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Volumn 14, Issue 11, 2014, Pages 873-883

Strategic role of nuclear inositide signalling in myelodysplastic syndromes therapy

Author keywords

Akt; Azacitidine; Erythroid differentiation; Erythropoietin; Myelodysplastic syndromes; Myeloid differentiation; Nuclear inositides; Phospholipase C 1

Indexed keywords

AZACITIDINE; CALCIUM; CYCLIN D3; DIACYLGLYCEROL; DNA METHYLTRANSFERASE; ERYTHROPOIETIN; G PROTEIN COUPLED RECEPTOR; HEMOGLOBIN; HISTONE DEACETYLASE; INOSITIDE; INOSITOL 1, 4, 5 TRISPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 155; MICRORNA 21; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4, 5 BISPHOSPHATE PHOSPHODIESTERASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUGAR ALCOHOL; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84911415867     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557514666141013125936     Document Type: Article
Times cited : (20)

References (85)
  • 1
    • 84885769048 scopus 로고    scopus 로고
    • The physiological roles of primary phospholipase C
    • Yang, Y.R.; Follo, M.Y.; Cocco, L.; Suh, P.G., The physiological roles of primary phospholipase C. Adv. Biol. Regul., 2013, 53, (3), 232-241.
    • (2013) Adv. Biol. Regul. , vol.53 , Issue.3 , pp. 232-241
    • Yang, Y.R.1    Follo, M.Y.2    Cocco, L.3    Suh, P.G.4
  • 2
    • 84885789398 scopus 로고    scopus 로고
    • Reflections on the days of phospholipase C
    • Rhee, S.G., Reflections on the days of phospholipase C. Adv. Biol. Regul., 2013, 53, (3), 223-231.
    • (2013) Adv. Biol. Regul. , vol.53 , Issue.3 , pp. 223-231
    • Rhee, S.G.1
  • 3
    • 0034927336 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C
    • Rhee, S.G., Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem., 2001, 70, 281-312.
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 281-312
    • Rhee, S.G.1
  • 4
    • 84862778234 scopus 로고    scopus 로고
    • Role of phospholipase Cepsilon in physiological phosphoinositide signaling networks
    • Smrcka, A.V.; Brown, J.H.; Holz, G.G., Role of phospholipase Cepsilon in physiological phosphoinositide signaling networks. Cellular Signalling, 2012, 24, (6), 1333-1343.
    • (2012) Cellular Signalling , vol.24 , Issue.6 , pp. 1333-1343
    • Smrcka, A.V.1    Brown, J.H.2    Holz, G.G.3
  • 5
    • 84885763427 scopus 로고    scopus 로고
    • Phospholipase C-beta in immune cells
    • Kawakami, T.; Xiao, W., Phospholipase C-beta in immune cells. Adv. Biol. Regul., 2013, 53, (3), 249-257.
    • (2013) Adv. Biol. Regul. , vol.53 , Issue.3 , pp. 249-257
    • Kawakami, T.1    Xiao, W.2
  • 6
    • 84885694702 scopus 로고    scopus 로고
    • Phospholipase C-beta1 and schizophrenia-related behaviors
    • Koh, H.Y., Phospholipase C-beta1 and schizophrenia-related behaviors. Adv. Biol. Regul., 2013, 53, (3), 242-248.
    • (2013) Adv. Biol. Regul. , vol.53 , Issue.3 , pp. 242-248
    • Koh, H.Y.1
  • 7
    • 84885828101 scopus 로고    scopus 로고
    • Role of phospholipase C-beta in RNA interference
    • Philip, F.; Sahu, S.; Caso, G.; Scarlata, S., Role of phospholipase C-beta in RNA interference. Adv. Biol. Regul., 2013, 53, (3), 319-330.
