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Volumn 13, Issue 1, 2013, Pages 28-34

Cognitive dysfunction: An emerging concept of a new diabetic complication in the elderly

Author keywords

Alzheimer's disease type dementia; Hypoglycemia; Insulin resistance; Neurocognitive assessment; Vascular dementia

Indexed keywords

ACETYLCHOLINE; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1; INSULIN; OLANZAPINE; QUETIAPINE;

EID: 84871969895     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2012.00922.x     Document Type: Review
Times cited : (59)

References (79)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 4
    • 80555157642 scopus 로고    scopus 로고
    • Glucose tolerance status and risk of dementia in the community: the Hisayama study
    • Ohara T, Doi Y, Ninomiya T etal. Glucose tolerance status and risk of dementia in the community: the Hisayama study. Neurology 2011; 77: 1126-1134.
    • (2011) Neurology , vol.77 , pp. 1126-1134
    • Ohara, T.1    Doi, Y.2    Ninomiya, T.3
  • 5
    • 77956364857 scopus 로고    scopus 로고
    • Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study
    • Matsuzaki T, Sasaki K, Tanizaki Y etal. Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology 2010; 75: 764-770.
    • (2010) Neurology , vol.75 , pp. 764-770
    • Matsuzaki, T.1    Sasaki, K.2    Tanizaki, Y.3
  • 6
    • 2442424380 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of Alzheimer's disease and decline in cognitive function
    • Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Benette DA. Diabetes mellitus and risk of Alzheimer's disease and decline in cognitive function. Arch Neurol 2004; 61: 661-666.
    • (2004) Arch Neurol , vol.61 , pp. 661-666
    • Arvanitakis, Z.1    Wilson, R.S.2    Bienias, J.L.3    Evans, D.A.4    Benette, D.A.5
  • 7
    • 0036227542 scopus 로고    scopus 로고
    • Honolulu-Asia Aging Study. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies
    • Peila R, Rodriguez BL, Launer LJ. Honolulu-Asia Aging Study. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies. Diabetes 2002; 51: 1256-1262.
    • (2002) Diabetes , vol.51 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 8
    • 3242765976 scopus 로고    scopus 로고
    • Fasting insulin and incident dementia in an elderly population of Japanese-American men
    • Peila R, Rodriguez BL, White LR, Launer LJ. Fasting insulin and incident dementia in an elderly population of Japanese-American men. Neurology 2004; 63: 228-233.
    • (2004) Neurology , vol.63 , pp. 228-233
    • Peila, R.1    Rodriguez, B.L.2    White, L.R.3    Launer, L.J.4
  • 9
    • 28444491100 scopus 로고    scopus 로고
    • Cognitive decline and dementia in diabetes - systematic overview of prospective observational studies
    • Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes - systematic overview of prospective observational studies. Diabetologia 2005; 48: 2460-2469.
    • (2005) Diabetologia , vol.48 , pp. 2460-2469
    • Cukierman, T.1    Gerstein, H.C.2    Williamson, J.D.3
  • 10
    • 67649742213 scopus 로고    scopus 로고
    • Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials
    • Kopf D, Frölich L. Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials. J Alzheimers Dis 2009; 16: 677-685.
    • (2009) J Alzheimers Dis , vol.16 , pp. 677-685
    • Kopf, D.1    Frölich, L.2
  • 12
    • 80052059865 scopus 로고    scopus 로고
    • Risk factors and preventive interventions for Alzheimer disease: state of the science
    • Daviglus ML, Plassman BL, Pirzada A etal. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol 2011; 68: 1185-1190.
    • (2011) Arch Neurol , vol.68 , pp. 1185-1190
    • Daviglus, M.L.1    Plassman, B.L.2    Pirzada, A.3
  • 13
    • 80051669619 scopus 로고    scopus 로고
    • The projected effect of risk factor reduction on Alzheimer's disease prevalence
    • Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011; 10: 819-828.
