Vitamin e and D regulation of allergic asthma immunopathogenesis

International Immunopharmacology

Volumn 23, Issue 1, 2014, Pages 364-372

  Cook Mills, Joan M ^a   Avila, Pedro C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Animal models; Asthma Tocopherol; Human; Vitamin D; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; VITAMIN D;

ALLERGIC ASTHMA; HUMAN; IMMUNOPATHOGENESIS; NONHUMAN; REGULATORY MECHANISM; REVIEW; ANIMAL; ASTHMA; BREATHING; CLINICAL TRIAL (TOPIC); DIET THERAPY; DIETARY SUPPLEMENT; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ASTHMA; CLINICAL TRIALS AS TOPIC; DIETARY SUPPLEMENTS; HUMANS; HYPERSENSITIVITY; RESPIRATION; SIGNAL TRANSDUCTION; VITAMIN D; VITAMIN E;

EID: 84910644095     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.08.007     Document Type: Review

References (130)

1. F.D. Martinez Genes, environments, development and asthma: a reappraisal Eur Respir J 29 2007 179 184
2. J. Bousquet, P.J. Bousquet, P. Godard, and J.P. Daures The public health implications of asthma Bull World Health Organ 83 2005 548 554
3. W.M. Vollmer, M.L. Osborne, and A.S. Buist 20-Year trends in the prevalence of asthma and chronic airflow obstruction in an HMO Am J Respir Crit Care Med 157 1998 1079 1084
4. E. Friebele The attack of asthma Environ Health Perspect 104 1996 22 25
5. R. Uauy, D.R. Hoffman, E.E. Birch, D.G. Birch, D.M. Jameson, and J. Tyson Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula J Pediatr 124 1994 612 620
6. J.M. Cook-Mills, and C.A. McCary Isoforms of vitamin E differentially regulate inflammation Endocr Metab Immune Disord Drug Targets 10 2010 348 366
7. C.A. McCary, H. Abdala-Valencia, S. Berdnikovs, and J.M. Cook-Mills Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of alpha-tocopherol and gamma-tocopherol's effects J Immunol 186 2011 3674 3685
8. S. Berdnikovs, H. Abdala-Valencia, C. McCary, M. Somand, R. Cole, and A. Garcia Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment J Immunol 182 2009 4395 4405
9. M.E. Marchese, R. Kumar, L.A. Colangelo, P.C. Avila, D.R. Jacobs Jr., and M. Gross The vitamin E isoforms alpha-tocopherol and gamma-tocopherol have opposite associations with spirometric parameters: the CARDIA study Respir Res 15 2014 31
10. S.C. Hunter, and E.B. Cahoon Enhancing vitamin E in oilseeds: unraveling tocopherol and tocotrienol biosynthesis Lipids 42 2007 97 108
11. S.W. Leonard, E. Paterson, J.K. Atkinson, R. Ramakrishnan, C.E. Cross, and M.G. Traber Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production Free Radic Biol Med 38 2005 857 866
12. D.L. Bella, B.C. Schock, Y. Lim, S.W. Leonard, C. Berry, and C.E. Cross Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress Lipids 41 2006 105 112
13. C.A. Redlich, J.N. Grauer, A.M. Van Bennekum, S.L. Clever, R.B. Ponn, and W.S. Blaner Characterization of carotenoid, vitamin A, and alpha-tocopherol levels in human lung tissue and pulmonary macrophages Am J Respir Crit Care Med 154 1996 1436 1443
14. W. Zou, S.K. Noh, K.Q. Owen, and S.I. Koo Dietary l-carnitine enhances the lymphatic absorption of fat and alpha-tocopherol in ovariectomized rats J Nutr 135 2005 753 756
15. L. Cavalier, K. Ouahchi, H.J. Kayden, S. Di Donato, L. Reutenauer, and J.L. Mandel Ataxia with isolated vitamin E deficiency: heterogeneity of mutations and phenotypic variability in a large number of families Am J Hum Genet 62 1998 301 310
16. I. Sundl, M. Guardiola, G. Khoschsorur, R. Sola, J.C. Vallve, and G. Godas Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene-1131T > C variant and associations with plasma lipids and lipid peroxidation J Lipid Res 48 2007 2506 2513
17. M. Guardiola, J. Ribalta, D. Gomez-Coronado, M.A. Lasuncion, M. de Oya, and C. Garces The apolipoprotein A5 (APOA5) gene predisposes Caucasian children to elevated triglycerides and vitamin E (four provinces study) Atherosclerosis 212 2010 543 547