    • (2013) Adv. Biol. Regul. , vol.53 , Issue.3 , pp. 319-330
    • Philip, F.1    Sahu, S.2    Caso, G.3    Scarlata, S.4
  • 8
    • 0026693238 scopus 로고
    • Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells
    • Martelli, A.M.; Gilmour, R.S.; Bertagnolo, V.; Neri, L.M.; Manzoli, L.; Cocco, L., Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells. Nature, 1992, 358, (6383), 242-245.
    • (1992) Nature , vol.358 , Issue.6383 , pp. 242-245
    • Martelli, A.M.1    Gilmour, R.S.2    Bertagnolo, V.3    Neri, L.M.4    Manzoli, L.5    Cocco, L.6
  • 11
    • 21344448380 scopus 로고    scopus 로고
    • Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation
    • Faenza, I.; Billi, A.M.; Follo, M.Y.; Fiume, R.; Martelli, A.M.; Cocco, L.; Manzoli, L., Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation. Antican. Res., 2005, 25, (3B), 2039-2041.
    • (2005) Antican. Res. , vol.25 , Issue.3B , pp. 2039-2041
    • Faenza, I.1    Billi, A.M.2    Follo, M.Y.3    Fiume, R.4    Martelli, A.M.5    Cocco, L.6    Manzoli, L.7
  • 12
    • 27144527300 scopus 로고    scopus 로고
    • Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: A central intermediary in nuclear lipid-dependent signal transduction
    • Martelli, A.M.; Fiume, R.; Faenza, I.; Tabellini, G.; Evangelista, C.; Bortul, R.; Follo, M.Y.; Fala, F.; Cocco, L., Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction. Histology and Histopathology, 2005, 20, (4), 1251-1260.
    • (2005) Histology and Histopathology , vol.20 , Issue.4 , pp. 1251-1260
    • Martelli, A.M.1    Fiume, R.2    Faenza, I.3    Tabellini, G.4    Evangelista, C.5    Bortul, R.6    Follo, M.Y.7    Fala, F.8    Cocco, L.9
  • 14
    • 84887966427 scopus 로고    scopus 로고
    • Cyclin D3 critically regulates the balance between self-renewal and differentiation in skeletal muscle stem cells
    • De Luca, G.; Ferretti, R.; Bruschi, M.; Mezzaroma, E.; Caruso, M., Cyclin D3 critically regulates the balance between self-renewal and differentiation in skeletal muscle stem cells. Stem cells (Dayton, Ohio), 2013, 31, (11), 2478-2491.
    • (2013) Stem cells (Dayton, Ohio) , vol.31 , Issue.11 , pp. 2478-2491
    • De Luca, G.1    Ferretti, R.2    Bruschi, M.3    Mezzaroma, E.4    Caruso, M.5
  • 18
    • 48749108800 scopus 로고    scopus 로고
    • Deregulation of signaling pathways in acute myeloid leukemia
    • Scholl, C.; Gilliland, D.G.; Frohling, S., Deregulation of signaling pathways in acute myeloid leukemia. Seminars in oncology, 2008, 35, (4), 336-345.
    • (2008) Seminars in oncology , vol.35 , Issue.4 , pp. 336-345
    • Scholl, C.1    Gilliland, D.G.2    Frohling, S.3
  • 19
    • 45149121372 scopus 로고    scopus 로고
    • The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
    • Chiarini, F.; Del Sole, M.; Mongiorgi, S.; Gaboardi, G.C.; Cappellini, A.; Mantovani, I.; Follo, M.Y.; McCubrey, J.A.; Martelli, A.M., The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia, 2008, 22, (6), 1106-1116.
    • (2008) Leukemia , vol.22 , Issue.6 , pp. 1106-1116
    • Chiarini, F.1    Del Sole, M.2    Mongiorgi, S.3    Gaboardi, G.C.4    Cappellini, A.5    Mantovani, I.6    Follo, M.Y.7    McCubrey, J.A.8    Martelli, A.M.9
  • 20
    • 27844553839 scopus 로고    scopus 로고
    • AKT crystal structure and AKTspecific inhibitors
    • Kumar, C.C.; Madison, V., AKT crystal structure and AKTspecific inhibitors. Oncogene, 2005, 24, (50), 7493-7501.
