Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 7, 2013, Pages

  Aistrup, Gary L ^a   Gupta, Deepak K ^a   Kelly, James E ^a   O'Toole, Matthew J ^a   Nahhas, Amanda ^a   Chirayil, Nimi ^a   Misener, Sol ^a   Beussink, Lauren ^a   Singh, Neha ^a   Ng, Jason ^a   Reddy, Mahendra ^a   Mongkolrattanothai, Thitipong ^a   El Bizri, Nesrine ^b   Rajamani, Sridharan ^b   Shryock, John C ^b   Belardinelli, Luiz ^b   Shah, Sanjiv J ^a   Wasserstrom, J Andrew ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

Calcium handling; Heart failure; Late INa; Ranolazine; T tubule

Indexed keywords

CALCIUM; RYANODINE RECEPTOR 2; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DISEASE COURSE; ECHOCARDIOGRAPHY; HEART DISEASE; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; TRANSVERSE TUBULAR SYSTEM;

CALCIUM HANDLING; HEART FAILURE; LATE INA; RANOLAZINE; T-TUBULE;

ACETANILIDES; ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART FAILURE; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MYOCYTES, CARDIAC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PIPERAZINES; RATS; RATS, INBRED SHR; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SODIUM-CALCIUM EXCHANGER; TIME FACTORS;

EID: 84884933257     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00401.2013     Document Type: Article

References (41)

1. 2+ signaling, cardiac alternans, and ventricular arrhythmias in intact rat heart. Circ Res 99: e65-e73, 2006.
2. 2+ overload and oxidative stress and improved mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res 64: 381-392, 2011.
3. Antzelevitch C, Belardinelli L, Wu L, Fraser H, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordiero JM, Goodrow RJ Jr, Scornik F, Perez G. Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent. J Cardiovasc Pharmacol Ther 9, Suppl 1: S65-S83, 2004.
4. Balijepalli RC, Kamp TJ. Cardiomyocyte transverse tubule loss leads the way to heart failure. Future Cardiol 7: 39-42, 2011.
5. Balijepalli RC, Lokuta AJ, Maertz NA, Buck JM, Haworth RA, Valdivia HH, Kamp TJ. Depletion of t-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure. Cardiovasc Res 59: 67-77, 2003.
6. Belardinelli L, Antzelevitch C, Fraser H. Inhibition of late (sustained/persistent) sodium current: a potential drug target to reduce intracellular sodium-dependent calcium overload and its detrimental effects on cardiomyocyte function. Eur Heart J 6, Suppl 1: 13-17, 2004.
7. Brette F, Orchard C. T-tubule function in mammalian cardiac myocytes. Circ Res 92: 1182-1192, 2003.
8. 2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes. Circ Res 97: 1009-1017, 2005.
9. Everett TH, Kok LC, Vaughn RH, Moorman R, Haines DE. Frequency domain algorithm for quantifying atrial fibrillation organization to increase defibrillation efficacy. IEEE Trans Biomed Eng 48: 969-978, 2001.
10. Ju YK, Saint DA, Gage PW. Hypoxia increases persistent sodium current in rat ventricular myocytes. J Physiol 497: 337-347, 1996.
11. Kapur S, Aistrup GL, Sharma R, Kelly JE, Arora R, Zheng J, Veramasuneni M, Kadish AH, Balke CW, Wasserstrom JA. Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 299: H1843-H1853, 2010.
12. 2+ transient alternans and repolarization alternans susceptibility in the intact rat heart. Am J Physiol Heart Circ Physiol 296: H1491-H1512, 2009.
13. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 109: 3208-3214, 2004.
14. 2+ release in murine cardiomyocytes following myocardial infarction. J Physiol 574: 519-533, 2006.
15. Lyon AR, MacLeod KT, Zhang Y, Garcia E, Kanda GK, Lab MJ, Korchev YE, Harding SE, Gorelik J. Loss of t-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci USA 106: 6854-6859, 2009.
16. 2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences. Am J Physiol Heart Circ Physiol 294: H1597-H1608, 2008.
17. Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail 9: 219-227, 2007.
18. 2+-and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest 117: 2431-2444, 2007.
19. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355: 251-259, 2006.
20. Parikh A, Mantravadi R, Kozhevnikov D, Roche MA, Ye Y, Owen LJ, Puglisi JL, Abramson JJ, Salama G. Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarizations and torsade de pointes in long QT type 2. Heart Rhythm 9: 953-960, 2012.
21. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking t-wave alternans to the genesis of cardiac fibrillation. Circulation 99: 1385-1394, 1999.
22. i handling in the failing human heart. Cardiovasc Res 57: 874-886, 2003.
23. i and contractility in nonfailing and failing human myocardium. Circulation 106: 447-453, 2002.
24. Pogwizd SM, Sipido KR, Verdonck F, Bers DM. Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis. Cardiovasc Res 57: 887-896, 2003.
25. Restrepo JG, Karma A. Spatiotemporal intracellular calcium dynamics during cardiac alternans. Chaos 19: 037115, 2009.
26. Shiferaw Y, Sato D, Karma A. Coupled dynamics of voltage and calcium in paced cardiac cells. Phys Rev E Stat Nonlin Soft Matter Phys 71: 021903, 2005.
27. Shorofsky SR, Aggarwal R, Corretti M, Baffa JM, Strum JM, Al-Seikhan BA, Kobayashi YM, Jones LR, Wier WG, Balke CW. Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks. Circ Res 84: 424-434, 1999.
28. Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci USA 103: 4305-4310, 2006.
29. + current. Basic Res Cardiol 106: 263-272, 2011.
30. Undrovinas A, Maltsev VA. Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart. Cardiovasc Hematol Agents Med Chem 6: 348-359, 2008.
31. + transport mechanisms in cardiac hypertrophy and failure. J Mol Cell Cardiol 35: 5-25, 2003.
32. + concentration and altered Na/K pump activity in hypertrophied canine ventricular cells. Cardiovasc Res 57: 1035-1043, 2003.
33. 2+ cycling in intact rat heart: a comparison of sex differences. Am J Physiol Heart Circ Physiol 295: H1895-H1904, 2008.
34. Wasserstrom JA, Sharma R, Kapur S, Kelly JE, Kadish AH, Balke CW, Aistrup GL. Multiple defects in intracellular calcium cycling in whole failing rat heart. Circ Heart Fail 2: 223-232, 2009.
35. Wei S, Guo A, Chen B, Kutschke W, Xie YP, Zimmerman K, Weiss RM, Anderson ME, Cheng H, Song LS. T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res 107: 520-531, 2010.
36. Weiss JN, Karma A, Shiferaw Y, Chen PS, Garfinkel A, Qu Z. From pulsus to pulseless: the saga of cardiac alternans. Circ Res 98: 1244-1253, 2006.
37. Weiss JN, Nivala M, Garfinkel A, Qu Z. Alternans and arrhythmias: from cell to heart. Circ Res 108: 98-112, 2011.
38. + current in the heart. Am J Physiol Heart Circ Physiol 297: H1048-H1057, 2009.
39. Wu Y, Clusin WT. Calcium transient alternans in blood-perfused ischemic hearts: Observations with fluorescent indicator fura red. Am J Physiol Heart Circ Physiol 273: H2161-H2169, 1997.
40. + influx activates CaMKII in rat ventricular myocytes and N1325S mice. Am J Physiol Cell Physiol 301: C577-C586, 2011.
41. Zhang T, Yong S, Drinko JK, Popovic ZB, Shryock JC, Belardinelli L, Wang QK. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. Int J Cardiol 147: 239-245, 2011.