A novel potential biocompatible hyperbranched polyspermine for efficient lung cancer gene therapy

International Journal of Pharmaceutics

Volumn 478, Issue 1, 2015, Pages 19-30

  Xie, Rong Lin ^a   Jang, Yoon Jeong ^b   Xing, Lei ^a   Zhang, Bing Feng ^a   Wang, Feng Zhen ^a   Cui, Peng Fei ^a   Cho, Myung Haing ^b,c   Jiang, Hu Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Aerosol delivery; Biocompatibility; Citric acid; Hyperbranched polyspermine; Lung cancer

Indexed keywords

DRUG CARRIER; GENE THERAPY AGENT; HYPERBRANCHED POLYSPERMINE; K RAS PROTEIN; PROTEIN KINASE B; SHORT HAIRPIN RNA; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; CITRIC ACID; DNA; GREEN FLUORESCENT PROTEIN; SMALL INTERFERING RNA; SPERMINE;

A549 CELL LINE; AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; BLOOD COMPATIBILITY; CANCER GENE THERAPY; CARCINOGENESIS; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE AGGREGATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MALE; MOUSE; MTS ASSAY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; ONE POT SYNTHESIS; POLYMERIZATION; PROTEIN EXPRESSION; TUMOR VOLUME; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ERYTHROCYTE; GENE TRANSFER; GENETICS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CITRIC ACID; DNA; ERYTHROCYTES; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HEMOLYSIS; HUMANS; LUNG NEOPLASMS; MALE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, SMALL INTERFERING; SPERMINE; TUMOR BURDEN;

EID: 84910619872     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.11.014     Document Type: Article

References (34)

