메뉴 건너뛰기




Volumn 69, Issue 11, 2014, Pages 1311-1324

Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline

Author keywords

Aging; Cognitive impairment; Gene expression; Hippocampus

Indexed keywords

TRANSCRIPTOME;

EID: 84911081891     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu091     Document Type: Article
Times cited : (39)

References (65)
  • 1
    • 0742323532 scopus 로고    scopus 로고
    • Insights into the ageing mind: A view from cognitive neuroscience
    • doi:10.1038/ nrn1323
    • Hedden T, Gabrieli JD. Insights into the ageing mind: A view from cognitive neuroscience. Nat Rev Neurosci. 2004;5:87-96. doi:10.1038/ nrn1323
    • (2004) Nat Rev Neurosci. , vol.5 , pp. 87-96
    • Hedden, T.1    Gabrieli, J.D.2
  • 2
    • 64649103491 scopus 로고    scopus 로고
    • Aging, vascular risk, and cognition: Blood glucose, pulse pressure, and cognitive performance in healthy adults
    • doi:10.1037/a0014283
    • Dahle CL, Jacobs BS, Raz N. Aging, vascular risk, and cognition: Blood glucose, pulse pressure, and cognitive performance in healthy adults. Psychol Aging. 2009;24:154-162. doi:10.1037/a0014283
    • (2009) Psychol Aging. , vol.24 , pp. 154-162
    • Dahle, C.L.1    Jacobs, B.S.2    Raz, N.3
  • 3
    • 84871969895 scopus 로고    scopus 로고
    • Cognitive dysfunction: An emerging concept of a new diabetic complication in the elderly
    • doi:10.1111/j.1447-0594.2012.00922.x
    • Umegaki H, Hayashi T, Nomura H, et al. Cognitive dysfunction: An emerging concept of a new diabetic complication in the elderly. Geriatr Gerontol Int. 2013;13:28-34. doi:10.1111/j.1447-0594.2012.00922.x
    • (2013) Geriatr Gerontol Int. , vol.13 , pp. 28-34
    • Umegaki, H.1    Hayashi, T.2    Nomura, H.3
  • 5
    • 0024439790 scopus 로고
    • Evidence for task-dependent memory dysfunction in the aged monkey
    • Rapp PR, Amaral DG. Evidence for task-dependent memory dysfunction in the aged monkey. J Neurosci. 1989;9:3568-3576.
    • (1989) J Neurosci. , vol.9 , pp. 3568-3576
    • Rapp, P.R.1    Amaral, D.G.2
  • 6
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp PR, Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci USA. 1996;93:9926-9930.
    • (1996) Proc Natl Acad Sci USA. , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 7
    • 0027772145 scopus 로고
    • The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice
    • Gower AJ, Lamberty Y. The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice. Behav Brain Res. 1993;57:163-173.
    • (1993) Behav Brain Res. , vol.57 , pp. 163-173
    • Gower, A.J.1    Lamberty, Y.2
  • 8
    • 0036839248 scopus 로고    scopus 로고
    • Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits
    • Rapp PR, Deroche PS, Mao Y, Burwell RD. Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits. Cereb Cortex. 2002;12:1171-1179.
