immune modulation as hedonic fingerprints: Proteomic profiling in the chronic mild stress depression model. J Psychopharmacol 26:1569-1583.
11. Bloch M, Rubinow DR, Schmidt PJ, Lotsikas A, Chrousos GP, Cizza G. 2005. Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depression. J Clin Endocrinol Metab 90:695-699.
12. Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. 2000. Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 157:924-930.
13. Browning M, Holmes EA, Harmer CJ. 2010. The modification of attentional bias to emotional information: A review of the techniques, mechanisms, and relevance to emotional disorders. CognAffect Behav Neurosci 10:8-20.
14. Brummelte S, Galea LA. 2010. Depression during pregnancy and postpartum: Contribution of stress and ovarian hormones. ProgNeuropsychopharmacol Biol Psychiatry 34:766-776.
15. Bunck M, Czibere L, Horvath C, Graf C, Frank E, Kessler MS, Murgatroyd C, Muller-Myhsok B, Gonik M, Weber P, et al. 2009. A hypomorphic vasopressin allele prevents anxiety-related behavior. PLoS One 4:e5129.
16. Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, et al. 2013. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493:532-536.
17. Chen G, Henter ID, Manji HK. 2010. Translational research in bipolar disorder: Emerging insights from genetically based models. Mol Psychiatry 15:883-895.
18. Chourbaji S, Pfeiffer N, Dormann C, Brandwein C, Fradley R, Sheardown M, Gass P. 2010. The suitability of 129SvEv mice for studying depressivelike behaviour: Both males and females develop learned helplessness. Behav Brain Res 211:105-110.
19. Christensen T, Bisgaard CF, Wiborg O. 2011. Biomarkers of anhedonic-like behavior, antidepressant drug refraction, and stress resilience in a rat model of depression. Neuroscience 196:66-79.
20. Couillard-Despres S, Wuertinger C, Kandasamy M, Caioni M, Stadler K, Aigner R, Bogdahn U, Aigner L. 2009. Ageing abolishes the effects of fluoxetine on neurogenesis. Mol Psychiatry 14:856-864.
21. Crabbe JC, Wahlsten D, Dudek BC. 1999. Genetics of mouse behavior: Interactions with laboratory environment. Science 284:1670-1672.
22. Crowley JJ, Blendy JA, Lucki I. 2005. Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Psychopharmacology (Berl) 183:257-264.
23. Cryan JF, Holmes A. 2005. The ascent of mouse: Advances in modelling human depression and anxiety. Nat Rev Drug Discov 4:775-790.
24. Cryan JF, Hoyer D, Markou A. 2003.Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents. Biol Psychiatry 54:49-58.
25. Cryan JF, Markou A, Lucki I. 2002. Assessing antidepressant activity in rodents: Recent developments and future needs. Trends Pharmacol Sci 23:238-245.
26. Cryan JF, McGrath C, Leonard BE, Norman TR. 1998. Combining pindolol and paroxetine in an animal model of chronic antidepressant action: Can early onset of action be detected? Eur J Pharmacol 352:23-28.
27. Cryan JF, McGrath C, Leonard BE, Norman TR. 1999. Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. Pharmacol Biochem Behav 63:333-338.
28. Cryan JF, Mombereau C, Vassout A. 2005. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29:571-625.
29. Cryan JF, O'Leary OF. 2010. Neuroscience. A glutamate pathway to fasteracting antidepressants? Science 329:913-914.
30. Cryan JF, Slattery DA. 2007. Animal models of mood disorders: Recent developments. Curr Opin Psychiatry 20:1-7.
31. Cryan JF, Slattery DA. 2010. Animal models of depression - Where are we going? In: Cryan JF, Leonard BE, editors. Experimental Models of Depression and the Mechanisms of Action of Antidepressants. Basal: S. Karger, A.G.
32. Dalla C, Pitychoutis PM, Kokras N, Papadopoulou-Daifoti Z. 2010. Sex differences in animal models of depression and antidepressant response. Basic Clin Pharmacol Toxicol 106:226-233.
33. Dalla C, Pitychoutis PM, Kokras N, Papadopoulou-Daifoti Z. 2011. Sex differences in response to stress and expression of depressive-like behaviours in the rat. Curr Top Behav Neurosci 8:97-118.
34. Der-Avakian A, Markou A. 2010. Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats. Neuroscience 170:1189-1198.
35. Der-Avakian A, Mazei-Robison MS, Kesby JP, Nestler EJ, Markou A. 2014. Enduring deficits in brain reward function after chronic social defeat in rats: Susceptibility, resilience, and antidepressant response. Biol Psychiatry. doi:10.1016/j.biopsych.2014.01.013. Jan 31. [Epub ahead of print]
36. Disner SG, Beevers CG, Haigh EA, Beck AT. 2011. Neural mechanisms of the cognitive model of depression. Nat Rev Neurosci 12:467-477.
