Activation of the transcription factor Oct-1 in response to DNA damage

Cancer Research

Volumn 60, Issue 22, 2000, Pages 6276-6280

  Zhao, Hongcheng ^a   Jin, Shunqian ^a   Fan, Feiyue ^a   Fan, Wenhong ^a   Tong, Tong ^a   Zhan, Qimin ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; DNA DAMAGE; DNA REPAIR; GENE ACTIVATION; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG CARCINOMA; PRIORITY JOURNAL;

DNA DAMAGE; DNA, NEOPLASM; DNA-BINDING PROTEINS; ELECTROPHORESIS; HELA CELLS; HOST CELL FACTOR C1; HUMANS; METHYL METHANESULFONATE; MUTAGENS; OCTAMER TRANSCRIPTION FACTOR-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033692790     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Participation of p53 protein in the cellular response to DNA damage
2. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
3. Life, death, and the pursuit of apoptosis
4. Genomic instability: First step to carcinogenesis
5. DNA replication and cancer
6. Signaling events controlling the molecular response to genotoxic stress
7. Genotoxic-stress-response genes and growth-arrest genes gadd, MyD, and other genes induced by treatments eliciting growth arrest
8. Radiation-induced activation of transcription factors in mammalian cells
9. DNA-damage inducible genes
10. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents
11. Induction of fos RNA by DNA-damaging agents
12. UVB-induced DNA breaks interfere with transcriptional induction of c-fos
13. Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation
14. WAF1, a potential mediator of p53 tumor suppression
15. The p53-dependent γ-ray response of GADD45
16. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
17. Tumor suppressor p53 is a direct transcriptional activator of the human bar gene
18. The POU domain is a bipartite DNA-binding structure
19. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeobox subdomain
20. Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements
21. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter
22. Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element
23. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene
24. Two regulatory elements for immunoglobulin κ light chain gene expression
25. Complex pattern of immunoglobulin μ gene expression in normal and transgenic mice: Nonoverlapping regulatory sequences govern distinct tissue specificities
26. Purified octamer binding transcription factors stimulate RNA polymerase III-mediated transcription of the 7SK RNA gene
27. Octamer-dependent in vivo expression of the endothelial cell-specific TIE2 gene
28. Oct-1 binds promoter elements required for transcription of the GnRH gene
29. Oct-1 is involved in the transcriptional repression of the von Willebrand factor gene promoter
30. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)
31. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors
32. Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases
33. Differential phosphorylation of the transcription factor Oct1 during the cell cycle
34. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
35. Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding
36. Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation
37. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
38. Breast cancer genes and DNA repair
39. Functional interaction between Oct-1 and retinoid X receptor
40. Recruitment of octamer transcription factors to DNA by glucocorticoid receptor
41. Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation
42. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
43. GADD45 induction of a G2/M cell cycle checkpoint