Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative

Chemico-Biological Interactions

Volumn 180, Issue 1, 2009, Pages 54-60

  Chen, Tianfeng ^a,b   Wong, Yum Shing ^b   Zheng, Wenjie ^a   Liu, Jie ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Caspase; Mitochondria; p53; Selenadiazole derivative; Selenium

Indexed keywords

ANTHRAX[1,2 C] [1,2,5]SELENADIAZOLO 6,11 DIONE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ORGANOSELENIUM DERIVATIVE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL XL; PROTEIN P53; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL DEATH; CELL POPULATION; CELL STRAIN MCF 7; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RNA INTERFERENCE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MODELS, MOLECULAR; ORGANOSELENIUM COMPOUNDS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 65349131815     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.12.010     Document Type: Article

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