Regulation of angiogene sis by SPARC and angiostatin: Implications for tumor cell biology

Seminars in Cancer Biology

Volumn 7, Issue 3, 1996, Pages 139-146

  Jendraschak, Ellen ^a   Sage, E Helene ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Angiogenesis; Angiostatin; Endothelial cells; Growth factors; SPARC

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOSTATIN; GROWTH FACTOR; OSTEONECTIN; PLASMINOGEN; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN;

ANGIOGENESIS; BASEMENT MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; EXTRACELLULAR MATRIX; GENE EXPRESSION; MONOCYTE; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; T LYMPHOCYTE; TUMOR CELL; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 0030012507     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.1996.0019     Document Type: Article

References (68)

1. Sage H, Vernon RB, Decker J, Funk S, Iruela-Arispe ML (1989) Distribution of the calcium-binding protein SPARC in tissues of embryonic and adult mice. J Histochem Cytochem 37:819-829
2. Sage H, Tupper J, Bramson R (1986) Endothelial cell injury in vitro is associated with increased secretion of an Mr 43,000 glycoprotein ligand. J Cell Physiol 127:373-387
3. Sage H, Johnson C, Bornstein P (1984) Characterization of a novel serum albumin-binding glycoprotein secreted by endohelial cells in culture. J Biol Chem 259:3993-4007
4. Mason IJ, Taylor A, Williams JG, Sage H, Hogan BL (1986) Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J (Eur Mol Biol Organ) 5:1465-1472
5. Termine JD, Kleinmann HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (1981) Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26:99-105
6. Mann K, Deutzmann R, Paulsson M, Timpl R (1987) Solubilization of protein BM-40 from a basement membrane tumor with chelating agents and evidence for its identity with osteonectin and SPARC. FEBS Lett 218:167-172
7. Kelm RJ, Mann KG (1990) Human platelet osteonectin: release, surface expression, and partial characterization. Blood 75:1105-1113
8. Clezardin P, Malaval L, Morel MC, Guichard J, Lecompte T, Trzeciak MC, Dechavanne M, Breton-Gorius J, Delmas PD, Kaplan C (1991) Osteonectin is an alpha-granule component involved with thrombospondin in platelet aggregation. J Bone Min Res 6:1059-1070
9. Swaroop A, Hogan BL, Francke U (1988) Molecular analysis of the cDNA for human SPARC/ osteonectin/ BM40: sequence, expression, and localization of the gene to chromosome 5q31-q33. Genomics 2:37-47
10. Lankat-Buttgereit B, Mann K, Deutzmann R, Timpl R, Krieg T (1988) Cloning and complete amino acid sequences of human and murine basement membrane protein BM40 (SPARC, osteonectin). FEBS Lett 236:352-356
11. Villarreal XC, Mann KG, Long GL (1989) Structure of human osteonectin based upon analysis of cDNA and genomic sequences. Biochemistry 28:6483-6491
12. Young MF, Bolander ME, Day AA, Ramis CI, Gehron Robey P, Yamada Y, Termine JD (1986) Osteonectin mRNA: distribution in normal and transformed cells. Nucl Acid Res 14:4483-4497
13. Engel J, Taylor W, Paulsson M, Sage H, Hogan BL (1987) Calcium binding domains and calcium-induced conformational transition of SPARC/ BM-40/ osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. Biochemistry 26:6958-6965
14. Boultwood J, Fidler C, Lewis S, Kelly S, Sheridan H, Littlewood TJ, Buckle VJ, Wainscoat JS (1994) Molecular mapping of uncharacteristically small 5q deletions in two patients with the 5q-syndrome: delineation of the critical region on 5q and identification of a 5q-breakpoint. Genomics 19:4254-32
15. Wrana JL, Overall CM, Sodek J (1991) Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. Eur J Biochem 197:519-528