    • (2002) Cereb Cortex. , vol.12 , pp. 1171-1179
    • Rapp, P.R.1    Deroche, P.S.2    Mao, Y.3    Burwell, R.D.4
  • 10
    • 4544322402 scopus 로고    scopus 로고
    • The aging brain: Morphomolecular senescence of cortical circuits
    • doi:10.1016/j. tins.2004. 07.013
    • Hof PR, Morrison JH. The aging brain: Morphomolecular senescence of cortical circuits. Trends Neurosci. 2004;27:607-613. doi:10.1016/j. tins.2004.07.013
    • (2004) Trends Neurosci. , vol.27 , pp. 607-613
    • Hof, P.R.1    Morrison, J.H.2
  • 11
    • 81255193416 scopus 로고    scopus 로고
    • The hippocampal neuroproteome with aging and cognitive decline: Past progress and future directions
    • doi:10.3389/fnagi.2011.00008
    • Vanguilder HD, Freeman WM. The hippocampal neuroproteome with aging and cognitive decline: Past progress and future directions. Front Aging Neurosci. 2011;3:8. doi:10.3389/fnagi.2011.00008
    • (2011) Front Aging Neurosci. , vol.3 , pp. 8
    • Vanguilder, H.D.1    Freeman, W.M.2
  • 12
    • 77549083704 scopus 로고    scopus 로고
    • Neuroinflammation and cognitive aging
    • doi:10.1007/s11920-009-0082-1
    • Ownby RL. Neuroinflammation and cognitive aging. Curr Psychiatry Rep. 2010;12:39-45. doi:10.1007/s11920-009-0082-1
    • (2010) Curr Psychiatry Rep. , vol.12 , pp. 39-45
    • Ownby, R.L.1
  • 13
    • 84877142544 scopus 로고    scopus 로고
    • Region-specific genetic alterations in the aging hippocampus: Implications for cognitive aging
    • doi:10.3389/fnagi.2010.00140
    • Burger C. Region-specific genetic alterations in the aging hippocampus: Implications for cognitive aging. Front Aging Neurosci. 2010;2:140. doi:10.3389/fnagi.2010.00140
    • (2010) Front Aging Neurosci. , vol.2 , pp. 140
    • Burger, C.1
  • 14
    • 84863669043 scopus 로고    scopus 로고
    • Session III Mechanisms of age-related cognitive change and targets for intervention: Inflammatory, oxidative, and metabolic processes
    • doi:10.1093/gerona/ gls112
    • Craft S, Foster TC, Landfield PW, Maier SF, Resnick SM, Yaffe K. Session III: Mechanisms of age-related cognitive change and targets for intervention: Inflammatory, oxidative, and metabolic processes. J Gerontol A Biol Sci Med Sci. 2012;67:754-759. doi:10.1093/gerona/ gls112
    • (2012) J Gerontol A Biol Sci Med Sci. , vol.67 , pp. 754-759
    • Craft, S.1    Foster, T.C.2    Landfield, P.W.3    Maier, S.F.4    Resnick, S.M.5    Yaffe, K.6
  • 15
    • 60849111389 scopus 로고    scopus 로고
    • Hippocampal and cognitive aging across the lifespan: A bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment
    • doi:10.1523/JNEUROSCI.4599-08.2009
    • Kadish I, Thibault O, Blalock EM, et al. Hippocampal and cognitive aging across the lifespan: A bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci. 2009;29:1805-1816. doi:10.1523/JNEUROSCI.4599-08.2009
    • (2009) J Neurosci. , vol.29 , pp. 1805-1816
    • Kadish, I.1    Thibault, O.2    Blalock, E.M.3
  • 16
    • 33947534891 scopus 로고    scopus 로고
    • Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
    • doi:10.1523/ JNEUROSCI.4163-06. 2007
    • Rowe WB, Blalock EM, Chen KC, et al. Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. J Neurosci. 2007;27:3098-3110. doi:10.1523/ JNEUROSCI.4163-06.2007
    • (2007) J Neurosci. , vol.27 , pp. 3098-3110
    • Rowe, W.B.1    Blalock, E.M.2    Chen, K.C.3
  • 17
    • 60649107794 scopus 로고    scopus 로고
    • Cognitive performance and age-related changes in the hippocampal proteome
    • doi:10.1016/j. neuroscience.2008. 12.004
    • Freeman WM, VanGuilder HD, Bennett C, Sonntag WE. Cognitive performance and age-related changes in the hippocampal proteome. Neuroscience. 2009;159:183-195. doi:10.1016/j. neuroscience.2008.12.004
    • (2009) Neuroscience. , vol.159 , pp. 183-195
    • Freeman, W.M.1    Vanguilder, H.D.2    Bennett, C.3    Sonntag, W.E.4
  • 18
    • 79955956256 scopus 로고    scopus 로고
    • Hippocampal dysregulation of synaptic plasticity-Associated proteins with age-related cognitive decline
