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Volumn 15, Issue 18, 2014, Pages 2641-2652

Novel therapies for thyroid cancer

Author keywords

Cabozantinib; Differentiated thyroid cancer; Medullary thyroid cancer; Sorafenib; Tyrosine kinase inhibitors; Vandetanib

Indexed keywords

CABOZANTINIB; CALCITONIN; IMATINIB; LENVATINIB; LIOTHYRONINE; MOTESANIB; SORAFENIB; THALIDOMIDE; THYROXINE; VANDETANIB; VASCULOTROPIN INHIBITOR; ANILIDE; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; VASCULOTROPIN RECEPTOR;

EID: 84910619732     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2014.969240     Document Type: Review
Times cited : (12)

References (101)
  • 1
    • 78649946814 scopus 로고    scopus 로고
    • Analysis of the rising incidence of thyroid cancer using the surveillance, epidemiology and end results national cancer data registry
    • 1147-52.discussion
    • Cramer JD, Fu P, Harth KC, et al. Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry. Surgery 2010;148(6): 1147-52.discussion 1152-3
    • (2010) Surgery , vol.148 , Issue.6 , pp. 1152-1153
    • Cramer, J.D.1    Fu, P.2    Harth, K.C.3
  • 2
    • 84878638727 scopus 로고    scopus 로고
    • Worldwide increasing incidence of thyroid cancer: Update on epidemiology and risk factors
    • Pellegriti G, Frasca F, Regalbuto C, et al. Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013;2013: 965212
    • (2013) J Cancer Epidemiol , vol.2013 , pp. 965212
    • Pellegriti, G.1    Frasca, F.2    Regalbuto, C.3
  • 3
    • 33646442046 scopus 로고    scopus 로고
    • Increasing incidence of thyroid cancer in the united states, 1973-2002
    • Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 2006;295(18): 2164-7
    • (2006) JAMA , vol.295 , Issue.18 , pp. 2164-2167
    • Davies, L.1    Welch, H.G.2
  • 5
    • 34648834395 scopus 로고    scopus 로고
    • Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis
    • Sampson E, Brierley JD, Le LW, et al. Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis. Cancer 2007;110(7): 1451-6
    • (2007) Cancer , vol.110 , Issue.7 , pp. 1451-1456
    • Sampson, E.1    Brierley, J.D.2    Le, L.W.3
  • 6
    • 84865589843 scopus 로고    scopus 로고
    • The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland
    • Nixon IJ, Whitcher MM, Palmer FL, et al. The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid 2012;22(9): 884-9
    • (2012) Thyroid , vol.22 , Issue.9 , pp. 884-889
    • Nixon, I.J.1    Whitcher, M.M.2    Palmer, F.L.3
  • 7
    • 0027943619 scopus 로고
    • Long-Term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer
    • Available from Accessed 9 September 2013]
    • Mazzaferri EL, Jhiang SM. Long-Term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994.97(5): 418-28. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7977430 [Accessed 9 September 2013]
    • (1994) Am J Med , vol.97 , Issue.5 , pp. 418-428
    • Mazzaferri, E.L.1    Jhiang, S.M.2
  • 8
    • 33747642244 scopus 로고    scopus 로고
    • Long-Term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: Benefits and limits of radioiodine therapy
    • Durante C, Haddy N, Baudin E, et al. Long-Term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 2006;91(8): 2892-9
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.8 , pp. 2892-2899
    • Durante, C.1    Haddy, N.2    Baudin, E.3
  • 9
    • 78650005350 scopus 로고    scopus 로고
    • Diagnosis and treatment of thyroid cancer-polish guidelines
    • Available from [Accessed 9 September 2013]
    • Jarza?b B, Sporny S, Lange D, et al. [Diagnosis and treatment of thyroid cancer-polish guidelines]. Endokrynol Pol 61(5): 518-68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21049469 [Accessed 9 September 2013]
    • Endokrynol Pol , vol.61 , Issue.5 , pp. 518-568
    • Jarzab, B.1    Sporny, S.2    Lange, D.3
  • 10
    • 33745684505 scopus 로고    scopus 로고
    • European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
    • Pacini F, Schlumberger M, Dralle H, et al. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol 2006;154(6): 787-803
    • (2006) Eur J Endocrinol , vol.154 , Issue.6 , pp. 787-803
    • Pacini, F.1    Schlumberger, M.2    Dralle, H.3
  • 11
    • 70449370231 scopus 로고    scopus 로고
    • Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    • Cooper DS, Doherty GM, Haugen BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19(11): 1167-214
    • (2009) Thyroid , vol.19 , Issue.11 , pp. 1167-1214
    • Cooper, D.S.1    Doherty, G.M.2    Haugen, B.R.3
  • 12
    • 84055184770 scopus 로고    scopus 로고
    • Approach to the patient with advanced differentiated thyroid cancer
    • Schlumberger M, Sherman SI. Approach to the patient with advanced differentiated thyroid cancer. Eur J Endocrinol 2012;166(1): 5-11
    • (2012) Eur J Endocrinol , vol.166 , Issue.1 , pp. 5-11
    • Schlumberger, M.1    Sherman, S.I.2
