Oral administration of inosine produces antidepressant-like effects in mice

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Muto, Junko ^a,b   Lee, Hosung ^b,c   Lee, Hyunjin ^b,c   Uwaya, Akemi ^b,c   Park, Jonghyuk ^a,b   Nakajima, Sanae ^b,c,d   Nagata, Kazufumi ^b,c   Ohno, Makoto ^a   Ohsawa, Ikuroh ^e   Mikami, Toshio ^b  

^a NIPPON SPORT SCIENCE UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c Graduate School of Medicine   (Japan)

^d KYORITSU WOMEN'S UNIVERSITY   (Japan)

^e TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE RECEPTOR; ANTIDEPRESSANT AGENT; INOSINE;

ANIMAL; ARTICLE; BRAIN; C57BL MOUSE; DEPRESSION; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RAT; TREATMENT OUTCOME; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSION; INOSINE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; TREATMENT OUTCOME;

EID: 84894797635     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04199     Document Type: Article

References (49)

1. Litsky, M. L., Hohl, C. M., Lucas, J. H. & Jurkowitz, M. S. Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia. Brain Res 821, 426-432 (1999). (Pubitemid 29222807)
2. Benowitz, L. I., Goldberg, D. E.&Irwin,N. Inosine stimulates axon growth in vitro and in the adult CNS. Prog Brain Res 137, 389-399 (2002). (Pubitemid 35460958)
3. Benowitz, L. I. & Carmichael, S. T. Promoting axonal rewiring to improve outcome after stroke. Neurobiol Dis 37, 259-266 (2009).
4. Szabo, G. et al. Effects of inosine on reperfusion injury after heart transplantation. Eur J Cardiothorac Surg 30, 96-102 (2006). (Pubitemid 43850335)
5. Veres, G. et al. Effects of inosine on reperfusion injury after cardiopulmonary bypass. J Cardiothorac Surg 5, 106 (2010).
6. Jin, X., Shepherd, R. K., Duling, B. R. & Linden, J. Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J Clin Invest 100, 2849-2857 (1997). (Pubitemid 28007555)
7. Hasko, G., Sitkovsky, M. V. & Szabo, C. Immunomodulatory and neuroprotective effects of inosine. Trends Pharmacol Sci 25, 152-157 (2004). (Pubitemid 38264506)
8. Ralevic, V. & Burnstock, G. Receptors for purines and pyrimidines. Pharmacol Rev 50, 413-492 (1998). (Pubitemid 28477681)
9. Fredholm, B. B., AP, I. J., Jacobson, K. A., Klotz, K. N. & Linden, J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53, 527-552 (2001). (Pubitemid 33136237)
10. Souza, L. F. et al. Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells: possible participation in TNF-alpha modulation of ERK 1/2. Life Sci 77, 3117-3126 (2005). (Pubitemid 41423747)
11. El Yacoubi, M. et al. Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Br J Pharmacol 134, 68-77 (2001). (Pubitemid 32835469)
12. Guinzberg, R. et al. Inosine released after hypoxia activates hepatic glucose liberation through A3 adenosine receptors. Am J Physiol Endocrinol Metab 290, E940-951 (2006).
13. Tomaselli, B., Nedden, S. Z., Podhraski, V. & Baier-Bitterlich, G. p42/44 MAPK is an essential effector for purine nucleoside-mediated neuroprotection of hypoxic PC12 cells and primary cerebellar granule neurons. Mol Cell Neurosci 38, 559-568 (2008).
14. Le Port, A. et al. Association between Dietary Patterns and Depressive Symptoms Over Time: A 10-Year Follow-Up Study of the GAZEL Cohort. PLoS One 7, e51593 (2012).
15. Zhu, W. L. et al. Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol Res 65, 74-80 (2012).
16. Zhang, L. et al. Curcumin produces antidepressant effects via activating MAPK/ ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice. Behav Brain Res 235, 67-72 (2012).
17. Hanson, N. D., Owens, M. J. & Nemeroff, C. B. Depression, antidepressants, and neurogenesis: a critical reappraisal. Neuropsychopharmacology. 36, 2589-2602 (2011).
18. Mineur, Y. S., Belzung, C. & Crusio, W. E. Functional implications of decreases in neurogenesis following chronic mild stress in mice. Neuroscience 150, 251-259 (2007). (Pubitemid 350198721)
19. Madsen, T. M. et al. Increased neurogenesis in a model of electroconvulsive therapy. Biol Psychiatry 47, 1043-1049 (2000). (Pubitemid 30336212)
20. Liu, Q. et al. Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress. Pharmacogenomics J 8, 375-383 (2008).
21. Kaster, M. P. et al. Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neurosci Lett 355, 21-24 (2004). (Pubitemid 38077175)
22. Marek, G. J. Activation of adenosine1 receptors induces antidepressant-like, antiimpulsive effects on differential reinforcement of low-rate 72-s behavior in rats. J Pharmacol Exp Ther 341, 564-570 (2012).