    • (2011) Lancet Neurol , vol.10 , pp. 819-828
    • Barnes, D.E.1    Yaffe, K.2
  • 14
    • 0016823810 scopus 로고
    • "Mini-Mental State": a practical method of grading the cognitive function of patients or the clinician
    • Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method of grading the cognitive function of patients or the clinician. J Psychiatr Res 1978; 12: 189-198.
    • (1978) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 15
    • 34347346094 scopus 로고    scopus 로고
    • Differential mini-mental state examination profiles of older people with diabetes mellitus with early Alzheimer's disease
    • Sakurai T, Kuranaga M, Akisaki T, Takata T, Endo H, Yokono K. Differential mini-mental state examination profiles of older people with diabetes mellitus with early Alzheimer's disease. J Am Geriatr Soc 2007; 55: 955-956.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 955-956
    • Sakurai, T.1    Kuranaga, M.2    Akisaki, T.3    Takata, T.4    Endo, H.5    Yokono, K.6
  • 16
    • 0027936688 scopus 로고
    • Discrimination between stages of Alzheimer's disease with subsets of Mini-Mental State Examination items. An analysis of Consortium to Establish a Registry for Alzheimer's Disease data
    • Fillenbaum GG, Wilkinson WE, Welsh KA, Mohs RC. Discrimination between stages of Alzheimer's disease with subsets of Mini-Mental State Examination items. An analysis of Consortium to Establish a Registry for Alzheimer's Disease data. Arch Neurol 1994; 51: 916-921.
    • (1994) Arch Neurol , vol.51 , pp. 916-921
    • Fillenbaum, G.G.1    Wilkinson, W.E.2    Welsh, K.A.3    Mohs, R.C.4
  • 17
    • 64249141005 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition
    • van den Berg E, Kloppenborg RP, Kessels RP, Kappelle LJ, Biessels GJ. Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition. Biochim Biophys Acta 2009; 1792: 470-481.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 470-481
    • Van Den Berg, E.1    Kloppenborg, R.P.2    Kessels, R.P.3    Kappelle, L.J.4    Biessels, G.J.5
  • 18
    • 47049129183 scopus 로고    scopus 로고
    • Glucose control levels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysfunction in diabetic elderly
    • Umegaki H, Kawamura T, Mogi N, Umemura T, Kanai A, Sano T. Glucose control levels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysfunction in diabetic elderly. Age Ageing 2008; 37: 458-461.
    • (2008) Age Ageing , vol.37 , pp. 458-461
    • Umegaki, H.1    Kawamura, T.2    Mogi, N.3    Umemura, T.4    Kanai, A.5    Sano, T.6
  • 20
    • 0003472502 scopus 로고
    • American Psychiatric Association., 3rd edn. Washington, DC: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd edn. Washington, DC: American Psychiatric Association, 1985.
    • (1985) Diagnostic and Statistical Manual of Mental Disorders
  • 21
    • 77956231757 scopus 로고    scopus 로고
    • The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
    • Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol 2010; 120: 287-296.
    • (2010) Acta Neuropathol , vol.120 , pp. 287-296
    • Iadecola, C.1
  • 22
    • 35748972367 scopus 로고    scopus 로고
    • Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders
    • Yamagishi S, Ueda S, Okuda S. Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders. Curr Pharm Des 2007; 13: 2832-2836.
    • (2007) Curr Pharm Des , vol.13 , pp. 2832-2836
    • Yamagishi, S.1    Ueda, S.2    Okuda, S.3
  • 23
    • 70449732132 scopus 로고    scopus 로고
    • Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
    • Valente T, Gella A, Fernàndez-Busquets X, Unzeta M, Durany N. Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiol Dis 2010; 37: 67-76.
    • (2010) Neurobiol Dis , vol.37 , pp. 67-76
    • Valente, T.1    Gella, A.2    Fernàndez-Busquets, X.3    Unzeta, M.4    Durany, N.5
  • 24
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007; 8: 57-69.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 25
    • 0037221379 scopus 로고    scopus 로고
    • The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment
    • Watson GS, Craft S. The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 2003; 17: 27-45.