37. Donahue RJ, Muschamp JW, Russo SJ, Nestler EJ, Carlezon WA Jr. 2014. Effects of striatal deltaFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice. Biol Psychiatry. doi:10.1016/j. biopsych.2013.12.014. Jan 8. [Epub ahead of print]
38. Duman RS, Aghajanian GK. 2012. Synaptic dysfunction in depression: Potential therapeutic targets. Science 338:68-72.
39. Einat H. 2007a. Different behaviors and different strains: Potential new ways to model bipolar disorder. Neurosci Biobehav Rev 31:850-857.
40. Einat H. 2007b. Establishment of a battery of simple models for facets of bipolar disorder: A practical approach to achieve increased validity, better screening and possible insights into endophenotypes of disease. Behav Genet 37:244-255.
41. Elliott R, Ogilvie A, Rubinsztein JS, Calderon G, Dolan RJ, Sahakian BJ. 2004. Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania. Biol Psychiatry 55:1163-1170.
42. Elliott R, Sahakian BJ, Michael A, Paykel ES, Dolan RJ. 1998. Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression. Psychol Med 28:559-571.
43. Enkel T, Gholizadeh D, von Bohlen Und Halbach O, Sanchis-Segura C, Hurlemann R, Spanagel R, Gass P, Vollmayr B. 2010. Ambiguous-cue interpretation is biased under stress- and depression-like states in rats. Neuropsychopharmacology 35:1008-1015.
44. Eshel N, Roiser JP. 2010. Reward and punishment processing in depression. Biol Psychiatry 68:118-124.
45. Finger BC, Dinan TG, Cryan JF. 2011. High-fat diet selectively protects against the effects of chronic social stress in the mouse. Neuroscience 192:351-360.
46. Frazer A, Morilak DA. 2005. What should animal models of depression model? Neurosci Biobehav Rev 29:515-523.
47. Fuchs E. 2005. Social stress in tree shrews as an animal model of depression: An example of a behavioral model of a CNS disorder. CNS Spectr 10:182-190.
48. Geyer MA, Markou A. 1995. Animal models of psychiatric disorders. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology-The 4th generation of progress. New York: Raven. p. 787-798.
49. Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160:636-645.
50. Gould TD, Einat H. 2007. Animal models of bipolar disorder and mood stabilizer efficacy: A critical need for improvement. Neurosci Biobehav Rev 31:825-831.
51. Gould TD, Gottesman II. 2006. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 5:113-119.
52. Guo J, Fisher KA, Darcy R, Cryan JF, O'Driscoll C. 2010. Therapeutic targeting in the silent era: Advances in non-viral siRNA delivery. Mol Biosyst 6:1143-1161.
53. Gutierrez-Lobos K, Scherer M, Anderer P, Katschnig H. 2002. The influence of age on the female/male ratio of treated incidence rates in depression. BMC Psychiatry 2:3.
54. Hales CA, Stuart SA, Anderson MH, Robinson ES. 2014. Modelling Cognitive affective biases in major depressive disorder using rodents. Br J Pharmacol. doi:10.1111/bph.12603. Jan 28. [Epub ahead of print]
55. Hamani C, Diwan M, Macedo CE, Brandao ML, Shumake J, Gonzalez- Lima F, Raymond R, Lozano AM, Fletcher PJ, Nobrega JN. 2010. Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats. Biol Psychiatry 67:117-124.
56. Harro J. 2013. Animal models of depression vulnerability. Curr Top Behav Neurosci 14:29-54.
57. Hasler G, Drevets WC, Manji HK, Charney DS. 2004. Discovering endophenotypes for major depression. Neuropsychopharmacology 29:1765-1781.
58. Hasler G, Neumeister A, van der Veen JW, Tumonis T, Bain EE, Shen J, DrevetsWC, Charney DS. 2005. Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry 58:969-973.
59. Hasler G, Northoff G. 2011. Discovering imaging endophenotypes for major depression. Mol Psychiatry 16:604-619.
60. Henn FA, Vollmayr B. 2005. Stress models of depression: Forming genetically vulnerable strains. Neurosci Biobehav Rev 29:799-804.
61. Henry BL, Minassian A, Young JW, Paulus MP, Geyer MA, Perry W. 2010. Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev 34:1296-1306.