16. Reed MJ, Vernon RB, Abrass IB, Sage EH (1994) TGF-beta 1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors. J Cell Physiol 158:169-179
17. Ford R, Wang G, Jannati P, Adler D, Racanelli P, Higgins PJ, Staiano-Coico L (1993) Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: regulation via a TGF-beta-dependent pathway. Exp Cell Res 206:261-275
18. Chandrasekhar S, Harvey AK, Johnson MG, Becker GW (1994) Osteonectin/ SPARC is a product of articular chondrocytes/ cartilage and is regulated by cytokines and growth factors. Biochim Biophys Acta 1221:7-14
19. Young MF, Findlay DM, Dominguez P, Burbelo PD, McQuillan C, Kopp JB, Gehron Robey P, Termine JD (1989) Osteonectin promoter. DNA sequence analysis and S1 endonuclease site potentially associated with transcriptional control in bone cells. J Biol Chem 264:450-456
20. Ibaraki K, Gehron Robey P, Young MF (1993) Partial characterization of a novel 'GGA' factor which binds to the osteonectin promoter in bovine bone cells. Gene 130:225-232
21. McVey JH, Nomura S, Kelly P, Mason IJ, Hogan BL (1988) Characterization of the mouse SPARC/ osteonectin gene. Intron/ exon organization and an unusual promoter region. J Biol Chem 263:11111-11116
22. Nomura S, Hashmi S, McVey JH, Ham J, Parker M, Hogan BL (1989) Evidence for positive and negative regulatory elements in the 5′-flanking sequence of the mouse spare (osteonectin) gene. J Biol Chem 264:12201-12207
23. Howe CC, Overton GC, Sawicki J, Solter D, Stein P, Strickland S (1988) Expression of SPARC/osteonectin transcript in murine embryos and gonads. Differentiation 37:20-25
24. Wewer UM, Albrechtsen R, Fisher LW, Young MF, Termine JD (1988) Osteonectin/ SPARC/ BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane. Am J Pathol 132:345-355
25. Colombo MP, Biondi G, Galasso D, Baracetti P, Howe CC, Parmiani G (1989) Osteonectin transcript and metastatic behavior in v-Ki-ras transformed fibroblasts. Int J Cancer Suppl 4:76-77
26. Porter PL, Sage EH, Lane TF, Funk SE, Gown AM (1995) Distribution of SPARC in normal and neoplastic human tissue. J Histochem Cytochem 43:791-800
27. 2+-binding extracellular protein associated with endothelial cell injury and proliferation. J Mol Cell Cardiol 21:13-22
28. Neri M, Descalzi CF, Cancedda R (1992) Heat-shock response in cultured chick embryo chondrocytes. Osteonectin is a secreted heat-shock protein. Eur J Biochem 205:569-574
29. Kudo H, Hirayoshi K, Kitagawa Y, Imamura S, Nagata K(1994) Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses. Exp Cell Res 212:219-224
30. Sauk JJ, Smith T, Silbergeld EK, Fowler BA, Somerman MJ (1992) Lead inhibits secretion of osteonectin/ SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/ 2.8 cells. Toxicol Appl Pharmacol 116:240-247
31. Iruela-Arispe ML, Diglio CA, Sage EH (1991) Modulation of extracellular matrix proteins by endothelial cells undergoing angiogenesis in vitro. Arterioscler Thromb 11:805-815
32. Iruela-Arispe ML, Hasselaar P, Sage H (1991) Differential expression of extracellular proteins is correlated with angiogenesis in vitro. Lab Invest 64:174-186
33. Lane TF, Iruela-Arispe ML, Johnson RS, Sage EH (1994) SPARC is a source of copper-binding peptides that stimulate angiogenesis. J Cell Biol 125:929-943
34. 2+-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Proc Natl Acad Sci USA 88:2648-2652
35. Funk SE, Sage EH (1993) Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts. J Cell Physiol 154:53-63
36. 2+-binding EF-hand sequence. J Cell Biochem 57:127-140
37. Yost JC, Sage EH (1993) Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence containing a calcium-binding EF hand. J Biol Chem 268:25790-25796
38. Iruela-Arispe ML, Lane TF, Redmond D, ReillyM, Bolender RP, Kavanagh TJ, Sage EH (1995) Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo. Mol Biol Cell 6:327-343
