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Volumn 362, Issue , 2012, Pages 235-245

Nuclear PI-PLC β1 and myelodysplastic syndromes: From bench to clinics

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; CYCLIN D3; DNA METHYLTRANSFERASE INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H4; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PHOSPHOINOSITIDE SPECIFIC PHOSPHOLIPASE C BETA1; PHOSPHOINOSITIDE SPECIFIC PHOSPHOLIPASE C BETA3; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 1; STAT5 PROTEIN; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 84870031043     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-5025-8_11     Document Type: Article
Times cited : (16)

References (50)
  • 1
    • 0019952276 scopus 로고
    • Proposals for the classification of the myelodysplastic syndromes
    • Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51:189-199 (Pubitemid 12073508)
    • (1982) British Journal of Haematology , vol.51 , Issue.2 , pp. 189-199
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 2
    • 58149174109 scopus 로고    scopus 로고
    • Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers
    • Braiteh F, Soriano AO, Garcia-Manero G et al (2008) Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers. Clin Cancer Res 14:6296-6301
    • (2008) Clin Cancer Res , vol.14 , pp. 6296-6301
    • Braiteh, F.1    Soriano, A.O.2    Garcia-Manero, G.3
  • 3
    • 34247354963 scopus 로고    scopus 로고
    • Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage
    • DOI 10.1182/blood-2006-07-036335
    • Cain JA, Xiang Z, O'Neal J et al (2007) Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage. Blood 109:3906-3914 (Pubitemid 46641743)
    • (2007) Blood , vol.109 , Issue.9 , pp. 3906-3914
    • Cain, J.A.1    Xiang, Z.2    O'Neal, J.3    Kreisel, F.4    Colson, A.5    Luo, H.6    Hennighausen, L.7    Tomasson, M.H.8
  • 6
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment
    • Daskalakis M, Nguyen TT, Nguyen C et al (2002) Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood 100:2957-2964
    • (2002) Blood , vol.100 , pp. 2957-2964
    • Daskalakis, M.1    Nguyen, T.T.2    Nguyen, C.3
  • 8
    • 0034730764 scopus 로고    scopus 로고
    • A role for nuclear phospholipase Cbeta1 in cell cycle control
    • Faenza I, Matteucci A, Manzoli L et al (2000) A role for nuclear phospholipase Cbeta1 in cell cycle control. J Biol Chem 275:30520-30524
    • (2000) J Biol Chem , vol.275 , pp. 30520-30524
    • Faenza, I.1    Matteucci, A.2    Manzoli, L.3
  • 9
    • 33847035243 scopus 로고    scopus 로고
    • Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter
    • Faenza I, Ramazzotti G, Bavelloni A et al (2007) Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter. Endocrinology 148:1108-1117
    • (2007) Endocrinology , vol.148 , pp. 1108-1117
    • Faenza, I.1    Ramazzotti, G.2    Bavelloni, A.3
  • 10
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E et al (2009) Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 10:223-232
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 11
  • 12
    • 61449104807 scopus 로고    scopus 로고
    • Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression
    • Fiume R, Ramazzotti G, Teti G et al (2009) Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression. FASEB J 23:957-966
    • (2009) FASEB J , vol.23 , pp. 957-966
    • Fiume, R.1    Ramazzotti, G.2    Teti, G.3
  • 13
    • 34249316814 scopus 로고    scopus 로고
    • Real-time PCR as a tool for quantitative analysis of PI-PLCbeta1 gene expression in myelodysplastic syndrome
    • Follo MY, Bosi C, Finelli C et al (2006) Real-time PCR as a tool for quantitative analysis of PI-PLCbeta1 gene expression in myelodysplastic syndrome. Int J Mol Med 18:267-271
