-
1
-
-
77349122303
-
Protein kinase C: Poised to signal
-
CrossRef PubMed
-
Newton, A.C. (2010) Protein kinase C: poised to signal. Am. J. Physiol. Endocrinol. Metab. 298, E395-E402 CrossRef PubMed
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
, pp. E395-E402
-
-
Newton, A.C.1
-
2
-
-
0027418818
-
Molecular cloning and characterization of PKCθ, a novel member of the protein kinase C gene family expressed predominantly in hematopoietic cells
-
PubMed
-
Baier, G., Telford, D., Giampa, L., Coggeshall, K.M., Baier-Bitterlich, G., Isakov, N. and Altman, A. (1993) Molecular cloning and characterization of PKCθ, a novel member of the protein kinase C gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268, 4997-5004 PubMed
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4997-5004
-
-
Baier, G.1
Telford, D.2
Giampa, L.3
Coggeshall, K.M.4
Baier-Bitterlich, G.5
Isakov, N.6
Altman, A.7
-
3
-
-
84877112053
-
In and out of the bull's eye: Protein kinase Cs in the immunological synapse
-
CrossRef PubMed
-
Kong, K.-F. and Altman, A. (2013) In and out of the bull's eye: protein kinase Cs in the immunological synapse. Trends Immunol. 34, 234-242 CrossRef PubMed
-
(2013)
Trends Immunol.
, vol.34
, pp. 234-242
-
-
Kong, K.-F.1
Altman, A.2
-
4
-
-
84870545526
-
PKCθ-mediated signal delivery from the TCR/CD28 surface receptors
-
CrossRef PubMed
-
Isakov, N. and Altman, A. (2012) PKCθ-mediated signal delivery from the TCR/CD28 surface receptors. Front. Immunol. 3, 273 CrossRef PubMed
-
(2012)
Front. Immunol.
, vol.3
, pp. 273
-
-
Isakov, N.1
Altman, A.2
-
5
-
-
1642299050
-
PKCθ signals activation versus tolerance in vivo
-
CrossRef PubMed
-
Berg-Brown, N.N., Gronski, M.A., Jones, R.G., Elford, A.R., Deenick, E.K., Odermatt, B., Littman, D.R. and Ohashi, P.S. (2004) PKCθ signals activation versus tolerance in vivo. J. Exp. Med. 199, 743-752 CrossRef PubMed
-
(2004)
J. Exp. Med.
, vol.199
, pp. 743-752
-
-
Berg-Brown, N.N.1
Gronski, M.A.2
Jones, R.G.3
Elford, A.R.4
Deenick, E.K.5
Odermatt, B.6
Littman, D.R.7
Ohashi, P.S.8
-
6
-
-
80054895503
-
A motif in the V3 domain of the kinase PKCθ determines its localization in the immunological synapse and functions in T cells via association with CD28
-
CrossRef PubMed
-
Kong, K.F., Yokosuka, T., Canonigo-Balancio, A.J., Isakov, N., Saito, T. and Altman, A. (2011) A motif in the V3 domain of the kinase PKCθ determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat. Immunol. 12, 1105-1112 CrossRef PubMed
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1105-1112
-
-
Kong, K.F.1
Yokosuka, T.2
Canonigo-Balancio, A.J.3
Isakov, N.4
Saito, T.5
Altman, A.6
-
7
-
-
18844473151
-
PKCθ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
-
CrossRef PubMed
-
Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L. et al. (2000) PKCθ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404, 402-407 CrossRef PubMed
-
(2000)
Nature
, vol.404
, pp. 402-407
-
-
Sun, Z.1
Arendt, C.W.2
Ellmeier, W.3
Schaeffer, E.M.4
Sunshine, M.J.5
Gandhi, L.6
Annes, J.7
Petrzilka, D.8
Kupfer, A.9
Schwartzberg, P.L.10
-
8
-
-
0038620475
-
Protein kinase C θ affects Ca2+ mobilization and NFAT activation in primary mouse T cells
-
CrossRef PubMed
-
Pfeifhofer, C., Kofler, K., Gruber, T., Tabrizi, N.G., Lutz, C., Maly, K., Leitges, M. and Baier, G. (2003) Protein kinase C θ affects Ca2+ mobilization and NFAT activation in primary mouse T cells. J. Exp. Med. 197, 1525-1535 CrossRef PubMed