18. P. Huebbe, L. Jofre-Monseny, and G. Rimbach Alpha-tocopherol transport in the lung is affected by the apoE genotype - studies in transgenic apoE3 and apoE4 mice IUBMB Life 61 2009 453 456
19. Y. Yoshida, Y. Saito, L.S. Jones, and Y. Shigeri Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants J Biosci Bioeng 104 2007 439 445
20. M.H. Keiko Nishio, Yoko Akazawa, Mototada Shichiri, Hitoshi Iwahashi, Y.Y. Yoshihisa Hagihara, and Etsuo Niki Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols Redox Biol 1 2013 97 103
21. P.H. Huang, H.C. Chuang, C.C. Chou, H. Wang, S.L. Lee, and H.C. Yang Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1 Sci Signal 6 2013 ra19
22. A. Patel, F. Liebner, T. Netscher, K. Mereiter, and T. Rosenau Vitamin E chemistry. Nitration of non-alpha-tocopherols: products and mechanistic considerations J Org Chem 72 2007 6504 6512
23. L. Fakhrzadeh, J.D. Laskin, and D.L. Laskin Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50 Am J Physiol Lung Cell Mol Physiol 287 2004 L279 L285
24. M.L. Hernandez, J.G. Wagner, R. Aline Kala, K. Mills, H.B. Wells, and N.E. Alexis Vitamin E gamma-tocopherol reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers Free Radic Biol Med 60 2013 56 62
25. J. Wiser, N.E. Alexis, Q. Jiang, W. Wu, C. Robinette, and R. Roubey In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects Free Radic Biol Med 45 2008 40 49
26. J.G. Wagner, J.R. Harkema, Q. Jiang, B. Illek, B.N. Ames, and D.B. Peden Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats Toxicol Pathol 37 2009 481 491
27. J.G. Wagner, Q. Jiang, J.R. Harkema, B.N. Ames, B. Illek, and R.A. Roubey Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma Clin Exp Allergy 38 2008 501 511
28. A. Hamahata, P. Enkhbaatar, E.R. Kraft, M. Lange, S.W. Leonard, and M.G. Traber Gamma-tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury Free Radic Biol Med 45 2008 425 433
29. J.M. Cook-Mills, M.E. Marchese, and H. Abdala-Valencia Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants Antioxid Redox Signal 15 2011 1607 1638
30. J.M. Cook-Mills Eosinophil-endothelial cell interactions. Eosinophils in health and disease Lee JJaR, H.F. Eosinophils in health and disease 2012 Elsevier 139 153
31. H. Abdala-Valencia, S. Berdnikovs, and J.M. Cook-Mills Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCalpha in human microvascular endothelial cells PLoS One 7 2012 e41054
32. C.A. McCary, Y. Yoon, C. Panagabko, W. Cho, J. Atkinson, and J.M. Cook-Mills Vitamin E isoforms directly bind PKCalpha and differentially regulate activation of PKCalpha Biochem J 441 2012 189 198
33. H. Abdala-Valencia, S. Berdnikovs, and J.M. Cook-Mills Vitamin E isoforms as modulators of lung inflammation Nutrients 5 2013 4347 4363
34. N. Okamoto, T. Murata, H. Tamai, H. Tanaka, and H. Nagai Effects of alpha tocopherol and probucol supplements on allergen-induced airway inflammation and hyperresponsiveness in a mouse model of allergic asthma Int Arch Allergy Immunol 141 2006 172 180
35. U. Mabalirajan, J. Aich, G.D. Leishangthem, S.K. Sharma, A.K. Dinda, and B. Ghosh Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model J Appl Physiol 107 2009 1285 1292
36. J. Suchankova, M. Voprsalova, M. Kottova, V. Semecky, and P. Visnovsky Effects of oral alpha-tocopherol on lung response in rat model of allergic asthma Respirology 11 2006 414 421
37. C.W. Mahoney, and A. Azzi Vitamin E inhibits protein kinase C activity Biochem Biophys Res Commun 154 1988 694 697
38. Q. Jiang, S. Christen, M.K. Shigenaga, and B.N. Ames Gamma-tocopherol, the major form of vitamin E in the us diet, deserves more attention Am J Clin Nutr 74 2001 714 722
