Rational design of cancer-targeted BSA protein nanoparticles as radiosensitizer to overcome cancer radioresistance

ACS Applied Materials and Interfaces

Volumn 6, Issue 21, 2014, Pages 19217-19228

  Huang, Yanyu ^a   Luo, Yi ^a   Zheng, Wenjie ^a   Chen, Tianfeng ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

bovine serum albumin nanoparticles; cancer targeted nanosystem; folate; radiosensitization; radiotherapy

Indexed keywords

BIOCOMPATIBILITY; CELL DEATH; DISEASES; HEAVY METALS; LIGHT ABSORPTION; MAMMALS; NANOPARTICLES; PLASMONS; RADIOTHERAPY; REFRACTIVE INDEX; SURFACE PLASMON RESONANCE; TUMORS;

BOVINE SERUM ALBUMINS; CANCER RADIOTHERAPIES; COMBINED TREATMENT; FOLATE; HIGH REFRACTIVE INDEX; INTERFACIAL EFFECTS; PROTEIN NANOPARTICLES; RADIO-SENSITIZATION;

NANOSYSTEMS;

BOVINE SERUM ALBUMIN; FOLIC ACID; NANOPARTICLE; RADIOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE;

CELL SHAPE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HUMAN; NANOMEDICINE; RADIOTHERAPY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; X RAY;

CELL LINE, TUMOR; CELL SHAPE; DRUG DELIVERY SYSTEMS; FOLIC ACID; HUMANS; NANOMEDICINE; NANOPARTICLES; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY; REACTIVE OXYGEN SPECIES; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION; X-RAYS;

EID: 84910114187     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am505246w     Document Type: Article

References (52)