    • (2006) Int J Mol Med , vol.18 , pp. 267-271
    • Follo, M.Y.1    Bosi, C.2    Finelli, C.3
  • 14
    • 38349023105 scopus 로고    scopus 로고
    • PI-PLCbeta-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes
    • Follo MY, Finelli C, Bosi C et al (2008) PI-PLCbeta-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes. Leukemia 22:198-200
    • (2008) Leukemia , vol.22 , pp. 198-200
    • Follo, M.Y.1    Finelli, C.2    Bosi, C.3
  • 15
    • 60149098150 scopus 로고    scopus 로고
    • Phosphoinositide-phospholipase Cbeta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia
    • Follo MY, Finelli C, Clissa C et al (2009a) Phosphoinositide- phospholipase Cbeta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia. J Clin Oncol 27:782-790
    • (2009) J Clin Oncol , vol.27 , pp. 782-790
    • Follo, M.Y.1    Finelli, C.2    Clissa, C.3
  • 16
    • 70349753260 scopus 로고    scopus 로고
    • Reduction of phosphoinositide-phospholipase Cbeta1 methylation predicts the responsiveness to azacitidine in high-risk MDS
    • Follo MY, Finelli C, Mongiorgi S et al (2009b) Reduction of phosphoinositide-phospholipase Cbeta1 methylation predicts the responsiveness to azacitidine in high-risk MDS. Proc Natl Acad Sci U S A 106:16811-16816
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16811-16816
    • Follo, M.Y.1    Finelli, C.2    Mongiorgi, S.3
  • 17
    • 79751534358 scopus 로고    scopus 로고
    • Synergistic induction of PI-PLCbeta1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes
    • Follo MY, Finelli C, Mongiorgi S et al (2011) Synergistic induction of PI-PLCbeta1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes. Leukemia 25:271-280
    • (2011) Leukemia , vol.25 , pp. 271-280
    • Follo, M.Y.1    Finelli, C.2    Mongiorgi, S.3
  • 19
    • 77951713970 scopus 로고    scopus 로고
    • Nuclear inositide signaling in myelodysplastic syndromes
    • Follo MY, Mongiorgi S, Finelli C et al (2010) Nuclear inositide signaling in myelodysplastic syndromes. J Cell Biochem 109:1065-1071
    • (2010) J Cell Biochem , vol.109 , pp. 1065-1071
    • Follo, M.Y.1    Mongiorgi, S.2    Finelli, C.3
  • 20
    • 0036193046 scopus 로고    scopus 로고
    • Cell cycle control genes and hematopoietic cell differentiation
    • DOI 10.1080/10428190290005973
    • Furukawa Y (2002) Cell cycle control genes and hematopoietic cell differentiation. Leuk Lymphoma 43:225-231 (Pubitemid 34202099)
    • (2002) Leukemia and Lymphoma , vol.43 , Issue.2 , pp. 225-231
    • Furukawa, Y.1
  • 22
    • 37549022694 scopus 로고    scopus 로고
    • DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Griffiths EA, Gore SD (2008) DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol 45:23-30
    • (2008) Semin Hematol , vol.45 , pp. 23-30
    • Griffiths, E.A.1    Gore, S.D.2
  • 23
    • 39749189446 scopus 로고    scopus 로고
    • Red blood cell transfusions and iron overload in the treatment of patients with myelodysplasic syndromes
    • DOI 10.1002/cncr.23280
    • Jabbour E, Kantarjian HM, Koller C, Taher A (2008) Red blood cell transfusions and iron overload in the treatment of patients with myelodysplastic syndromes. Cancer 112:1089-1095 (Pubitemid 351304594)
    • (2008) Cancer , vol.112 , Issue.5 , pp. 1089-1095
    • Jabbour, E.1    Kantarjian, H.M.2    Koller, C.3    Taher, A.4
  • 27
    • 0026693238 scopus 로고
    • Nuclear localization and signalling activity of phosphoinositidase Cbeta in Swiss 3T3 cells
    • Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, Cocco L (1992) Nuclear localization and signalling activity of phosphoinositidase Cbeta in Swiss 3T3 cells. Nature 358:242-245