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7493-7501
    • Kumar, C.C.1    Madison, V.2
  • 21
    • 84893249799 scopus 로고    scopus 로고
    • PI3K and cancer: Lessons, challenges and opportunities
    • Fruman, D.A.; Rommel, C., PI3K and cancer: lessons, challenges and opportunities. Nat. Rev., 2014, 13, (2), 140-156.
    • (2014) Nat. Rev. , vol.13 , Issue.2 , pp. 140-156
    • Fruman, D.A.1    Rommel, C.2
  • 22
    • 79952293503 scopus 로고    scopus 로고
    • Activation of mTORC2 by association with the ribosome
    • Zinzalla, V.; Stracka, D.; Oppliger, W.; Hall, M.N., Activation of mTORC2 by association with the ribosome. Cell, 2011, 144, (5), 757-768.
    • (2011) Cell , vol.144 , Issue.5 , pp. 757-768
    • Zinzalla, V.1    Stracka, D.2    Oppliger, W.3    Hall, M.N.4
  • 23
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante, M.; Sabatini, D.M., mTOR signaling in growth control and disease. Cell, 2012, 149, (2), 274-293.
    • (2012) Cell , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 24
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
    • Huang, J.; Manning, B.D., The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem. J., 2008, 412, (2), 179-190.
    • (2008) Biochem. J. , vol.412 , Issue.2 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 28
    • 84859802096 scopus 로고    scopus 로고
    • Integrating novel signaling pathways involved in erythropoiesis
    • Ingley, E., Integrating novel signaling pathways involved in erythropoiesis. IUBMB life, 2012, 64, (5), 402-410.
    • (2012) IUBMB life , vol.64 , Issue.5 , pp. 402-410
    • Ingley, E.1
  • 29
    • 33745763267 scopus 로고    scopus 로고
    • Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor
    • Wang, Y.; Wu, J.; Wang, Z., Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor. Mol. Biol. Cell, 2006, 17, (5), 2267-2277.
    • (2006) Mol. Biol. Cell , vol.17 , Issue.5 , pp. 2267-2277
    • Wang, Y.1    Wu, J.2    Wang, Z.3
  • 31
    • 84865654433 scopus 로고    scopus 로고
    • Phosphoinositides signalling in cancer: Focus on PI3K and PLC
    • Raimondi, C.; Falasca, M., Phosphoinositides signalling in cancer: focus on PI3K and PLC. Adv. Biol. Regul., 2012, 52, (1), 166-182.
    • (2012) Adv. Biol. Regul. , vol.52 , Issue.1 , pp. 166-182
    • Raimondi, C.1    Falasca, M.2
  • 33
    • 33344458617 scopus 로고    scopus 로고
    • AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation
    • Ghaffari, S.; Kitidis, C.; Zhao, W.; Marinkovic, D.; Fleming, M.D.; Luo, B.; Marszalek, J.; Lodish, H.F., AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood, 2006, 107, (5), 1888-1891.
    • (2006) Blood , vol.107 , Issue.5 , pp. 1888-1891
    • Ghaffari, S.1    Kitidis, C.2    Zhao, W.3    Marinkovic, D.4    Fleming, M.D.5    Luo, B.6    Marszalek, J.7    Lodish, H.F.8
  • 35
    • 84892888839 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management
    • Garcia-Manero, G., Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management. Am. J. Hematol., 2014, 89, (1), 97-108.
    • (2014) Am. J. Hematol. , vol.89 , Issue.1 , pp. 97-108
    • Garcia-Manero, G.1
  • 38
    • 2942666283 scopus 로고    scopus 로고
    • Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia
    • Lo Vasco, V.R.; Calabrese, G.; Manzoli, L.; Palka, G.; Spadano, A.; Morizio, E.; Guanciali-Franchi, P.; Fantasia, D.; Cocco, L., Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia. Leukemia, 2004, 18, (6), 1122-1126.
