Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway

International Journal of Molecular Medicine

Volumn 27, Issue 3, 2011, Pages 407-415

  Huang, Lili ^a   Zhang, Zefu ^b   Zhang, Sheng ^a   Ren, Jinghua ^a   Zhang, Ruiguang ^a   Zeng, Hui ^a   Li, Qingfeng ^a   Wu, Gang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Angiogenesis; Celastrol; Hypoxia inducible factor 1 ; Metastasis

Indexed keywords

CELASTROL; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRIPTERYGIUM WILFORDII EXTRACT;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL HYPOXIA; DRUG SCREENING ASSAYS, ANTITUMOR; HEP G2 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PLANT ROOTS; RNA, MESSENGER; RNA, NEOPLASM; TRIPTERYGIUM; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79551612454     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.600     Document Type: Article

References (30)

1. Hockel M and Vaupel P: Biological consequences of tumor hypoxia. Semin Oncol 28: 36-41, 2001.
2. Greco O, Marples B, Joiner MC and Scott SD: How to overcome (and exploit) tumor hypoxia for targeted gene therapy. J Cell Physiol 197: 312-325, 2003. (Pubitemid 37487030)
3. Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR and Dewhirst MW: Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma. Cancer Res 56: 941-943, 1996.
4. Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
5. Wang GL and Semenza GL: Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270: 1230-1237, 1995.
6. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and Simons JW: Overexpression of hypoxia-inducible factor 1-alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835, 1999.
7. Blagosklonny MV: Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy. Int J Oncol 19: 257-262, 2001.
8. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW and Ratcliffe PJ: Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94: 8104-8109, 1997
9. Salminen A, Lehtonen M, Paimela T and Kaarniranta K: Celastrol: molecular targets of Thunder God Vine. Biochem Biophys Res Commun 394: 439-442, 2010.
10. Zhang T, Hamza A, Cao X, Wang B, Yu S, Zhan CG and Sun D: A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther 7: 162-170, 2008.
11. Katschinski DM, Le L, Heinrich D, Wagner KF, Hofer T, Schindler SG and Wenger RH: Heat induction of the unphosphorylated form of hypoxia inducible factor-1α is dependent on heat shock protein 90 activity. J Biol Chem 277: 9262-9267, 2002.
12. Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F and Neckers LM: Hsp90 regulates a von Hippel Lindau-independent hypoxia inducible factor-1 alpha-degradative pathway. J Biol Chem 277: 29936-29944, 2002.
13. Zhou J, Schmid T, Frank R and Brune B: PI3K/Akt is required for heat shock proteins to protect hypoxia inducible factor 1α from pVHL-independent degradation. J Biol Chem 279: 13506-13513, 2004. (Pubitemid 38468875)
14. Ibrahim NO, Hahn T, Franke C, Stiehl DP, Wirthner R, Wenger RH and Katschinski DM: Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors. Cancer Res 65: 11094-11100, 2005.
15. Liao D, Corle C, Seagroves TN and Johnson RS: Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563-572, 2007 (Pubitemid 46192193)
16. Boutin AT, Weidemann A, Fu Z, et al: Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell 133: 223-234, 2008. (Pubitemid 351508305)
17. Potter C and Harris AL: Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle 3: 164-167, 2004. (Pubitemid 40268690)
18. Robertson N, Potter C and Harris AL: Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res 64: 6160-6165, 2004. (Pubitemid 39129417)
19. McCarty MF, Barroso-Aranda J and Contreras F: Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy. Med Hypotheses 74: 789-797, 2010.
20. Sethi G, Ahn KS, Pandey MK and Aggarwal BB: Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 109: 2727-2735, 2007 (Pubitemid 46482064)
21. Yang H, Chen D, Cui QC, Yuan X and Dou QP: Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine,' is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66: 4758-4765, 2006.
22. Walcott SE and Heikkila JJ: Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells. Comp Biochem Physiol A Mol Integr Physiol 156: 285-293, 2010.
23. Pang X, Yi Z, Zhang J, Lu B, Sung B, Qu W, Aggarwal BB and Liu M: Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res 70: 1951-1959, 2010.
24. Huang Y, Zhou Y, Fan Y and Zhou D: Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett 264: 101-106, 2008.
25. Kallio PJ, Wilson WJ, O'Brien S, Makino Y and Poellinger L: Regulation of the hypoxia-inducible transcription factor 1 by the ubiquitin-proteasome pathway. J Biol Chem 274: 6519-6525, 1999. (Pubitemid 29111068)
26. Alqawi O, Moghaddas M and Singh G: Effects of geldanamycin on HIF-1α mediated angiogenesis and invasion in prostate cancer cells. Prostate Cancer Prostatic Dis 9: 126-135, 2006.
27. van Lieshout T, Stanisz J, Espiritu V, Richardson M and Singh G: A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane. Int J Oncol 23: 745-750, 2003.
28. Banerji U: Heat shock protein 90 as a drug target: some like it hot. Clin Cancer Res 15: 9-14, 2009.
29. Zhang T, Li Y, Yu Y, Zou P, Jiang Y and Sun D: Characterization of celastrol to inhibit hsp90 and cdc37 interaction. J Biol Chem 284: 35381-35389, 2009.
30. Duffy MJ, McGowan PM and Gallagher WM: Cancer invasion and metastasis: changing views. J Pathol 214: 283-293, 2008.