  • 13
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Data Base report on 53 856 cases of thyroid carcinoma treated in the US 1985-1995 [see commetns
    • Available from [Accessed 9 September 2013]
    • Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53, 856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]. Cancer 1998.83(12): 2638-48. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9874472 [Accessed 9 September 2013]
    • (1998) Cancer , vol.83 , Issue.12 , pp. 2638-2648
    • Hundahl, S.A.1    Fleming, I.D.2    Fremgen, A.M.3    Menck, H.R.4
  • 14
    • 84899477812 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: A retrospective study of the tuthyref network
    • Massicotte M-H, Brassard M, Claude-Desroches M, et al. Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: a retrospective study of the TUTHYREF network. Eur J Endocrinol 2014;170(4): 575-82
    • (2014) Eur J Endocrinol , vol.170 , Issue.4 , pp. 575-582
    • Massicotte, M.-H.1    Brassard, M.2    Claude-Desroches, M.3
  • 15
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma: Demographic, clinical, and pathologic predictors of survival in 1252 cases
    • Roman S, Lin R, Sosa JA. Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer 2006;107(9): 2134-42
    • (2006) Cancer , vol.107 , Issue.9 , pp. 2134-2142
    • Roman, S.1    Lin, R.2    Sosa, J.A.3
  • 16
    • 84910649951 scopus 로고    scopus 로고
    • Nccn clinical practice guidelines in oncologyn (nccn guielines); Thyroid carcinoma nccn guidel version 2
    • Available from
    • Tuttle R, Ball D, Byrd D, Al E. NCCN Clinical practice guidelines in oncologyn (NCCN Guielines); thyroid carcinoma. NCCN Guidel Version 2. Oncologist 2010;15: 212-3. Available from: www.The Oncologist.com
    • (2010) Oncologist , vol.15 , pp. 212-212
    • Tuttle, R.1    Ball, D.2    Byrd, D.3
  • 17
    • 84872304581 scopus 로고    scopus 로고
    • 2012 European thyroid association guidelines for metastatic medullary thyroid cancer
    • Schlumberger M, Bastholt L, Dralle H, et al. 2012 European thyroid association guidelines for metastatic medullary thyroid cancer. Eur Thyroid J 2012;1(1): 5-14
    • (2012) Eur Thyroid J , vol.1 , Issue.1 , pp. 5-14
    • Schlumberger, M.1    Bastholt, L.2    Dralle, H.3
  • 18
    • 67749130797 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Management guidelines of the american thyroid association
    • Kloos RT, Eng C, Evans DB, et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 2009;19(6): 565-612
    • (2009) Thyroid , vol.19 , Issue.6 , pp. 565-612
    • Kloos, R.T.1    Eng, C.2    Evans, D.B.3
  • 19
    • 79960179069 scopus 로고    scopus 로고
    • Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population
    • Ahmed M, Barbachano Y, Riddell A, et al. Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population. Eur J Endocrinol 2011;165(2): 315-22
    • (2011) Eur J Endocrinol , vol.165 , Issue.2 , pp. 315-322
    • Ahmed, M.1    Barbachano, Y.2    Riddell, A.3
  • 20
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in advanced thyroid cancer
    • Gupta-Abramson V, Troxel AB, Nellore A, et al. Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol 2008;26(29): 4714-19
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4714-4719
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 21
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • Lam ET, Ringel MD, Kloos RT, et al. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol 2010;28(14): 2323-30
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 22
    • 63849265332 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in metastatic thyroid cancer
    • Kloos RT, Ringel MD, Knopp M V, et al. Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol 2009;27(10): 1675-84
    • (2009) J Clin Oncol , vol.27 , Issue.10 , pp. 1675-1684
    • Kloos, R.T.1    Ringel, M.D.2    Knopp, M.V.3
  • 23
    • 46449117698 scopus 로고    scopus 로고
    • Motesanib diphosphate in progressive differentiated thyroid cancer
    • Sherman SI, Wirth LJ, Droz J-P, et al. Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 2008;359(1): 31-42
    • (2008) N Engl J Med , vol.359 , Issue.1 , pp. 31-42
    • Sherman, S.I.1    Wirth, L.J.2    Droz, J.-P.3
  • 24
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • Schlumberger MJ, Elisei R, Bastholt L, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009;27(23): 3794-801
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3
  • 25
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EEW, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol 2008;26(29): 4708-13
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4708-4713
    • Cohen, E.E.W.1    Rosen, L.S.2    Vokes, E.E.3
  • 26
    • 77957359933 scopus 로고    scopus 로고
    • Efficacy of pazopanib in progressive radioiodine-refractory metastatic differentiated thyroid cancers: Results of a phase 2 consortium study