1. O.M. Abdel-Salam, E.R. Youness, N.A. Mohammed, S.M. Morsy, E.A. Omara, and A.A. Sleem Citric acid effects on brain and liver oxidative stress in lipopolysaccharide-treated mice J. Med. Food 17 2014 588 598
2. J.C. Allen Biochemistry of the polyamines Cell Biochem. Funct. 1 1983 131 140
3. A.H. Bucay The biological significance of cancer: mitochondria as a cause of cancer and the inhibition of glycolysis with citrate as a cancer treatment Med. Hypotheses 69 2007 826 828
4. A.H. Bucay Hypothesis proved citric acid (citrate) does improve cancer: a case of a patient suffering from medullary thyroid cancer Med. Hypotheses 73 2009 271
5. A.H. Bucay Clinical report: a patient with primary peritoneal mesothelioma that has improved after taking citric acid orally Clin. Res. Hepatol. Gastroenterol. 35 2011 241
6. A.H. Bucay A comment to the article published in the APJCP by Choi and co-workers about the treatment of cancer with citric acid Asian Pac. J. Cancer Prev. 13 2012 6541
7. H.L. Cao, Y. Zheng, J.A. Zhou, W.X. Wang, and A. Pandit A novel hyperbranched polyester made from aconitic acid (B3) and di(ethylene glycol) (A2) Polym. Int. 60 2011 630 634
8. M.E. Davis, Z. Chen, and D.M. Shin Nanoparticle therapeutics: an emerging treatment modality for cancer Nat. Rev. Drug Discov. 7 2008 771 782
9. D.M. Domanski, B. Klajnert, and M. Bryszewska Influence of PAMAM dendrimers on human red blood cells Bioelectrochemistry 63 2004 189 191
10. C. Gao, and D.Y. Yan Synthesis of hyperbranched polymers from commercially available A(2) and BB′(2) type monomers Chem. Commun. 1 2001 107 108
11. K. Guk, H. Lim, B. Kim, M. Hong, G. Khang, and D. Lee Acid-cleavable ketal containing poly(beta-amino ester) for enhanced siRNA delivery Int. J. Pharm. 453 2013 541 550
12. K. Hagiwara, M. Nakata, Y. Koyama, and T. Sato The effects of coating pDNA/chitosan complexes with chondroitin sulfate on physicochemical characteristics and cell transfection Biomaterials 33 2012 7251 7260
13. H.L. Jiang, Y.K. Kim, R. Arote, J.W. Nah, M.H. Cho, Y.J. Choi, T. Akaike, and C.S. Cho Chitosan-graft-polyethylenimine as a gene carrier J. Control. Release 117 2007 273 280
14. H.L. Jiang, J.T. Kwon, E.M. Kim, Y.K. Kim, R. Arote, D. Jere, H.J. Jeong, M.K. Jang, J.W. Nah, C.X. Xu, I.K. Park, M.H. Cho, and C.S. Cho Galactosylated poly(ethylene glycol)-chitosan-graft-polyethylenimine as a gene carrier for hepatocyte-targeting J. Control. Release 131 2008 150 157
15. H.L. Jiang, S.H. Hong, Y.K. Kim, M.A. Islam, H.J. Kim, Y.J. Choi, J.W. Nah, K.H. Lee, K.W. Han, C. Chae, C.S. Cho, and M.H. Cho Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy Int. J. Pharm. 420 2011 256 265
16. H.L. Jiang, H.T. Lim, Y.K. Kim, R. Arote, J.Y. Shin, J.T. Kwon, J.E. Kim, J.H. Kim, D. Kim, C. Chae, J.W. Nah, Y.J. Choi, C.S. Cho, and M.H. Cho Chitosan-graft-spermine as a gene carrier in vitro and in vivo Eur. J. Pharm. Biopharm. 77 2011 36 42
17. M. Jikei, S.H. Chon, M. Kakimoto, S. Kawauchi, T. Imase, and J. Watanebe Synthesis of hyperbranched aromatic polyamide from aromatic diamines and trimesic acid Macromolecules 32 1999 2061 2064
18. T.H. Kim, H.L. Jiang, D. Jere, I.K. Park, M.H. Cho, J.W. Nah, Y.J. Choi, T. Akaike, and C.S. Cho Chemical modification of chitosan as a gene carrier in vitro and in vivo Prog. Polym. Sci. 32 2007 726 753
19. Y.K. Kim, C.S. Cho, M.H. Cho, and H.L. Jiang Spermine-alt-poly(ethylene glycol) polyspermine as a safe and efficient aerosol gene carrier for lung cancer therapy J. Biomed. Mater. Res. Part A 102 2013 2230 2237
20. B. Kruspig, A. Nilchian, S. Orrenius, B. Zhivotovsky, and V. Gogvadze Citrate kills tumor cells through activation of apical caspases Cell. Mol. Life Sci. 69 2012 4229 4237
21. X.H. Luo, F.W. Huang, S.Y. Qin, H.F. Wang, J. Feng, X.Z. Zhang, and R.X. Zhuo A strategy to improve serum-tolerant transfection activity of polycation vectors by surface hydroxylation Biomaterials 32 2011 9925 9939
22. M. Morille, C. Passirani, A. Vonarbourg, A. Clavreul, and J.P. Benoit Progress in developing cationic vectors for non-viral systemic gene therapy against cancer Biomaterials 29 2008 3477 3496
23. H. Namazi, S. Motamedi, and M. Namvari Synthesis of new functionalized citric acid-based dendrimers as nanocarrier agents for drug delivery BioImpacts 1 2011 63 69
24. W.C. Pitt, G.W. Witmer, S.M. Jojola, and H. Sin Potential citric acid exposure and toxicity to Hawaiian hoary bats (Lasiurus cinereus semotus) associated with Eleutherodactylus frog control Ecotoxicology 23 2014 429 436
25. J.S. Remy, B. Abdallah, M.A. Zanta, O. Boussif, J.P. Behr, and B. Demeneix Gene transfer with lipospermines and polyethylenimines Adv. Drug Deliv. Rev. 30 1998 85 95
26. M.D. Scott, K.L. Murad, F. Koumpouras, M. Talbot, and J.W. Eaton Chemical camouflage of antigenic determinants: stealth erythrocytes Proc. Natl. Acad. Sci. U. S. A. 94 1997 7566 7571
27. K. Slizewska The citric acid-modified, enzyme-resistant dextrin from potato starch as a potential prebiotic Acta Bochim. Pol. 60 2013 671 675
28. Y.X. Sun, B. Yang, S. Chen, Q. Lei, J. Feng, X.F. Qiu, N.G. Dong, R.X. Zhuo, and X.Z. Zhang Oligoamines grafted hyperbranched polyether as high efficient and serum-tolerant gene vectors Colloids Surf. B-Biointerfaces 111 2013 732 740
29. S.H. Welling, F. Hubalek, J. Jacobsen, D.J. Brayden, U.L. Rahbek, and S.T. Buckley The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition Eur. J. Pharm. Biopharm. 86 2013 544 551
30. J. Xu, Y.Q. Chen, H.J. Zhang, L. Tang, K. Wang, J.H. Zhang, X.S. Chen, and Z.G. Mao Production of citric acid using its extraction wastewater treated by anaerobic digestion and ion exchange in an integrated citric acid-methane fermentation process Bioprocess Biosyst. Eng. 37 2014 1659 1668
31. J. Yang, A.R. Webb, and G.A. Ameer Novel citric acid-based biodegradable elastomers for tissue engineering Adv. Mater. 16 2004 511 516
32. J.H. Yang, Y. Liu, H.B. Wang, L. Liu, W. Wang, C.D. Wang, Q. Wang, and W.G. Liu The biocompatibility of fatty acid modified dextran-agmatine bioconjugate gene delivery vector Biomaterials 33 2012 604 613
33. X.Q.T. Zhang, H. Hoshi, R. De Laporte, L. Qiu, H. Xu, X. Shea, and L.D. Ameer Sustained transgene expression via citric acid-based polyester elastomers Biomaterials 30 2009 2632 2641
34. B. Ziemba, G. Matuszko, M. Bryszewska, and B. Klajnert Influence of dendrimers on red blood cells Cell. Mol. Biol. Lett. 17 2012 21 35