    • doi:10.1016/j.nbd.2011.03.012
    • VanGuilder HD, Farley JA, Yan H, et al. Hippocampal dysregulation of synaptic plasticity-Associated proteins with age-related cognitive decline. Neurobiol Dis. 2011;43:201-212. doi:10.1016/j.nbd.2011.03.012
    • (2011) Neurobiol Dis. , vol.43 , pp. 201-212
    • Vanguilder, H.D.1    Farley, J.A.2    Yan, H.3
  • 19
    • 79251599573 scopus 로고    scopus 로고
    • Gene expression in the hippocampus: Regionally specific effects of aging and caloric restriction
    • doi:10.1016/j. mad.2010.10.006
    • Zeier Z, Madorsky I, Xu Y, Ogle WO, Notterpek L, Foster TC. Gene expression in the hippocampus: Regionally specific effects of aging and caloric restriction. Mech Ageing Dev. 2011;132:8-19. doi:10.1016/j. mad.2010.10.006
    • (2011) Mech Ageing Dev. , vol.132 , pp. 8-19
    • Zeier, Z.1    Madorsky, I.2    Xu, Y.3    Ogle, W.O.4    Notterpek, L.5    Foster, T.C.6
  • 20
    • 79960137052 scopus 로고    scopus 로고
    • Prominent hippocampal CA3 gene expression profile in neurocognitive aging
    • doi:10.1016/j.neurobiolaging.2009.10.005
    • Haberman RP, Colantuoni C, Stocker AM, Schmidt AC, Pedersen JT, Gallagher M. Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Neurobiol Aging. 2011;32:1678-1692. doi:10.1016/j.neurobiolaging.2009.10.005
    • (2011) Neurobiol Aging. , vol.32 , pp. 1678-1692
    • Haberman, R.P.1    Colantuoni, C.2    Stocker, A.M.3    Schmidt, A.C.4    Pedersen, J.T.5    Gallagher, M.6
  • 21
    • 80053629791 scopus 로고    scopus 로고
    • Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment
    • doi:10.1186/1742-2094-8-138
    • VanGuilder HD, Bixler GV, Brucklacher RM, et al. Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. J Neuroinflammation. 2011;8:138. doi:10.1186/1742-2094-8-138
    • (2011) J Neuroinflammation. , vol.8 , pp. 138
    • Van Guilder, H.D.1    Bixler, G.V.2    Brucklacher, R.M.3
  • 22
    • 84858709747 scopus 로고    scopus 로고
    • Hippocampal expression of myelin-Associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory
    • doi:10.1111/j.1471-4159.2012.07671.x
    • Vanguilder HD, Bixler GV, Sonntag WE, Freeman WM. Hippocampal expression of myelin-Associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. J Neurochem. 2012;121:77-98. doi:10.1111/j.1471-4159.2012.07671.x
    • (2012) J Neurochem. , vol.121 , pp. 77-98
    • Vanguilder, H.D.1    Bixler, G.V.2    Sonntag, W.E.3    Freeman, W.M.4
  • 23
    • 84876675046 scopus 로고    scopus 로고
    • Expression of NgR1-Antagonizing proteins decreases with aging and cognitive decline in rat hippocampus
    • doi:10.1007/s10571-013-9929-4
    • VanGuilder Starkey HD, Bixler GV, Sonntag WE, Freeman WM. Expression of NgR1-Antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. Cell Mol Neurobiol. 2013;33:483-488. doi:10.1007/s10571-013-9929-4
    • (2013) Cell Mol Neurobiol. , vol.33 , pp. 483-488
    • Vanguilder Starkey, H.D.1    Bixler, G.V.2    Sonntag, W.E.3    Freeman, W.M.4
  • 25
    • 84865116410 scopus 로고    scopus 로고
    • Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging
    • VanGuilder Starkey HD, Van Kirk CA, Bixler GV, et al. Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. J Mol Neurosci. 2012;48:111-126.
    • (2012) J Mol Neurosci. , vol.48 , pp. 111-126
    • Vanguilder Starkey, H.D.1    Van Kirk, C.A.2    Bixler, G.V.3
  • 27
    • 79251579038 scopus 로고    scopus 로고
    • Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy
    • VanGuilder HD, Bixler GV, Kutzler L, et al. Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. PLoS ONE. 2011;6:e16271.
    • (2011) PLoS ONE. , vol.6 , pp. e16271
    • Van Guilder, H.D.1    Bixler, G.V.2    Kutzler, L.3
  • 30
    • 84876668009 scopus 로고    scopus 로고
    • Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition
    • VanGuilder Starkey HD, Sonntag WE, Freeman WM. Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition. Eur J Neurosci. 2013;37:1643-1658.