    • Bible KC, Suman VJ, Molina JR, et al. Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol 2010;11(10): 962-72
    • (2010) Lancet Oncol , vol.11 , Issue.10 , pp. 962-972
    • Bible, K.C.1    Suman, V.J.2    Molina, J.R.3
  • 27
    • 84899948210 scopus 로고    scopus 로고
    • A multicenter phase 2 trial of pazopanib in metastatic and progressive medullary thyroid carcinoma: MC057H
    • Bible KC, Suman VJ, Molina JR, et al. A multicenter phase 2 trial of pazopanib in metastatic and progressive medullary thyroid carcinoma: MC057H. J Clin Endocrinol Metab 2014;99(5): 1687-93
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.5 , pp. 1687-1693
    • Bible, K.C.1    Suman, V.J.2    Molina, J.R.3
  • 28
    • 77649112149 scopus 로고    scopus 로고
    • Efficacy of sunitinib in advanced medullary thyroid carcinoma: Intermediate results of phase ii thysu
    • author reply 214
    • Ravaud A, de la Fouchardieggggre C, Asselineau J, et al. Efficacy of sunitinib in advanced medullary thyroid carcinoma: intermediate results of phase II THYSU. Oncologist 2010;15(2): 212-13.author reply 214
    • (2010) Oncologist , vol.15 , Issue.2 , pp. 212-213
    • Ravaud, A.1    De La Fouchardieggggre, C.2    Asselineau, J.3
  • 29
    • 78049462514 scopus 로고    scopus 로고
    • Phase ii study of daily sunitinib in fdg-pet-positive iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
    • Carr LL, Mankoff DA, Goulart BH, et al. Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res 2010;16(21): 5260-8
    • (2010) Clin Cancer Res , vol.16 , Issue.21 , pp. 5260-5268
    • Carr, L.L.1    Mankoff, D.A.2    Goulart, B.H.3
  • 30
    • 84865552505 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomised double-blind phase 2 trial
    • Leboulleux S, Bastholt L, Krause T, et al. Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. Lancet Oncol 2012;13(9): 897-905
    • (2012) Lancet Oncol , vol.13 , Issue.9 , pp. 897-905
    • Leboulleux, S.1    Bastholt, L.2    Krause, T.3
  • 31
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • Wells SA, Robinson BG, Gagel RF, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol 2012;30(2): 134-41
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 134-141
    • Wells, S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 32
    • 84890571003 scopus 로고    scopus 로고
    • Cabozantinib in progressive medullary thyroid cancer
    • Elisei R, Schlumberger MJ, Muddddller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol 2013;31(29): 3639-46
    • (2013) J Clin Oncol , vol.31 , Issue.29 , pp. 3639-3646
    • Elisei, R.1    Schlumberger, M.J.2    Muddddller, S.P.3
  • 33
    • 84904855170 scopus 로고    scopus 로고
    • Sorafenib in radioactive iodine-refractory locally advanced or metastatic differentiated thyroid cancer: A randomised double-blind phase 3 trial
    • Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet 2014;384(9940): 319-28
    • (2014) Lancet , vol.384 , Issue.9940 , pp. 319-328
    • Brose, M.S.1    Nutting, C.M.2    Jarzab, B.3
  • 34
    • 84910633715 scopus 로고    scopus 로고
    • A phase 3, multicenter, double blind, placebo-controlled trial of lenvatinib (e7080) in patients 131irefractory differentiated thyroid cancer (select
    • Suppl
    • Schlumberger M, Tahara M, Wirth L, et al. A phase 3, multicenter, double blind, placebo-controlled trial of lenvatinib (E7080) in patients 131Irefractory differentiated thyroid cancer (SELECT). J Clin Oncol 2014;32(Suppl): LBA6008
    • (2014) J Clin Oncol , vol.32 , pp. LBA6008
    • Schlumberger, M.1    Tahara, M.2    Wirth, L.3
  • 35
    • 0032894774 scopus 로고    scopus 로고
    • RET proto-oncogene in the development of human cancer
    • Available from [Accessed 17 July 2014]
    • Eng C. RET proto-oncogene in the development of human cancer. J Clin Oncol 1999.17(1): 380-93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10458257 [Accessed 17 July 2014]
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 380-393
    • Eng, C.1
  • 36
    • 84894574242 scopus 로고    scopus 로고
    • RET revisited: Expanding the oncogenic portfolio
    • Mulligan LM. RET revisited: expanding the oncogenic portfolio. Nat Rev Cancer 2014;14(3): 173-86
    • (2014) Nat Rev Cancer , vol.14 , Issue.3 , pp. 173-186
    • Mulligan, L.M.1
  • 37
    • 0028898296 scopus 로고
    • Mutation of the ret protooncogene in sporadic medullary thyroid carcinoma
    • Eng C, Mulligan LM, Smith DP, et al. Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma. Genes Chromosomes Cancer 1995;12(3): 209-12
    • (1995) Genes Chromosomes Cancer , vol.12 , Issue.3 , pp. 209-212
    • Eng, C.1    Mulligan, L.M.2    Smith, D.P.3
  • 38
    • 40849094269 scopus 로고    scopus 로고
    • Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: A 10-year follow-up study
