Contribution of ALDH2 polymorphism to alcoholism-associated hypertension

Recent Patents on Endocrine, Metabolic and Immune Drug Discovery

Volumn 8, Issue 3, 2014, Pages 180-185

  Hu, Nan ^a   Zhang, Yingmei ^a,b   Nair, Sreejayan ^a   Culver, Bruce W ^a   Ren, Jun ^a,b  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acetaldehyde; Alcohol; Cardiovascular complications; Hypertension; Metabolism; Mitochondrial aldehyde dehydrogenase

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOLISM; ARTICLE; BIOACCUMULATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ENDOTHELIUM INJURY; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RISK FACTOR; COMPLICATION; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION; PATENT;

ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ETHANOL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; MUTATION; PATENTS AS TOPIC; POLYMORPHISM, GENETIC;

EID: 84911437784     PISSN: 18722148     EISSN: 22123334     Source Type: Journal    
DOI: 10.2174/1872214808666141020162000     Document Type: Article

References (75)

1. Lang CH, Frost RA, Summer AD, Vary TC. Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Int J Biochem Cell Biol 2005; 37(10): 2180-95.
2. Preedy VR, Adachi J, Peters TJ, Worrall S, Parkkila S, Niemela O, et al. Recent advances in the pathology of alcoholic myopathy. Alcohol Clin Exp Res 2001; 25(5 Suppl ISBRA): 54S-9S.
3. Richardson PJ, Patel VB, Preedy VR. Alcohol and the myocardium. Novartis Found Symp 1998; 216: 35-45.
4. Spies CD, Sander M, Stangl K, Fernandez-Sola J, Preedy VR, Rubin E, et al. Effects of alcohol on the heart. Curr Opin Crit Care 2001; 7(5): 37-43.
5. Guo R, Ren J. Alcohol and acetaldehyde in public health: From marvel to menace. Int J Environ Res Public Health 2010; 7(4): 1285-301.
6. Laonigro I, Correale M, Di Biase M, Altomare E. Alcohol abuse and heart failure. Eur J Heart Fail 2009; 11(5): 453-62.
7. Liang Q, Carlson EC, Borgerding AJ, Epstein PN. A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. J Pharmacol Exp Ther 1999; 291(2): 766-72.
8. Skotzko CE, Vrinceanu A, Krueger L, Freudenberger R. Alcohol use and congestive heart failure: Incidence, importance, and approaches to improved history taking. Heart Fail Rev 2009; 14(1): 51-5.
9. Schoppet M, Maisch B. Alcohol and the heart. Herz 2001; 26(5): 345-52.
10. Ohira T, Tanigawa T, Tabata M, Imano H, Kitamura A, Kiyama M, et al. Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among Japanese men. Hypertension 2009; 53(1): 13-9.
11. Hering D, Kucharska W, Kara T, Somers VK, Narkiewicz K. Potentiated sympathetic and hemodynamic responses to alcohol in hypertensive vs. normotensive individuals. J Hypertens 2011; 29(3): 537-41.
12. Bessembinders K, Wielders J, van de Wiel A. Severe hypertriglyceridemia influenced by alcohol (SHIBA). Alcohol Alcohol 2011; 46 (2): 113-6.
13. George A, Figueredo VM. Alcohol and arrhythmias: A comprehensive review. J Cardiovasc Med 2010; 11(4): 221-8.
14. Beilin LJ, Puddey IB. Alcohol, hypertension and cardiovascular disease-implications for management. Clin Exp Hypertens 1993; 15(6): 1157-70.
15. Kloner RA, Rezkalla SH. To drink or not to drink? That is the question. Circulation 2007; 116(11): 1306-17.
16. Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Arch Intern Med 2006; 166(22): 2437-45.
17. Camargo CA, Jr., Hennekens CH, Gaziano JM, Glynn RJ, Manson JE, Stampfer MJ. Prospective study of moderate alcohol consumption and mortality in US male physicians. Arch Intern Med 1997; 157(1): 79-85.
18. Kawano Y. Physio-pathological effects of alcohol on the cardiovascular system: Its role in hypertension and cardiovascular disease. Hypertension Res 2010; 33(3): 181-91.
19. Manzo-Avalos S, Saavedra-Molina A. Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health 2010; 7(12): 4281-304.
20. Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and ldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 2004; 63(1): 49-63.
21. Hintz KK, Relling DP, Saari JT, Borgerding AJ, Duan J, Ren BH, et al. Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Alcohol Clin Exp Res 2003; 27(7): 1090-8.
