Refractoriness of sarcoplasmic reticulum Ca 2+ release determines Ca 2+ alternans in atrial myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 11, 2012, Pages

  Shkryl, Vyacheslav M ^a   Maxwell, Joshua T ^a   Domeier, Timothy L ^a   Blatter, Lothar A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Calcium alternans; Refractoriness; Ryanodine receptor; Sarcoplasmic reticulum calcium release

Indexed keywords

CAFFEINE; NITROFEN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; VOLTAGE GATED CALCIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; HEART ATRIUM ARRHYTHMIA; HEART MUSCLE CELL; HEART PACING; NONHUMAN; PHOTOLYSIS; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CALCIUM; CARDIAC PACING, ARTIFICIAL; MODELS, ANIMAL; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RABBITS; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SARCOPLASMIC RETICULUM; TIME FACTORS;

EID: 84861785805     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00079.2012     Document Type: Article

References (69)

1. 2+ signaling, cardiac alternans, and ventricular arrhythmias in intact rat heart. Circ Res 99: e65-e73. 2006.
2. Aistrup GL, Shiferaw Y, Kapur S, Kadish AH, Wasserstrom JA. Mechanisms underlying the formation and dynamics of subcellular calcium alternans in the intact rat heart. Circ Res 104: 639-649, 2009.
3. Bassani JW, Yuan W, Bers DM. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol Cell Physiol 268: C1313-C1319, 1995.
4. Belevych A, Kubalova Z, Terentyev D, Hamlin RL, Carnes CA, Gyorke S. Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure. Biophys J 93: 4083-4092, 2007.
5. Belevych AE, Terentyev D, Viatchenko-Karpinski S, Terentyeva R, Sridhar A, Nishijima Y, Wilson LD, Cardounel AJ, Laurita KR, Carnes CA, Bilman GE, Gyorke S. Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death. Cardiovasc Res 84: 387-395, 2009.
6. Blatter LA, Kockskamper J, Sheehan KA, Zima AV, Huser J, Lipsius SL. Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes. J Phvsiol 546: 19-31, 2003.
7. 2+ blinks: rapid nanoscopic store calcium signaling. Proc Natl Acad Sci USA 102: 3099-3104, 2005.
8. i waves in cardiac myocytes. Am J Physiol Cell Physiol 270: C148-C159, 1996.
9. Cheng H, Lederer WJ, Cannell MB. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262: 740-744, 1993.
10. 2+ dynamics and the stability of ventricular tachycardia. Biophys J 77: 2930-2941, 1999.
11. Clusin WT. Mechanisms of calcium transient and action potential alternans in cardiac cells and tissues. Am J Physiol Heart Circ Physiol 294: H1-H10, 2008.
12. Cutler MJ, Wan X, Laurita KR, Hajjar RJ, Rosenbaum DS. Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans. Circ Arrhythm Electrophysiol 2: 686-694, 2009.
13. de Diego C, Chen F, Xie LH, Dave AS, Thu M, Rongey C, Weiss JN, Valderrabano M. Cardiac altemans in embryonic mouse ventricles. Am J Physiol Heart Circ Physiol 294: H433-H440, 2008.
14. 2+ transient in rat ventricular myocytes. Circ Res 91: 585-593, 2002.
15. Diaz ME, O'Neill S., Eisner DA. Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac altemans. Circ Res 94: 650-656, 2004.
16. 2+ release termination by ryanodine receptor sensitization and in heart failure. J Physiol 587: 5197-5209, 2009.
17. Eisner DA, Choi HS, Diaz ME, O'Neill S., Trafford AW. Integrative analysis of calcium cycling in cardiac muscle. Circ Res 87: 1087-1094, 2000.