    • (2003) CNS Drugs , vol.17 , pp. 27-45
    • Watson, G.S.1    Craft, S.2
  • 26
    • 0002096610 scopus 로고    scopus 로고
    • Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas
    • Hardman JG, Gilman AG, Limbird LE, eds., 9th edn. New York: McGraw-Hill
    • Davis SN, Granner DK. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: Hardman JG, Gilman AG, Limbird LE, eds. Gilman and Goodman's the Pharmacological Basis of Therapeutics, 9th edn. New York: McGraw-Hill, 1996; 1487-1517.
    • (1996) Gilman and Goodman's the Pharmacological Basis of Therapeutics , pp. 1487-1517
    • Davis, S.N.1    Granner, D.K.2
  • 28
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • Havrankova J, Roth J, Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 1978; 272: 827-829.
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 29
    • 0034508636 scopus 로고    scopus 로고
    • Insulin receptors and insulin action in the nervous system
    • Freychet P. Insulin receptors and insulin action in the nervous system. Diabetes Metab Res Rev 2000; 16: 390-392.
    • (2000) Diabetes Metab Res Rev , vol.16 , pp. 390-392
    • Freychet, P.1
  • 30
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
    • Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247-268.
    • (2005) J Alzheimers Dis , vol.8 , pp. 247-268
    • Rivera, E.J.1    Goldin, A.2    Fulmer, N.3    Tavares, R.4    Wands, J.R.5    de la Monte, S.M.6
  • 31
    • 60549084867 scopus 로고    scopus 로고
    • Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    • De Felice FG, Vieira MN, Bomfim TR etal. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci USA 2009; 106: 1971-1976.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1971-1976
    • De Felice, F.G.1    Vieira, M.N.2    Bomfim, T.R.3
  • 32
    • 20844458090 scopus 로고    scopus 로고
    • Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    • Lacor PN, Buniel MC, Chang L etal. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 2004; 24: 10191-10200.
    • (2004) J Neurosci , vol.24 , pp. 10191-10200
    • Lacor, P.N.1    Buniel, M.C.2    Chang, L.3
  • 33
    • 64249129005 scopus 로고    scopus 로고
    • Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    • Zhao WQ, Townsend M. Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta 2009; 1792: 482-496.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 482-496
    • Zhao, W.Q.1    Townsend, M.2
  • 34
    • 0031907459 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype
    • Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D Jr. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 1998; 50: 164-168.
    • (1998) Neurology , vol.50 , pp. 164-168
    • Craft, S.1    Peskind, E.2    Schwartz, M.W.3    Schellenberg, G.D.4    Raskind, M.5    Porte Jr., D.6
  • 35
    • 84855613853 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer disease and Amnestic mild cognitive impairment: a pilot clinical trial
    • Craft S, Baker LD, Montine TJ etal. Intranasal insulin therapy for Alzheimer disease and Amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2012; 69: 29-38.
    • (2012) Arch Neurol , vol.69 , pp. 29-38
    • Craft, S.1    Baker, L.D.2    Montine, T.J.3
  • 36
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127: 481-496.
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey, W.H.4
  • 37
    • 3543142498 scopus 로고    scopus 로고
    • Intranasal insulin reportedly improves memory and attention in humans
    • Benedict C, Hallschmid M, Hatke A etal. Intranasal insulin reportedly improves memory and attention in humans. Psychoneuroendocrinology 2004; 29: 1326-1334.
    • (2004) Psychoneuroendocrinology , vol.29 , pp. 1326-1334
    • Benedict, C.1    Hallschmid, M.2    Hatke, A.3
  • 38
    • 36448936053 scopus 로고    scopus 로고
    • Common pathological processes in Alzheimer disease and type 2 diabetes: a review
    • Li L, Hölscher C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 2007; 56: 384-402.
    • (2007) Brain Res Rev , vol.56 , pp. 384-402
    • Li, L.1    Hölscher, C.2
  • 39
    • 79956158458 scopus 로고    scopus 로고
    • Molecular mechanisms linking diabetes mellitus and Alzheimer disease: β-amyloid peptide, insulin signaling, and neuronal function
    • Takeda S, Sato N, Rakugi H, Morishita R. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: β-amyloid peptide, insulin signaling, and neuronal function. Mol Biosyst 2011; 7: 1822-1827.
