Engineering the oxygen sensing regulation results in an enhanced recombinant human hemoglobin production by Saccharomyces cerevisiae

Biotechnology and Bioengineering

Volumn 112, Issue 1, 2015, Pages 181-188

  Martínez, José L ^a   Liu, Lifang ^a   Petranovic, Dina ^a   Nielsen, Jens ^a,b  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b Chalmers University of Technology   (Denmark)

Author keywords

HAP1; HEM13; Heme biosynthesis; Human hemoglobin; Protein production

Indexed keywords

BIOCHEMISTRY; BLOOD SUBSTITUTES; ESCHERICHIA COLI; HEMOGLOBIN; METABOLIC ENGINEERING; OXYGEN; OXYGEN SENSORS; PRODUCTION PLATFORMS; PROTEINS; YEAST;

CELL PROTEIN CONTENT; CELLULAR PROTEINS; GENETICALLY MODIFIED ORGANISMS; HAP1; HEM13; HEME BIOSYNTHESIS; PROTEIN PRODUCTION; SYNTHETIC POLYMERS;

RECOMBINANT PROTEINS;

CELL PROTEIN; GLUCOSE; RECOMBINANT HEMOGLOBIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HAP1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HAP1 PROTEIN, S CEREVISIAE; HEME; HEMOGLOBIN; OXYGEN; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ANAEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; FUNGUS GROWTH; GENE DELETION; GROWTH RATE; METABOLIC ENGINEERING; NONHUMAN; OXYGEN SENSING; PLASMID; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; ANAEROBIC GROWTH; GENE INACTIVATION; GENETICS; HUMAN; METABOLISM; PROCEDURES; PROTEIN ENGINEERING;

SACCHAROMYCES CEREVISIAE;

ANAEROBIOSIS; DNA-BINDING PROTEINS; GENE KNOCKOUT TECHNIQUES; HEME; HEMOGLOBINS; HUMANS; OXYGEN; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

EID: 84911398453     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25347     Document Type: Article

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