T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling

Journal of Molecular and Cellular Cardiology

Volumn 79, Issue , 2015, Pages 32-41

  Nivala, Michael ^a   Song, Zhen ^a   Weiss, James N ^a   Qu, Zhilin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alternans; Arrhythmias; Heart failure; Remodeling; T tubule disruption

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; CALCIUM;

ACTION POTENTIAL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HIDDEN MARKOV MODEL; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEMBRANE DAMAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SODIUM CALCIUM EXCHANGE; T WAVE; TRANSVERSE TUBULAR SYSTEM; BIOLOGICAL MODEL; CALCIUM SIGNALING; CARDIAC MUSCLE CELL; COMPUTER SIMULATION; DOWN REGULATION; GENETICS; HEART FAILURE; HEART VENTRICLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SARCOPLASMIC RETICULUM;

ACTION POTENTIALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; COMPUTER SIMULATION; DOWN-REGULATION; HEART FAILURE; HEART VENTRICLES; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84911395808     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.10.018     Document Type: Article

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