Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females

Journal of Human Genetics

Volumn 48, Issue 8, 2003, Pages 404-409

  Ohsawa, Ikuroh ^a   Kamino, Kouzin ^a,b   Nagasaka, Keiko ^a   Ando, Fujiko ^c   Niino, Naoakira ^c   Shimokata, Hiroshi ^c   Ohta, Shigeo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Aldehyde dehydrogenase; Alzheimer's disease; Gene polymorphism; Lipid peroxides; Population based study

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; LIPID; LIPID PEROXIDE; PLASMA PROTEIN;

ADULT; AGED; ALDH2 GENE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DRINKING BEHAVIOR; ENZYME DEFICIENCY; FEMALE; GENDER; GENE; HEART INFARCTION; HUMAN; HYPERTENSION; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PHENOTYPE;

ADULT; AGED; FEMALE; HUMANS; LIPID PEROXIDES; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL DISEASES;

EID: 0141533147     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-003-0046-y     Document Type: Article

References (33)

1. Amamoto K, Okamura T, Tamaki S, Kita Y, Tsujita Y, Kadowaki T, Nakamura Y, Ueshima H (2002) Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. Hypertens Res 25:857-864
2. Bosron WF, Li TK (1986) Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6:502-510
3. Chan PH (2001) Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 21:2-14
4. Crabb DW (1990) Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption. J Clin Invest 85:311-315
5. Crabb DW, Edenberg HJ, Bosron WF, Li TK (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 83:314-316
6. Dexter DT, Holley AE, Flitter WD, Slater TF, Wells FR, Daniel SE, Lees AJ, Jenner P, Marsden CD (1994) Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov Disord 9:92-97
7. Farres J, Wang X, Takahashi K, Cunningham SJ, Wang TT, Weiner H (1994) Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 269:13854-13860
8. Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, Kowall NW, Brown RH Jr, Beal MF (1997) Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 69:2064-2074
9. Goedde HW, Harada S, Agarwal DP (1979) Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet 51:331-334
10. Hartley DP, Ruth JA, Petersen DR (1995) The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase. Arch Biochem Biophys 316:197-205
11. Itoh T, Matsumoto M, Nakamura M, Okada A, Shirahashi N, Hougaku H, Hashimoto H, Sakaguchi M, Handa N, Takeshita T, Morimoto K, Hori M (1997) Effects of daily alcohol intake on the blood pressure differ depending on an individual's sensitivity to alcohol: oriental flushing as a sign to stop drinking for health reasons. J Hypertens 15:1211-1217
12. Kamino K, Nagasaka K, Imagawa M, Yamamoto H, Yoneda H, Ueki A, Kitamura S, Namekata K, Miki T, Ohta S (2000) Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. Biochem Biophys Res Commun 273:192-196
13. Kawamoto T, Matsuno K, Kodama Y, Murata K, Matsuda S (1994) ALDH2 polymorphism and biological monitoring of toluene. Arch Environ Health 49:332-336
14. Lovell MA, Ehmann WD, Mattson MP, Markesbery WR (1997) Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease. Neurobiol Aging 18:457-461
15. Mark RJ, Pang Z, Geddes JW, Uchida K, Mattson MP (1997) Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci 17:1046-1054
16. Markesbery WR, Carney JM (1999) Oxidative alterations in Alzheimer's disease. Brain Pathol 9:133-146
17. Montine KS, Olson SJ, Amarnath V, Whetsell WO Jr, Graham DG, Montine TJ (1997) Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. Am J Pathol 150:437-443
18. Ohsawa I, Nishimaki K, Yasuda C, Kamino K, Ohta S (2003) Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J. Neuchem 84:1110-1117
19. Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, Kasarskis E, Mattson MP (1998) Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann Neurol 44:819-824
20. Praticò D, Delanty N (2000) Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am J Med 109:577-585
21. Praticò D, Uryu K, Leight S, Trojanoswki JQ, Lee VM-Y (2001) Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci 21:4183-4187
22. Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68:2092-2097
23. Shimokata H, Yamada Y, Nakagawa M, Okubo R, Saido T, Funakoshi A, Miyasaka K, Ohta S, Tsujimoto G, Tanaka M, Ando F, Niino N (2000) Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 10:S46-55
24. Singh S, Fritze G, Fang BL, Harada S, Paik YK, Eckey R, Agarwal DP, Goedde HW (1989) Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. Hum Genet 83:119-121
25. Suzuki Y, Muramatsu T, Taniyama M, Atsumi Y, Kawaguchi R, Higuchi S, Hosokawa K, Asahina T, Murata C, Matsuoka K (1996) Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia 39:1115-1118
26. (Leu(UUR)) mutation at position 3243. Diabetes Care 19:1423-1425
27. Takagi S, Baba S, Iwai N, Fukuda M, Katsuya T, Higaki J, Mannami T, Ogata J, Goto Y, Ogihara T (2001) The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Hypertens Res 24:365-370
28. Takagi S, Iwai N, Yamauchi R, Kojima S, Yasuno S, Baba T, Terashima M, Tsutsumi Y, Suzuki S, Morii I, Hanai S, Ono K, Baba S, Tomoike H, Kawamura A, Miyazaki S, Nonogi H, Goto Y (2002) Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res 25:677-681
29. Uchida K, Stadtman ER (1992). Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc Natl Acad Sci USA 89:4544-4548
30. Xiao Q, Weiner H, Crabb DW (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 98:2027-2032
31. Yokoyama A, Muramatsu T, Ohmori T, Makuuchi H, Higuchi S, Matsushita S, Yoshino K, Maruyama K, Nakano M, Ishii H (1996) Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. Cancer 77:1986-1990
32. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19:1383-1387
33. Yoshida A, Huang IY, Ikawa M (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 81:258-261