22. Jankala H, Eriksson CJP, Petersen NE, Harkonen M, Maki T. Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats. Alcohol Alcohol 2000; 35(4): 331-5.
23. Nishimura FT, Fukunaga T, Kajiura H, Umeno K, Takakura H, Ono T, et al. Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects. Auton Neurosci 2002; 102(1-2): 60-70.
24. Watanabe A, Kobayashi M, Hobara N, Nakatsukasa H, Nagashima H, Fujimoto A. A report of unusually high blood ethanol and acetaldehyde levels in two surviving patients. Alcohol Clin Exp Res 1985; 9(1): 14-6.
25. Espinet C, Argiles JM. Ethanol and acetaldehyde concentrations in the rat foeto-maternal system after an acute ethanol administration given to the mother. Arch Int Physiol Biochim 1984; 92(5): 339-44.
26. Nuutinen H, Lindros KO, Salaspuro M. Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics. Alcohol Clin Exp Res 1983; 7(2): 163-8.
27. Oba T, Maeno Y, Ishida K. Differential contribution of clinical amounts of acetaldehyde to skeletal and cardiac muscle dysfunction in alcoholic myopathy. Curr Pharm Des 2005; 11(6): 791-80.
28. Chen YC, Lu RB, Peng GS, Wang MF, Wang HK, Ko HC, et al. Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol Clin Exp Res 1999; 23(12): 1853-60.
29. Nakao LS, Kadiiska MB, Mason RP, Grijalba MT, Augusto O. Metabolism of acetaldehyde to methyl and acetyl radicals: in vitro and in vivo electron paramagnetic resonance spin-trapping studies. Free Radic Biol Med 2000; 29(8): 721-9.
30. Ren J, Wold LE. Mechanisms of alcoholic heart disease. Ther Adv Cardiovasc Dis 2008; 2(6): 497-506.
31. Zhang X, Li SY, Brown RA, Ren J. Ethanol and acetaldehyde in alcoholic cardiomyopathy: From bad to ugly en route to oxidative stress. Alcohol 2004; 32(3): 175-86.
32. Pragst F, Auwaerter V, Sporkert F, Spiegel K. Analysis of fatty acid ethyl esters in hair as possible markers of chronically elevated alcohol consumption by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS). Forensic Sci Int 2001; 121(1-2): 76-88.
33. Lange LG, Sobel BE. Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J Clin Invest 1983; 72(2): 724-31.
34. Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43(2): 109-42.
35. Chen Z, Stamler JS. Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med 2006; 16(8): 259-65.
36. Bosron WF, Lumeng L, Li TK. Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Mol Aspects Med 1988; 10(2): 147-58.
37. Kim DJ, Choi IG, Park BL, Lee BC, Ham BJ, Yoon S, et al. Major genetic components underlying alcoholism in Korean population. Hum Mol Genet 2008; 17(6): 854-8.
38. Zintzaras E, Stefanidis I, Santos M, Vidal F. Do alcoholmetabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology 2006; 43(2): 352-61.
39. Chen YC, Peng GS, Wang MF, Tsao TP, Yin SJ. Polymorphism of ethanol-metabolism genes and alcoholism: Correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. Chem Biol Interact 2009; 178(1-3): 2-7.
40. Peng GS, Yin SJ. Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. Hum Genomics 2009; 3(2): 121-7.
41. Yao CT, Cheng CA, Wang HK, Chiu SW, Chen YC, Wang MF, et al. The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese. Hum Genomics 2011; 5(6): 569-76.
42. Li H, Borinskaya S, Yoshimura K, Kalina N, Marusin A, Stepanov VA, et al. Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. Ann Hum Genet 2009; 73(Pt 3): 335-45.
43. Ohsawa I, Kamino K, Nagasaka K, Ando F, Niino N, Shimokata H, et al. Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in communitydwelling females. J Hum Genet 2003; 48(8): 404-9.
44. Kawamoto T, Matsuno K, Kodama Y, Murata K, Matsuda S. ALDH2 polymorphism and biological monitoring of toluene. Arch Environ Health 1994; 49(5): 332-6.
45. Farres J, Wang X, Takahashi K, Cunningham SJ, Wang TT, Weiner H. Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 1994; 269(19): 13854-60.
46. Yokoyama A, Muramatsu T, Ohmori T, Makuuchi H, Higuchi S, Matsushita S, et al. Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. Cancer 1996; 77(10): 1986-90.