    • Elisei R, Cosci B, Romei C, et al. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. J Clin Endocrinol Metab 2008;93(3): 682-7
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.3 , pp. 682-687
    • Elisei, R.1    Cosci, B.2    Romei, C.3
  • 39
    • 67349168712 scopus 로고    scopus 로고
    • Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas
    • Moura MM, Cavaco BM, Pinto AE, et al. Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas. Br J Cancer 2009;100(11): 1777-83
    • (2009) Br J Cancer , vol.100 , Issue.11 , pp. 1777-1783
    • Moura, M.M.1    Cavaco, B.M.2    Pinto, A.E.3
  • 40
    • 39649096941 scopus 로고    scopus 로고
    • Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas
    • Dvorakova S, Vaclavikova E, Sykorova V, et al. Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas. Mol Cell Endocrinol 2008;284(1-2): 21-7
    • (2008) Mol Cell Endocrinol , vol.284 , Issue.1-2 , pp. 21-27
    • Dvorakova, S.1    Vaclavikova, E.2    Sykorova, V.3
  • 41
    • 84874824354 scopus 로고    scopus 로고
    • Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma
    • Giunti S, Antonelli A, Amorosi A, Santarpia L. Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma. Int J Endocrinol 2013;2013: 803171
    • (2013) Int J Endocrinol , vol.2013 , pp. 803171
    • Giunti, S.1    Antonelli, A.2    Amorosi, A.3    Santarpia, L.4
  • 42
    • 0038664387 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma
    • Available from [Accessed 13 July 2014]
    • Cohen Y, Xing M, Mambo E, et al. BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 2003.95(8): 625-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12697856 [Accessed 13 July 2014]
    • (2003) J Natl Cancer Inst , vol.95 , Issue.8 , pp. 625-627
    • Cohen, Y.1    Xing, M.2    Mambo, E.3
  • 43
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of braf mutations in thyroid cancer: Genetic evidence for constitutive activation of the ret/ptc-ras-braf signaling pathway in papillary thyroid carcinoma
    • Available from [Accessed 13 July 2014]
    • Kimura ET, Nikiforova MN, Zhu Z, et al. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003.63(7): 1454-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12670889 [Accessed 13 July 2014]
    • (2003) Cancer Res , vol.63 , Issue.7 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3
  • 44
    • 33645069923 scopus 로고    scopus 로고
    • BRAF is a therapeutic target in aggressive thyroid carcinoma
    • Salvatore G, De Falco V, Salerno P, et al. BRAF is a therapeutic target in aggressive thyroid carcinoma. Clin Cancer Res 2006;12(5): 1623-9
    • (2006) Clin Cancer Res , vol.12 , Issue.5 , pp. 1623-1629
    • Salvatore, G.1    De Falco, V.2    Salerno, P.3
  • 45
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer 2005;12(2): 245-62
    • (2005) Endocr Relat Cancer , vol.12 , Issue.2 , pp. 245-262
    • Xing, M.1
  • 46
    • 82055208201 scopus 로고    scopus 로고
    • New targeted therapies for thyroid cancer
    • Antonelli A, Fallahi P, Ferrari SM, et al. New targeted therapies for thyroid cancer. Curr Genomics 2011;12(8): 626-31
    • (2011) Curr Genomics , vol.12 , Issue.8 , pp. 626-631
    • Antonelli, A.1    Fallahi, P.2    Ferrari, S.M.3
  • 47
    • 33847072340 scopus 로고    scopus 로고
    • RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis
    • Ciampi R, Nikiforov YE. RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis. Endocrinology 2007;148(3): 936-41
    • (2007) Endocrinology , vol.148 , Issue.3 , pp. 936-941
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 49
    • 77951673111 scopus 로고    scopus 로고
    • Thyroid cancer: Current molecular perspectives
    • Giusti F, Falchetti A, Franceschelli F, et al. Thyroid cancer: current molecular perspectives. J Oncol 2010;2010: 351679
    • (2010) J Oncol , vol.2010 , pp. 351679
    • Giusti, F.1    Falchetti, A.2    Franceschelli, F.3
  • 50
    • 84875361065 scopus 로고    scopus 로고
    • Molecular pathogenesis and mechanisms of thyroid cancer
    • Xing M. Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer 2013;13(3): 184-99
    • (2013) Nat Rev Cancer , vol.13 , Issue.3 , pp. 184-199
    • Xing, M.1
  • 51
    • 9844249675 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid
    • Soh EY, Duh QY, Sobhi SA, et al. Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid. J Clin Endocrinol Metab 1997;82(11): 3741-7
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.11 , pp. 3741-3747
    • Soh, E.Y.1    Duh, Q.Y.2    Sobhi, S.A.3
  • 52
    • 33751095944 scopus 로고    scopus 로고
    • Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: Relationship to type and tumour behaviour
    • De la Torre NG, Buley I, Wass JA, Turner HE. Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour. Endocr Relat Cancer 2006;13(3): 931-44
    • (2006) Endocr Relat Cancer , vol.13 , Issue.3 , pp. 931-944