    • (1992) Nature , vol.358 , pp. 242-245
    • Martelli, A.M.1    Gilmour, R.S.2    Bertagnolo, V.3    Neri, L.M.4    Manzoli, L.5    Cocco, L.6
  • 28
    • 77952853306 scopus 로고    scopus 로고
    • Histone deacetylases and epigenetic therapies of hematological malignancies
    • Mercurio C, Minucci S, Pelicci PG (2010) Histone deacetylases and epigenetic therapies of hematological malignancies. Pharmacol Res 62:18-34
    • (2010) Pharmacol Res , vol.62 , pp. 18-34
    • Mercurio, C.1    Minucci, S.2    Pelicci, P.G.3
  • 29
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • DOI 10.1038/nrc1779
    • Minucci S, Pelicci PG (2006) Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6:38-51 (Pubitemid 43054973)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.1 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 30
    • 31744448235 scopus 로고    scopus 로고
    • Molecularly targeted therapies in myelodysplastic syndromes and acute myeloid leukemias
    • DOI 10.1007/s00277-005-0051-7
    • Morgan MA, Reuter CW (2006) Molecularly targeted therapies in myelodysplastic syndromes and acute myeloid leukemias. Ann Hematol 85:139-163 (Pubitemid 43174269)
    • (2006) Annals of Hematology , vol.85 , Issue.3 , pp. 139-163
    • Morgan, M.A.1    Reuter, C.W.M.2
  • 31
    • 67650901198 scopus 로고    scopus 로고
    • Chromatin maps, histone modifications and leukemia
    • Neff T, Armstrong SA (2009) Chromatin maps, histone modifications and leukemia. Leukemia 23:1243-1251
    • (2009) Leukemia , vol.23 , pp. 1243-1251
    • Neff, T.1    Armstrong, S.A.2
  • 33
    • 62749110450 scopus 로고    scopus 로고
    • Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex
    • O'Carroll SJ, Mitchell MD, Faenza I, Cocco L, Gilmour RS (2009) Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex. Cell Signal 21:926-935
    • (2009) Cell Signal , vol.21 , pp. 926-935
    • O'Carroll, S.J.1    Mitchell, M.D.2    Faenza, I.3    Cocco, L.4    Gilmour, R.S.5
  • 34
    • 51649088622 scopus 로고    scopus 로고
    • PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
    • Park S, Chapuis N, Bardet V et al (2008) PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia 22:1698-1706
    • (2008) Leukemia , vol.22 , pp. 1698-1706
    • Park, S.1    Chapuis, N.2    Bardet, V.3
  • 35
    • 70350726344 scopus 로고    scopus 로고
    • A phase I study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia
    • Perl AE, Kasner MT, Tsai DE et al (2009) A phase I study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia. Clin Cancer Res 15:6732-6739
    • (2009) Clin Cancer Res , vol.15 , pp. 6732-6739
    • Perl, A.E.1    Kasner, M.T.2    Tsai, D.E.3
  • 38
    • 34548131144 scopus 로고    scopus 로고
    • CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    • DOI 10.1038/sj.leu.2404796, PII 2404796
    • Raj K, John A, Ho A et al (2007) CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 21:1937-1944 (Pubitemid 47299967)
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 1937-1944
    • Raj, K.1    John, A.2    Ho, A.3    Chronis, C.4    Khan, S.5    Samuel, J.6    Pomplun, S.7    Thomas, N.S.B.8    Mufti, G.J.9
  • 39
    • 0033639119 scopus 로고    scopus 로고
    • Stat5 is essential for the myelo-and lymphoproliferative disease induced by TEL/JAK2
    • Schwaller J, Parganas E, Wang D et al (2000) Stat5 is essential for the myelo-and lymphoproliferative disease induced by TEL/JAK2. Mol Cell 6:693-704
    • (2000) Mol Cell , vol.6 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3
  • 40
    • 58049221263 scopus 로고    scopus 로고
    • Relationship of treatment-related cytopenias and response to lenalidomide in patients with lower-risk myelodysplastic syndromes