    • (2004) Leukemia , vol.18 , Issue.6 , pp. 1122-1126
    • Lo Vasco, V.R.1    Calabrese, G.2    Manzoli, L.3    Palka, G.4    Spadano, A.5    Morizio, E.6    Guanciali-Franchi, P.7    Fantasia, D.8    Cocco, L.9
  • 40
    • 77955910371 scopus 로고    scopus 로고
    • Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: Not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor
    • author reply e388-389
    • Damm, F.; Lange, K.; Heuser, M.; Oberack Morgan, M.; Wagner, K.; Krauter, J.; Schlegelberger, B.; Ganser Aer T.; Gohring, G., Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor. J. Clin. Oncol., 2010, 28, (22), e384-387; author reply e388-389.
    • (2010) J. Clin. Oncol , vol.28 , Issue.22 , pp. e384-387
    • Damm, F.1    Lange, K.2    Heuser, M.3    Oberack Morgan, M.4    Wagner, K.5    Krauter, J.6    Schlegelberger, B.7    Ganser Aer, T.8    Gohring, G.9
  • 47
    • 84899117261 scopus 로고    scopus 로고
    • Epigenetics and oncology
    • Mummaneni, P.; Shord, S.S., Epigenetics and oncology. Pharmacotherapy, 2014, 34, (5), 495-505.
    • (2014) Pharmacotherapy , vol.34 , Issue.5 , pp. 495-505
    • Mummaneni, P.1    Shord, S.S.2
  • 48
    • 39649122136 scopus 로고    scopus 로고
    • Cancer epigenetics: Modifications, screening, and therapy
    • Gal-Yam, E.N.; Saito, Y.; Egger, G.; Jones, P.A., Cancer epigenetics: modifications, screening, and therapy. Ann. Rev. Med., 2008, 59, 267-280.
    • (2008) Ann. Rev. Med. , vol.59 , pp. 267-280
    • Gal-Yam, E.N.1    Saito, Y.2    Egger, G.3    Jones, P.A.4
  • 49
    • 79751528245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia
    • Quintas-Cardama, A.; Santos, F.P.; Garcia-Manero, G., Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia. Leukemia, 2011, 25, (2), 226-235.
    • (2011) Leukemia , vol.25 , Issue.2 , pp. 226-235
    • Quintas-Cardama, A.1    Santos, F.P.2    Garcia-Manero, G.3
  • 50
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci, S.; Pelicci, P.G., Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer, 2006, 6, (1), 38-51.
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.1 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 52
    • 47149109822 scopus 로고    scopus 로고
    • MicroRNAs in normal and malignant hematopoiesis
    • Garzon, R.; Croce, C.M., MicroRNAs in normal and malignant hematopoiesis. Curr. Opin. Hematol., 2008, 15, (4), 352-358.
    • (2008) Curr. Opin. Hematol. , vol.15 , Issue.4 , pp. 352-358
    • Garzon, R.1    Croce, C.M.2
  • 54
    • 84895175958 scopus 로고    scopus 로고
    • Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes
    • Kim, Y.; Cheong, J.W.; Kim, Y.K.; Eom, J.I.; Jeung, H.K.; Kim, S.J.; Hwang, D.; Kim, J.S.; Kim, H.J.; Min, Y.H., Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes. PloS One, 2014, 9, (2), e86933.
    • (2014) PloS One , vol.9 , Issue.2 , pp. e86933
    • Kim, Y.1    Cheong, J.W.2    Kim, Y.K.3    Eom, J.I.4    Jeung, H.K.5    Kim, S.J.6    Hwang, D.7    Kim, J.S.8    Kim, H.J.9    Min, Y.H.10
  • 56
    • 35448934364 scopus 로고    scopus 로고
    • Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome
    • Kerbauy, D.B.; Deeg, H.J., Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome. Exp. hematol., 2007, 35, (11), 1739-1746.