39. S.A. Talegawkar, E.J. Johnson, T. Carithers, H.A. Taylor Jr., M.L. Bogle, and K.L. Tucker Total alpha-tocopherol intakes are associated with serum alpha-tocopherol concentrations in African American adults J Nutr 137 2007 2297 2303
40. J.G. Bieri, and R.P. Evarts Tocopherols and fatty acids in American diets. The recommended allowance for vitamin E J Am Diet Assoc 62 1973 147 151
41. J.G. Bieri, and R.P. Evarts Vitamin E adequacy of vegetable oils J Am Diet Assoc 66 1975 134 139
42. M. Meydani, J.S. Cohn, J.B. Macauley, J.R. McNamara, J.B. Blumberg, and E.J. Schaefer Postprandial changes in the plasma concentration of alpha- and gamma-tocopherol in human subjects fed a fat-rich meal supplemented with fat-soluble vitamins J Nutr 119 1989 1252 1258
43. C. Sanchez-Moreno, S.E. Dorfman, A.H. Lichtenstein, and A. Martin Dietary fat type affects vitamins C and E and biomarkers of oxidative status in peripheral and brain tissues of golden Syrian hamsters J Nutr 134 2004 655 660
44. Y. Gobel, B. Koletzko, H.J. Bohles, I. Engelsberger, D. Forget, and A. Le Brun Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants J Pediatr Gastroenterol Nutr 37 2003 161 167
45. G. Devereux, and A. Seaton Diet as a risk factor for atopy and asthma J Allergy Clin Immunol 115 2005 1109 1117
46. H.S. Zahran, and C. Bailey Factors associated with asthma prevalence among racial and ethnic groups - united states, 2009-2010 behavioral risk factor surveillance system J Asthma 11 2013 11
47. R.R. Jacobs, B. Boehlecke, M. van Hage-Hamsten, and R. Rylander Bronchial reactivity, atopy, and airway response to cotton dust Am Rev Respir Dis 148 1993 19 24
48. R.J. Delfino, P.J. Quintana, J. Floro, V.M. Gastanaga, B.S. Samimi, and M.T. Kleinman Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter Environ Health Perspect 112 2004 932 941
49. H. Koskela, H. Tukiainen, A. Kononoff, and H. Pekkarinen Effect of whole-body exposure to cold and wind on lung function in asthmatic patients Chest 105 1994 1728 1731
50. P.D. Blanc, M.D. Eisner, P.P. Katz, I.H. Yen, C. Archea, and G. Earnest Impact of the home indoor environment on adult asthma and rhinitis J Occup Environ Med 47 2005 362 372
51. S.T. Weiss Diet as a risk factor for asthma CIBA Found Symp 206 1997 244 257
52. R.J. Troisi, W.C. Willett, S.T. Weiss, D. Trichopoulos, B. Rosner, and F.E. Speizer A prospective study of diet and adult-onset asthma Am J Respir Crit Care Med 151 1995 1401 1408
53. L. Dow, M. Tracey, A. Villar, D. Coggon, B.M. Margetts, and M.J. Campbell Does dietary intake of vitamins C and E influence lung function in older people? Am J Respir Crit Care Med 154 1996 1401 1404
54. H.A. Smit, L. Grievink, and C. Tabak Dietary influences on chronic obstructive lung disease and asthma: a review of the epidemiological evidence Proc Nutr Soc 58 1999 309 319
55. C. Tabak, H.A. Smit, L. Rasanen, F. Fidanza, A. Menotti, and A. Nissinen Dietary factors and pulmonary function: a cross sectional study in middle aged men from three European countries Thorax 54 1999 1021 1026
56. A. Hoskins, J.L. Roberts II, G. Milne, L. Choi, and R. Dworski Natural-source d-alpha-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo Allergy 67 2012 676 682
57. P.J. Pearson, S.A. Lewis, J. Britton, and A. Fogarty Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial Thorax 59 2004 652 656
58. S. Martindale, G. McNeill, G. Devereux, D. Campbell, G. Russell, and A. Seaton Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life Am J Respir Crit Care Med 171 2005 121 128
59. G. Devereux Early life events in asthma - diet Pediatr Pulmonol 42 2007 663 673
60. S. Allen, J.R. Britton, and J.A. Leonardi-Bee Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis Thorax 64 2009 610 619
61. O. Kalayci, T. Besler, K. Kilinc, B.E. Sekerel, and Y. Saraclar Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma Turk J Pediatr 42 2000 17 21