39. Pickart L, Lovejoy S (1987) Biological activity of human plasma copper-binding growth factor glycyl-L-histidyl-L-lysine. Methods Enzymol 147:314-328
40. Sage EH (1992) Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro. Biochem Cell Biol 70:579-592
41. 2+-dependent binding to the extracellular matrix. J Cell Biol 109:341-356
42. 2+-binding sites modulate cell shape. J Cell Biol 111:3065-3076
43. Everitt EA, Sage EH (1992) Expression of SPARC is correlated with altered morphologies in transfected F9 embryonal carcinoma cells. Exp Cell Res 199:134-146
44. 2+. Biochem Cell Biol 70:56-62
45. 2+-binding EF-hand. J Cell Biochem 57:341-350
46. Goldblum SE, Ding X, Funk SE, Sage EH (1994) SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function. Proc Natl Acad Sci USA 91:3448-3452
47. Tremble PM, Lane TF, Sage EH, Werb Z (1993) SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway. J Cell Biol 121:1433-1444
48. Hasselaar P, Loskutoff DJ, Sawdey M, Sage EH (1991) SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells. J Biol Chem 266:13178-13184
49. Lane TF, Iruela-Arispe ML, Sage EH (1992) Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1. J Biol Chem 267:16736-16745
50. Iruela-Arispe ML, Bornstein P, Sage EH (1991) Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro. Proc Natl Acad Sci USA 88:5026-5030
51. Folkman J, Klagsbrun M (1987) Angiogenesis factors. Science 235:442-447
52. Folkman J, Shing Y (1992) Angiogenesis. J Biol Chem 267:10931-10934
53. Plate KH, Breier G, Weich HA, Risau W (1992) Vascular endothelial growth factor is a potent tumor angiogenesis factor in human gliomas in vivo. Nature 359:845-848
54. Pepper MS, Belin D, Montesano R, Orci L, Vassalli J-D (1990) Transforming growth factor beta-1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol 111:743-755
55. Brogi E, Wu TG, Namiki A, Isner JM (1994) Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only. Circulation 90:649-652
56. Battegay EJ, Rupp J, Iruela-Arispe ML, Sage EH, Pech M (1994) PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. J Cell Biol 125:917-928
57. Iruela-Arispe ML, Sage EH (1993) Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF-beta 1. J Cell Biochem 52:414-430
58. Raines EW, Lane TF, Iruela-Arispe ML, Ross R, Sage EH (1992) The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci USA 89:1281-1285
59. Hasselaar P, Sage EH (1992) SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells. J Cell Biochem 49:272-283
60. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao X Sage EH, Folkman J (1994) Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79:315-328
61. Holmgren L, O'Reilly MS, Folkman J (1995) Dormancy of micrometastasis: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1:149-153
62. Lane TF, Sage EH (1994) The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J 8:163-173
63. Jendraschak E, Kaminski WE, Hessel F, Kiefl R, von Schacky C (1993) Growth factor mRNA profiles in unstimulated human mononuclear cells: identification of genes which are constitutively and variably expressed. Biochem Biophys Res Commun 196:25-31
64. Kaminski WE, Jendraschak E, Kiefl R, von Schacky C (1993) Dietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood 81:1871-1879
65. Kaminski WE, Jendraschak E, Baumann K, Kiefl R, Fischer S, Marcus AT, Broekman MJ, von Schacky C (1996) Human mononuclear cells express 12-LX: Coordinated mRNA regulation with 5-LX and FLAP genes. Blood 87:331-340
66. Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801-809
67. Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185-188
68. Bornstein P (1995) Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin-1. J Cell Biol 130:503-506