18. Eisner DA, Diaz ME, Li Y, O'Neill S., Trafford AW. Stability and instability of regulation of intracellular calcium. Exp Physiol 90: 3-12, 2005.
19. Eisner DA, Li Y, O'Neill SC. Alternans of intracellular calcium: mechanism and significance. Heart Rhythm 3: 743-745, 2006.
20. Ellis-Davies GC. DM-nitrophen AM is caged magnesium. Cell Calcium 39: 471-473, 2006.
21. Euler DE. Cardiac alternans: mechanisms and pathophysiological significance. Cardiovasc Res 42: 583-590, 1999.
22. Florea SM, Blatter LA. The role of mitochondria for the regulation of cardiac alternans. Front Physiol 1: 1-9, 2010.
23. Fox JJ, McHarg JL, Gilmour RF Jr. Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol 282: H516-H530, 2002.
24. Gaeta SA, Bub G, Abbott GW, Christini DJ. Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res 105: 335-342, 2009.
25. 2+ in cardiac myocytes. J Gen Physiol 132: 721-730, 2008.
26. Hiromoto K, Shimizu H, Furukawa Y, Kanemori T, Mine T, Masuyama T, Ohyanagi M. Discordant repolarization alternans-induced atrial fibrillation is suppressed by verapamil. Circ J 69: 1368-1373, 2005.
27. Huser J, Lipsius SL, Blatter LA. Calcium gradients during excitationcontraction coupling in cat atrial myocytes. J Physiol 494: 641-651, 1996.
28. Huser J, Wang YG, Sheehan KA, Cifuentes F, Lipsius SL, Blatter LA. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol 524: 795-806, 2000.
29. Jordan PN, Christini DJ. Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans. Am J Physiol Heart Circ Physiol 293: H2109-H2118, 2007.
30. 2+ pump function to electrical and mechanical alternans. J Electrocardiol 36: 125-135, 2003.
31. Kaplan JH, Ellis-Davies GC. Photolabile chelators for the rapid photo-release of divalent cations. Proc Natl Acad Sci USA 85: 6571-6575, 1988.
32. 2+ waves in cat atrial myocytes. J Physiol 545: 65-79, 2002.
33. 2+ release during excitation-contraction coupling in atrial myocytes. Biophys J 81: 2590-2605, 2001.
34. 2+ release by glycolysis in cat atrial myocytes. J Physiol 564: 697-714, 2005.
35. 2+-alternans in intact mouse hearts. J Mol Cell Cardiol 52: 21-31, 2012.
36. 2+ release in subepicardial myocytes of intact beating mouse hearts: effect of exogenous buffers. Am J Physiol Heart Circ Physiol 298: H2138-H2153, 2010.
37. Laurita KR, Rosenbaum DS. Cellular mechanisms of arrhythmogenic cardiac alternans. Prog Biophys Mol Biol 97: 332-347, 2008.
38. 2+ alternans in rat ventricular myocytes. J Physiol 587: 1283-1292, 2009.
39. Mackenzie L, Bootman MD, Berridge MJ, Lipp P. Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. J Physiol 530: 417-429, 2001.
40. Mackenzie L, Roderick HL, Berridge MJ, Conway SJ, Bootman MD. The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci 117: 6327-6337, 2004.
41. Myles RC, Burton FL, Cobbe SM, Smith GL. The link between repolarisation alternans and ventricular arrhythmia: does the cellular phenomenon extend to the clinical problem? J Mol Cell Cardiol 45: 1-10, 2008.
42. Narayan SM, Bode F, Karasik PL, Franz MR. Alternans of atrial action potentials during atrial flutter as a precursor to atrial fibrillation. Circulation 106: 1968-1973, 2002.
43. Nattel S. New ideas about atrial fibrillation 50 years on. Nature 415: 219-226, 2002.
44. Picht E, DeSantiago J, Blatter LA, Bers DM. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res 99: 740-748, 2006.