    • (2013) Eur J Neurosci. , vol.37 , pp. 1643-1658
    • Vanguilder Starkey, H.D.1    Sonntag, W.E.2    Freeman, W.M.3
  • 31
    • 84884829963 scopus 로고    scopus 로고
    • ExpressionBlast: Mining large, unstructured expression databases
    • doi:10.1038/nmeth.2630
    • Zinman GE, Naiman S, Kanfi Y, Cohen H, Bar-Joseph Z. ExpressionBlast: Mining large, unstructured expression databases. Nat Methods. 2013;10:925-926. doi:10.1038/nmeth.2630
    • (2013) Nat Methods. , vol.10 , pp. 925-926
    • Zinman, G.E.1    Naiman, S.2    Kanfi, Y.3    Cohen, H.4    Bar-Joseph, Z.5
  • 32
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • Lein ES, Hawrylycz MJ, Ao N, et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature. 2007;445:168-176.
    • (2007) Nature. , vol.445 , pp. 168-176
    • Lein, E.S.1    Hawrylycz, M.J.2    Ao, N.3
  • 34
    • 1942457291 scopus 로고    scopus 로고
    • Defining a molecular atlas of the hippocampus using DNA microarrays and high-Throughput in situ hybridization
    • doi:10.1523/ JNEUROSCI.4710-03. 2004
    • Lein ES, Zhao X, Gage FH. Defining a molecular atlas of the hippocampus using DNA microarrays and high-Throughput in situ hybridization. J Neurosci. 2004;24:3879-3889. doi:10.1523/ JNEUROSCI.4710-03.2004
    • (2004) J Neurosci. , vol.24 , pp. 3879-3889
    • Lein, E.S.1    Zhao, X.2    Gage, F.H.3
  • 35
    • 0035905027 scopus 로고    scopus 로고
    • Transcriptional profiling reveals strict boundaries between hippocampal subregions
    • Zhao X, Lein ES, He A, Smith SC, Aston C, Gage FH. Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol. 2001;441:187-196.
    • (2001) J Comp Neurol. , vol.441 , pp. 187-196
    • Zhao, X.1    Lein, E.S.2    He, A.3    Smith, S.C.4    Aston, C.5    Gage, F.H.6
  • 36
    • 62149130772 scopus 로고    scopus 로고
    • Quantitative transcriptional neuroanatomy of the rat hippocampus: Evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers
    • doi:10.1002/hipo.20502
    • Greene JG, Borges K, Dingledine R. Quantitative transcriptional neuroanatomy of the rat hippocampus: Evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers. Hippocampus. 2009;19:253-264. doi:10.1002/hipo.20502
    • (2009) Hippocampus. , vol.19 , pp. 253-264
    • Greene, J.G.1    Borges, K.2    Dingledine, R.3
  • 37
    • 0034816368 scopus 로고    scopus 로고
    • Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein
    • doi:10.1006/ bbrc.2001. 5022
    • Furukawa Y, Kawasoe T, Daigo Y, et al. Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein. Biochem Biophys Res Commun. 2001;284:643-649. doi:10.1006/ bbrc.2001.5022
    • (2001) Biochem Biophys Res Commun. , vol.284 , pp. 643-649
    • Furukawa, Y.1    Kawasoe, T.2    Daigo, Y.3
  • 38
    • 77951796664 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior
    • doi:10.1523/ JNEUROSCI.0550-10.2010
    • Caronia G, Wilcoxon J, Feldman P, Grove EA. Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci. 2010;30:6291-6301. doi:10.1523/ JNEUROSCI.0550-10.2010
    • (2010) J Neurosci. , vol.30 , pp. 6291-6301
    • Caronia, G.1    Wilcoxon, J.2    Feldman, P.3    Grove, E.A.4
  • 39
    • 84876269766 scopus 로고    scopus 로고
    • Bone morphogenic protein signaling is a major determinant of dentate development
    • doi:10.1523/JNEUROSCI.0128-13.2013
    • Choe Y, Kozlova A, Graf D, Pleasure SJ. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci. 2013;33:6766-6775. doi:10.1523/JNEUROSCI.0128-13.2013
    • (2013) J Neurosci. , vol.33 , pp. 6766-6775
    • Choe, Y.1    Kozlova, A.2    Graf, D.3    Pleasure, S.J.4
  • 40
    • 0030757397 scopus 로고    scopus 로고
    • HNMP-1: A novel hematopoietic and neural membrane protein differentially regulated in neural development and injury
    • Bolin LM, McNeil T, Lucian LA, et al. HNMP-1: A novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. J Neurosci. 1997;17:5493-5502.
