-
1
-
-
79955689408
-
Breast cancer: A neglected disease for the majority of affected women worldwide
-
Ginsburg OM and Love RR: Breast cancer: a neglected disease for the majority of affected women worldwide. Breast J 17: 289-295, 2011.
-
(2011)
Breast J
, vol.17
, pp. 289-295
-
-
Ginsburg, O.M.1
Love, R.R.2
-
2
-
-
79952211366
-
Phenotypic heterogeneity of breast cancer stem cells
-
Lorico A and Rappa G: Phenotypic heterogeneity of breast cancer stem cells. J Oncol 2011: 135039, 2011.
-
(2011)
J Oncol
, vol.2011
, pp. 135039
-
-
Lorico, A.1
Rappa, G.2
-
3
-
-
84855990693
-
Mammary gland morphological and gene expression changes underlying pregnancy protection of breast cancer tumorigenesis
-
Misra Y, Bentley PA, Bond JP, Tighe S, Hunter T and Zhao FQ: Mammary gland morphological and gene expression changes underlying pregnancy protection of breast cancer tumorigenesis. Physiol Genomics 44: 76-88, 2012.
-
(2012)
Physiol Genomics
, vol.44
, pp. 76-88
-
-
Misra, Y.1
Bentley, P.A.2
Bond, J.P.3
Tighe, S.4
Hunter, T.5
Zhao, F.Q.6
-
4
-
-
7444265760
-
The changing global patterns of female breast cancer incidence and mortality
-
Bray F, McCarron P and Parkin DM: The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res 6: 229-239, 2004.
-
(2004)
Breast Cancer Res
, vol.6
, pp. 229-239
-
-
Bray, F.1
McCarron, P.2
Parkin, D.M.3
-
5
-
-
79959520764
-
Molecular stratification of triple-negative breast cancers
-
Perou CM: Molecular stratification of triple-negative breast cancers. Oncologist 16 (Suppl 1): S61-S70, 2011.
-
(2011)
Oncologist
, vol.16
, Issue.SUPPL. 1
-
-
Perou, C.M.1
-
6
-
-
77957591579
-
Targeting breast cancer stem cells
-
Liu S and Wicha MS: Targeting breast cancer stem cells. J Clin Oncol 28: 4006-4401, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4006-4401
-
-
Liu, S.1
Wicha, M.S.2
-
8
-
-
79952415961
-
Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein
-
Hartlerode A, Odate S, Shim I, Brown J and Scully R: Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PloS One 6: e16501, 2011.
-
(2011)
PloS One
, vol.6
-
-
Hartlerode, A.1
Odate, S.2
Shim, I.3
Brown, J.4
Scully, R.5
-
9
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antibiotic
-
Vezina C, Kudelski A and Sehgal SN: Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28: 721-726, 1975.
-
(1975)
I. Taxonomy of the Producing Streptomycete and Isolation of the Active Principle. J Antibiot (Tokyo)
, vol.28
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
10
-
-
36749081539
-
MTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK and Puigserver P: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450: 736-740, 2007
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
11
-
-
1542373685
-
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
-
Kelly DP and Scarpulla RC: Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18: 357-368, 2004.
-
(2004)
Genes Dev
, vol.18
, pp. 357-368
-
-
Kelly, D.P.1
Scarpulla, R.C.2
-
12
-
-
38449092832
-
Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators
-
Spiegelman BM: Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Found Symp 287: 60-69, 2007.
-
(2007)
Novartis Found Symp
, vol.287
, pp. 60-69
-
-
Spiegelman, B.M.1
-
13
-
-
33845674997
-
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle
-
Arany Z, Lebrasseur N, Morris C, et al: The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab 5: 35-46, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 35-46
-
-
Arany, Z.1
Lebrasseur, N.2
Morris, C.3
-
14
-
-
0037452677
-
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5
-
Czubryt MP, McAnally J, Fishman GI and Olson EN: Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci USA 100: 1711-1716, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1711-1716
-
-
Czubryt, M.P.1
McAnally, J.2
Fishman, G.I.3
Olson, E.N.4
-
15
-
-
77449117200
-
Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: Role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)
-
Attia RR, Connnaughton S, Boone LR, et al: Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha). J Biol Chem 285: 2375-2385, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 2375-2385
-
-
Attia, R.R.1
Connnaughton, S.2
Boone, L.R.3
-
16
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
Schieke SM, Phillips D, McCoy JP Jr, et al: The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 281: 27643-27652, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 27643-27652
-
-
Schieke, S.M.1
Phillips, D.2
McCoy Jr., J.P.3
-
17
-
-
76049099052
-
Direct control of mitochondrial function by mTOR
-
Ramanathan A and Schreiber SL: Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci USA 106: 22229-22232, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 22229-22232
-
-
Ramanathan, A.1
Schreiber, S.L.2
-
18
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, Puigserver P, Andersson U, et al: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124, 1999.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
-
19
-
-
0038036024
-
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1β) in muscle cells
-
St-Pierre J, Lin J, Krauss S, et al: Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1β) in muscle cells. J Biol Chem 278: 26597-26603, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 26597-26603
-
-
St-Pierre, J.1
Lin, J.2
Krauss, S.3
-
20
-
-
0344081177
-
Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status
-
Hardie DG: Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144: 5179-5183, 2003.