1. Lord, C. J.; Ashworth, A. The DNA Damage Response and Cancer Therapy Nature 2012, 481, 287-294
2. Fan, W. P.; Shen, B.; Bu, W. B.; Chen, F.; Zhao, K. L.; Zhang, S. J.; Zhou, L. P.; Peng, W. J.; Xiao, Q. F.; Xing, H. Y.; Liu, J. N.; Ni, D. L.; He, Q. J.; Shi, J. L. Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging J. Am. Chem. Soc. 2013, 135, 6494-6503
3. Pan, Y.; Zhang, Q.; Atsaves, V.; Yang, H.; Claret, F. X. Suppression of Jab1/CSN5 Induces Radio- and Chemo-sensitivity in Nasopharyngeal Carcinoma Through Changes to the DNA Damage and Repair Pathways Oncogene 2013, 32, 2756-2766
4. Beskow, C.; Skikuniene, J.; Holgersson, A.; Nilsson, B.; Lewensohn, R.; Kanter, L.; Viktorsson, K. Radioresistant Cervical Cancer Shows Upregulation of the NHEJ Proteins DNA-PKcs, Ku70 and Ku86 Br. J. Cancer 2009, 101, 816-821
5. Wang, M.; Morsbach, F.; Sander, D.; Gheorghiu, L.; Nanda, A.; Benes, C.; Kriegs, M.; Krause, M.; Dikomey, E.; Baumann, M.; Dahm-Daphi, J.; Settleman, J.; Willers, H. EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks Cancer Res. 2011, 71, 6261-6269
6. Gu, J. L.; Su, S. S.; Li, Y. S.; He, Q. J.; Zhong, F. Y.; Shi, J. L. Surface Modification-Complexation Strategy for Cisplatin Loading in Mesoporous Nanoparticles J. Phys. Chem. Lett. 2010, 1, 3446-3450
7. Werner, M. E.; Copp, J. A.; Karve, S.; Cummings, N. D.; Sukumar, R.; Li, C. X.; Napier, M. E.; Chen, R. C.; Cox, A. D.; Wang, A. Z. Folate-Targeted Polymeric Nanoparticle Formulation of Docetaxel Is an Effective Molecularly Targeted Radiosensitizer with Efficacy Dependent on the Timing of Radiotherapy ACS Nano 2011, 5, 8990-8998
8. Corde, S.; Balosso, J.; Elleaume, H.; Renier, M.; Joubert, A.; Biston, M. C.; Adam, J. F.; Charvet, A. M.; Brochard, T.; Le Bas, J. F.; Esteve, F.; Foray, N. Synchrotron Photoactivation of Cisplatin Elicits an Extra Number of DNA Breaks that Stimulate RAD51-Mediated Repair Pathways Cancer Res. 2003, 63, 3221-3227
9. Sinha, R.; El-Bayoumy, K. Apoptosis Is a Critical Cellular Event in Cancer Chemoprevention and Chemotherapy by Selenium Compounds Curr. Cancer Drug Targets 2004, 4, 13-28
10. Li, S.; Zhou, Y.; Wang, R.; Zhang, H.; Dong, Y.; Ip, C. Selenium Sensitizes MCF-7 Breast Cancer Cells to Doxorubicin-Induced Apoptosis Through Modulation of Phospho-AKT and Its Downstream Substrates Mol. Cancer Ther. 2007, 6, 1031-1038
11. Chen, T.; Wong, Y. S.; Zheng, W.; Liu, J. Caspase- and p53-Dependent Apoptosis in Breast Carcinoma Cells Induced by a Synthetic Selenadiazole Derivative Chem.-Biol. Interact. 2009, 180, 54-60
12. Chen, T.; Wong, Y. S. Selenocystine Induces S-Phase Arrest and Apoptosis in Human Breast Adenocarcinoma MCF-7 Cells by Modulating ERK and AKT Phosphorylation J. Agric. Food Chem. 2008, 56, 10574-10581
13. Luo, Y.; Li, X.; Huang, X.; Wong, Y. S.; Chen, T.; Zhang, Y.; Zheng, W. 1,4-Diselenophene-1,4-diketone Triggers Caspase-Dependent Apoptosis in Human Melanoma A375 Cells through Induction of Mitochondrial Dysfunction Chem. Pharm. Bull. 2013, 59, 1227-1232
14. Luo, Y.; Li, X. L.; Chen, T. F.; Wang, Y.; Zheng, W. J. Synthesis of a Novel Thiophene Derivative that Induces Cancer Cell Apoptosis Through Modulation of AKT and MAPK Pathways MedChemComm 2012, 3, 1143-1146
15. Liu, X.; Law, W. C.; Jeon, M.; Wang, X.; Liu, M.; Kim, C.; Prasad, P. N.; Swihart, M. T. Cu2-x Se Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for in Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping Adv. Healthcare Mater. 2013, 2, 952-957
16. Barrow, S. J.; Funston, A. M.; Wei, X. Z.; Mulvaney, P. DNA-Directed Self-Assembly and Optical Properties of Discrete 1D, 2D and 3D Plasmonic Structures Nano Today 2013, 8138-8167