    • De La Torre, N.G.1    Buley, I.2    Wass, J.A.3    Turner, H.E.4
  • 53
    • 0035090293 scopus 로고    scopus 로고
    • Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma
    • Klein M, Vignaud JM, Hennequin V, et al. Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma. J Clin Endocrinol Metab 2001;86(2): 656-8
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.2 , pp. 656-658
    • Klein, M.1    Vignaud, J.M.2    Hennequin, V.3
  • 54
    • 0032778530 scopus 로고    scopus 로고
    • Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features
    • Bunone G, Vigneri P, Mariani L, et al. Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am J Pathol 1999;155(6): 1967-76
    • (1999) Am J Pathol , vol.155 , Issue.6 , pp. 1967-1976
    • Bunone, G.1    Vigneri, P.2    Mariani, L.3
  • 55
    • 71749093075 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and the thyroid
    • Sherman SI. Tyrosine kinase inhibitors and the thyroid. Best Pract Res Clin Endocrinol Metab 2009;23(6): 713-22
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , Issue.6 , pp. 713-722
    • Sherman, S.I.1
  • 56
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Available from [Accessed 9 July 2014]
    • Carlomagno F, Vitagliano D, Guida T, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002.62(24): 7284-90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12499271 [Accessed 9 July 2014]
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 57
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Available from [Accessed 9 July 2014]
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002.62(16): 4645-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12183421 [Accessed 9 July 2014]
    • (2002) Cancer Res , vol.62 , Issue.16 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 58
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA, Gosnell JE, Gagel RF, et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 2010;28(5): 767-72
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 767-772
    • Wells, S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 59
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A, et al. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2010;95(6): 2664-71
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3
  • 60
    • 84881256059 scopus 로고    scopus 로고
    • Vandetanib in children and adolescents with multiple endocrine neoplasia type 2B associated medullary thyroid carcinoma
    • Fox E, Widemann BC, Chuk MK, et al. Vandetanib in children and adolescents with multiple endocrine neoplasia type 2B associated medullary thyroid carcinoma. Clin Cancer Res 2013;19(15): 4239-48
    • (2013) Clin Cancer Res , vol.19 , Issue.15 , pp. 4239-4248
    • Fox, E.1    Widemann, B.C.2    Chuk, M.K.3
  • 61
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (xl184) a novel met and vegfr2 inhibitor simultaneously suppresses metastasis angiogenesis and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther 2011;10(12): 2298-308
    • (2011) Mol Cancer Ther , vol.10 , Issue.12 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 62
    • 84885638118 scopus 로고    scopus 로고
    • In vitro and in vivo activity of cabozantinib (xl184), an inhibitor of ret, met, and vegfr2, in a model of medullary thyroid cancer
    • Bentzien F, Zuzow M, Heald N, et al. In vitro and in vivo activity of cabozantinib (XL184), an inhibitor of RET, MET, and VEGFR2, in a model of medullary thyroid cancer. Thyroid 2013;23(12): 1569-77
    • (2013) Thyroid , vol.23 , Issue.12 , pp. 1569-1577
    • Bentzien, F.1    Zuzow, M.2    Heald, N.3
  • 63
    • 77749240452 scopus 로고    scopus 로고
    • 184 a met vegfr-2 and ret kinase inhibitor for the treatment of thyroid cancer glioblastoma multiforme and nsclc
    • Available from [Accessed 12 July 2014]
    • Zhang Y, Guessous F, Kofman A, et al.-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. IDrugs 2010.13(2): 112-21. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3268517&tool=pmcentrez&rendertype=abstract [Accessed 12 July 2014]
    • (2010) IDrugs , vol.13 , Issue.2 , pp. 112-121
    • Zhang, Y.1    Guessous, F.2    Kofman, A.3
  • 64
    • 79959936054 scopus 로고    scopus 로고
    • Activity of xl184 (cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
    • Kurzrock R, Sherman SI, Ball DW, et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol 2011;29(19): 2660-6
    • (2011) J Clin Oncol , vol.29 , Issue.19 , pp. 2660-2666
    • Kurzrock, R.1    Sherman, S.I.2    Ball, D.W.3
  • 65
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64(19): 7099-109
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 66
    • 33644747449 scopus 로고    scopus 로고
    • BAY 43-9006 inhibition of oncogenic RET mutants
    • Carlomagno F, Anaganti S, Guida T, et al. BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst 2006;98(5): 326-34