47. Itoh T, Matsumoto M, Nakamura M, Okada A, Shirahashi N, Hougaku H, et al. Effects of daily alcohol intake on the blood pressure differ depending on an individual's sensitivity to alcohol: Oriental flushing as a sign to stop drinking for health reasons. J Hypertens 1997; 15(11): 1211-7.
48. Amamoto K, Okamura T, Tamaki S, Kita Y, Tsujita Y, Kadowaki T, et al. Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. Hypertension Res 2002; 25(6): 857-64.
49. Takagi S, Baba S, Iwai N, Fukuda M, Katsuya T, Higaki J, et al. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: The Suita study. Hypertension Res 2001; 24(4): 365-70.
50. Takagi S, Iwai N, Yamauchi R, Kojima S, Yasuno S, Baba T, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertension Res 2002; 25(5): 677-81.
51. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316(5830): 1488-91.
52. Iwai N, Tago N, Yasui N, Kokubo Y, Inamoto N, Tomoike H, et al. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. J Hypertens 2004; 22(6): 1119-26.
53. Hasi T, Hao L, Yang L, Su XL. Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: A case control study. Genet Mol Res 2011; 10(1): 537-43.
54. Cunningham CC, Bailey SM. Ethanol consumption and liver mitochondria function. Biol Signals Recept 2001; 10(3-4): 271-82.
55. Gomez-Quiroz L, Bucio L, Souza V, Escobar C, Farfan B, Hernandez E, et al. Interleukin 8 response and oxidative stress in HepG2 cells treated with ethanol, acetaldehyde or lipopolysaccharide. Hepatology Res 2003; 26(2): 134-41.
56. Uchida K. Role of reactive aldehyde in cardiovascular diseases. Free Radic Biol Med 2000; 28(12): 1685-96.
57. Jin L, Ying Z, Webb RC. Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 2004; 287(4): H1495-500.
58. Rodriguez-Martinez MA, Garcia-Cohen EC, Baena AB, Gonzalez R, Salaices M, Marin J. Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved. Br J Pharmacol 1998; 125(6): 1329-35.
59. Schnackenberg CG, Welch WJ, Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: Role of nitric oxide. Hypertension 1998; 32(1): 59-64.
60. Wu R, Millette E, Wu L, de Champlain J. Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats. J Hypertens 2001; 19(4): 741-8.
61. Choi H, Tostes RC, Webb RC. Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice. J Am Soc Hypertens 2011; 5(3): 154-60.
62. Nakagawa T, Kajiwara A, Saruwatari J, Hamamoto A, Kaku W, Oniki K, et al. The combination of mitochondrial low enzymeactivity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption. Pharmacogenet Genomics 2013; 23(1): 34-7.
63. Zhang Y, Ren J. ALDH2 in alcoholic heart diseases: Molecular mechanism and clinical implications. Pharmacol Ther 2011; 132(1): 86-95.
64. Mochly-Rosen, D. Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2. US7560241 (2009).
65. Sen S, Kundu BK, Wu HC, Hashmi SS, Guthrie P, Locke LW, et al. Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J Am Heart Assoc 2013; 2(3): e004796.
66. Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010; 584(7): 1287-95.
67. Zhang Y, Xu X, Ren J. MTOR overactivation and interrupted autophagy flux in obese hearts: A dicey assembly? Autophagy 2013; 9(6): 939-41.
68. Wang Y, Du F, Zhao H, Yu X, Liu J, Xiao Y, et al. Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients. PloS One 2014; 9(7): e103161.
69. Wang H, Pan Q, Gao Q, Kang P, Li M, He P, et al. Correlation of aldehyde dehydrogenase-2 gene polymorphism with hypertension in patients with coronary heart disease complicated by diabetes mellitus. South Med J 2013; 33(4): 542-5.
70. Abelman, M. Quinazolinone derivatives as ALDH-2 inhibitors. US7951813 (2011).
71. Graupe, M. ALDH-2 inhibitors in the treatment of addiction. US8673966 (2014).
72. Zablocki, J. ALDH-2 inhibitors in the treatment of addiction. US8158810 (2012).
73. Lewis SJ, Smith GD. Alcohol, ALDH2, and esophageal cancer: A meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev 2005; 14(8): 1967-71.
74. Eriksson CJ. The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 2001; 25(5 Suppl ISBRA): 15S-32S.
75. Chen L, Davey Smith G, Harbord RM, Lewis SJ. Alcohol intake and blood pressure: A systematic review implementing a Mendelian randomization approach. PLoS Med 2008; 5(3): e52.