62. F.J. Kelly, I. Mudway, A. Blomberg, A. Frew, and T. Sandstrom Altered lung antioxidant status in patients with mild asthma Lancet 354 1999 482 483
63. H.J. Schunemann, B.J. Grant, J.L. Freudenheim, P. Muti, R.W. Browne, and J.A. Drake The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population Am J Respir Crit Care Med 163 2001 1246 1255
64. N.O. Al-Abdulla, L.M. Al Naama, and M.K. Hassan Antioxidant status in acute asthmatic attack in children J Pak Med Assoc 60 2010 1023 1027
65. H.F. Deluca Historical overview of vitamin D D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 3 12
66. M.F. Holick Vitamin D deficiency N Engl J Med 357 2007 266 281
67. M.F. Holick Photobiology of vitamin D D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 13 22
68. R. Bouillon The vitamin D binding protein DBP D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 13 22
69. Institute of Medicine I. Dietary reference intakes for calcium and vitamin D. Committee to review dietary reference intakes for calcium and vitamin D 2011
70. M.F. Holick, N.C. Binkley, H.A. Bischoff-Ferrari, C.M. Gordon, D.A. Hanley, and R.P. Heaney Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited J Clin Endocrinol Metab 97 2012 1153 1158
71. C.J. Rosen, S.A. Abrams, J.F. Aloia, P.M. Brannon, S.K. Clinton, and R.A. Durazo-Arvizu IOM committee members respond to endocrine society vitamin D guideline J Clin Endocrinol Metab 97 2012 1146 1152
72. G. Jones, and D.E. Prosser The activating enzymes of vitamin D metabolism (25- and 1a-hydroxylases) D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 23 42
73. D. Feldman, J.W. Pike, and J.S. Adams Vitamin D 2011 Academic Press London
74. R. Vieth The pharmacology of vitamin D D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 1041 1056
75. J.H. White Vitamin D, and innate immunity D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 1777 1787
76. P.T. Liu The role of vitamin D in innate immunity: antimicrobial activity, oxidative stress and barrier function D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 1777 1787
77. R.A. Brockman-Schneider, R.J. Pickles, and J.E. Gern Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication PLoS One 9 2014 e86755
78. A. Banerjee, G. Damera, R. Bhandare, S. Gu, Y. Lopez-Boado, and R. Panettieri Jr. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells Brit J Pharmacol 155 2008 84 92
79. G. Damera, H.W. Fogle, P. Lim, E.A. Goncharova, H. Zhao, and A. Banerjee Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1 Brit J Pharmacol 158 2009 1429 1441
80. P. Sambrook Glucocorticoids and vitamin D D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 1233 1244
81. L. Adorini Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes Ann N Y Acad Sci 987 2003 258 261
82. J.E. Vasiliou, S. Lui, S.A. Walker, V. Chohan, E. Xystrakis, and A. Bush Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease Allergy 2014 [Epub ahead of print]
83. L. Adorini Control of adaptive immunity by vitamin D receptor agonists D. Feldman, J.W. Pike, J.S. Adams, Vitamin D 2011 Academic Press London 1789 1809
84. C.R. Gale, S.M. Robinson, N.C. Harvey, M.K. Javaid, B. Jiang, and C.N. Martyn Princess Anne Hospital Study G. Maternal vitamin D status during pregnancy and child outcomes Eur J Clin Nutr 62 2008 68 77
85. E. Hypponen, U. Sovio, M. Wjst, S. Patel, J. Pekkanen, and A.L. Hartikainen Infant vitamin D supplementation and allergic conditions in adulthood: Northern Finland birth cohort 1966 Ann N Y Acad Sci 1037 2004 84 95
86. M. Wjst The vitamin D slant on allergy Pediatr Allergy Immunol 17 2006 477 483
87. M. Wjst, and S. Dold Genes, factor x, and allergens: what causes allergic diseases? Allergy 54 1999 757 759