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1525-1535
-
-
Pfeifhofer, C.1
Kofler, K.2
Gruber, T.3
Tabrizi, N.G.4
Lutz, C.5
Maly, K.6
Leitges, M.7
Baier, G.8
-
9
-
-
18944383647
-
A diacylglycerol-PKC-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells
-
CrossRef PubMed
-
Roose, J.P., Mollenauer, M., Gupta, V.A., Stone, J. and Weiss, A. (2005) A diacylglycerol-PKC-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol. Cell. Biol. 25, 4426-4441 CrossRef PubMed
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 4426-4441
-
-
Roose, J.P.1
Mollenauer, M.2
Gupta, V.A.3
Stone, J.4
Weiss, A.5
-
10
-
-
48749103031
-
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity
-
CrossRef PubMed
-
Hermann-Kleiter, N., Gruber, T., Lutz-Nicoladoni, C., Thuille, N., Fresser, F., Labi, V., Schiefermeier, N., Warnecke, M., Huber, L., Villunger, A. et al. (2008) The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity 29, 205-216 CrossRef PubMed
-
(2008)
Immunity
, vol.29
, pp. 205-216
-
-
Hermann-Kleiter, N.1
Gruber, T.2
Lutz-Nicoladoni, C.3
Thuille, N.4
Fresser, F.5
Labi, V.6
Schiefermeier, N.7
Warnecke, M.8
Huber, L.9
Villunger, A.10
-
11
-
-
70349576538
-
PKCθ modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation
-
CrossRef PubMed
-
Gruber, T., Hermann-Kleiter, N., Hinterleitner, R., Fresser, F., Schneider, R., Gastl, G., Penninger, J. M. and Baier, G. (2009) PKCθ modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci. Signal. 2, ra30 CrossRef PubMed
-
(2009)
Sci. Signal.
, vol.2
, pp. ra30
-
-
Gruber, T.1
Hermann-Kleiter, N.2
Hinterleitner, R.3
Fresser, F.4
Schneider, R.5
Gastl, G.6
Penninger, J.M.7
Baier, G.8
-
12
-
-
58749114028
-
Loss of protein kinase C θ, Bcl10, or Malt1 selectively impairs proliferation and NF-κB activation in the CD4+ T cell subset
-
CrossRef PubMed
-
Kingeter, L.M. and Schaefer, B.C. (2008) Loss of protein kinase C θ, Bcl10, or Malt1 selectively impairs proliferation and NF-κB activation in the CD4+ T cell subset. J. Immunol. 181, 6244-6254 CrossRef PubMed
-
(2008)
J. Immunol.
, vol.181
, pp. 6244-6254
-
-
Kingeter, L.M.1
Schaefer, B.C.2
-
13
-
-
41149167494
-
T cell fate and function: PKCθ and beyond
-
CrossRef PubMed
-
Marsland, B.J. and Kopf, M. (2008) T cell fate and function: PKCθ and beyond. Trends Immunol. 29, 179-185 CrossRef PubMed
-
(2008)
Trends Immunol.
, vol.29
, pp. 179-185
-
-
Marsland, B.J.1
Kopf, M.2
-
15
-
-
33845589222
-
Involvement of GATA3 in PKCθ-induced Th2 cytokine expression
-
CrossRef PubMed
-
Stevens, L., Htut, T.M., White, D., Li, X., Hanidu, A., Stearns, C., Labadia, M.E., Li, J., Brown, M. and Yang, J. (2006) Involvement of GATA3 in PKCθ-induced Th2 cytokine expression. Eur. J. Immunol. 36, 3305-3314 CrossRef PubMed
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 3305-3314
-
-
Stevens, L.1
Htut, T.M.2
White, D.3
Li, X.4
Hanidu, A.5
Stearns, C.6
Labadia, M.E.7
Li, J.8
Brown, M.9
Yang, J.10
-
16
-
-
3242790172
-
PKCθ is critical for the development of in vivo Th2 cell but not Th1 cell responses
-
CrossRef PubMed
-
Marsland, B.J., Soos, T.J., Späth, G., Littman, D.R. and Kopf, M. (2004) PKCθ is critical for the development of in vivo Th2 cell but not Th1 cell responses. J. Exp. Med. 200, 181-189 CrossRef PubMed
-
(2004)
