Alcohol, ALDH2, and esophageal cancer: A meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach

Cancer Epidemiology Biomarkers and Prevention

Volumn 14, Issue 8, 2005, Pages 1967-1971

  Lewis, Sarah J ^a   Smith, George Davey ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CARCINOGEN; GENE PRODUCT; PROTEIN SUBUNIT;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALDH2 GENE; ARTICLE; CANCER EPIDEMIOLOGY; CLINICAL TRIAL; ENVIRONMENTAL EXPOSURE; ESOPHAGUS CANCER; GENE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MEDICAL GENETICS; MENDELIAN RANDOMIZATION; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZATION; RISK FACTOR;

ACETALDEHYDE; ALCOHOL DEHYDROGENASE; ESOPHAGEAL NEOPLASMS; ETHANOL; GENOTYPE; HUMANS; MALE; RANDOM ALLOCATION; RISK FACTORS;

EID: 23844550544     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-05-0196     Document Type: Article

References (25)

1. Davey Smith G, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
2. Davey Smith G, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004;33:30-42.
3. Clayton D, McKeigue PM. Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 2001;358:1356-60.
4. Keavney B. Commentary: Katan's remarkable foresight: genes and causality 18 years on. Int J Epidemiol 2004;33:11-4.
5. Tobin MD, Minelli C, Burton PR, Thompson JR. Commentary: development of Mendelian randomization: from hypothesis test to 'Mendelian deconfounding'. Int J Epidemiol 2004;33:26-9.
6. Thomas DC, Conti DV. Commentary: the concept of 'Mendelian randomization'. Int J Epidemiol 2004;33:21-5.
7. IARC. Alcohol drinking. IARC monographs on the evaluation of carcinogenic risks to humans. Vol.44. Lyon: IARC; 1988.
8. Brennan P, Boffetta P. Mechanistic considerations in the molecular epidemiology of head and neck cancer. IARC Sci Publ 2004;157:393-414.
9. Blot WJ. Alcohol and cancer. Cancer Res 1992;52:2119-23s.
10. Bosron WF, Li TK. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 1986;6:502-10.
11. Yoshida A, Huang IY, Ikawa M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A 1984;81:258-61.
12. Enomoto N, Takase S, Yasuhara M, Takada A. Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 1991;15:141-4.
13. Hori H, Kawano T, Endo M, Yuasa Y. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. J Clin Gastroenterol 1997;25:R568-75.
14. Chao YC, Wang LS, Hsieh TY, Chu CW, Chang FY, Chu HC. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. Am J Gastroenterol 2000;95:2958-64.
15. Matsuo K, Hamajima N, Shinoda M, et al. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. Carcinogenesis 2001;22:913-6.
16. Yokoyama A, Muramatsu T, Omori T, et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 2001;22:433-9.
17. Boonyaphiphat P, Thongsuksai P, Sriplung H, Puttawibul P. Lifestyle habits and generic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett 2002;186:193-9.
18. Itoga S, Nomura F, Makino Y, et al. Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer. Alcohol Clin Exp Res 2002;26:15-9S.
19. Yokoyama A, Kato H, Yokoyama T, et al. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis 2002;23:1851-9.
20. Higgins JP, Thompson SG, Deeks JJ, Airman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
21. Sterne JAC, Bradburn MJ, Egger M. Meta-analysis in Stata. In: Egger M, Davey Smith G, Airman D, editors. Systematic reviews in health care: meta-analysis in context. 2nd ed. London: BMJ;2001. p. 347-69.
22. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
23. Inoue M, Tsugane S. Impact of alcohol drinking on total cancer risk: data from a large-scale population-based cohort study in Japan. Br J Cancer 2005;92:182-7.
24. Takagi S, Iwai N, Yamauchi R, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res 2002;25:677-81.
25. Gutjahr E, Gmel G, Rehm J. Relation between average alcohol consumption and disease: an overview. Eur Addict Res 2001;7:117-27.