    • (2006) J Natl Cancer Inst , vol.98 , Issue.5 , pp. 326-334
    • Carlomagno, F.1    Anaganti, S.2    Guida, T.3
  • 67
    • 72949106263 scopus 로고    scopus 로고
    • Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
    • Hoftijzer H, Heemstra KA, Morreau H, et al. Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2009;161(6): 923-31
    • (2009) Eur J Endocrinol , vol.161 , Issue.6 , pp. 923-931
    • Hoftijzer, H.1    Heemstra, K.A.2    Morreau, H.3
  • 69
    • 78650030826 scopus 로고    scopus 로고
    • Treatment with sorafenib in advanced thyroid cancer-A case report
    • Available from [Accessed 13 July 2014]
    • Krajewska J, Olczyk T, Roskosz J, et al. Treatment with sorafenib in advanced thyroid cancer-A case report. Endokrynol Pol 61.5): 492-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21049464 [Accessed 13 July 2014]
    • Endokrynol Pol , vol.61 , Issue.5 , pp. 492-496
    • Krajewska, J.1    Olczyk, T.2    Roskosz, J.3
  • 70
    • 84864668516 scopus 로고    scopus 로고
    • Brain metastasis from follicular thyroid carcinoma: Treatment with sorafenib
    • Shen Y, Ruan M, Luo Q, et al. Brain metastasis from follicular thyroid carcinoma: treatment with sorafenib. Thyroid 2012;22(8): 856-60
    • (2012) Thyroid , vol.22 , Issue.8 , pp. 856-860
    • Shen, Y.1    Ruan, M.2    Luo, Q.3
  • 71
    • 66749114268 scopus 로고    scopus 로고
    • The successful use of sorafenib to treat pediatric papillary thyroid carcinoma
    • Waguespack SG, Sherman SI, Williams MD, et al. The successful use of sorafenib to treat pediatric papillary thyroid carcinoma. Thyroid 2009;19(4): 407-12
    • (2009) Thyroid , vol.19 , Issue.4 , pp. 407-412
    • Waguespack, S.G.1    Sherman, S.I.2    Williams, M.D.3
  • 72
    • 84892169229 scopus 로고    scopus 로고
    • Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation
    • Iyer P, Mayer JL, Ewig JM. Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation. Thyroid 2014;24(1): 169-74
    • (2014) Thyroid , vol.24 , Issue.1 , pp. 169-174
    • Iyer, P.1    Mayer, J.L.2    Ewig, J.M.3
  • 73
    • 53049085556 scopus 로고    scopus 로고
    • Multi-kinase inhibitor e7080 suppresses lymph node and lung metastases of human mammary breast tumor mda-mb-231 via inhibition of vascular endothelial growth factor-receptor (vegf-r) 2 and vegf-r3 kinase
    • Matsui J, Funahashi Y, Uenaka T, et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res 2008;14(17): 5459-65
    • (2008) Clin Cancer Res , vol.14 , Issue.17 , pp. 5459-5465
    • Matsui, J.1    Funahashi, Y.2    Uenaka, T.3
  • 74
    • 79960554999 scopus 로고    scopus 로고
    • E7080, a multi-Targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion
    • Glen H, Mason S, Patel H, et al. E7080, a multi-Targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion. BMC Cancer 2011;11: 309
    • (2011) BMC Cancer , vol.11 , pp. 309
    • Glen, H.1    Mason, S.2    Patel, H.3
  • 75
    • 84883811272 scopus 로고    scopus 로고
    • Antitumor activities of the targeted multi-Tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models
    • Okamoto K, Kodama K, Takase K, et al. Antitumor activities of the targeted multi-Tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models. Cancer Lett 2013;340(1): 97-103
    • (2013) Cancer Lett , vol.340 , Issue.1 , pp. 97-103
    • Okamoto, K.1    Kodama, K.2    Takase, K.3
  • 76
    • 84902334839 scopus 로고    scopus 로고
    • Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib
    • Dadu R, Devine C, Hernandez M, et al. Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib. J Clin Endocrinol Metab 2014;99(6): 2086-94
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.6 , pp. 2086-2094
    • Dadu, R.1    Devine, C.2    Hernandez, M.3
  • 77
    • 84857158314 scopus 로고    scopus 로고
    • Incidence and risk of QTc interval prolongation among cancer patients treated with vandetanib: A systematic review and meta-Analysis
    • Zang J, Wu S, Tang L, et al. Incidence and risk of QTc interval prolongation among cancer patients treated with vandetanib: a systematic review and meta-Analysis. PLoS One 2012;7(2): e30353
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e30353
    • Zang, J.1    Wu, S.2    Tang, L.3
  • 78
    • 84872491531 scopus 로고    scopus 로고
    • Vandetanib: too dangerous in medullary thyroid cancer. Available from [Accessed 14 July 2014]
    • Vandetanib: too dangerous in medullary thyroid cancer. Prescrire Int 2012.21(131): 233. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23185843 [Accessed 14 July 2014]
    • (2012) Prescrire Int , vol.21 , Issue.131 , pp. 233
  • 79
    • 79953249278 scopus 로고    scopus 로고
    • Response to sorafenib at a low dose in patients with radioiodine-refractory pulmonary metastases from papillary thyroid carcinoma