-
(2003)
Endocrinology
, vol.144
, pp. 5179-5183
-
-
Hardie, D.G.1
-
21
-
-
0037323971
-
AMP-activated protein kinase, super metabolic regulator
-
Kemp BE, Stapleton D, Campbell DJ, et al: AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans 31: 162-168, 2003.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 162-168
-
-
Kemp, B.E.1
Stapleton, D.2
Campbell, D.J.3
-
22
-
-
0037626492
-
Reduction of the individual cancer risk by physical exercise
-
Willer A: Reduction of the individual cancer risk by physical exercise. Onkologie 26: 283-289, 2003.
-
(2003)
Onkologie
, vol.26
, pp. 283-289
-
-
Willer, A.1
-
23
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, et al: AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30: 214-226, 2008.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
-
24
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, et al: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728, 2000.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
-
25
-
-
0033560109
-
AMP-activated protein kinase: An ultrasensitive system for monitoring cellular energy charge
-
Hardie DG, Salt IP, Hawley SA and Davies SP: AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem J 338: 717-722, 1999.
-
(1999)
Biochem J
, vol.338
, pp. 717-722
-
-
Hardie, D.G.1
Salt, I.P.2
Hawley, S.A.3
Davies, S.P.4
-
26
-
-
35348886043
-
Physiological functions of Atg6/Beclin 1: A unique autophagy-related protein
-
Cao Y and Klionsky DJ: Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res 17: 839-849, 2007.
-
(2007)
Cell Res
, vol.17
, pp. 839-849
-
-
Cao, Y.1
Klionsky, D.J.2
-
28
-
-
0038682372
-
Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo
-
Meirhaeghe A, Crowley V, Lenaghan C, et al: Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J 373: 155-165, 2003.
-
(2003)
Biochem J
, vol.373
, pp. 155-165
-
-
Meirhaeghe, A.1
Crowley, V.2
Lenaghan, C.3
-
29
-
-
0042232315
-
PGC-1βeta in the regulation of hepatic glucose and energy metabolism
-
Lin J, Tarr PT, Yang R, et al: PGC-1βeta in the regulation of hepatic glucose and energy metabolism. J Biol Chem 278: 30843-30848, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 30843-30848
-
-
Lin, J.1
Tarr, P.T.2
Yang, R.3
-
30
-
-
33644660537
-
PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
-
Finck BN and Kelly DP: PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 116: 615-622, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 615-622
-
-
Finck, B.N.1
Kelly, D.P.2
-
31
-
-
34249727164
-
Transcriptional coregulators in the control of energy homeostasis
-
Feige JN and Auwerx J: Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol 17: 292-301, 2007.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 292-301
-
-
Feige, J.N.1
Auwerx, J.2
-
32
-
-
0041662261
-
Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients
-
Peralba JM, DeGraffenried L, Friedrichs W, et al: Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clin Cancer Res 9: 2887-2892, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2887-2892
-
-
Peralba, J.M.1
Degraffenried, L.2
Friedrichs, W.3
-
33
-
-
9144233506
-
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
-
Boulay A, Zumstein-Mecker S, Stephan C, et al: Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 64: 252-261, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 252-261
-
-
Boulay, A.1
Zumstein-Mecker, S.2
Stephan, C.3
-
34
-
-
24744465206
-
The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling
-
Basso AD, Mirza A, Liu G, Long BJ, Bishop WR and Kirschmeier P: The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. J Biol Chem 280: 31101-31108, 2005.
-
(2005)
Role in FTI Enhancement of Taxane and Tamoxifen Anti-tumor Activity. J Biol Chem
, vol.280
, pp. 31101-31108
-
-
Basso, A.D.1
Mirza, A.2
Liu, G.3
Long, B.J.4
Bishop, W.R.5
Kirschmeier, P.6
-
35
-
-
69949126976
-
AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells
-
Harhaji-Trajkovic L, Vilimanovich U, Kravic-Stevovic T, Bumbasirevic V and Trajkovic V: AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. J Cell Mol Med 13: 3644-3654, 2009.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 3644-3654
-
-
Harhaji-Trajkovic, L.1
Vilimanovich, U.2
Kravic-Stevovic, T.3
Bumbasirevic, V.4
Trajkovic, V.5
-
36
-
-
62649146372
-
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
-
Herrero-Martin G, Høyer-Hansen M, Garcia-Garcia C, et al: TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 28: 677-685, 2009.
-
(2009)
EMBO J
, vol.28
, pp. 677-685
-
-
Herrero-Martin, G.1
Høyer-Hansen, M.2
Garcia-Garcia, C.3
|