17. Luo, Z.; Ding, X. W.; Hu, Y.; Wu, S. J.; Xiang, Y.; Zeng, Y. F.; Zhang, B. L.; Yan, H.; Zhang, H. C.; Zhu, L. L.; Liu, J. J.; Li, J. H.; Cai, K. Y.; Zhao, Y. L. Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitro and in Vivo ACS Nano 2013, 7, 10271-10284
18. Kakuta, T.; Takashima, Y.; Nakahata, M.; Otsubo, M.; Yamaguchi, H.; Harada, A. Preorganized Hydrogel: Self-Healing Properties of Supramolecular Hydrogels Formed by Polymerization of Host-Guest-Monomers that Contain Cyclodextrins and Hydrophobic Guest Groups Adv. Mater. 2013, 25, 2849-2853
19. Peng, L.; Peng, X.; Liu, B.; Wu, C.; Xie, Y.; Yu, G. Ultrathin Two-Dimensional MnO2/Graphene Hybrid Nanostructures for High-Performance, Flexible Planar Supercapacitors Nano Lett. 2013, 13, 2151-2157
20. Caracciolo, G.; Cardarelli, F.; Pozzi, D.; Salomone, F.; Maccari, G.; Bardi, G.; Capriotti, A. L.; Cavaliere, C.; Papi, M.; Lagana, A. Selective Targeting Capability Acquired with a Protein Corona Adsorbed on the Surface of 1,2-Dioleoyl-3-trimethylammonium Propane/DNA Nanoparticles ACS Appl. Mater. Interfaces 2013, 5, 13171-13179
21. Zhao, M. X.; Hu, B. L.; Gu, Z.; Joo, K. I.; Wang, P.; Tang, Y. Degradable Polymeric Nanocapsule for Efficient Intracellular Delivery of a High Molecular Weight Tumor-Selective Protein Complex Nano Today 2013, 8, 11-20
22. Taratula, O.; Kuzmov, A.; Shah, M.; Garbuzenko, O. B.; Minko, T. Nanostructured Lipid Carriers as Multifunctional Nanomedicine Platform for Pulmonary Co-Delivery of Anticancer Drugs and siRNA J. Controlled Release 2013, 171, 349-357
23. Park, S.; Kang, S.; Chen, X. Y.; Kim, E. J.; Kim, J.; Kim, N.; Kim, J.; Jin, M. M. Tumor Suppression via Paclitaxel-Loaded Drug Carriers that Target Inflammation Marker Upregulated in Tumor Vasculature and Macrophages Biomaterials 2013, 34, 598-605
24. Kratz, F. Albumin as a Drug Carrier: Design of Prodrugs, Drug Conjugates and Nanoparticles J. Controlled Release 2008, 132, 171-183
25. Heukers, R.; Altintas, I.; Raghoenath, S.; De Zan, E.; Pepermans, R.; Roovers, R. C.; Haselberg, R.; Hennink, W. E.; Schiffelers, R. M.; Kok, R. J.; Henegouwen, P. M. P. V. B. E. Targeting Hepatocyte Growth Factor Receptor (Met) Positive Tumor Cells Using Internalizing Nanobody-Decorated Albumin Nanoparticles Biomaterials 2014, 35, 601-610
26. Zhang, S. F.; Kucharski, C.; Doschak, M. R.; Sebald, W.; Uludag, H. Polyethylenimine-PEG Coated Albumin Nanoparticles for BMP-2 Delivery Biomaterials 2010, 31, 952-963
27. Mohanta, V.; Madras, G.; Patil, S. Layer-by-Layer Assembled Thin Film of Albumin Nanoparticles for Delivery of Doxorubicin J. Phys. Chem. C 2012, 116, 5333-5341
28. Xie, L. L.; Tong, W. J.; Yu, D. H.; Xu, J. Q.; Li, J.; Gao, C. Y. Bovine Serum Albumin Nanoparticles Modified with Multilayers and Aptamers for pH-Responsive and Targeted Anti-Cancer Drug Delivery J. Mater. Chem. 2012, 22, 6053-6060
29. Bae, S.; Ma, K.; Kim, T. H.; Lee, E. S.; Oh, K. T.; Park, E. S.; Lee, K. C.; Youn, Y. S. Doxorubicin-Loaded Human Serum Albumin Nanoparticles Surface-Modified with TNF-Related Apoptosis-Inducing Ligand and Transferrin for Targeting Multiple Tumor Types Biomaterials 2012, 33, 1536-1546
30. Destito, G.; Yeh, R.; Rae, C. S.; Finn, M. G.; Manchester, M. Folic Acid-Mediated Targeting of Cowpea Mosaic Virus Particles to Tumor Cells Chem. Biol. 2007, 14, 1152-1162
31. Harada, H.; Kizaka-Kondoh, S.; Li, G.; Itasaka, S.; Shibuya, K.; Inoue, M.; Hiraoka, M. Significance of HIF-1-Active Cells in Angiogenesis and Radioresistance Oncogene 2007, 26, 7508-7516
32. Iftner, T.; Elbel, M.; Schopp, B.; Hiller, T.; Loizou, J. I.; Caldecott, K. W.; Stubenrauch, F. Interference of Papillomavirus E6 Protein with Single-Strand Break Repair by Interaction with XRCC1 EMBO J. 2002, 21, 4741-4748