88. O. Jirapongsananuruk, I. Melamed, and D.Y. Leung Additive immunosuppressive effects of 1,25-dihydroxyvitamin D3 and corticosteroids on Th1, but not Th2, responses J Allergy Clin Immunol 106 2000 981 985
89. J.M. Lemire, D.C. Archer, L. Beck, and H.L. Spiegelberg Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions J Nutr 125 1995 1704S 1708S
90. A.A. Ginde, M.C. Liu, and C.A. Camargo Jr. Demographic differences and trends of vitamin D insufficiency in the us population, 1988-2004 Arch Intern Med 169 2009 626 632
91. C.A. Camargo Jr., S.L. Rifas-Shiman, A.A. Litonjua, J.W. Rich-Edwards, S.T. Weiss, and D.R. Gold Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age Am J Clin Nutr 85 2007 788 795
92. G. Devereux, A.A. Litonjua, S.W. Turner, L.C. Craig, G. McNeill, and S. Martindale Maternal vitamin D intake during pregnancy and early childhood wheezing Am J Clin Nutr 85 2007 853 859
93. A.A. Litonjua, and S.T. Weiss Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 120 2007 1031 1035
94. A.A. Litonjua, N.E. Lange, V.J. Carey, S. Brown, N. Laranjo, and B.J. Harshfield The vitamin D antenatal asthma reduction trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children Contemp Clin Trials 38 2014 37 50
95. C. Norizoe, N. Akiyama, T. Segawa, H. Tachimoto, H. Mezawa, and H. Ida Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial Pediatr Int 56 2014 6 12
96. P.N. Black, and R. Scragg Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey Chest 128 2005 3792 3798
97. J.M. Brehm, J.C. Celedon, M.E. Soto-Quiros, L. Avila, G.M. Hunninghake, and E. Forno Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica Am J Respir Crit Care Med 179 2009 765 771
98. A.C. Wu, K. Tantisira, L. Li, A.L. Fuhlbrigge, S.T. Weiss, and A. Litonjua Effect of vitamin D and inhaled corticosteroid treatment on lung function in children Am J Respir Crit Care Med 186 2012 508 513
99. E.R. Sutherland, E. Goleva, L.P. Jackson, A.D. Stevens, and D.Y. Leung Vitamin D levels, lung function, and steroid response in adult asthma Am J Respir Crit Care Med 181 2010 699 704
100. E. Xystrakis, S. Kusumakar, S. Boswell, E. Peek, Z. Urry, and D.F. Richards Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients J Clin Investig 116 2006 146 155
101. G. Devereux, A. Wilson, A. Avenell, G. McNeill, and W.D. Fraser A case-control study of vitamin D status and asthma in adults Allergy 65 2010 666 667
102. X.M. Mai, A. Langhammer, C.A. Camargo Jr., and Y. Chen Serum 25-hydroxyvitamin D levels and incident asthma in adults: the HUNT study Am J Epidemiol 176 2012 1169 1176
103. E. Goleva, D.A. Searing, L.P. Jackson, B.N. Richers, and D.Y. Leung Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma J Allergy Clin Immunol 129 2012 1243 1251
104. M. Castro, T.S. King, S.J. Kunselman, M.D. Cabana, L. Denlinger, and F. Holguin Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial JAMA 311 2014 2083 2091
105. B. Muehleisen, and R.L. Gallo Vitamin D in allergic disease: shedding light on a complex problem J Allergy Clin Immunol 131 2013 324 329
106. G. Paul, J.M. Brehm, J.F. Alcorn, F. Holguin, S.J. Aujla, and J.C. Celedon Vitamin D and asthma Am J Respir Crit Care Med 185 2012 124 132
107. E.M. Hollams Vitamin D and atopy and asthma phenotypes in children Curr Opin Allergy Clin Immunol 12 2012 228 234
108. C.A. Camargo Jr., T. Ingham, K. Wickens, R. Thadhani, K.M. Silvers, and M.J. Epton Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma Pediatrics 127 2011 e180 e187
109. S.A. Quraishi, E.A. Bittner, K.B. Christopher, and C.A. Camargo Jr. Vitamin D status and community-acquired pneumonia: results from the third national health and nutrition examination survey PLoS One 8 2013 e81120
110. K. Amrein, S.A. Quraishi, A.A. Litonjua, F.K. Gibbons, T.R. Pieber, and C.A. Camargo Jr. Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study J Clin Endocrinol Metab 99 2014 1461 1469
