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Volumn 74, Issue 21, 2014, Pages 6107-6118

Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGFβ-activating miR424-503 gene cluster

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MICRORNA; MICRORNA 424; MICRORNA 503; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; SMURF2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; MIRN424 MICRORNA, HUMAN; MIRN503 MICRORNA, HUMAN; SMAD7 PROTEIN, HUMAN; SMURF2 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

EID: 84910141016     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0389     Document Type: Article
Times cited : (35)

References (50)
  • 1
    • 84856447171 scopus 로고    scopus 로고
    • ERalpha, microRNAs, and the epithelial-mesenchymal transition in breast cancer
    • Guttilla IK, Adams BD, White BA. ERalpha, microRNAs, and the epithelial-mesenchymal transition in breast cancer. Trends Endocrinol Metab 2012;23:73-82.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 73-82
    • Guttilla, I.K.1    Adams, B.D.2    White, B.A.3
  • 2
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006;12:895-904.
    • (2006) Nat Med , vol.12 , pp. 895-904
    • Steeg, P.S.1
  • 4
    • 84873365269 scopus 로고    scopus 로고
    • MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis
    • Cai J, Guan H, Fang L, Yang Y, Zhu X, Yuan J, et al. MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis. J Clin Invest 2013;123:566-79.
    • (2013) J Clin Invest , vol.123 , pp. 566-579
    • Cai, J.1    Guan, H.2    Fang, L.3    Yang, Y.4    Zhu, X.5    Yuan, J.6
  • 5
    • 58149236744 scopus 로고    scopus 로고
    • Roles of TGFbeta in metastasis
    • Padua D, Massague J. Roles of TGFbeta in metastasis. Cell Res 2009;19:89-102.
    • (2009) Cell Res , vol.19 , pp. 89-102
    • Padua, D.1    Massague, J.2
  • 6
    • 0027742864 scopus 로고
    • Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma
    • Dalal BI, Keown PA, Greenberg AH. Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol 1993;143:381-9.
    • (1993) Am J Pathol , vol.143 , pp. 381-389
    • Dalal, B.I.1    Keown, P.A.2    Greenberg, A.H.3
  • 7
    • 0242552529 scopus 로고    scopus 로고
    • Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1
    • Muraoka RS, Koh Y, Roebuck LR, Sanders ME, Brantley-Sieders D, Gorska AE, et al. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol 2003;23:8691-703.
    • (2003) Mol Cell Biol , vol.23 , pp. 8691-8703
    • Muraoka, R.S.1    Koh, Y.2    Roebuck, L.R.3    Sanders, M.E.4    Brantley-Sieders, D.5    Gorska, A.E.6
  • 8
    • 0842333147 scopus 로고    scopus 로고
    • Prognostic significance of transforming growth factor beta receptor II in estrogen receptor-negative breast cancer patients
    • Buck MB, Fritz P, Dippon J, Zugmaier G, Knabbe C. Prognostic significance of transforming growth factor beta receptor II in estrogen receptor-negative breast cancer patients. Clin Cancer Res 2004;10:491-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 491-498
    • Buck, M.B.1    Fritz, P.2    Dippon, J.3    Zugmaier, G.4    Knabbe, C.5
  • 9
    • 34248185926 scopus 로고    scopus 로고
    • Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
    • Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, et al. Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest 2007;117:1305-13.
    • (2007) J Clin Invest , vol.117 , pp. 1305-1313
    • Biswas, S.1    Guix, M.2    Rinehart, C.3    Dugger, T.C.4    Chytil, A.5    Moses, H.L.6
  • 10
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 12
    • 0036313090 scopus 로고    scopus 로고
    • Smad7: A new key player in TGF-beta-associated disease
    • Nakao A, Okumura K, Ogawa H. Smad7: a new key player in TGF-beta-associated disease. Trends Mol Med 2002;8:361-3.
    • (2002) Trends Mol Med , vol.8 , pp. 361-363
    • Nakao, A.1    Okumura, K.2    Ogawa, H.3
  • 13
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    • Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 1997;89:1165-73.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3    Cai, J.4    Xu, Y.Y.5    Grinnell, B.W.6
  • 14
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
    • Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 2000;6:1365-75.
    • (2000) Mol Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6
  • 15
    • 1942534004 scopus 로고    scopus 로고
    • Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation
    • Izzi L, Attisano L. Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene 2004;23:2071-8.
    • (2004) Oncogene , vol.23 , pp. 2071-2078
    • Izzi, L.1    Attisano, L.2
  • 16
    • 62149136344 scopus 로고    scopus 로고
    • Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer
    • Wang P, Fan J, Chen Z, Meng ZQ, Luo JM, Lin JH, et al. Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer. Ann Surg Oncol 2009;16:826-35.
    • (2009) Ann Surg Oncol , vol.16 , pp. 826-835
    • Wang, P.1    Fan, J.2    Chen, Z.3    Meng, Z.Q.4    Luo, J.M.5    Lin, J.H.6
  • 17
    • 58149086804 scopus 로고    scopus 로고
    • Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells
    • Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, et al. Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. J Biol Chem 2008;283:35660-7.
    • (2008) J Biol Chem , vol.283 , pp. 35660-35667
    • Fukunaga, E.1    Inoue, Y.2    Komiya, S.3    Horiguchi, K.4    Goto, K.5    Saitoh, M.6
  • 18
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136:215-33.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 19
    • 75149124701 scopus 로고    scopus 로고
    • MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    • Sachdeva M, Mo YY. MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1. Cancer Res 2010;70:378-87.
    • (2010) Cancer Res , vol.70 , pp. 378-387
    • Sachdeva, M.1    Mo, Y.Y.2
  • 20
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007;449:682-8.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 21
    • 84910145972 scopus 로고    scopus 로고
    • Doing good science: Authenticating cell line identity
    • Dunham JH, Guthmiller P. Doing good science: authenticating cell line identity. Promega Notes 2009;101:15-18.
    • (2009) Promega Notes , vol.101 , pp. 15-18
    • Dunham, J.H.1    Guthmiller, P.2
  • 22
    • 15044347036 scopus 로고    scopus 로고
    • Stable transfection of Acanthamoeba castellanii
    • Peng Z, Omaruddin R, Bateman E. Stable transfection of Acanthamoeba castellanii. Biochim Biophys Acta 2005;1743:93-100.
    • (2005) Biochim Biophys Acta , vol.1743 , pp. 93-100
    • Peng, Z.1    Omaruddin, R.2    Bateman, E.3
  • 23
    • 84855461449 scopus 로고    scopus 로고
    • MicroRNA-30e∗ promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-kappaB/IkappaBalpha negative feedback loop
    • Jiang L, Lin C, Song L, Wu J, Chen B, Ying Z, et al. MicroRNA-30e∗ promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-kappaB/IkappaBalpha negative feedback loop. J Clin Invest 2012;122:33-47.
    • (2012) J Clin Invest , vol.122 , pp. 33-47
    • Jiang, L.1    Lin, C.2    Song, L.3    Wu, J.4    Chen, B.5    Ying, Z.6
  • 24
    • 0023664635 scopus 로고
    • Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes
    • Matsudaira P. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J Biol Chem 1987;262:10035-8.
    • (1987) J Biol Chem , vol.262 , pp. 10035-10038
    • Matsudaira, P.1
  • 25
    • 0031406786 scopus 로고    scopus 로고
    • Immunofluorescence and glutaraldehyde fixation. A new procedure based on the Schiff-quenching method
    • Tagliaferro P, Tandler CJ, Ramos AJ, Pecci Saavedra J, Brusco A. Immunofluorescence and glutaraldehyde fixation. A new procedure based on the Schiff-quenching method. J Neurosci Methods 1997;77:191-7.
    • (1997) J Neurosci Methods , vol.77 , pp. 191-197
    • Tagliaferro, P.1    Tandler, C.J.2    Ramos, A.J.3    Pecci Saavedra, J.4    Brusco, A.5
  • 26
    • 75149163985 scopus 로고    scopus 로고
    • Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes
    • Wang WX, Wilfred BR, Hu YL, Stromberg AJ, Nelson PT. Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA 2010;16:394-404.
    • (2010) RNA , vol.16 , pp. 394-404
    • Wang, W.X.1    Wilfred, B.R.2    Hu, Y.L.3    Stromberg, A.J.4    Nelson, P.T.5
  • 27
    • 0032926691 scopus 로고    scopus 로고
    • Immuno-LCM: Laser capture microdissection of immunostained frozen sections for mRNA analysis
    • Fend F, Emmert-Buck MR, Chuaqui R, Cole K, Lee J, Liotta LA, et al. Immuno-LCM: laser capture microdissection of immunostained frozen sections for mRNA analysis. Am J Pathol 1999;154:61-6.
    • (1999) Am J Pathol , vol.154 , pp. 61-66
    • Fend, F.1    Emmert-Buck, M.R.2    Chuaqui, R.3    Cole, K.4    Lee, J.5    Liotta, L.A.6
  • 28
    • 84872078405 scopus 로고    scopus 로고
    • An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
    • Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, et al. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med 2013;19:74-82.
    • (2013) Nat Med , vol.19 , pp. 74-82
    • Kim, J.1    Kang, Y.2    Kojima, Y.3    Lighthouse, J.K.4    Hu, X.5    Aldred, M.A.6
  • 29
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
    • Lagna G, Hata A, Hemmati-Brivanlou A, Massague J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 1996;383:832-6.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massague, J.4
  • 30
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 32
    • 27844514155 scopus 로고    scopus 로고
    • Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo
    • Javelaud D, Delmas V, Moller M, Sextius P, Andre J, Menashi S, et al. Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Oncogene 2005;24:7624-9.
    • (2005) Oncogene , vol.24 , pp. 7624-7629
    • Javelaud, D.1    Delmas, V.2    Moller, M.3    Sextius, P.4    Andre, J.5    Menashi, S.6
  • 33
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    • Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006;17:41-58.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 34
    • 0034533657 scopus 로고    scopus 로고
    • Signaling of transforming growth factor-beta family members through Smad proteins