    • Chen L, Shen Y, Luo Q, et al. Response to sorafenib at a low dose in patients with radioiodine-refractory pulmonary metastases from papillary thyroid carcinoma. Thyroid 2011;21(2): 119-24
    • (2011) Thyroid , vol.21 , Issue.2 , pp. 119-124
    • Chen, L.1    Shen, Y.2    Luo, Q.3
  • 80
    • 84899080821 scopus 로고    scopus 로고
    • Sorafenib in the treatment of radioiodine-refractory differentiated thyroid cancer: A meta-Analysis
    • Shen C-T, Qiu Z-L, Luo Q-Y. Sorafenib in the treatment of radioiodine-refractory differentiated thyroid cancer: a meta-Analysis. Endocr Relat Cancer 2014;21(2): 253-61
    • (2014) Endocr Relat Cancer , vol.21 , Issue.2 , pp. 253-261
    • Shen, C.-T.1    Qiu, Z.-L.2    Luo, Q.-Y.3
  • 81
    • 84902591108 scopus 로고    scopus 로고
    • Sorafenib Induced hand foot skin rash in FLT3 ITD mutated acute myeloid leukemia-A case report and review of literature
    • Senapati J, Devasia AJ, Ganapule A, et al. Sorafenib Induced hand foot skin rash in FLT3 ITD mutated acute myeloid leukemia-A case report and review of literature. Mediterr J Hematol Infect Dis 2014;6(1): e2014016
    • (2014) Mediterr J Hematol Infect Dis , vol.6 , Issue.1 , pp. e2014016
    • Senapati, J.1    Devasia, A.J.2    Ganapule, A.3
  • 82
    • 80053160399 scopus 로고    scopus 로고
    • A phase ii trial of the multitargeted kinase inhibitor e7080 in advanced radioiodine (rai)-refractory differentiated thyroid cancer (dtc
    • Suppl
    • Sherman S, Jarzab B, Cabanillas M, et al. A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). J Clin Oncol 2011;29(Suppl): 5503
    • (2011) J Clin Oncol , vol.29 , pp. 5503
    • Sherman, S.1    Jarzab, B.2    Cabanillas, M.3
  • 83
    • 84866761175 scopus 로고    scopus 로고
    • A phase ii trial of multitargeted kinase inhibitor lenvatinib (e7080) in advanced medullary thyroid cancer (mtc
    • Suppl
    • Schlumberger M, Jarzab B, Cabanillas M, et al. A phase II trial of multitargeted kinase inhibitor lenvatinib (E7080) in advanced medullary thyroid cancer (MTC). J Clin Oncol 2012;30(Suppl): 5591
    • (2012) J Clin Oncol , vol.30 , pp. 5591
    • Schlumberger, M.1    Jarzab, B.2    Cabanillas, M.3
  • 84
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer 2007;96(12): 1788-95
    • (2007) Br J Cancer , vol.96 , Issue.12 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 85
    • 84912119952 scopus 로고    scopus 로고
    • Lenvatinib for the treatment of follicular and papillary thyroid cancer
    • Krajewska J, Jarzab B. Lenvatinib for the treatment of follicular and papillary thyroid cancer. Expert Opin Orphan Drugs 2014; doi: 10.1517/21678707.2014.962514
    • (2014) Expert Opin Orphan Drugs
    • Krajewska, J.1    Jarzab, B.2
  • 86
    • 84897970656 scopus 로고    scopus 로고
    • Risks of proteinuria associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: A systematic review and meta-Analysis
    • Zhang Z-F, Wang T, Liu L-H, Guo H-Q. Risks of proteinuria associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: a systematic review and meta-Analysis. PLoS One 2014;9(3): e90135
    • (2014) PLoS One , vol.9 , Issue.3 , pp. e90135
    • Zhang, Z.-F.1    Wang, T.2    Liu, L.-H.3    Guo, H.-Q.4
  • 87
    • 84893805528 scopus 로고    scopus 로고
    • Risk of gastrointestinal perforation in cancer patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: A systematic review and meta-Analysis
    • Qi W-X, Sun Y-J, Tang L-N, et al. Risk of gastrointestinal perforation in cancer patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-Analysis. Crit Rev Oncol Hematol 2014;89(3): 394-403
    • (2014) Crit Rev Oncol Hematol , vol.89 , Issue.3 , pp. 394-403
    • Qi, W.-X.1    Sun, Y.-J.2    Tang, L.-N.3
  • 88
    • 84964316190 scopus 로고    scopus 로고
    • Congestive heart failure risk in cancer patients treated with vegfr-Tkis: A systematic review and meta-Analysis of 36 clinical trials
    • Qi W, Shen Z, Tang L, Yao Y. Congestive heart failure risk in cancer patients treated with VEGFR-TKIs: a systematic review and meta-Analysis of 36 clinical trials. Br J Clin Pharmacol 2014;78(4): 748-62
    • (2014) Br J Clin Pharmacol , vol.78 , Issue.4 , pp. 748-762
    • Qi, W.1    Shen, Z.2    Tang, L.3    Yao, Y.4
  • 89
    • 84876142760 scopus 로고    scopus 로고
    • Risk of venous thromboembolic events associated with vegfr-Tkis: A systematic review and meta-Analysis
    • Qi W-X, Min D-L, Shen Z, et al. Risk of venous thromboembolic events associated with VEGFR-TKIs: a systematic review and meta-Analysis. Int J Cancer 2013;132(12): 2967-74
    • (2013) Int J Cancer , vol.132 , Issue.12 , pp. 2967-2974
    • Qi, W.-X.1    Min, D.-L.2    Shen, Z.3
  • 90
    • 72449132908 scopus 로고    scopus 로고
    • VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management
    • Izzedine H, Massard C, Spano JP, et al. VEGF signalling inhibition-induced proteinuria: mechanisms, significance and management. Eur J Cancer 2010;46(2): 439-48