    • (2011) Mol Biosyst , vol.7 , pp. 1822-1827
    • Takeda, S.1    Sato, N.2    Rakugi, H.3    Morishita, R.4
  • 40
    • 21044455285 scopus 로고    scopus 로고
    • Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology
    • Beeri MS, Silverman JM, Davis KL etal. Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology. J Gerontol A Biol Sci Med Sci 2005; 60: 471-475.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 471-475
    • Beeri, M.S.1    Silverman, J.M.2    Davis, K.L.3
  • 41
    • 33845704496 scopus 로고    scopus 로고
    • Diabetes is related to cerebral infarction but not to AD pathology in older persons
    • Arvanitakis Z, Schneider JA, Wilson RS etal. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 2006; 7: 960-1965.
    • (2006) Neurology , vol.7 , pp. 960-1965
    • Arvanitakis, Z.1    Schneider, J.A.2    Wilson, R.S.3
  • 42
    • 34848835838 scopus 로고    scopus 로고
    • Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes
    • Manschot SM, Biessels GJ, de Valk H etal. Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia 2007; 50: 2388-2397.
    • (2007) Diabetologia , vol.50 , pp. 2388-2397
    • Manschot, S.M.1    Biessels, G.J.2    de Valk, H.3
  • 43
    • 19444364576 scopus 로고    scopus 로고
    • Asymptomatic cerebral infarction on brain MR images and cognitive function in elderly diabetic patients
    • Araki A, Ito H. Asymptomatic cerebral infarction on brain MR images and cognitive function in elderly diabetic patients. Geriatr Gerontol Int 2002; 2: 206-214.
    • (2002) Geriatr Gerontol Int , vol.2 , pp. 206-214
    • Araki, A.1    Ito, H.2
  • 44
    • 33749001980 scopus 로고    scopus 로고
    • Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus. Japanese elderly diabetes intervention trial (J-EDIT)
    • Akisaki T, Sakurai T, Takata T etal. Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus. Japanese elderly diabetes intervention trial (J-EDIT). Diabetes Metab Res Rev 2006; 22: 376-384.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 376-384
    • Akisaki, T.1    Sakurai, T.2    Takata, T.3
  • 45
    • 79955697004 scopus 로고    scopus 로고
    • Neurovascular coupling in cognitive impairment associated with diabetes mellitus
    • Mogi M, Horiuchi M. Neurovascular coupling in cognitive impairment associated with diabetes mellitus. Circ J 2011; 75: 1042-1048.
    • (2011) Circ J , vol.75 , pp. 1042-1048
    • Mogi, M.1    Horiuchi, M.2
  • 46
    • 35848949798 scopus 로고    scopus 로고
    • Cell-cell signaling in the neurovascular unit
    • Lok J, Gupta P, Guo S etal. Cell-cell signaling in the neurovascular unit. Neurochem Res 2007; 32: 2032-2045.
    • (2007) Neurochem Res , vol.32 , pp. 2032-2045
    • Lok, J.1    Gupta, P.2    Guo, S.3
  • 47
    • 79955521915 scopus 로고    scopus 로고
    • Chongqing Ageing Study Group. Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease
    • Li J, Wang YJ, Zhang M etal. Chongqing Ageing Study Group. Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 2011; 76: 1485-1491.
    • (2011) Neurology , vol.76 , pp. 1485-1491
    • Li, J.1    Wang, Y.J.2    Zhang, M.3
  • 48
    • 70349334173 scopus 로고    scopus 로고
    • Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
    • Deschaintre Y, Richard F, Leys D, Pasquier F. Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. Neurology 2009; 73: 674-680.
    • (2009) Neurology , vol.73 , pp. 674-680
    • Deschaintre, Y.1    Richard, F.2    Leys, D.3    Pasquier, F.4
  • 49
    • 43349087108 scopus 로고    scopus 로고
    • An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study
    • doi: 10.1186/1471-2458-8-54.