33. Franken, N. A.; Rodermond, H. M.; Stap, J.; Haveman, J.; van Bree, C. Clonogenic Assay of Cells in Vitro Nat. Protoc. 2006, 1, 2315-2319
34. Chen, T. F.; Wong, Y. S. Selenocystine Induces Reactive Oxygen Species-Mediated Apoptosis in Human Cancer Cells Biomed. Pharmacother. 2009, 63, 105-113
35. Huang, Y.; He, L.; Liu, W.; Fan, C.; Zheng, W.; Wong, Y. S.; Chen, T. Selective Cellular Uptake and Induction of Apoptosis of Cancer-Targeted Selenium Nanoparticles Biomaterials 2013, 34, 7106-7116
36. Chen, T. F.; Wong, Y. S. Selenocystine Induces Caspase-Independent Apoptosis in MCF-7 Human Breast Carcinoma Cells with Involvement of p53 Phosphorylation and Reactive Oxygen Species Generation Int. J. Biochem. Cell Biol. 2009, 41, 666-676
37. Nagata, S. Apoptosis by Death Factor Cell. 1997, 88, 355-365
38. Thorburn, A. Death Receptor-Induced Cell Killing Cell Signalling 2004, 16, 139-44
39. Aggarwal, B. B. Signalling Pathways of the TNF Superfamily: A Double-Edged Sword Nat. Rev. Immunol. 2003, 3, 745-756
40. Hengartner, M. O. The Biochemistry of Apoptosis Nature 2000, 407, 770-776
41. Tay, C. Y.; Fang, W.; Setyawati, M. I.; Chia, S. L.; Tan, K. S.; Hong, C. H.; Leong, D. T. Nano-Hydroxyapatite and Nano-Titanium Dioxide Exhibit Different Subcellular Distribution and Apoptotic Profile in Human Oral Epithelium ACS Appl. Mater. Interfaces 2014, 6, 6248-6256
42. Tsukamoto, H.; Shibata, K.; Kajiyama, H.; Terauchi, M.; Nawa, A.; Kikkawa, F. Aminopeptidase N (APN)/CD13 Inhibitor, Ubenimex, Enhances Radiation Sensitivity in Human Cervical Cancer BMC Cancer 2008, 8, 1-8
43. Kim, J. G.; Bae, J. H.; Kim, J. A.; Heo, K.; Yang, K.; Yi, J. M. Combination Effect of Epigenetic Regulation and Iionizing Radiation in Colorectal Cancer Cells PloS one 2014, 9, 1-10
44. Pelicano, H.; Carney, D.; Huang, P. ROS Stress in Cancer Cells and Therapeutic Implications Drug Resist. Updates 2004, 7, 97-110
45. Zhang, X. D.; Luo, Z.; Chen, J.; Shen, X.; Song, S.; Sun, Y.; Fan, S.; Fan, F.; Leong, D. T.; Xie, J. Ultrasmall Au(10-12)(SG)(10-12) Nanomolecules for High Tumor Specificity and Cancer Radiotherapy Adv. Mater. 2014, 26, 4565-4568
46. Zhang, X. D.; Chen, J.; Luo, Z.; Wu, D.; Shen, X.; Song, S. S.; Sun, Y. M.; Liu, P. X.; Zhao, J.; Huo, S.; Fan, S.; Fan, F.; Liang, X. J.; Xie, J. Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy Adv. Healthcare Mater. 2014, 3, 133-141
47. Horie, M.; Kato, H.; Fujita, K.; Endoh, S.; Iwahashi, H. In Vitro Evaluation of Cellular Response Induced by Manufactured Nanoparticles Chem. Res. Toxicol. 2013, 25, 605-619
48. Setyawati, M. I.; Yuan, X.; Xie, J.; Leong, D. T. The Influence of Lysosomal Stability of Silver Nanomaterials on Their Toxicity to Human Cells Biomaterials 2013, 35, 6707-6715
49. Raingeaud, J.; Gupta, S.; Rogers, J. S.; Dickens, M.; Han, J.; Ulevitch, R. J.; Davis, R. J. Pro-Inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-Activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine J. Biol. Chem. 1995, 270, 7420-7426
50. Nam, S. Y.; Seo, H. H.; Park, H. S.; An, S.; Kim, J. Y.; Yang, K. H.; Kim, C. S.; Jeong, M.; Jin, Y. W. Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival After Ionizing Radiation J. Biol. Chem. 2010, 285, 31157-31163
51. Xia, S.; Zhao, Y.; Yu, S.; Zhang, M. Activated PI3K/AKT/COX-2 Pathway Induces Resistance to Radiation in Human Cervical Cancer Hela Cells Cancer Biother. Radiopharm. 2010, 25, 317-323
52. Fritz, G.; Brachetti, C.; Kaina, B. Lovastatin Causes Sensitization of Hela Cells to Ionizing Radiation-Induced Apoptosis by The Abrogation of G2 Blockage Int. J. Radiat. Biol. 2003, 79, 601-610