Inhibiting Geranylgeranylation Increases Neurite Branching and Differentially Activates Cofilin in Cell Bodies and Growth Cones

Molecular Neurobiology

Volumn 50, Issue 1, 2014, Pages 49-59

  Samuel, Filsy ^a   Reddy, Jairus ^b   Kaimal, Radhika ^b   Segovia, Vianey ^b   Mo, Huanbiao ^b   Hynds, Di Anna L ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TEXAS WOMAN'S UNIVERSITY   (United States)

Author keywords

Actin microfilaments; Growth cones; Neurite outgrowth; Posttranslational modifications; Prenylation

Indexed keywords

ACTIN; CHOLESTEROL; COFILIN; GERANYLGERANIOL; MEVINOLIN; COFILIN 1; DITERPENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ELONGATION; CELL FUNCTION; CELL LYSATE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; GERANYLGERANYLATION; GROWTH CONE; NERVE FIBER GROWTH; NEURITE; NEUROBLASTOMA CELL; NONHUMAN; PERIKARYON; PROTEIN PHOSPHORYLATION; PROTEIN PRENYLATION; WHOLE CELL; ANIMAL; CELL BODY; CELL SHAPE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; CELL BODY; CELL LINE, TUMOR; CELL SHAPE; COFILIN 1; DITERPENES; GROWTH CONES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; NEURITES; PROTEIN PRENYLATION; RATS;

EID: 84911002979     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8653-5     Document Type: Article

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