    • Gao L, Matthews FE, Sargeant LA etal. An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study. BMC Public Health 2008; 8: 54;doi: 10.1186/1471-2458-8-54.
    • (2008) BMC Public Health , vol.8 , pp. 54
    • Gao, L.1    Matthews, F.E.2    Sargeant, L.A.3
  • 50
    • 57649101378 scopus 로고    scopus 로고
    • LSA Study Group. Diabetes as a risk factor for cognitive decline in older patients
    • Maggi S, Limongi F, Noale M etal. LSA Study Group. Diabetes as a risk factor for cognitive decline in older patients. Dement Geriatr Cogn Disord 2009; 27: 24-33.
    • (2009) Dement Geriatr Cogn Disord , vol.27 , pp. 24-33
    • Maggi, S.1    Limongi, F.2    Noale, M.3
  • 51
    • 79959696586 scopus 로고    scopus 로고
    • Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) study. AR, Selvin E
    • Christman AL, Matsushita K, Gottesman RF etal. Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) study. AR, Selvin E. Diabetologia 2011; 54: 1645-1652.
    • (2011) Diabetologia , vol.54 , pp. 1645-1652
    • Christman, A.L.1    Matsushita, K.2    Gottesman, R.F.3
  • 52
    • 61849132879 scopus 로고    scopus 로고
    • Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial; Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes(ACCORD-MIND)Investigators
    • Cukierman-Yaffe T, Gerstein HC, Williamson JD etal. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial; Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes(ACCORD-MIND)Investigators. Diabetes Care 2009; 32: 221-226.
    • (2009) Diabetes Care , vol.32 , pp. 221-226
    • Cukierman-Yaffe, T.1    Gerstein, H.C.2    Williamson, J.D.3
  • 53
    • 80054748660 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
    • Launer LJ, Miller ME, Williamson JD etal. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol 2011; 10: 969-977.
    • (2011) Lancet Neurol , vol.10 , pp. 969-977
    • Launer, L.J.1    Miller, M.E.2    Williamson, J.D.3
  • 54
    • 0027360102 scopus 로고
    • Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus
    • Gradman TJ, Laws A, Thompson LW, Reaven GM. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 1993; 41: 1305-1312.
    • (1993) J Am Geriatr Soc , vol.41 , pp. 1305-1312
    • Gradman, T.J.1    Laws, A.2    Thompson, L.W.3    Reaven, G.M.4
  • 55
    • 0027155903 scopus 로고
    • The effect of improved glycemic control on cognitive functions in the elderly patient with diabetes
    • Meneilly GS, Cheung E, Tessier D, Yakura C, Tuokko H. The effect of improved glycemic control on cognitive functions in the elderly patient with diabetes. J Gerontol 1993; 48: M117-M121.
    • (1993) J Gerontol , vol.48
    • Meneilly, G.S.1    Cheung, E.2    Tessier, D.3    Yakura, C.4    Tuokko, H.5
  • 56
    • 0031046175 scopus 로고    scopus 로고
    • Cognitive function in elderly non-insulin-dependent diabetic patients before and after inpatient treatment for metabolic control
    • Naor M, Steingruber HJ, Westhoff K, Schottenfeld-Naor Y, Gries AF. Cognitive function in elderly non-insulin-dependent diabetic patients before and after inpatient treatment for metabolic control. J Diabetes Complications 1997; 11: 40-46.
    • (1997) J Diabetes Complications , vol.11 , pp. 40-46
    • Naor, M.1    Steingruber, H.J.2    Westhoff, K.3    Schottenfeld-Naor, Y.4    Gries, A.F.5
  • 57
    • 0037266118 scopus 로고    scopus 로고
    • Short-term effects of improved glycemic control on cognitive function in patients with type 2 diabetes
    • Hewer W, Mussell M, Rist F, Kulzer B, Bergis K. Short-term effects of improved glycemic control on cognitive function in patients with type 2 diabetes. Gerontology 2003; 49: 86-92.