J. Exp. Med.
, vol.200
, pp. 181-189
-
-
Marsland, B.J.1
Soos, T.J.2
Späth, G.3
Littman, D.R.4
Kopf, M.5
-
17
-
-
77955285003
-
Protective Toxoplasma gondii-specific T cell responses require T cell-specific expression of PKCθ
-
CrossRef PubMed
-
Nishanth, G., Sakowicz-Burkiewicz, M., Händel, U., Kliche, S., Wang, X., Naumann, M., Deckert, M. and Schlüter, D. (2010) Protective Toxoplasma gondii-specific T cell responses require T cell-specific expression of PKCθ. Infect. Immun. 78, 3454-3464 CrossRef PubMed
-
(2010)
Infect. Immun.
, vol.78
, pp. 3454-3464
-
-
Nishanth, G.1
Sakowicz-Burkiewicz, M.2
Händel, U.3
Kliche, S.4
Wang, X.5
Naumann, M.6
Deckert, M.7
Schlüter, D.8
-
18
-
-
26444476013
-
Innate signals compensate for the absence of PKCθ during in vivo CD8+ T cell effector and memory responses
-
CrossRef PubMed
-
Marsland, B.J., Nembrini, C., Schmitz, N., Abel, B., Krautwald, S., Bachmann, M.F. and Kopf, M. (2005) Innate signals compensate for the absence of PKCθ during in vivo CD8+ T cell effector and memory responses. Proc. Natl. Acad. Sci. U.S.A. 102, 14374-14379 CrossRef PubMed
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 14374-14379
-
-
Marsland, B.J.1
Nembrini, C.2
Schmitz, N.3
Abel, B.4
Krautwald, S.5
Bachmann, M.F.6
Kopf, M.7
-
19
-
-
79251528221
-
PKCθ is required for development of experimental cerebral malaria
-
CrossRef PubMed
-
Fauconnier, M., Bourigault, M.-L., Meme, S., Szeremeta, F., Palomo, J., Danneels, A., Charron, S., Fick, L., Jacobs, M., Beloeil, J.-C. et al. (2011) PKCθ is required for development of experimental cerebral malaria. Am. J. Pathol. 178, 212-221 CrossRef PubMed
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 212-221
-
-
Fauconnier, M.1
Bourigault, M.-L.2
Meme, S.3
Szeremeta, F.4
Palomo, J.5
Danneels, A.6
Charron, S.7
Fick, L.8
Jacobs, M.9
Beloeil, J.-C.10
-
20
-
-
84900535626
-
Inhibition of PKCθ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
-
PubMed
-
Li, Z., Abdullah, C.S. and Jin, Z.-Q. (2014) Inhibition of PKCθ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy. Br. J. Pharmacol. 171, 2913-2924 PubMed
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 2913-2924
-
-
Li, Z.1
Abdullah, C.S.2
Jin, Z.-Q.3
-
21
-
-
84856850591
-
PKCθ ablation improves healing in a mouse model of muscular dystrophy
-
CrossRef PubMed
-
Madaro, L., Pelle, A., Nicoletti, C., Crupi, A., Marrocco, V., Bossi, G., Soddu, S. and Bouché , M. (2012) PKCθ ablation improves healing in a mouse model of muscular dystrophy. PLoS ONE 7, e31515 CrossRef PubMed
-
(2012)
PLoS ONE
, vol.7
, pp. e31515
-
-
Madaro, L.1
Pelle, A.2
Nicoletti, C.3
Crupi, A.4
Marrocco, V.5
Bossi, G.6
Soddu, S.7
Bouché, M.8
-
22
-
-
47949130474
-
A critical role for PKCθ-mediated T cell survival in cardiac allograft rejection
-
CrossRef PubMed
-
Manicassamy, S., Yin, D., Zhang, Z., Molinero, L.L., Alegre, M.-L. and Sun, Z. (2008) A critical role for PKCθ-mediated T cell survival in cardiac allograft rejection. J. Immunol. 181, 513-520 CrossRef PubMed
-
(2008)
J. Immunol.
, vol.181
, pp. 513-520
-
-
Manicassamy, S.1
Yin, D.2
Zhang, Z.3
Molinero, L.L.4
Alegre, M.-L.5
Sun, Z.6
-
23
-
-
67349256328
-
PKCθ cooperates with PKCα in alloimmune responses of T cells in vivo
-
CrossRef PubMed
-
Gruber, T., Hermann-Kleiter, N., Pfeifhofer-Obermair, C., Lutz-Nicoladoni, C., Thuille, N., Letschka, T., Barsig, J., Baudler, M., Li, J., Metzler, B. et al. (2009) PKCθ cooperates with PKCα in alloimmune responses of T cells in vivo. Mol. Immunol. 46, 2071-2079 CrossRef PubMed
-
(2009)
Mol. Immunol.
