An Oct-1-based, feed-forward mechanism of apoptosis inhibited by co-culture with Raji B-cells: Towards a model of the cancer cell/B-cell microenvironment

Experimental and Molecular Pathology

Volumn 97, Issue 3, 2014, Pages 585-589

  Szekeres, Karoly ^a   Koul, Rudra ^a   Mauro, James ^a   Lloyd, Mark ^b   Johnson, Joseph ^b   Blanck, George ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

B cell microenvironment; Bladder carcinoma; Feed forward apoptosis; Interferon gamma; Oct 1; Transcription factors

Indexed keywords

GAMMA INTERFERON; OCTAMER TRANSCRIPTION FACTOR 1; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; BINDING SITE; BLADDER CARCINOMA; CANCER INHIBITION; CARCINOMA CELL; CELL ADHESION; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; INTRACELLULAR SIGNALING; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAJI CELL LINE; TUMOR MICROENVIRONMENT; GENETICS; HUMAN; IMMUNOLOGY; NEOPLASM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; B-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; HUMANS; INTERFERON-GAMMA; NEOPLASMS; OCTAMER TRANSCRIPTION FACTOR-1; TUMOR MICROENVIRONMENT;

EID: 84910614318     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.09.010     Document Type: Article

References (19)

1. Abell K., Bilancio A., Clarkson R.W., Tiffen P.G., Altaparmakov A.I., Burdon T.G., Asano T., Vanhaesebroeck B., Watson C.J. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nat. Cell Biol. 2005, 7(4):392-398.
2. Batista U., Garvas M., Nemec M., Schara M., Veranic P., Koklic T. Effects of different detachment procedures on viability, nitroxide reduction kinetics and plasma membrane heterogeneity of V-79 cells. Cell Biol. Int. 2010, 34(6):663-668.
3. Berry D.E., Lu Y., Schmidt B., Fallon P.G., O'Connell C., Hu S.X., Xu H.J., Blanck G. Retinoblastoma protein inhibits IFN-gamma induced apoptosis. Oncogene 1996, 12(8):1809-1819.
4. Carreno L.J., Gonzalez P.A., Kalergis A.M. Modulation of T cell function by TCR/pMHC binding kinetics. Immunobiology 2006, 211(1-2):47-64.
5. Field S.J., Tsai F.Y., Kuo F., Zubiaga A.M., Kaelin W.G., Livingston D.M., Orkin S.H., Greenberg M.E. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996, 85(4):549-561.
6. Gatzka M., Walsh C.M. Apoptotic signal transduction and T cell tolerance. Autoimmunity 2007, 40(6):442-452.
7. Hafezi F., Marti A., Grimm C., Wenzel A., Reme C.E. Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors. Vis. Res. 1999, 39(15):2511-2518.
8. Lee J.E., Lim M.S., Park J.H., Park C.H., Koh H.C. Nuclear NF-kappaB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells. Neurotoxicology 2014, 42C:58-70.
9. Marti A., Jehn B., Costello E., Keon N., Ke G., Martin F., Jaggi R. Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells. Oncogene 1994, 9(4):1213-1223.
10. Mauro J.A., Blanck G. Functionally distinct gene classes as bigger or smaller transcription factor traps: a possible stochastic component to sequential gene expression programs in cancer. Gene 2014, 536(2):398-406.
11. Osborne A., Zhang H., Yang W.M., Seto E., Blanck G. Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. Mol. Cell. Biol. 2001, 21(19):6495-6506.
12. Osborne A.R., Zhang H., Fejer G., Palubin K.M., Niesen M.I., Blanck G. Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter. J. Biol. Chem. 2004, 279(28):28911-28919.
13. Palubin K.M., Goodwin B.L., Niesen M.I., Le E.A., Osborne A.R., Blanck G. A direct mechanistic link between growth control and a tumor cell immune function: increased interleukin-8 secretion accounts for elimination of Oct-1 antisense transformants from scid mice. Anticancer Res. 2006, 26(3A):1733-1738.
14. Pillai S., Szekeres K., Lawrence N.J., Chellappan S.P., Blanck G. Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR. Gene 2013, 512(2):403-407.
15. Sikora E., Grassilli E., Radziszewska E., Bellesia E., Barbieri D., Franceschi C. Transcription factors DNA-binding activity in rat thymocytes undergoing apoptosis after heat-shock or dexamethasone treatment. Biochem. Biophys. Res. Commun. 1993, 197(2):709-715.
16. Wen J., Krishan A., Thomas R.A. NASA/American Cancer Society High-Resolution Flow Cytometry Project - II. Effect of pH and DAPI concentration on dual parametric analysis of DNA/DAPI fluorescence and electronic nuclear volume. Cytometry 2001, 43(1):12-15.
17. Xu L., Niesen M.I., Blanck G. Linkage of a tumor immune function and cell cycle de-regulation via a gene regulatory network subcircuit. Mol. Immunol. 2009, 46(4):569-575.
18. Yamasaki L., Jacks T., Bronson R., Goillot E., Harlow E., Dyson N.J. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 1996, 85(4):537-548.
19. Zhao H., Jin S., Fan F., Fan W., Tong T., Zhan Q. Activation of the transcription factor Oct-1 in response to DNA damage. Cancer Res. 2000, 60(22):6276-6280.