    • (2003) Gerontology , vol.49 , pp. 86-92
    • Hewer, W.1    Mussell, M.2    Rist, F.3    Kulzer, B.4    Bergis, K.5
  • 59
    • 33747083535 scopus 로고    scopus 로고
    • Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics
    • Abbatecola AM, Rizzo MR, Barbieri M etal. Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics. Neurology 2006; 67: 235-240.
    • (2006) Neurology , vol.67 , pp. 235-240
    • Abbatecola, A.M.1    Rizzo, M.R.2    Barbieri, M.3
  • 60
    • 8144224919 scopus 로고    scopus 로고
    • Effects of improved glycae Large prospective study are warranted regarding this issue
    • Mussell M, Hewer W, Kulzer B, Bergis K, Rist F. Effects of improved glycae Large prospective study are warranted regarding this issue. Diabet Med 2004; 21: 1253-1256.
    • (2004) Diabet Med , vol.21 , pp. 1253-1256
    • Mussell, M.1    Hewer, W.2    Kulzer, B.3    Bergis, K.4    Rist, F.5
  • 61
    • 36148959683 scopus 로고    scopus 로고
    • Insulin resistance and postprandial hyperglycemia the bad companions in natural history of diabetes: effects on health of vascular tree
    • Di Filippo C, Verza M, Coppola L, Rossi F, D'Amico M, Marfella R. Insulin resistance and postprandial hyperglycemia the bad companions in natural history of diabetes: effects on health of vascular tree. Curr Diabetes Rev 2007; 3: 268-273.
    • (2007) Curr Diabetes Rev , vol.3 , pp. 268-273
    • Di Filippo, C.1    Verza, M.2    Coppola, L.3    Rossi, F.4    D'Amico, M.5    Marfella, R.6
  • 62
    • 64749114159 scopus 로고    scopus 로고
    • Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
    • Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009; 301: 1565-1572.
    • (2009) JAMA , vol.301 , pp. 1565-1572
    • Whitmer, R.A.1    Karter, A.J.2    Yaffe, K.3    Quesenberry Jr., C.P.4    Selby, J.V.5
  • 64
    • 80052737323 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities
    • Article ID ;doi: 10.1155/2011/281674.
    • Mossello E, Ballini E, Boncinelli M etal. Glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities. Exp Diabetes Res 2011; 31: Article ID 281674;doi: 10.1155/2011/281674.
    • (2011) Exp Diabetes Res , vol.31 , pp. 281674
    • Mossello, E.1    Ballini, E.2    Boncinelli, M.3
  • 65
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean PL, Parthsarathy V, Faivre E, Hölscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011; 31: 6587-6594.
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Hölscher, C.4
  • 66
    • 44949098333 scopus 로고    scopus 로고
    • Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment
    • CD005381.
    • Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev 2008; (16): CD005381.
    • (2008) Cochrane Database Syst Rev , Issue.16
    • Angevaren, M.1    Aufdemkampe, G.2    Verhaar, H.J.3    Aleman, A.4    Vanhees, L.5
  • 67
    • 62249177925 scopus 로고    scopus 로고
    • Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence
    • Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med 2009; 39: 3-11.
    • (2009) Psychol Med , vol.39 , pp. 3-11
    • Hamer, M.1    Chida, Y.2
  • 68
    • 5344237365 scopus 로고    scopus 로고
    • The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis
    • Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 2004; 85: 1694-1704.
    • (2004) Arch Phys Med Rehabil , vol.85 , pp. 1694-1704
    • Heyn, P.1    Abreu, B.C.2    Ottenbacher, K.J.3
  • 69
    • 0033672908 scopus 로고    scopus 로고
    • Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study
    • Sinclair AJ, Girling AJ, Bayer AJ. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study. Diabetes Res Clin Pract 2000; 50: 203-212.