    • (2007) Exp. hematol. , vol.35 , Issue.11 , pp. 1739-1746
    • Kerbauy, D.B.1    Deeg, H.J.2
  • 58
    • 84886629827 scopus 로고    scopus 로고
    • Physiology and pharmacology of erythropoietin
    • Jelkmann, W., Physiology and pharmacology of erythropoietin. Transfus. Med. Hemother., 2013, 40, (5), 302-309.
    • (2013) Transfus. Med. Hemother. , vol.40 , Issue.5 , pp. 302-309
    • Jelkmann, W.1
  • 59
    • 84866748197 scopus 로고    scopus 로고
    • The effect of erythropoietin on normal and neoplastic cells
    • Elliott, S.; Sinclair, A.M., The effect of erythropoietin on normal and neoplastic cells. Biologics, 2012, 6, 163-189.
    • (2012) Biologics , vol.6 , pp. 163-189
    • Elliott, S.1    Sinclair, A.M.2
  • 60
    • 54049113367 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietindependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation
    • Buck, I.; Morceau, F.; Cristofanon, S.; Heintz, C.; Chateauvieux, S.; Reuter, S.; Dicato, M.; Diederich, M., Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietindependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation. Biochem. Pharmacol., 2008, 76, (10), 1229-1239.
    • (2008) Biochem. Pharmacol. , vol.76 , Issue.10 , pp. 1229-1239
    • Buck, I.1    Morceau, F.2    Cristofanon, S.3    Heintz, C.4    Chateauvieux, S.5    Reuter, S.6    Dicato, M.7    Diederich, M.8
  • 62
    • 84867622112 scopus 로고    scopus 로고
    • Treatment of low-risk myelodysplastic syndrome: Hematopoietic growth factors erythropoietins and thrombopoietins
    • Santini, V., Treatment of low-risk myelodysplastic syndrome: hematopoietic growth factors erythropoietins and thrombopoietins. Seminars in Hematology, 2012, 49, (4), 295-303.
    • (2012) Seminars in Hematology , vol.49 , Issue.4 , pp. 295-303
    • Santini, V.1
  • 63
    • 79952092841 scopus 로고    scopus 로고
    • Hypomethylating agents and other novel strategies in myelodysplastic syndromes
    • Garcia-Manero, G.; Fenaux, P., Hypomethylating agents and other novel strategies in myelodysplastic syndromes. J. Clin. Oncol., 2011, 29, (5), 516-523.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.5 , pp. 516-523
    • Garcia-Manero, G.1    Fenaux, P.2
  • 68
    • 58149305491 scopus 로고    scopus 로고
    • Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells
    • Missiroli, S.; Etro, D.; Buontempo, F.; Ye, K.; Capitani, S.; Neri, L.M., Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells. Int. J. Biochem. Cell Biol., 2009, 41, (3), 570-577.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , Issue.3 , pp. 570-577
    • Missiroli, S.1    Etro, D.2    Buontempo, F.3    Ye, K.4    Capitani, S.5    Neri, L.M.6
  • 69
    • 80053209138 scopus 로고    scopus 로고
    • Treatment of higher-risk myelodysplastic syndrome
    • Garcia-Manero, G., Treatment of higher-risk myelodysplastic syndrome. Seminars in Oncology, 2011, 38, (5), 673-681.
    • (2011) Seminars in Oncology , vol.38 , Issue.5 , pp. 673-681
    • Garcia-Manero, G.1
  • 71
    • 77949364616 scopus 로고    scopus 로고
    • Azacitidine for the treatment of lower risk myelodysplastic syndromes : A retrospective study of 74 patients enrolled in an Italian named patient program
    • Musto, P.; Maurillo, L.; Spagnoli, A.; Gozzini, A.; Rivellini, F.; Lunghi, M.; Villani, O.; Aloe-Spiriti, M.A.; Venditti, A.; Santini, V., Azacitidine for the treatment of lower risk myelodysplastic syndromes : a retrospective study of 74 patients enrolled in an Italian named patient program. Cancer, 2010, 116, (6), 1485-1494.