62. Herman L, Hougland T, El-Mallakh RS. 2007. Mimicking human bipolar ion dysregulation models mania in rats. Neurosci Biobehav Rev 31:874-881.
63. Hillerer KM, Neumann ID, Slattery DA. 2012. From stress to postpartum mood and anxiety disorders: How chronic peripartum stress can impair maternal adaptations. Neuroendocrinology 95:22-38.
64. Jacobson LH, Cryan JF. 2007. Feeling strained? Influence of genetic background on depression-related behavior in mice: A review. Behav Genet 37:171-213.
65. Joel D, Yankelevitch-Yahav R. 2014. Reconceptualizing sex, brain and psychopathology: Interaction, interaction, interaction. Br J Pharmacol.
66. Katz RJ. 1981. Animal model of depression: Effects of electroconvulsive shock therapy. Neurosci Biobehav Rev 5:273-277.
67. Keen-Rhinehart E, Michopoulos V, Toufexis DJ, Martin EI, Nair H, Ressler KJ, Davis M, Owens MJ, Nemeroff CB,Wilson ME. 2009. Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. Mol Psychiatry 14:37-50.
68. Kelly JP,Wrynn AS, Leonard BE. 1997. The olfactory bulbectomized rat as a model of depression: An update. Pharmacol Ther 74:299-316.
69. Kendler KS, Gardner CO, Prescott CA. 1999. Clinical characteristics of major depression that predict risk of depression in relatives. Arch Gen Psychiatry 56:322-327.
70. Kessler RC. 2003. Epidemiology of women and depression. J Affect Disord 74:5-13.
71. Kinsey SG, Bailey MT, Sheridan JF, Padgett DA. 2008. The inflammatory response to social defeat is increased in older mice. Physiol Behav 93:628-636.
72. Kokras N, Dalla C. 2014. Sex Differences in animal models of psychiatric disorders. Br J Pharmacol. doi:10.1111/bph.12710. Apr 4. [Epub ahead of print]
73. Kokras N, Dalla C, Papadopoulou-Daifoti Z. 2011. Sex differences in pharmacokinetics of antidepressants. Expert Opin Drug Metab Toxicol 7:213-226.
74. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, et al. 2007. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131:391-404.
75. Kronenberg G, Gertz K, Heinz A, Endres M. 2014. Of mice and men- Modeling post-stroke depression experimentally. Br J Pharmacol. doi:10.1111/bph.12775. May 19. [Epub ahead of print]
76. Landgraf R, Kessler MS, Bunck M, Murgatroyd C, Spengler D, Zimbelmann M, Nussbaumer M, Czibere L, Turck CW, Singewald N, et al. 2007. Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I. Neurosci Biobehav Rev 31:89-102.
77. Leonard B, Maes M. 2012. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 36:764-785.
78. Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. 2010. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329:959-964.
79. Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas- Senas L, Wiborg O, Haddjeri N, Pineyro G, et al. 2007. Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 55:712-725.
80. Lucki I. 1997. The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 8:523-532.
81. Maes M. 2008. The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett 29:287-291.
82. Malkesman O, Austin DR, Chen G, Manji HK. 2009. Reverse translational strategies for developing animal models of bipolar disorder. Dis Model Mech 2:238-245.
83. Malkesman O, Scattoni ML, Paredes D, Tragon T, Pearson B, Shaltiel G, Chen G, Crawley JN, Manji HK. 2010. The female urine sniffing test: A novel approach for assessing reward-seeking behavior in rodents. Biol Psychiatry 67:864-871.
84. Markou A, Chiamulera C, Geyer MA, Tricklebank M, Steckler T. 2009. Removing obstacles in neuroscience drug discovery: The future path for animal models. Neuropsychopharmacology 34:74-89.
85. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH. 2005. Deep brain stimulation for treatment-resistant depression. Neuron 45:651-660.
86. McArthur R, Borsini F. 2006. Animal models of depression in drug discovery: A historical perspective. Pharmacol Biochem Behav 84:436-452.
87. McClelland S, Korosi A, Cope J, Ivy A, Baram TZ. 2011. Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem 96:79-88.
88. Michaud CM, Murray CJ, Bloom BR. 2001. Burden of disease-Implications for future research. JAMA 285:535-539.
89. Miller AH, Maletic V, Raison CL. 2009. Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65:732-741.
90. Mnie-Filali O, Faure C, Lambas-Senas L, El Mansari M, Belblidia H, Gondard E, Etievant A, Scarna H, Didier A, Berod A, et al. 2011. Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy. Neuropsychopharmacology 36:1275-1288.