45. Picht E, Zima AV, Blatter LA, Bers DM. SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol 293: C1073-C1081. 2007.
46. Pruvot EJ, Katra RP, Rosenbaum DS, Laurita KR. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circ Res 94: 1083-1090, 2004.
47. Ramay HR, Liu OZ, Sobie EA. Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity. Cardiovasc Res 91: 598-605, 2011.
48. Rosenbaum DS. T wave alternans: a mechanism of arrhythmogenesis comes of age after 100 years. J Cardiovasc Electrophysiol 12: 207-209, 2001.
49. Rovetti R, Cui X, Garfinkel A, Weiss JN, Qu Z. Spark-induced sparks as a mechanism of intracellular calcium alternans in cardiac myocytes. Circ Res 106: 1582-1591, 2010.
50. Rubenstein DS, Lipsius SL. Premature beats elicit a phase reversal of mechanoelectrical altemans in cat ventricular myocytes. A possible mechanism for reentrant arrhythmias. Circulation 91: 201-214, 1995.
51. Sato D, Shiferaw Y, Garfinkel A, Weiss JN, Qu Z, Karma A. Spatially discordant alternans in cardiac tissue: role of calcium cycling. Circ Res 99: 520-527. 2006.
52. 2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci USA 95: 15096-15101, 1998.
53. Sheehan KA, Blatter LA. Regulation of junctional and non-junctional sarcoplasmic reticulum calcium release in excitation-contraction coupling in cat atrial myocytes. J Physiol 546: 119-135, 2003.
54. Shkryl VM, Littwitz C, Domeier TL, Blatter LA. Refractoriness of ryanodine receptors during calcium alternans in rabbit atrial myocytes. Biophys J 98: 103a, 2010.
55. Sobie EA, Song LS, Lederer WJ. Local recovery of Ca2+ release in rat ventricular myocytes. J Physiol 565: 441-447, 2005.
56. 2+ release and vulnerability to arrhythmias. J Cardiovasc Electrophysiol 17, Suppl 1: S64-S70, 2006.
57. 2+ release refractoriness in heart muscle. Circ Res 95: 807-813. 2004.
58. Ter Keurs HE, Boyden PA. Calcium and arrhythmogenesis. Physiol Rev 87: 457-506, 2007.
59. Trafford AW, Sibbring GC, Diaz ME, Eisner DA. The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes. Cell Calcium 28: 269-276, 2000.
60. Walker ML, Rosenbaum DS. Cellular altemans as mechanism of cardiac arrhythmogenesis. Heart Rhythm 2: 1383-1386, 2005.
61. Walker ML, Rosenbaum DS. Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death. Cardiovasc Res 57: 599-614, 2003.
62. Wan X, Laurita KR, Pruvot EJ, Rosenbaum DS. Molecular correlates of repolarization altemans in cardiac myocytes. J Mol Cell Cardiol 39: 419-428, 2005.
63. Weiss JN, Karma A, Shiferaw Y, Chen PS, Garfinkel A, Qu Z. From pulsus to pulseless: the saga of cardiac alternans. Circ Res 98: 1244-1253, 2006.
64. Weiss JN, Nivala M, Garfinkel A, Qu Z. Alternans and arrhythmias: from cell to heart. Circ Res 108: 98-112, 2011.
65. Wohlfart B. Analysis of mechanical alternans in rabbit papillary muscle. Acta Physiol Scand 115: 405-414, 1982.
66. 2+ release in rat atrial myocytes. Circ Res 92: el-e11, 2003.
67. Wu Y, Clusin WT. Calcium transient alternans in blood-perfused ischemic hearts: observations with fluorescent indicator fura red. Am J Physiol Heart Circ Physiol 273: H2161-H2169, 1997.
68. Xie LH, Sato D, Garfinkel A, Qu Z, Weiss JN. Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, up-take, and leak. Biophys J 95: 3100-3110, 2008.
69. Zima AV, Picht E, Bers DM, Blatter LA. Spark and non-spark mediated SR calcium leak in rabbit ventricular myocytes. Biophys J 94: 171, 2008.