, vol.46
, pp. 2071-2079
-
-
Gruber, T.1
Hermann-Kleiter, N.2
Pfeifhofer-Obermair, C.3
Lutz-Nicoladoni, C.4
Thuille, N.5
Letschka, T.6
Barsig, J.7
Baudler, M.8
Li, J.9
Metzler, B.10
-
24
-
-
72849123229
-
PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice
-
CrossRef PubMed
-
Valenzuela, J.O., Iclozan, C., Hossain, M.S., Prlic, M., Hopewell, E., Bronk, C.C., Wang, J., Celis, E., Engelman, R.W., Blazar, B.R. et al. (2009) PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J. Clin. Invest. 119, 3774-3786 CrossRef PubMed
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3774-3786
-
-
Valenzuela, J.O.1
Iclozan, C.2
Hossain, M.S.3
Prlic, M.4
Hopewell, E.5
Bronk, C.C.6
Wang, J.7
Celis, E.8
Engelman, R.W.9
Blazar, B.R.10
-
25
-
-
84887761550
-
Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice
-
CrossRef PubMed
-
Haarberg, K.M.K., Li, J., Heinrichs, J., Wang, D., Liu, C., Bronk, C.C., Kaosaard, K., Owyang, A.M., Holland, S., Masuda, E. et al. (2013) Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. Blood 122, 2500-2511 CrossRef PubMed
-
(2013)
Blood
, vol.122
, pp. 2500-2511
-
-
Haarberg, K.M.K.1
Li, J.2
Heinrichs, J.3
Wang, D.4
Liu, C.5
Bronk, C.C.6
Kaosaard, K.7
Owyang, A.M.8
Holland, S.9
Masuda, E.10
-
26
-
-
44749089787
-
Impaired anti-leukemic immune response in PKCθ-deficient mice
-
CrossRef PubMed
-
Garaude, J., Kaminski, S., Charni, S., Aguilò, J.I., Jacquet, C., Plays, M., Hernandez, J., Rodriguez, F., Hipskind, R.A., Anel, A. et al. (2008) Impaired anti-leukemic immune response in PKCθ-deficient mice. Mol. Immunol. 45, 3463-3469 CrossRef PubMed
-
(2008)
Mol. Immunol.
, vol.45
, pp. 3463-3469
-
-
Garaude, J.1
Kaminski, S.2
Charni, S.3
Aguilò, J.I.4
Jacquet, C.5
Plays, M.6
Hernandez, J.7
Rodriguez, F.8
Hipskind, R.A.9
Anel, A.10
-
27
-
-
84869238945
-
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKCθ and reactive oxygen species
-
CrossRef PubMed
-
Giambra, V., Jenkins, C.R., Wang, H., Lam, S.H., Shevchuk, O.O., Nemirovsky, O., Wai, C., Gusscott, S., Chiang, M.Y., Aster, J.C. et al. (2012) NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKCθ and reactive oxygen species. Nat. Med. 18, 1693-1698 CrossRef PubMed
-
(2012)
Nat. Med.
, vol.18
, pp. 1693-1698
-
-
Giambra, V.1
Jenkins, C.R.2
Wang, H.3
Lam, S.H.4
Shevchuk, O.O.5
Nemirovsky, O.6
Wai, C.7
Gusscott, S.8
Chiang, M.Y.9
Aster, J.C.10
-
28
-
-
38649118188
-
Protein kinase C θ plays a fundamental role in different types of chronic colitis
-
CrossRef PubMed
-
Nagahama, K., Ogawa, A., Shirane, K., Shimomura, Y., Sugimoto, K. and Mizoguchi, A. (2008) Protein kinase C θ plays a fundamental role in different types of chronic colitis. Gastroenterology 134, 459-469 CrossRef PubMed
-
(2008)
Gastroenterology
, vol.134
, pp. 459-469
-
-
Nagahama, K.1
Ogawa, A.2
Shirane, K.3
Shimomura, Y.4
Sugimoto, K.5
Mizoguchi, A.6
-
29
-
-
33746210212
-
PKCθ-deficient mice are protected from Th1-dependent antigen-induced arthritis
-
CrossRef PubMed
-
Healy, A.M., Izmailova, E., Fitzgerald, M., Walker, R., Hattersley, M., Silva, M., Siebert, E., Terkelsen, J., Picarella, D., Pickard, M.D. et al. (2006) PKCθ-deficient mice are protected from Th1-dependent antigen-induced arthritis. J. Immunol. 177, 1886-1893 CrossRef PubMed
-
(2006)