111. E. Yusupov, M. Li-Ng, S. Pollack, J.K. Yeh, M. Mikhail, and J.F. Aloia Vitamin D and serum cytokines in a randomized clinical trial Int J Endocrinol 2010 2010
112. M. Urashima, T. Segawa, M. Okazaki, M. Kurihara, Y. Wada, and H. Ida Randomized trial of vitamin D supplementation to prevent seasonal influenza a in schoolchildren Am J Clin Nutr 91 2010 1255 1260
113. C.A. Camargo Jr., D. Ganmaa, A.L. Frazier, F.F. Kirchberg, J.J. Stuart, and K. Kleinman Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia Pediatrics 130 2012 e561 e567
114. D.R. Murdoch, S. Slow, S.T. Chambers, L.C. Jennings, A.W. Stewart, and P.C. Priest Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial JAMA 308 2012 1333 1339
115. R.R. Das, M. Singh, I. Panigrahi, and S.S. Naik Vitamin D supplementation for the treatment of acute childhood pneumonia: a systematic review ISRN pediatr 2013 2013 459160
116. P. Bergman, A.U. Lindh, L. Bjorkhem-Bergman, and J.D. Lindh Vitamin D and respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials PLoS One 8 2013 e65835
117. E.C. Goodall, A.C. Granados, K. Luinstra, E. Pullenayegum, B.L. Coleman, and M. Loeb Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial BMC Infect Dis 14 2014 273
118. S.P. Boyle, V.L. Dobson, S.J. Duthie, D.C. Hinselwood, J.A. Kyle, and A.R. Collins Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study Eur J Clin Nutr 54 2000 774 782
119. A.M. Johnstone, G.E. Lobley, G.W. Horgan, D.M. Bremner, C.L. Fyfe, and P.C. Morrice Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile Br J Nutr 106 2011 282 291
120. A.M. Hodge, J.A. Simpson, M. Fridman, K. Rowley, D.R. English, and G.G. Giles Evaluation of an FFQ for assessment of antioxidant intake using plasma biomarkers in an ethnically diverse population Public Health Nutr 12 2009 2438 2447
121. S. Samman, G. Sivarajah, J.C. Man, Z.I. Ahmad, P. Petocz, and I.D. Caterson A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men J Nutr 133 2003 2188 2193
122. O.P. Heinonen, and D. Albanes The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The alpha-tocopherol, beta carotene cancer prevention study group N Engl J Med 330 1994 1029 1035
123. B. Zieden, A. Kaminskas, M. Kristenson, Z. Kucinskiene, B. Vessby, and A.G. Olsson Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease Arterioscler Thromb Vasc Biol 19 1999 967 971
124. H. Gylling, M. Hallikainen, M.J. Nissinen, and T.A. Miettinen The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins Clin Nutr 29 2010 112 118
125. I.A. Valimaki, T. Vuorimaa, M. Ahotupa, R. Kekkonen, R. Korpela, and T. Vasankari Decreased training volume and increased carbohydrate intake increases oxidized LDL levels Int J Sports Med 33 2012 291 296
126. I.D. Safronov, A.N. Trunov, and E.D. Kokareva Prooxidant-antioxidant factors in the blood of pregnant women with late gestosis of different severity Bull Exp Biol Med 146 2008 800 802
127. M.A. Ross, L.K. Crosley, K.M. Brown, S.J. Duthie, A.C. Collins, and J.R. Arthur Plasma concentrations of carotenoids and antioxidant vitamins in Scottish males: influences of smoking Eur J Clin Nutr 49 1995 861 865
128. L.S. Wu, T. Sjakste, R. Sakalauskas, B. Sitkauskiene, N. Paramonova, and E. Gasiuniene The burden of allergic asthma in children: a landscape comparison based on data from Lithuanian, Latvian, and Taiwanese populations Pediatr Neonatol 53 2012 276 282
129. M. Masoli, D. Fabian, S. Holt, and R. Beasley The global burden of asthma: executive summary of the GINA Dissemination Committee Report Allergy 59 2004 469 478
130. T. To, S. Stanojevic, G. Moores, A.S. Gershon, E.D. Bateman, and A.A. Cruz Global asthma prevalence in adults: findings from the cross-sectional world health survey BMC Public Health 12 2012 204