Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1)

Human Molecular Genetics

Volumn 23, Issue 22, 2014, Pages 6022-6033

  Tortelli, Brett ^a   Fujiwara, Hideji ^a   Bagel, Jessica H ^b   Zhang, Jessie ^a   Sidhu, Rohini ^a   Jiang, Xuntian ^a   Yanjanin, Nicole M ^c   Shankar, Roopa Kanakatti ^c   Carillo Carasco, Nuria ^d   Heiss, John ^d   Ottinger, Elizabeth ^e   Porter, Forbes D ^c   Schaffer, Jean E ^a   Vite, Charles H ^b   Ory, Daniel S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 24 HYDROXYCHOLESTEROL; BIOLOGICAL MARKER; CHOLESTEROL DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; EXPLORATORY RESEARCH; FELINE MODEL; FEMALE; GENE EXPRESSION; HUMAN; LIPID HOMEOSTASIS; LOW DRUG DOSE; LYSOSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NIEMANN PICK C1 DISEASE; NIEMANN PICK DISEASE; NONHUMAN; PATIENT MONITORING; PROTEIN BLOOD LEVEL; ADOLESCENT; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHILD; CLINICAL TRIAL; DISEASE MODEL; DRUG MONITORING; HOMEOSTASIS; NIEMANN-PICK DISEASE, TYPE C; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ANIMALS; BETA-CYCLODEXTRINS; BIOMARKERS; CHILD; CHOLESTEROL; DISEASE MODELS, ANIMAL; DRUG MONITORING; FEMALE; HOMEOSTASIS; HUMANS; MALE; MICE, INBRED BALB C; NIEMANN-PICK DISEASE, TYPE C; YOUNG ADULT;

EID: 84911379868     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu331     Document Type: Article

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