J. Immunol.
, vol.177
, pp. 1886-1893
-
-
Healy, A.M.1
Izmailova, E.2
Fitzgerald, M.3
Walker, R.4
Hattersley, M.5
Silva, M.6
Siebert, E.7
Terkelsen, J.8
Picarella, D.9
Pickard, M.D.10
-
30
-
-
28244464872
-
PKCθ controls Th1 cells in experimental autoimmune encephalomyelitis
-
CrossRef PubMed
-
Salek-Ardakani, S., So, T., Halteman, B.S., Altman, A. and Croft, M. (2005) PKCθ controls Th1 cells in experimental autoimmune encephalomyelitis. J. Immunol. 175, 7635-7641 CrossRef PubMed
-
(2005)
J. Immunol.
, vol.175
, pp. 7635-7641
-
-
Salek-Ardakani, S.1
So, T.2
Halteman, B.S.3
Altman, A.4
Croft, M.5
-
31
-
-
33644512418
-
Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in PKCθ-deficient mice
-
CrossRef PubMed
-
Tan, S.-L., Zhao, J., Bi, C., Chen, X.C., Hepburn, D.L., Wang, J., Sedgwick, J.D., Chintalacharuvu, S.R. and Na, S. (2006) Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in PKCθ-deficient mice. J. Immunol. 176, 2872-2879 CrossRef PubMed
-
(2006)
J. Immunol.
, vol.176
, pp. 2872-2879
-
-
Tan, S.-L.1
Zhao, J.2
Bi, C.3
Chen, X.C.4
Hepburn, D.L.5
Wang, J.6
Sedgwick, J.D.7
Chintalacharuvu, S.R.8
Na, S.9
-
32
-
-
84862622067
-
PKCθ promotes Th17 differentiation via upregulation of Stat3
-
CrossRef PubMed
-
Kwon, M.-J., Ma, J., Ding, Y., Wang, R. and Sun, Z. (2012) PKCθ promotes Th17 differentiation via upregulation of Stat3. J. Immunol. 188, 5887-5897 CrossRef PubMed
-
(2012)
J. Immunol.
, vol.188
, pp. 5887-5897
-
-
Kwon, M.-J.1
Ma, J.2
Ding, Y.3
Wang, R.4
Sun, Z.5
-
33
-
-
84900441078
-
PKCθ regulates the phenotype of murine CD4+ Th17 cells
-
CrossRef PubMed
-
Wachowicz, K., Hermann-Kleiter, N., Meisel, M., Siegmund, K., Thuille, N. and Baier, G. (2014) PKCθ regulates the phenotype of murine CD4+ Th17 cells. PLoS ONE 9, e96401 CrossRef PubMed
-
(2014)
PLoS ONE
, vol.9
, pp. e96401
-
-
Wachowicz, K.1
Hermann-Kleiter, N.2
Meisel, M.3
Siegmund, K.4
Thuille, N.5
Baier, G.6
-
34
-
-
53549088614
-
Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice
-
CrossRef PubMed
-
Masocha, W., Amin, D.N., Kristensson, K. and Rottenberg, M.E. (2008) Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice. Scand. J. Immunol. 68, 484-491 CrossRef PubMed
-
(2008)
Scand. J. Immunol.