    • (1997) J Neurosci. , vol.17 , pp. 5493-5502
    • Bolin, L.M.1    McNeil, T.2    Lucian, L.A.3
  • 41
    • 38949111026 scopus 로고    scopus 로고
    • Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells
    • doi:10.1016/j.bcp.2007.11.006
    • Su D, Gudas LJ. Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. Biochem Pharmacol. 2008;75:1129-1160. doi:10.1016/j.bcp.2007.11.006
    • (2008) Biochem Pharmacol. , vol.75 , pp. 1129-1160
    • Su, D.1    Gudas, L.J.2
  • 42
    • 0037458166 scopus 로고    scopus 로고
    • FXYD proteins: New tissue-specific regulators of the ubiquitous Na K-ATPase
    • doi:10.1126/stke.2003.166.re1
    • Crambert G, Geering K. FXYD proteins: New tissue-specific regulators of the ubiquitous Na, K-ATPase. Sci STKE. 2003;2003:RE1. doi:10.1126/stke.2003.166.re1
    • (2003) Sci STKE. , vol.2003 , pp. RE1
    • Crambert, G.1    Geering, K.2
  • 43
    • 34247170462 scopus 로고    scopus 로고
    • FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice
    • doi:10.1093/hmg/ddm007
    • Deng V, Matagne V, Banine F, et al. FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genet. 2007;16:640-650. doi:10.1093/hmg/ddm007
    • (2007) Hum Mol Genet. , vol.16 , pp. 640-650
    • Deng, V.1    Matagne, V.2    Banine, F.3
  • 44
    • 84872847348 scopus 로고    scopus 로고
    • Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome
    • doi:10.1016/j.brainres.2012.12.009
    • Matagne V, Budden S, Ojeda SR, Raber J. Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome. Brain Res. 2013;1496:104-114. doi:10.1016/j.brainres.2012.12.009
    • (2013) Brain Res. , vol.1496 , pp. 104-114
    • Matagne, V.1    Budden, S.2    Ojeda, S.R.3    Raber, J.4
  • 45
    • 79955137934 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
    • doi:10.1152/jn.00866.2010
    • Faivre E, Gault VA, Thorens B, Holscher C. Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. J Neurophysiol. 2011;105:1574-1580. doi:10.1152/jn.00866.2010
    • (2011) J Neurophysiol. , vol.105 , pp. 1574-1580
    • Faivre, E.1    Gault, V.A.2    Thorens, B.3    Holscher, C.4
  • 46
    • 34547192748 scopus 로고    scopus 로고
    • Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels
    • doi:10.1016/j.neuron.2007.07.006
    • Goldfarb M, Schoorlemmer J, Williams A, et al. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron. 2007;55:449-463. doi:10.1016/j.neuron.2007.07.006
    • (2007) Neuron. , vol.55 , pp. 449-463
    • Goldfarb, M.1    Schoorlemmer, J.2    Williams, A.3
  • 47
    • 77957263704 scopus 로고    scopus 로고
    • Long-Term inactivation particle for voltage-gated sodium channels
    • doi:10.1113/jphysiol.2010.192559
    • Dover K, Solinas S, D'Angelo E, Goldfarb M. Long-Term inactivation particle for voltage-gated sodium channels. J Physiol (Lond). 2010;588(Pt 19):3695-3711. doi:10.1113/jphysiol.2010.192559
    • (2010) J Physiol (Lond). , vol.588 , pp. 3695-3711
    • Dover, K.1    Solinas, S.2    D'angelo, E.3    Goldfarb, M.4
  • 48
    • 0035873996 scopus 로고    scopus 로고
    • Fibroblast growth factor homologous factors are intracellular signaling proteins
    • Schoorlemmer J, Goldfarb M. Fibroblast growth factor homologous factors are intracellular signaling proteins. Curr Biol. 2001;11:793-797.
    • (2001) Curr Biol. , vol.11 , pp. 793-797
    • Schoorlemmer, J.1    Goldfarb, M.2
  • 49
    • 84875634684 scopus 로고    scopus 로고
    • Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-?B signaling in neurons
    • doi:10.1242/jcs.111880
    • Konig HG, Fenner BJ, Byrne JC, et al. Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-?B signaling in neurons. J Cell Sci. 2012;125(Pt 24):6058-6070. doi:10.1242/jcs.111880
    • (2012) J Cell Sci. , vol.125 , pp. 6058-6070
    • Konig, H.G.1    Fenner, B.J.2    Byrne, J.C.3
  • 50
    • 84870584668 scopus 로고    scopus 로고
    • Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
    • 2012;7:e50976 doi:10.1371/ journal.pone. 0050976
    • Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS ONE. 2012;7:e50976. doi:10.1371/ journal.pone.0050976
    • PLoS ONE.
