Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ros/akt/p70s6k signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Han, Xiaoxi ^a   Sun, Shengkun ^b   Zhao, Ming ^c   Cheng, Xiang ^c   Chen, Guozhu ^c   Lin, Song ^c   Guan, Yifu ^a   Yu, Xiaodan ^c  

^a CHINA MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c Beijing Institute of Basic Medical Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELASTROL; GLUCOSE TRANSPORTER 1; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROTEIN BNIP3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN; HIF1A PROTEIN, HUMAN; SLC2A1 PROTEIN, HUMAN; TRIPTERINE; TRITERPENE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER CELL LINE; CANCER CELL LINE; CANCER INHIBITION; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME REPRESSION; EXPOSURE; GENE TARGETING; GENETIC TRANSCRIPTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROSTATE CANCER CELL LINE; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; TUMOR CELL; UTERINE CERVIX CARCINOMA; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; MCF 7 CELL LINE; METABOLISM; NEOPLASM;

CELL LINE; CELL NUCLEUS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE TRANSPORTER TYPE 1; HELA CELLS; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MCF-7 CELLS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84911420350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112470     Document Type: Article

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