Expression of endoplasmic reticulum stress markers GRP78 and CHOP induced by oxidative stress in blue light-mediated damage of A2E-containing retinal pigment epithelium cells

Ophthalmic Research

Volumn 52, Issue 4, 2014, Pages 224-233

  Feng, Jingyang ^a   Chen, Xunjie ^a   Sun, Xiangjun ^a   Wang, Fenghua ^a,b   Sun, Xiaodong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Key Laboratory of Fundus Disease   (China)

Author keywords

Endoplasmic reticulum stress; Glucose related protein 78; N retinylidene N retinylethanolamine; Oxidative stress; Retinal pigment epithelium

Indexed keywords

ACETYLCYSTEINE; AGE RELATED LIPOFUSCIN N RETINYLIDENE N RETINYLETHANOLAMINE; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYDROETHIDINE; LIPOFUSCIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; A2-E (N-RETINYLIDENE-N-RETINYLETHANOLAMINE); BIOLOGICAL MARKER; DDIT3 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; RETINOID;

ADULT; ARTICLE; BLUE LIGHT; CELL DAMAGE; CELL PROLIFERATION ASSAY; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ILLUMINATION; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION; CELL LINE; CELL SURVIVAL; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; LIGHT; METABOLISM; PHYSIOLOGY; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS; HUMANS; LIGHT; MICROSCOPY, CONFOCAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; RETINOIDS; RNA, MESSENGER; TRANSCRIPTION FACTOR CHOP; TRANSFECTION;

EID: 84911481189     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000363387     Document Type: Article

References (42)

1. Gordois A, Cutler H, Pezzullo L, Gordon K, Cruess A, Winyard S, Hamilton W, Chua K: An estimation of the worldwide economic and health burden of visual impairment. Glob Public Health 2012; 7: 465-481.
2. Jager RD, Mieler WF, Miller JW: Age-related macular degeneration. N Engl J Med 2008; 358: 2606-2617.
3. Ambati J, Ambati BK, Yoo SH, Lanchulev S, Adamis AP: Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 2005; 48: 257-293.
4. Holz FG, Bellman C, Staudt S, Schütt F, Völcker HE: Fundus autofluorescence and development of geographic atrophy in agerelated macular degeneration. Invest Ophthalmol Vis Sci 2001; 42: 1051-1056.
5. Von Rückmann A, Fitzke FW, Bird AC: Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 1997; 38: 478-486.
6. Young RW: Solar radiation and age-related macular degeneration: Surv Ophthalmol 1998; 32: 252-269.
7. Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J: Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci U S A 1998; 95: 14609-14613.
8. Sparrow JR, Nakanishi K, Parish CA: The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2000; 41: 1981-1989.
9. Wu Y, Yanase E, Feng X, Siegel MM, Sparrow JR: Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc Natl Acad Sci U S A 2010; 16: 7275-7280.
10. Jarrett SG, Boulton ME: Consequences of oxidative stress in age-related macular degeneration. Mol Aspects Med 2012; 33: 399-417.
11. Ding X, Patel M, Chan CC: Molecular pathology of age-related macular degeneration. Prog Retin Eye Res 2009; 28: 1-18.
12. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP: Oxidative damage and protection of the RPE. Prog Retin Eye Res 2000; 19: 205-221.
13. Khandhadia S, Lotery A: Oxidation and agerelated macular degeneration: insights from molecular biology. Expert Rev Mol Med 2010; 12: 1-28.
14. Margrain TH, Boulton M, Marshall J, Sliney DH: Do blue light filters confer protection against age-related macular degeneration? Prog Retin Eye Res 2004; 23: 523-531.
15. Golden TR, Melov S: Mitochondrial DNA mutations, oxidative stress, and aging. Mech Ageing Dev 2001; 122: 1577-1589.
16. Higa A, Chevet E: Redox signaling loops in the unfolded protein response. Cell Signal 2012; 24: 1548-1555.
17. Zhang K, Kaufman RJ: The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 2006; 66: S102-S109.
18. Harding HP, Zhang Y, Ron D: Protein translation and folding are coupled by an endoplasmic- reticulum-resident kinase. Nature 1999; 397: 271-274.
19. Momoi T: Caspases involved in ER stress-mediated cell death. J Chem Neuroanat 2004; 28: 101-105.
20. Roussel BD, Kruppa AJ, Miranda E, Crowther DC, Lomas DA, Marciniak SJ: Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol 2013; 1: 105-118.
21. Lindholm D, Wootz H, Korhonen L: ER stress and neurodegenerative diseases. Cell Death Differ 2006; 3: 385-392.
22. Libby RT, Gould DB: Endoplasmic reticulum stress as a primary pathogenic mechanism leading to age-related macular degeneration. Adv Exp Med Biol 2010; 664: 403-409.
23. Salminen A, Kauppinen A, Hyttinen JM, Toropainen E, Kaarniranta K: Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Mol Med 2010; 16: 535-542.
24. Pfaffenbach KT, Lee AS: The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol 2011; 23: 150-156.
25. Oyadomari S, Mori M: Roles of CHOP/ GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004; 11: 381-389.
26. Sparrow JR, Boulton M: RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 2005; 80: 595-606.
27. Sparrow JR, Parish CA, Hashimoto M, Nakanishi K: A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci 1999; 40: 2988-2995.
28. Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K: Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE. Invest Ophthalmol Vis Sci 2002; 43: 1222-1227.
29. Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S, Itagaki Y: A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem 2003; 278: 18207-18213.
30. Kim SR, Jockusch S, Itagaki Y, Turro NJ, Sparrow JR: Mechanisms involved in A2E oxidation. Exp Eye Res 2008; 86: 975-982.
31. Winkler BS, Boulton ME, Gottsch JD, Sternberg P: Oxidative damage and age-related macular degeneration. Mol Vis 1999; 5: 32.
32. Beatty S, Koh H, Phil M, Henson D, Boulton M: The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000; 45: 115-134.
33. He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR: Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol 2008; 246: 677-683.
34. Bánhegyi G, Benedetti A, Csala M, Mandl J: Stress on redox. FEBS Lett 2007; 581: 3634-3640.
35. Marciniak SJ, Ron D: Endoplasmic reticulum stress signaling in disease. Physiol Rev 2006; 86: 1133-1149.
36. Yoshida H: ER stress and disease. FEBS J 2007; 274: 630-658.
37. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS: Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ 2010; 17: 488-498.
38. Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Chan PH: Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J Cereb Blood Flow Metab 2003; 23: 949-961.
39. Lee AS: The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 2005; 35: 373-381.
40. Ciccaglione AR, Marcantonio C, Tritarelli E, Equestre M, Vendittelli F, Costantino A, Geraci A, Rapicetta M: Activation of the ER stress gene gadd153 by hepatitis C virus sensitizes cells to oxidant injury. Virus Res 2007; 126: 128-138.
41. Zhu H, Qian J, Wang W, Yan Q, Xu Y, Jiang Y, Zhang L, Lu F, Hu W, Zhang X, Wang F, Sun X: RNA interference of GADD153 protects photoreceptors from endoplasmic reticulum stress-mediated apoptosis after retinal detachment. PLoS One 2013; 8:e59339.
42. Tang JR, Nakamura M, Okura T, Takata Y, Watanabe S, Yang ZH, Liu J, Kitami Y, Hiwada K: Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells. Biochem Biophys Res Commun 2002; 290: 1255-1259.