    • (2010) Eur J Cancer , vol.46 , Issue.2 , pp. 439-448
    • Izzedine, H.1    Massard, C.2    Spano, J.P.3
  • 91
    • 77956611236 scopus 로고    scopus 로고
    • A model of hypertension and proteinuria in cancer patients treated with the anti-Angiogenic drug E7080
    • Keizer RJ, Gupta A, Mac Gillavry MR, et al. A model of hypertension and proteinuria in cancer patients treated with the anti-Angiogenic drug E7080. J Pharmacokinet Pharmacodyn 2010;37(4): 347-63
    • (2010) J Pharmacokinet Pharmacodyn , vol.37 , Issue.4 , pp. 347-363
    • Keizer, R.J.1    Gupta, A.2    Mac Gillavry, M.R.3
  • 92
    • 62649174250 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and modifications of thyroid function tests: A review
    • Illouz F, Laboureau-Soares S, Dubois S, et al. Tyrosine kinase inhibitors and modifications of thyroid function tests: a review. Eur J Endocrinol 2009;160(3): 331-6
    • (2009) Eur J Endocrinol , vol.160 , Issue.3 , pp. 331-336
    • Illouz, F.1    Laboureau-Soares, S.2    Dubois, S.3
  • 93
    • 84877771688 scopus 로고    scopus 로고
    • Toxic cardiomyopathy leading to fatal acute cardiac failure related to vandetanib: A case report with histopathological analysis
    • Scheffel RS, Dora JM, Siqueira DR, et al. Toxic cardiomyopathy leading to fatal acute cardiac failure related to vandetanib: a case report with histopathological analysis. Eur J Endocrinol 2013;168(6): K51-4
    • (2013) Eur J Endocrinol , vol.168 , Issue.6 , pp. K51-K54
    • Scheffel, R.S.1    Dora, J.M.2    Siqueira, D.R.3
  • 94
    • 79954455226 scopus 로고    scopus 로고
    • Fatal heart failure after a 26-month combination of tyrosine kinase inhibitors in a papillary thyroid cancer
    • Toubert M-E, Vercellino L, Faugeron I, et al. Fatal heart failure after a 26-month combination of tyrosine kinase inhibitors in a papillary thyroid cancer. Thyroid 2011;21(4): 451-4
    • (2011) Thyroid , vol.21 , Issue.4 , pp. 451-454
    • Toubert, M.-E.1    Vercellino, L.2    Faugeron, I.3
  • 95
    • 84891719299 scopus 로고    scopus 로고
    • Long-Term cardiovascular mortality in patients with differentiated thyroid carcinoma: An observational study
    • Klein Hesselink EN, Klein Hesselink MS, de Bock GH, et al. Long-Term cardiovascular mortality in patients with differentiated thyroid carcinoma: an observational study. J Clin Oncol 2013;31(32): 4046-53
    • (2013) J Clin Oncol , vol.31 , Issue.32 , pp. 4046-4053
    • Klein Hesselink, E.N.1    Klein Hesselink, M.S.2    De Bock, G.H.3
  • 96
    • 84859500293 scopus 로고    scopus 로고
    • Incidence of thyroid hormone therapy in patients treated with sunitinib or sorafenib: A cohort study
    • Feldt S, Schuddddssel K, Quinzler R, et al. Incidence of thyroid hormone therapy in patients treated with sunitinib or sorafenib: a cohort study. Eur J Cancer 2012;48(7): 974-81
    • (2012) Eur J Cancer , vol.48 , Issue.7 , pp. 974-981
    • Feldt, S.1    Schuddddssel, K.2    Quinzler, R.3
  • 97
    • 84873650357 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor-induced thyroid disorders: A review and hypothesis
    • Makita N, Iiri T. Tyrosine kinase inhibitor-induced thyroid disorders: a review and hypothesis. Thyroid 2013;23(2): 151-9
    • (2013) Thyroid , vol.23 , Issue.2 , pp. 151-159
    • Makita, N.1    Iiri, T.2
  • 98
    • 84907215846 scopus 로고    scopus 로고
    • Thyroid effects of tyrosine kinase inhibitors
    • Epub 2014 May 15]
    • Illouz F, Braun D, Briet C, et al. Thyroid effects of tyrosine kinase inhibitors. Eur J Endocrinol 2014;171(3): 91-9; doi: 10.1530/EJE-14-0198. [Epub 2014 May 15]
    • (2014) Eur J Endocrinol , vol.171 , Issue.3 , pp. 91-99
    • Illouz, F.1    Braun, D.2    Briet, C.3
  • 99
    • 77955374095 scopus 로고    scopus 로고
    • Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination
    • Abdulrahman RM, Verloop H, Hoftijzer H, et al. Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination. J Clin Endocrinol Metab 2010;95(8): 3758-62
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.8 , pp. 3758-3762
    • Abdulrahman, R.M.1    Verloop, H.2    Hoftijzer, H.3
  • 100
    • 84862956363 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport
    • Braun D, Kim TD, le Coutre P, et al. Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport. J Clin Endocrinol Metab 2012;97(1): E100-5
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.1 , pp. E100-E105
    • Braun, D.1    Kim, T.D.2    Le Coutre, P.3
  • 101
    • 84877961253 scopus 로고    scopus 로고
    • Mechanisms of TKI-induced diarrhea in cancer patients
    • Bowen JM. Mechanisms of TKI-induced diarrhea in cancer patients. Curr Opin Support Palliat Care 2013;7(2): 162-7
    • (2013) Curr Opin Support Palliat Care , vol.7 , Issue.2 , pp. 162-167
    • Bowen, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.