    • Sekeres MA, Maciejewski JP, Giagounidis AA, Wride K, Knight R, Raza A, List AF (2008) Relationship of treatment-related cytopenias and response to lenalidomide in patients with lower-risk myelodysplastic syndromes. J Clin Oncol 26:5943-5949
    • (2008) J Clin Oncol , vol.26 , pp. 5943-5949
    • Sekeres, M.A.1    Maciejewski, J.P.2    Giagounidis, A.A.3    Wride, K.4    Knight, R.5    Raza, A.6    List, A.F.7
  • 41
    • 31344450167 scopus 로고    scopus 로고
    • Methylation inhibitor therapy in the treatment of myelodysplastic syndrome
    • Silverman LR, Mufti GJ (2005) Methylation inhibitor therapy in the treatment of myelodysplastic syndrome. Nat Clin Pract Oncol 2(Suppl 1):12-23
    • (2005) Nat Clin Pract Oncol , vol.2 , Issue.SUPPL. 1 , pp. 12-23
    • Silverman, L.R.1    Mufti, G.J.2
  • 42
    • 48049104551 scopus 로고    scopus 로고
    • Current treatment options and strategies for myelodysplastic syndromes
    • Srinivasan S, Schiffer CA (2008) Current treatment options and strategies for myelodysplastic syndromes. Expert Opin Pharmacother 9:1667-1678
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1667-1678
    • Srinivasan, S.1    Schiffer, C.A.2
  • 43
    • 43949136445 scopus 로고    scopus 로고
    • Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
    • DOI 10.1002/ijc.23607
    • Stresemann C, Lyko F (2008) Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int J Cancer 123:8-13 (Pubitemid 351705186)
    • (2008) International Journal of Cancer , vol.123 , Issue.1 , pp. 8-13
    • Stresemann, C.1    Lyko, F.2
  • 45
    • 70350755818 scopus 로고    scopus 로고
    • Myelodysplastic syndromes
    • Tefferi A, Vardiman JW (2009) Myelodysplastic syndromes. N Engl J Med 361:1872-1885
    • (2009) N Engl J Med , vol.361 , pp. 1872-1885
    • Tefferi, A.1    Vardiman, J.W.2
  • 46
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA et al (2009) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 114:937-951
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 47
    • 78650662553 scopus 로고    scopus 로고
    • Lyn-and PLCbeta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemialike disease
    • Xiao W, Ando T, Wang HY, Kawakami Y, Kawakami T (2010) Lyn-and PLCbeta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemialike disease. Blood 116:6003-6013
    • (2010) Blood , vol.116 , pp. 6003-6013
    • Xiao, W.1    Ando, T.2    Wang, H.Y.3    Kawakami, Y.4    Kawakami, T.5
  • 48
    • 67651152910 scopus 로고    scopus 로고
    • Tumor suppression by phospholipase Cbeta3 via SHP-1-mediated dephosphorylation of Stat5
    • Xiao W, Hong H, Kawakami Y et al (2009) Tumor suppression by phospholipase Cbeta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell 16:161-171
    • (2009) Cancer Cell , vol.16 , pp. 161-171
    • Xiao, W.1    Hong, H.2    Kawakami, Y.3
  • 49
    • 40549124306 scopus 로고    scopus 로고
    • Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5
    • DOI 10.1172/JCI34013
    • Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T (2008) Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest 118:924-934 (Pubitemid 351364600)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 924-934
    • Xiao, W.1    Hong, H.2    Kawakami, Y.3    Lowell, C.A.4    Kawakami, T.5
  • 50
    • 27144537855 scopus 로고    scopus 로고
    • PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death
    • DOI 10.1002/jcb.20549
    • Ye K (2005) PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death. J Cell Biochem 96:463-472 (Pubitemid 41504645)
    • (2005) Journal of Cellular Biochemistry , vol.96 , Issue.3 , pp. 463-472
    • Ye, K.1


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