    • Itoh S, Itoh F, Goumans MJ, Ten Dijke P. Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 2000;267:6954-67.
    • (2000) Eur J Biochem , vol.267 , pp. 6954-6967
    • Itoh, S.1    Itoh, F.2    Goumans, M.J.3    Ten Dijke, P.4
  • 36
    • 84879149544 scopus 로고    scopus 로고
    • miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling
    • Bhagat TD, Zhou L, Sokol L, Kessel R, Caceres G, Gundabolu K, et al. miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling. Blood 2013;121:2875-81.
    • (2013) Blood , vol.121 , pp. 2875-2881
    • Bhagat, T.D.1    Zhou, L.2    Sokol, L.3    Kessel, R.4    Caceres, G.5    Gundabolu, K.6
  • 37
    • 84871246002 scopus 로고    scopus 로고
    • The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer
    • Smith AL, Iwanaga R, Drasin DJ, Micalizzi DS, Vartuli RL, Tan AC, et al. The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 2012;31:5162-71.
    • (2012) Oncogene , vol.31 , pp. 5162-5171
    • Smith, A.L.1    Iwanaga, R.2    Drasin, D.J.3    Micalizzi, D.S.4    Vartuli, R.L.5    Tan, A.C.6
  • 38
    • 84881537520 scopus 로고    scopus 로고
    • Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells
    • Pincini A, Tornillo G, Orso F, Sciortino M, Bisaro B, LealMdel P, et al. Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle 2013;12:2409-22.
    • (2013) Cell Cycle , vol.12 , pp. 2409-2422
    • Pincini, A.1    Tornillo, G.2    Orso, F.3    Sciortino, M.4    Bisaro, B.5    LealMdel, P.6
  • 39
    • 84880255708 scopus 로고    scopus 로고
    • miRNA expression profiling of inflammatory breast cancer identifies a 5-miRNA signature predictive of breast tumor aggressiveness
    • Lerebours F, Cizeron-Clairac G, Susini A, Vacher S, Mouret-Fourme E, Belichard C, et al. miRNA expression profiling of inflammatory breast cancer identifies a 5-miRNA signature predictive of breast tumor aggressiveness. Int J Cancer 2013;133:1614-23.
    • (2013) Int J Cancer , vol.133 , pp. 1614-1623
    • Lerebours, F.1    Cizeron-Clairac, G.2    Susini, A.3    Vacher, S.4    Mouret-Fourme, E.5    Belichard, C.6
  • 41
    • 77957225240 scopus 로고    scopus 로고
    • Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death
    • Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, et al. Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol 2010;49:841-50.
    • (2010) J Mol Cell Cardiol , vol.49 , pp. 841-850
    • Zhang, X.1    Wang, X.2    Zhu, H.3    Zhu, C.4    Wang, Y.5    Pu, W.T.6
  • 42
    • 84893173665 scopus 로고    scopus 로고
    • MiR-424/503-mediated Rictor upregulation promotes tumor progression
    • Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, et al. MiR-424/503-mediated Rictor upregulation promotes tumor progression. PLoS One 2013;8:e80300.
    • (2013) PLoS One , vol.8 , pp. e80300
    • Oneyama, C.1    Kito, Y.2    Asai, R.3    Ikeda, J.4    Yoshida, T.5    Okuzaki, D.6
  • 43
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 2010;11:R90.
    • (2010) Genome Biol , vol.11 , pp. R90
    • Betel, D.1    Koppal, A.2    Agius, P.3    Sander, C.4    Leslie, C.5
  • 44
    • 76749157966 scopus 로고    scopus 로고
    • miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway
    • Li J, Donath S, Li Y, Qin D, Prabhakar BS, Li P. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet 2010;6:e1000795.
    • (2010) PLoS Genet , vol.6 , pp. e1000795
    • Li, J.1    Donath, S.2    Li, Y.3    Qin, D.4    Prabhakar, B.S.5    Li, P.6
  • 45
    • 77954954098 scopus 로고    scopus 로고
    • Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
    • Yu F, Deng H, Yao H, Liu Q, Su F, Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010;29:4194-204.
    • (2010) Oncogene , vol.29 , pp. 4194-4204
    • Yu, F.1    Deng, H.2    Yao, H.3    Liu, Q.4    Su, F.5    Song, E.6
  • 46
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011;147:275-92.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 47
    • 38049146022 scopus 로고    scopus 로고
    • The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation
    • Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M, et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci U S A 2007;104:19849-54.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19849-19854
    • Rosa, A.1    Ballarino, M.2    Sorrentino, A.3    Sthandier, O.4    De Angelis, F.G.5    Marchioni, M.6
  • 48
    • 78049424494 scopus 로고    scopus 로고
    • Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis
    • Ghosh G, Subramanian IV, Adhikari N, Zhang X, Joshi HP, Basi D, et al. Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis. J Clin Invest 2010;120:4141-54.
    • (2010) J Clin Invest , vol.120 , pp. 4141-4154
    • Ghosh, G.1    Subramanian, I.V.2    Adhikari, N.3    Zhang, X.4    Joshi, H.P.5    Basi, D.6
  • 49
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004;14:198-206.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 50
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997;3:177-82.
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4


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