, vol.68
, pp. 484-491
-
-
Masocha, W.1
Amin, D.N.2
Kristensson, K.3
Rottenberg, M.E.4
-
35
-
-
64149122243
-
PKC inhibitors: Potential in T cell-dependent immune diseases
-
CrossRef PubMed
-
Baier, G. and Wagner, J. (2009) PKC inhibitors: potential in T cell-dependent immune diseases. Curr. Opin. Cell Biol. 21, 262-267 CrossRef PubMed
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 262-267
-
-
Baier, G.1
Wagner, J.2
-
36
-
-
40449089827
-
Differential regulation of central nervous system autoimmunity by Th1 and Th17 cells
-
CrossRef PubMed
-
Stromnes, I.M., Cerretti, L.M., Liggitt, D., Harris, R.A. and Goverman, J.M. (2008) Differential regulation of central nervous system autoimmunity by Th1 and Th17 cells. Nat. Med. 14, 337-342 CrossRef PubMed
-
(2008)
Nat. Med.
, vol.14
, pp. 337-342
-
-
Stromnes, I.M.1
Cerretti, L.M.2
Liggitt, D.3
Harris, R.A.4
Goverman, J.M.5
-
37
-
-
70349736116
-
Cross-regulation of signaling pathways by IFN-γ: Implications for immune responses and autoimmune diseases
-
CrossRef PubMed
-
Hu, X. and Ivashkiv, L.B. (2009) Cross-regulation of signaling pathways by IFN-γ: implications for immune responses and autoimmune diseases. Immunity 31, 539-550 CrossRef PubMed
-
(2009)
Immunity
, vol.31
, pp. 539-550
-
-
Hu, X.1
Ivashkiv, L.B.2
-
38
-
-
60549086638
-
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
-
CrossRef PubMed
-
Martin-Orozco, N., Chung, Y., Chang, S.H., Wang, Y.-H. and Dong, C. (2009) Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur. J. Immunol. 39, 216-224 CrossRef PubMed
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 216-224
-
-
Martin-Orozco, N.1
Chung, Y.2
Chang, S.H.3
Wang, Y.-H.4
Dong, C.5
-
39
-
-
84878392088
-
Essentials of Th17 cell commitment and plasticity
-
CrossRef PubMed
-
Muranski, P. and Restifo, N.P. (2013) Essentials of Th17 cell commitment and plasticity. Blood 121, 2402-2414 CrossRef PubMed
-
(2013)
Blood
, vol.121
, pp. 2402-2414
-
-
Muranski, P.1
Restifo, N.P.2
-
40
-
-
78649603873
-
Genetic proof for the transient nature of the Th17 phenotype
-
CrossRef PubMed
-
Kurschus, F.C., Croxford, A.L., Heinen, A.P., Wörtge, S., Ielo, D. and Waisman, A. (2010) Genetic proof for the transient nature of the Th17 phenotype. Eur. J. Immunol. 40, 3336-3346 CrossRef PubMed
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 3336-3346
-
-
Kurschus, F.C.1
Croxford, A.L.2
Heinen, A.P.3
Wörtge, S.4
Ielo, D.5
Waisman, A.6
-
41
-
-
84873696767
-
Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T-helper cell subsets
-
CrossRef PubMed
-
Yamane, H. and Paul, W.E. (2013) Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T-helper cell subsets. Immunol. Rev. 252, 12-23 CrossRef PubMed
-
(2013)
Immunol. Rev.
, vol.252
, pp. 12-23
-
-
Yamane, H.1
Paul, W.E.2
-
42
-
-
78649693010
-
Low-strength T cell activation promotes Th17 responses
-
CrossRef PubMed
-
Purvis, H.A., Stoop, J.N., Mann, J., Woods, S., Kozijn, A.E., Hambleton, S., Robinson, J.H., Isaacs, J.D., Anderson, A.E. and Hilkens, C.M.U. (2010) Low-strength T cell activation promotes Th17 responses. Blood 116, 4829-4837 CrossRef PubMed
-
(2010)
Blood
, vol.116
, pp. 4829-4837
-
-
Purvis, H.A.1
Stoop, J.N.2
Mann, J.3
Woods, S.4
Kozijn, A.E.5
Hambleton, S.6
Robinson, J.H.7
Isaacs, J.D.8
Anderson, A.E.9
Hilkens, C.M.U.10
-
43
-
-
84856628204
-
Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation
-
CrossRef PubMed
-
Yoshida, H., Kimura, A., Fukaya, T., Sekiya, T., Morita, R., Shichita, T., Inoue, H. and Yoshimura, A. (2012) Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. Biochem. Biophys. Res. Commun. 418, 234-240 CrossRef PubMed
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.418
, pp. 234-240
-
-
Yoshida, H.1
Kimura, A.2
Fukaya, T.3
Sekiya, T.4
Morita, R.5
Shichita, T.6
Inoue, H.7
Yoshimura, A.8
-
44
-
-
10344239898
-
Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand
-
CrossRef PubMed
-
Singh, R.A.K. and Zhang, J.Z. (2004) Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. J. Immunol. 173, 7299-7307 CrossRef PubMed
-
(2004)