    • (2000) Diabetes Res Clin Pract , vol.50 , pp. 203-212
    • Sinclair, A.J.1    Girling, A.J.2    Bayer, A.J.3
  • 70
    • 77957151199 scopus 로고    scopus 로고
    • Low well-being, cognitive impairment and visual impairment associated with functional disabilities in elderly Japanese patients with diabetes mellitus
    • Araki A, Nakano T, Oba K etal. Low well-being, cognitive impairment and visual impairment associated with functional disabilities in elderly Japanese patients with diabetes mellitus. Geriatr Gerontol Int 2004; 4: 27-36.
    • (2004) Geriatr Gerontol Int , vol.4 , pp. 27-36
    • Araki, A.1    Nakano, T.2    Oba, K.3
  • 71
    • 33744728338 scopus 로고    scopus 로고
    • The impact of cognitive functioning on mortality and the development of functional disability in older adults with diabetes: the second longitudinal study on aging
    • doi: 10/1186/1471-2318-6-8.
    • McGuire LC, Ford ES, Ajani UA. The impact of cognitive functioning on mortality and the development of functional disability in older adults with diabetes: the second longitudinal study on aging. BMC Geriatr 2006; 6: 8; doi: 10/1186/1471-2318-6-8.
    • (2006) BMC Geriatr , vol.6 , pp. 8
    • McGuire, L.C.1    Ford, E.S.2    Ajani, U.A.3
  • 72
    • 75149163365 scopus 로고    scopus 로고
    • Late-life depression, mild cognitive impairment, and dementia: possible continuum?
    • Panza F, Frisardi V, Capurso C etal. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry 2010; 18: 98-116.
    • (2010) Am J Geriatr Psychiatry , vol.18 , pp. 98-116
    • Panza, F.1    Frisardi, V.2    Capurso, C.3
  • 73
    • 63349092786 scopus 로고    scopus 로고
    • Cognitive and psychosocial aspects of caring for elderly patients with diabetes
    • Iwata I, Munshi MN. Cognitive and psychosocial aspects of caring for elderly patients with diabetes. Curr Diab Rep 2009; 9: 140-146.
    • (2009) Curr Diab Rep , vol.9 , pp. 140-146
    • Iwata, I.1    Munshi, M.N.2
  • 75
    • 48649090520 scopus 로고    scopus 로고
    • Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults
    • Dotson VM, Resnick SM, Zonderman AB. Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults. Am J Geriatr Psychiatry 2008; 16: 318-330.
    • (2008) Am J Geriatr Psychiatry , vol.16 , pp. 318-330
    • Dotson, V.M.1    Resnick, S.M.2    Zonderman, A.B.3
  • 76
    • 32244438738 scopus 로고    scopus 로고
    • Depressive symptoms and cognitive decline in late life: a prospective epidemiological study
    • Ganguli M, Du Y, Dodge HH, Chang CC. Depressive symptoms and cognitive decline in late life: a prospective epidemiological study. Arch Gen Psychiatry 2006; 63: 153-160.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 153-160
    • Ganguli, M.1    Du, Y.2    Dodge, H.H.3    Chang, C.C.4
  • 77
    • 14644402417 scopus 로고    scopus 로고
    • Depression in diabetic patients: the relationship between mood and glycemic control
    • Lustman PJ, Clouse RE. Depression in diabetic patients: the relationship between mood and glycemic control. J Diabetes Complications 2005; 19: 113-122.
    • (2005) J Diabetes Complications , vol.19 , pp. 113-122
    • Lustman, P.J.1    Clouse, R.E.2
  • 79
    • 66149171513 scopus 로고    scopus 로고
    • Metabolic changes associated with second-generation antipsychotic use in Alzheimer's disease patients: the CATIE-AD study
    • Zheng L, Mack WJ, Dagerman KS, Hsiao JK, Lebowitz BD, Lyketsos CG. Metabolic changes associated with second-generation antipsychotic use in Alzheimer's disease patients: the CATIE-AD study. Am J Psychiatry 2009; 166: 583-590.
    • (2009) Am J Psychiatry , vol.166 , pp. 583-590
    • Zheng, L.1    Mack, W.J.2    Dagerman, K.S.3    Hsiao, J.K.4    Lebowitz, B.D.5    Lyketsos, C.G.6


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