    • Karch, C.M.1    Jeng, A.T.2    Nowotny, P.3    Cady, J.4    Cruchaga, C.5    Goate, A.M.6
  • 51
    • 84887247060 scopus 로고    scopus 로고
    • Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood
    • AddNeuroMed Consortium doi:10.1016/j.neurobiolaging.2013.08.002
    • Proitsi P, Lee SH, Lunnon K, et al.; AddNeuroMed Consortium. Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiol Aging. 2014;35:279-290. doi:10.1016/j.neurobiolaging.2013.08.002
    • (2014) Neurobiol Aging. , vol.35 , pp. 279-290
    • Proitsi, P.1    Lee, S.H.2    Lunnon, K.3
  • 52
    • 0141570875 scopus 로고    scopus 로고
    • Cordon-bleu is a conserved gene involved in neural tube formation
    • Carroll EA, Gerrelli D, Gasca S, et al. Cordon-bleu is a conserved gene involved in neural tube formation. Dev Biol. 2003;262:16-31.
    • (2003) Dev Biol. , vol.262 , pp. 16-31
    • Carroll, E.A.1    Gerrelli, D.2    Gasca, S.3
  • 53
    • 35348869727 scopus 로고    scopus 로고
    • Cordon-bleu is an actin nucleation factor and controls neuronal morphology
    • doi:10.1016/j.cell.2007.08.030
    • Ahuja R, Pinyol R, Reichenbach N, et al. Cordon-bleu is an actin nucleation factor and controls neuronal morphology. Cell. 2007;131:337-350. doi:10.1016/j.cell.2007.08.030
    • (2007) Cell. , vol.131 , pp. 337-350
    • Ahuja, R.1    Pinyol, R.2    Reichenbach, N.3
  • 54
    • 84870501850 scopus 로고    scopus 로고
    • The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-Actin binding protein Abp1
    • doi:10.1523/JNEUROSCI.0843-12.2012
    • Haag N, Schwintzer L, Ahuja R, et al. The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-Actin binding protein Abp1. J Neurosci. 2012;32:17842-17856. doi:10.1523/JNEUROSCI.0843-12.2012
    • (2012) J Neurosci. , vol.32 , pp. 17842-17856
    • Haag, N.1    Schwintzer, L.2    Ahuja, R.3
  • 55
    • 84866676186 scopus 로고    scopus 로고
    • Mice lacking the b2 adrenergic receptor have a unique genetic profile before and after focal brain ischaemia
    • AN20110020 doi:10.1042/AN20110020
    • White RE, Palm C, Xu L, et al. Mice lacking the b2 adrenergic receptor have a unique genetic profile before and after focal brain ischaemia. ASN Neuro. 2012;4:AN20110020. doi:10.1042/AN20110020
    • (2012) ASN Neuro. , pp. 4
    • White, R.E.1    Palm, C.2    Xu, L.3
  • 56
    • 70350365508 scopus 로고    scopus 로고
    • Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas
    • doi:10.1074/jbc.M109.013185
    • Sim H, Hu B, Viapiano MS. Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas. J Biol Chem. 2009;284:26547-26556. doi:10.1074/jbc.M109.013185
    • (2009) J Biol Chem. , vol.284 , pp. 26547-26556
    • Sim, H.1    Hu, B.2    Viapiano, M.S.3
  • 57
    • 0030876040 scopus 로고    scopus 로고
    • Age-related decreases in mRNA for brain nuclear receptors and target genes are reversed by retinoic acid treatment
    • Enderlin V, Pallet V, Alfos S, et al. Age-related decreases in mRNA for brain nuclear receptors and target genes are reversed by retinoic acid treatment. Neurosci Lett. 1997;229:125-129.
    • (1997) Neurosci Lett. , vol.229 , pp. 125-129
    • Enderlin, V.1    Pallet, V.2    Alfos, S.3
  • 58
    • 0030849198 scopus 로고    scopus 로고
    • Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: Effect of the administration of retinoids
    • Enderlin V, Alfos S, Pallet V, et al. Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: Effect of the administration of retinoids. FEBS Lett. 1997;412:629-632.