    • (2010) Cancer , vol.116 , Issue.6 , pp. 1485-1494
    • Musto, P.1    Maurillo, L.2    Spagnoli, A.3    Gozzini, A.4    Rivellini, F.5    Lunghi, M.6    Villani, O.7    Aloe-Spiriti, M.A.8    Venditti, A.9    Santini, V.10
  • 72
    • 71149101593 scopus 로고    scopus 로고
    • Review of azacitidine trials in Intermediate-2- and High-risk myelodysplastic syndromes
    • Fenaux, P.; Ades, L., Review of azacitidine trials in Intermediate-2- and High-risk myelodysplastic syndromes. Leukemia Res., 2009, 33 Suppl 2, S7-11.
    • (2009) Leukemia Res , vol.33 , pp. S7-11
    • Fenaux, P.1    Ades, L.2
  • 73
    • 5744248237 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors in myelodysplastic syndrome
    • Silverman, L.R., DNA methyltransferase inhibitors in myelodysplastic syndrome. Best Pract. Res., 2004, 17, (4), 585-594.
    • (2004) Best Pract. Res. , vol.17 , Issue.4 , pp. 585-594
    • Silverman, L.R.1
  • 77
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides, T., Chromatin modifications and their function. Cell, 2007, 128, (4), 693-705.
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 78
    • 0041347519 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
    • Johnstone, R.W.; Licht, J.D., Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell, 2003, 4, (1), 13-18.
    • (2003) Cancer Cell , vol.4 , Issue.1 , pp. 13-18
    • Johnstone, R.W.1    Licht, J.D.2
  • 79
    • 37549022694 scopus 로고    scopus 로고
    • DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Griffiths, E.A.; Gore, S.D., DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Seminars in Hematology, 2008, 45, (1), 23-30.
    • (2008) Seminars in Hematology , vol.45 , Issue.1 , pp. 23-30
    • Griffiths, E.A.1    Gore, S.D.2
  • 80
    • 55049098618 scopus 로고    scopus 로고
    • Future directions in myelodysplastic syndrome: Newer agents and the role of combination approaches
    • Gore, S.D.; Hermes-DeSantis, E.R., Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches. Cancer Control, 2008, 15 Suppl, 40-49.
    • (2008) Cancer Control , vol.15 , pp. 40-49
    • Gore, S.D.1    Hermes-Desantis, E.R.2
  • 83
    • 84884755154 scopus 로고    scopus 로고
    • Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation
    • Galdieri, L.; Chang, J.; Mehrotra, S.; Vancura, A., Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation. J. Biol. Chem., 2013, 288, (39), 27986-27998.
    • (2013) J. Biol. Chem. , vol.288 , Issue.39 , pp. 27986-27998
    • Galdieri, L.1    Chang, J.2    Mehrotra, S.3    Vancura, A.4
  • 85
    • 34249308840 scopus 로고    scopus 로고
    • The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
    • Follo, M.Y.; Mongiorgi, S.; Bosi, C.; Cappellini, A.; Finelli, C.; Chiarini, F.; Papa, V.; Libra, M.; Martinelli, G.; Cocco, L.; Martelli, A.M., The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. Cancer Res., 2007, 67, (9), 4287-4294
    • (2007) Cancer Res. , vol.67 , Issue.9 , pp. 4287-4294
    • Follo, M.Y.1    Mongiorgi, S.2    Bosi, C.3    Cappellini, A.4    Finelli, C.5    Chiarini, F.6    Papa, V.7    Libra, M.8    Martinelli, G.9    Cocco, L.10    Martelli, A.M.11


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