Cyclodextrin alleviates neuronal storage of cholesterol in Niemann-Pick C disease without evidence of detectable blood-brain barrier permeability

Journal of Inherited Metabolic Disease

Volumn 36, Issue 3, 2013, Pages 491-498

  Pontikis, Charles C ^a   Davidson, Cristin D ^b   Walkley, Steven U ^b   Platt, Frances M ^c   Begley, David J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG MEGADOSE; DRUG PENETRATION; DRUG TRANSPORT; LIPID STORAGE; MOUSE; NEWBORN; NIEMANN PICK DISEASE; NONHUMAN;

ANIMALS; BETA-CYCLODEXTRINS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CHOLESTEROL; DRUG EVALUATION, PRECLINICAL; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEURONS; NIEMANN-PICK DISEASES; PERFUSION; PROTEINS;

EID: 84877746094     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/s10545-012-9583-x     Document Type: Article

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