23. Duman, C. H., Schlesinger, L., Kodama, M., Russell, D. S. & Duman, R. S. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biol Psychiatry 61, 661-670 (2007). (Pubitemid 46328865)
24. Qi, H. et al. Antidepressants reverse the attenuation of the neurotrophic MEK/ MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation. Neuropharmacology 56, 37-46 (2009).
25. Krishnan, V. et al.Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391-404 (2007). (Pubitemid 47576141)
26. Tomaselli, B., Podhraski, V.,Heftberger, V., Bock, G. & Baier-Bitterlich, G. Purine nucleoside-mediated protection of chemical hypoxia-induced neuronal injuries involves p42/44 MAPK activation. Neurochem Int 46, 513-521 (2005). (Pubitemid 40552798)
27. zur Nedden, S., Tomaselli, B. & Baier-Bitterlich, G. HIF-1 alpha is an essential effector for purine nucleoside-mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons. J Neurochem 105, 1901-1914 (2008). (Pubitemid 351695372)
28. Paul, S., Elsinga, P. H., Ishiwata, K.,Dierckx, R. A.&van Waarde, A. AdenosineA1 receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging. Curr Med Chem 18, 4820-4835 (2011).
29. Kobayashi, S. & Millhorn, D. E. Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection. J Biol Chem 274, 20358-20365 (1999).
30. Pinna, A., Pontis, S., Borsini, F. & Morelli, M. Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease. Synapse 61, 606-614 (2007). (Pubitemid 46934007)
31. Nascimento, F. P. et al. Inosine reduces pain-related behavior in mice: involvement of adenosine A1 and A2A receptor subtypes and protein kinase C pathways. J Pharmacol Exp Ther 334, 590-598 (2010).
32. Yamamoto, T. et al. Effect of inosine on the plasma concentration of uridine and purine bases. Metabolism 51, 438-442 (2002). (Pubitemid 34406558)
33. Isakovic, A. J., Abbott, N. J. & Redzic, Z. B. Brain to blood efflux transport of adenosine: blood-brain barrier studies in the rat. JNeurochem 90, 272-286 (2004). (Pubitemid 38938213)
34. Parkinson, F. E. et al. Molecular biology of nucleoside transporters and their distributions and functions in the brain. Curr TopMed Chem 11, 948-972 (2011).
35. Migita, H. et al. Activation of adenosine A1 receptor-induced neural stem cell proliferation via MEK/ERK and Akt signaling pathways. J Neurosci Res 86, 2820-2828 (2008).
36. Maekawa, M. et al. NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus. Neurosci Res 63, 259-266 (2009).
37. Berton, O. et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311, 864-868 (2006). (Pubitemid 43228853)
38. Chuang, J. C. et al. A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol Psychiatry 67, 1075-1082 (2011).
39. Patterson, Z. R., Khazall, R., Mackay, H., Anisman, H. & Abizaid, A. Central Ghrelin Signaling Mediates the Metabolic Response of C57BL/6 Male Mice to Chronic Social Defeat Stress. Endocrinology (2012).
40. Asoh, S. et al. Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A 99, 17107-17112 (2002). (Pubitemid 36034106)
41. Banasr, M. et al. Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat. Biol Psychiatry 62, 496-504 (2007). (Pubitemid 47284039)
42. Porsolt, R. D., Le Pichon,M.&Jalfre, M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732 (1977). (Pubitemid 8073804)
43. Hollis, F., Wang, H., Dietz, D., Gunjan, A. & Kabbaj, M. The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats. Psychopharmacology (Berl) 211, 69-77 (2010).
44. Covington, H. E. 3rd. et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci 29, 11451-11460 (2009).
45. Zheng, H. et al. Beneficial effects of exercise and its molecular mechanisms on depression in rats. Behav Brain Res 168, 47-55 (2006). (Pubitemid 43152052)
46. Zhang, Y., Geiger, J. D. & Lautt, W. W. Improved high-pressure liquid chromatographic-fluorometric assay for measurement of adenosine in plasma. Am J Physiol 260, G658-664 (1991).
47. Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I. & Ohta, S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint inmice. Neuropsychopharmacology 34, 501-508 (2009).
48. Katz, R. J. Animal model of depression: pharmacological sensitivity of a hedonic deficit. Pharmacol Biochem Behav 16, 965-968 (1982). (Pubitemid 12081655)
49. Yamamoto, T. et al. Effect of inosine on the plasma concentration of uridine and purine bases. Metabolism 51, 438-442 (2002). (Pubitemid 34406558)