91. Murgatroyd C, Spengler D. 2011. Epigenetic programming of the HPA axis: Early life decides. Stress 14:581-589.
92. Naranjo CA, Tremblay LK, Busto UE. 2001. The role of the brain reward system in depression. Prog Neuropsychopharmacol Biol Psychiatry 25:781-823.
93. Naughton M, Clarke G, OF OL, Cryan JF, Dinan TG. 2014. A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. J Affect Disord 156:24-35.
94. Nelson JC, Mazure CM, Jatlow PI. 1995. Desipramine treatment of major depression in patients over 75 years of age. J Clin Psychopharmacol 15:99-105.
95. Nestler EJ, Hyman SE. 2010. Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161-1169.
96. Neumann ID, Wegener G, Homberg JR, Cohen H, Slattery DA, Zohar J, Olivier JD, Mathe AA. 2011. Animal models of depression and anxiety: What do they tell us about human condition? Prog Neuropsychopharmacol Biol Psychiatry 35:1357-1375.
97. Niciu MJ, Henter ID, Luckenbaugh DA, Zarate CA Jr, Charney DS. 2014. Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: Ketamine and other compounds. Annu Rev Pharmacol Toxicol 54:119-139.
98. Nollet M, Le Guisquet AM, Belzung C. 2013. Models of depression: Unpredictable chronic mild stress in mice. Curr Protoc Pharmacol Chapter 5: Unit 5 65.
99. O'Connor RM, Dinan TG, Cryan JF. 2012. Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression. Mol Psychiatry 17:359-376.
100. O'Connor RM, Grenham S, Dinan TG, Cryan JF. 2013. microRNAs as novel antidepressant targets: Converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus. Int J Neuropsychopharmacol 16:1885-1892.
101. O'Hara MW, McCabe JE. 2013. Postpartum depression: Current status and future directions. Annu Rev Clin Psychol 9:379-407.
102. O'Leary OF, Cryan JF. 2013. Towards translational rodent models of depression. Cell Tissue Res 354:141-153.
103. Opal MD, Klenotich SC, Morais M, Bessa J, Winkle J, Doukas D, Kay LJ, Sousa N, Dulawa SM. 2013. Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Mol Psychiatry. doi:10.1038/ mp.2013.164. Nov 19. [Epub ahead of print]
104. Perani CV, Slattery DA. 2014. Using Animal models to study postpartum psychiatric disorders. Br J Pharmacol. doi:10.1111/bph.12640. Feb 16. [Epub ahead of print]
105. Peters S, Slattery DA, Flor PJ, Neumann ID, Reber SO. 2013. Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice. Addict Biol 18:66-77.
106. Petit-Demouliere B, Chenu F, Bourin M. 2005. Forced swimming test in mice: A review of antidepressant activity. Psychopharmacology (Berl) 177:245-255.
107. Pollak DD, Monje FJ, Zuckerman L, Denny CA, Drew MR, Kandel ER. 2008. An animal model of a behavioral intervention for depression. Neuron 60:149-161.
108. Pollak DD, Rey CE, Monje FJ. 2010. Rodent models in depression research: classical strategies and new directions. Ann Med 42:252-264.
109. Pryce CR, Azzinnari D, Sigrist H, Gschwind T, Lesch KP, Seifritz E. 2012. Establishing a learned-helplessness effect paradigm in C57BL/6 mice: Behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se. Neuropharmacology 62:358-372.
110. Pryce CR, Azzinnari D, Spinelli S, Seifritz E, TegethoffM, Meinlschmidt G. 2011. Helplessness: A systematic translational review of theory and evidence for its relevance to understanding and treating depression. Pharmacol Ther 132:242-267.
111. Pryce CR, Feldon J. 2003. Long-term neurobehavioural impact of the postnatal environment in rats: Manipulations, effects and mediating mechanisms. Neurosci Biobehav Rev 27:57-71.
112. Pryce CR, Seifritz E. 2011. A translational research framework for enhanced validity of mouse models of psychopathological states in depression. Psychoneuroendocrinology 36:308-329.
113. Reber SO. 2012. Stress and animal models of inflammatory bowel disease- An update on the role of the hypothalamo-pituitary-adrenal axis. Psychoneuroendocrinology 37:1-19.
114. Reber SO, Birkeneder L, Veenema AH, Obermeier F, Falk W, Straub RH, Neumann ID. 2007. Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: Implications and mechanisms. Endocrinology 148:670-682.
115. Reber SO, Obermeier F, Straub RH, Falk W, Neumann ID. 2006. Chronic intermittent psychosocial stress (social defeat/overcrowding) in mice increases the severity of an acute DSS-induced colitis and impairs regeneration. Endocrinology 147:4968-4976.