    • (1997) FEBS Lett. , vol.412 , pp. 629-632
    • Enderlin, V.1    Alfos, S.2    Pallet, V.3
  • 59
    • 38149089548 scopus 로고    scopus 로고
    • Retinoid hyposignaling contributes to aging-related decline in hippocampal function in short-Term/working memory organization and long-Term declarative memory encoding in mice
    • doi:10.1523/JNEUROSCI.4065-07.2008
    • Mingaud F, Mormede C, Etchamendy N, et al. Retinoid hyposignaling contributes to aging-related decline in hippocampal function in short-Term/working memory organization and long-Term declarative memory encoding in mice. J Neurosci. 2008;28:279-291. doi:10.1523/JNEUROSCI.4065-07.2008
    • (2008) J Neurosci. , vol.28 , pp. 279-291
    • Mingaud, F.1    Mormede, C.2    Etchamendy, N.3
  • 60
    • 77951067503 scopus 로고    scopus 로고
    • Significance of vitamin A to brain function, behavior and learning
    • doi:10.1002/mnfr.200900246
    • Olson CR, Mello CV. Significance of vitamin A to brain function, behavior and learning. Mol Nutr Food Res. 2010;54:489-495. doi:10.1002/mnfr.200900246
    • (2010) Mol Nutr Food Res. , vol.54 , pp. 489-495
    • Olson, C.R.1    Mello, C.V.2
  • 61
    • 84876785281 scopus 로고    scopus 로고
    • Retinoids and glucocorticoids target common genes in hippocampal HT22 cells
    • doi:10.1111/jnc.12192
    • Brossaud J, Roumes H, Moisan MP, Pallet V, Redonnet A, Corcuff JB. Retinoids and glucocorticoids target common genes in hippocampal HT22 cells. J Neurochem. 2013;125:518-531. doi:10.1111/jnc.12192
    • (2013) J Neurochem. , vol.125 , pp. 518-531
    • Brossaud, J.1    Roumes, H.2    Moisan, M.P.3    Pallet, V.4    Redonnet, A.5    Corcuff, J.B.6
  • 62
    • 84891451546 scopus 로고    scopus 로고
    • Inosine enhances axon sprouting and motor recovery after spinal cord injury
    • doi:10.1371/journal. pone.0081948
    • Kim D, Zai L, Liang P, Schaffling C, Ahlborn D, Benowitz LI. Inosine enhances axon sprouting and motor recovery after spinal cord injury. PLoS ONE. 2013;8:e81948. doi:10.1371/journal. pone.0081948
    • (2013) PLoS ONE. , vol.8 , pp. e81948
    • Kim, D.1    Zai, L.2    Liang, P.3    Schaffling, C.4    Ahlborn, D.5    Benowitz, L.I.6
  • 63
    • 84895558085 scopus 로고    scopus 로고
    • Inosine improves functional recovery after experimental traumatic brain injury
    • doi:10.1016/j. brainres.2014.01.044
    • Dachir S, Shabashov D, Trembovler V, Alexandrovich AG, Benowitz LI, Shohami E. Inosine improves functional recovery after experimental traumatic brain injury. Brain Res. 2014;1555:78-88. doi:10.1016/j. brainres.2014.01.044
    • (2014) Brain Res. , vol.1555 , pp. 78-88
    • Dachir, S.1    Shabashov, D.2    Trembovler, V.3    Alexandrovich, A.G.4    Benowitz, L.I.5    Shohami, E.6
  • 64
    • 84894797635 scopus 로고    scopus 로고
    • Oral administration of inosine produces antidepressant-like effects in mice
    • doi:10.1038/ srep04199
    • Muto J, Lee H, Lee H, et al. Oral administration of inosine produces antidepressant-like effects in mice. Sci Rep. 2014;4:4199. doi:10.1038/ srep04199
    • (2014) Sci Rep. , vol.4 , pp. 4199
    • Muto, J.1    Lee, H.2    Lee, H.3
  • 65
    • 51449094431 scopus 로고    scopus 로고
    • Transthyretin: A key gene involved in the maintenance of memory capacities during aging
    • doi:10.1016/j.neurobiolaging.2007.04.007
    • Brouillette J, Quirion R. Transthyretin: A key gene involved in the maintenance of memory capacities during aging. Neurobiol Aging. 2008;29:1721-1732. doi:10.1016/j.neurobiolaging.2007.04.007
    • (2008) Neurobiol Aging. , vol.29 , pp. 1721-1732
    • Brouillette, J.1    Quirion, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.