AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL- 1

Journal of Biological Chemistry

Volumn 271, Issue 48, 1996, Pages 30517-30523

  Akeson, Ann L ^a   Woods, Connie W ^a   Hsieh, Lily C ^a   Bohnke, Rick A ^a   Ackermann, Bradley L ^a   Chan, Kenneth Y ^a   Robinson, James L ^a   Yanofsky, Stephen D ^b   Jacobs, Jeffrey W ^b   Barrett, Ronald W ^b   Bowlin, Terry L ^a  

^a SANOFI   (France)

^b AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; IODINE 125;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MONKEY; MOUSE; PRIORITY JOURNAL; RECEPTOR BLOCKING;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; E-SELECTIN; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; MACACA FASCICULARIS; MICE; PEPTIDE LIBRARY; PEPTIDES; PROTEINS; RECEPTORS, INTERLEUKIN-1; SIALOGLYCOPROTEINS; SPECIES SPECIFICITY;

ANIMALIA; MACACA FASCICULARIS; MURINAE;

EID: 10544225751     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.48.30517     Document Type: Article

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