J. Immunol.
, vol.173
, pp. 7299-7307
-
-
Singh, R.A.K.1
Zhang, J.Z.2
-
45
-
-
84872815448
-
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses
-
CrossRef PubMed
-
Meisel, M., Hermann-Kleiter, N., Hinterleitner, R., Gruber, T., Wachowicz, K., Pfeifhofer-Obermair, C., Fresser, F., Leitges, M., Soldani, C., Viola, A. et al. (2013) The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses. Immunity 38, 41-52 CrossRef PubMed
-
(2013)
Immunity
, vol.38
, pp. 41-52
-
-
Meisel, M.1
Hermann-Kleiter, N.2
Hinterleitner, R.3
Gruber, T.4
Wachowicz, K.5
Pfeifhofer-Obermair, C.6
Fresser, F.7
Leitges, M.8
Soldani, C.9
Viola, A.10
-
46
-
-
54349086262
-
Differential requirement of PKCθ in the development and function of natural regulatory T cells
-
CrossRef PubMed
-
Gupta, S., Manicassamy, S., Vasu, C., Kumar, A., Shang, W. and Sun, Z. (2008) Differential requirement of PKCθ in the development and function of natural regulatory T cells. Mol. Immunol. 46, 213-224 CrossRef PubMed
-
(2008)
Mol. Immunol.
, vol.46
, pp. 213-224
-
-
Gupta, S.1
Manicassamy, S.2
Vasu, C.3
Kumar, A.4
Shang, W.5
Sun, Z.6
-
47
-
-
84862072065
-
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway
-
CrossRef PubMed
-
Ma, J., Ding, Y., Fang, X., Wang, R. and Sun, Z. (2012) Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway. J. Immunol. 188, 5337-5347 CrossRef PubMed
-
(2012)
J. Immunol.
, vol.188
, pp. 5337-5347
-
-
Ma, J.1
Ding, Y.2
Fang, X.3
Wang, R.4
Sun, Z.5
-
48
-
-
77951158406
-
PKCθ mediates negative feedback on regulatory T cell function
-
CrossRef PubMed
-
Zanin-Zhorov, A., Ding, Y., Kumari, S., Attur, M., Hippen, K.L., Brown, M., Blazar, B.R., Abramson, S.B., Lafaille, J.J. and Dustin, M.L. (2010) PKCθ mediates negative feedback on regulatory T cell function. Science 328, 372-376 CrossRef PubMed
-
(2010)
Science
, vol.328
, pp. 372-376
-
-
Zanin-Zhorov, A.1
Ding, Y.2
Kumari, S.3
Attur, M.4
Hippen, K.L.5
Brown, M.6
Blazar, B.R.7
Abramson, S.B.8
Lafaille, J.J.9
Dustin, M.L.10
-
49
-
-
84874263059
-
PKCθ in natural killer cell function and anti-tumor immunity
-
CrossRef PubMed
-
Anel, A., Aguiló , J.I., Catalá n, E., Garaude, J., Rathore, M.G., Pardo, J. and Villalba, M. (2012) PKCθ in natural killer cell function and anti-tumor immunity. Front. Immunol. 3, 187 CrossRef PubMed
-
(2012)
Front. Immunol.
, vol.3
, pp. 187
-
-
Anel, A.1
Aguiló, J.I.2
Catalán, E.3
Garaude, J.4
Rathore, M.G.5
Pardo, J.6
Villalba, M.7
-
50
-
-
84876085816
-
TNFα alter cholesterol metabolism in human macrophages via PKCθ-dependent pathway
-
CrossRef PubMed
-
Ma, A.Z.S., Zhang, Q. and Song, Z.Y. (2013) TNFα alter cholesterol metabolism in human macrophages via PKCθ-dependent pathway. BMC Biochem. 14, 20 CrossRef PubMed
-
(2013)
BMC Biochem.
, vol.14
, pp. 20
-
-
Ma, A.Z.S.1
Zhang, Q.2
Song, Z.Y.3
|