116. Richter SH, Schick A, Hoyer C, Lankisch K, Gass P, Vollmayr B. 2012. A glass full of optimism: Enrichment effects on cognitive bias in a rat model of depression. Cogn Affect Behav Neurosci 12:527-542.
117. Romeas T, Morissette MC, Mnie-Filali O, Pineyro G, Boye SM. 2009. Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression. Psychopharmacology (Berl) 205:293-303.
118. Roose SP, Glassman AH, Attia E,Woodring S. 1994. Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia. Am J Psychiatry 151:1735-1739.
119. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, et al. 2007. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A 104:6406-6411.
120. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S,Weisstaub N, Lee J, Duman R, Arancio O, et al. 2003. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
121. Saul MC, Gessay GM, Gammie SC. 2012. A new mouse model for mania shares genetic correlates with human bipolar disorder. PLoS One 7: e38128.
122. Shaw AC, Goldstein DR, Montgomery RR. 2013. Age-dependent dysregulation of innate immunity. Nat Rev Immunol 13:875-887.
123. Slattery DA, Cryan JF. 2006. The role of GABAB receptors in depression and antidepressant-related behavioural responses. Drug Dev Res 67:477-494.
124. Slattery DA, Cryan JF. 2011. Animal models of depression - Where are we going? In: Cryan JF, Leonard BE, editors. Depression: From Psychopathology to Pharmacotherapy. Basel: S. Karger A.G.
125. Slattery DA, Cryan JF. 2012. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc 7:1009-1014.
126. Slattery DA, Markou A, Cryan JF. 2007. Evaluation of reward processes in an animal model of depression. Psychopharmacology (Berl) 190:555-568.
127. Slattery DA, Neumann ID, Cryan JF. 2011. Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat. J Psychopharmacol 25:1295-1303.
128. Slattery DA, Uschold N, Magoni M, Bar J, Popoli M, Neumann ID, Reber SO. 2012. Behavioural consequences of two chronic psychosocial stress paradigms: Anxiety without depression. Psychoneuroendocrinology 37:702-714.
129. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA. 2011. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:458-461.
130. Song C, Leonard BE. 2005. The olfactory bulbectomised rat as a model of depression. Neurosci Biobehav Rev 29:627-647.
131. Stuart SA, Butler P, Munafo MR, Nutt DJ, Robinson ES. 2013. A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38:1625-1635.
132. Szabo ST, Machado-Vieira R, Yuan P, Wang Y, Wei Y, Falke C, Cirelli C, Tononi G, Manji HK, Du J. 2009. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology 56:47-55.
133. Tanti A, Belzung C. 2010. Open questions in current models of antidepressant action. Br J Pharmacol 159:1187-1200.
134. Tremblay LK, Naranjo CA, Cardenas L, Herrmann N, Busto UE. 2002. Probing brain reward system function in major depressive disorder: Altered response to dextroamphetamine. Arch Gen Psychiatry 59:409-416.
135. Tremblay LK, Naranjo CA, Graham SJ, Herrmann N, Mayberg HS, Hevenor S, Busto UE. 2005. Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch Gen Psychiatry 62:1228-1236.
136. Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, et al. 2013. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493:537-541.
137. van der Stelt HM, Breuer ME, Olivier B, Westenberg HG. 2005. Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: An in vivo microdialysis study. Biol Psychiatry 57:1061-1067.
138. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, et al. 2011. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477:90-94.
139. Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K. 2012. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature 492:428-432.
140. Wong ML, Dong C, Andreev V, Arcos-Burgos M, Licinio J. 2012. Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. Mol Psychiatry 17:624-633.
141. Wong ML, Licinio J. 2001. Research and treatment approaches to depression. Nat Rev Neurosci 2:343-351.
142. Young JW, Henry BL, Geyer MA. 2011. Predictive animal models of mania: Hits, misses and future directions. Br J Pharmacol 164: 1263-1284.
143. Zarate CA Jr, Mathews D, Ibrahim L, Chaves JF, Marquardt C, Ukoh I, Jolkovsky L, Brutsche NE, Smith MA, Luckenbaugh DA. 2013a. A randomized trial of a low-trapping nonselective N-methyl- D-aspartate channel blocker in major depression. Biol Psychiatry 74:257-264.
144. Zarate CA Jr, Mathews DC, Furey ML. 2013b. Human biomarkers of rapid antidepressant effects. Biol Psychiatry 73:1142-1155.
145. Zarate CA Jr, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK. 2006. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63:856-864.