Development and invitro assessment of enzymatically-responsive poly(ethylene glycol) hydrogels for the delivery of therapeutic peptides

Biomaterials

Volumn 35, Issue 36, 2014, Pages 9719-9730

  Van Hove, Amy H ^a   G Beltejar, Michael John ^b   Benoit, Danielle S W ^a,b  

^a University of Rochester   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Controlled drug release; Enzymatically degradable; Hydrogel; Matrix metalloproteinase; Peptide

Indexed keywords

AMINO ACIDS; BIOACTIVITY; DEGRADATION; DRUG PRODUCTS; ENDOTHELIAL CELLS; PEPTIDES; POLYETHYLENE GLYCOLS; POLYOLS; SUBSTRATES;

CONTROLLED DRUG RELEASE; ENZYMATICALLY DEGRADABLE; MATRIX METALLOPROTEINASES; PLATFORM TECHNOLOGY; POLY(ETHYLENE GLYCOL) HYDROGEL; THERAPEUTIC APPLICATION; THERAPEUTIC PEPTIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR;

HYDROGELS;

CYSTEINE; MACROGOL; MATRIX METALLOPROTEINASE; PEPTIDE; PEPTIDE QK; PEPTIDE SPARC 113; PEPTIDE SPARC 118; UNCLASSIFIED DRUG; DELAYED RELEASE FORMULATION; HYDROGEL; MACROGOL DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENZYME DEGRADATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; HYDROGEL; METABOLISM; MOLECULAR GENETICS; SYNTHESIS; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINO ACID SEQUENCE; DELAYED-ACTION PREPARATIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGELS; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYETHYLENE GLYCOLS;

EID: 84911429419     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.08.019     Document Type: Article

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