Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: Role of tryptophan 102

Biochemical Journal

Volumn 425, Issue 1, 2010, Pages 265-274

  Esser, Julia ^a   Rakonjac, Marija ^a   Hofmann, Bettina ^b   Fischer, Lutz ^a,b   Provost, Patrick ^c   Schneider, Gisbert ^b   Steinhilber, Dieter ^b   Samuelsson, Bengt ^a   Radmark, Olof ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GOETHE UNIVERSITY   (Germany)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Arachidonic acid; Eicosanoid; Leukotriene; Oxylipin

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CELL CULTURE; PROTEINS;

ARACHIDONIC ACIDS; DIFFERENTIATED CELLS; EICOSANOID; LEUKOTRIENE; OXYLIPINS; STABILIZING EFFECTS; SUBCELLULAR LOCALIZATIONS; TRYPTOPHAN RESIDUES;

CELLS;

ARACHIDONATE 5 LIPOXYGENASE; CHAPERONE; COACTOSIN LIKE PROTEIN; TRYPTOPHAN; TRYPTOPHAN 102; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

EID: 72449124354     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090856     Document Type: Article

References (43)

1. Samuelsson, B. (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575
2. Peters-Golden, M. and Henderson, Jr, W. R. (2007) Leukotrienes. N. Engl. J. Med. 357, 1841-1854
3. Werz, O. and Steinhilber, D. (2006) Therapeutic options for 5-lipoxygenase inhibitors. Pharmacol. Ther. 112, 701-718
4. Chen, Y., Hu, Y., Zhang, H., Peng, C. and Li, S. (2009) Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat. Genet. 41, 783-792
5. Choi, J., Chon, J. K., Kim, S. and Shin, W. (2008) Conformational flexibility in mammalian 15S-lipoxygenase: reinterpretation of the crystallographic data. Proteins 70, 1023-1032
6. Gillmor, S. A., Villasenor, A., Fletterick, R., Sigal, E. and Browner, M. F. (1997) The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat. Struct. Biol. 4, 1003-1009
7. Rådmark, O., Werz, O., Steinhilber, D. and Samuelsson, B. (2007) 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem. Sci. 32, 332-341
8. Peters-Golden, M. and Brock, T. G. (2003) 5-lipoxygenase and FLAP. Prostaglandins Leukot. Essent. Fatty Acids 69, 99-109
9. Pergola, C., Dodt, G., Rossi, A., Neunhoeffer, E., Lawrenz, B., Northoff, H., Samuelsson, B., Rådmark, O., Sautebin, L. and Werz, O. (2008) ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Proc. Natl. Acad. Sci. U.S.A. 105, 19881-19886
10. de Hostos, E. L., Bradtke, B., Lottspeich, F. and Gerisch, G. (1993) Coactosin, a 17 kDa F-actin binding protein from Dictyostelium discoideum. Cell Motil. Cytoskeleton 26, 181-191
11. Provost, P., Samuelsson, B. and Rådmark, O. (1999) Interaction of 5-lipoxygenase with cellular proteins. Proc. Natl. Acad. Sci. U.S.A. 96, 1881-1885
12. Provost, P., Doucet, J., Hanmmarberg, T., Gerisch, G., Samuelsson, B. and Rådmark, O. (2001) 5-Lipoxygenase interacts with coactosin-like protein. J. Biol. Chem. 276, 16520-16527
13. Provost, P., Doucet, J., Stock, A., Gerisch, G., Samuelsson, B. and Rådmark, O. (2001) Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75. Biochem. J. 359, 255-263
14. Doucet, J., Provost, P., Samuelsson, B. and Rådmark, O. (2002) Molecular cloning and functional characterization of mouse coactosin-like protein. Biochem. Biophys. Res. Commun. 290, 783-789
15. Liepinsh, E., Rakonjac, M., Boissonneault, V., Provost, P., Samuelsson, B., Rådmark, O. and Otting, G. (2004) NMR structure of human coactosin-like protein. J. Biomol. NMR 30, 353-356
16. Rakonjac, M., Fischer, L., Provost, P., Werz, O., Steinhilber, D., Samuelsson, B. and Rådmark, O. (2006) Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc. Natl. Acad. Sci. U.S.A. 103, 13150-13155
17. Jin, E. H., Shim, S. C., Kim, H. G., Chae, S. C. and Chung, H. T. (2009) Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders. Exp. Mol. Med. 41, 354-361
18. Feisst, C., Pergola, C., Rakonjac, M., Rossi, A., Koeberle, A., Dodt, G., Hoffmann, M., Hoernig, C., Fischer, L., Steinhilber, D. et al. (2009) Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cell. Mol. Life Sci. 66, 2759-2771
19. Hammarberg, T., Provost, P., Persson, B. and Rådmark, O. (2000) The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity. J. Biol. Chem. 275, 38787-38793
20. Zhang, Y. Y., Hammarberg, T., Rådmark, O., Samuelsson, B., Ng, C. F., Funk, C. D. and Loscalzo, J. (2000) Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences. Biochem. J. 351, 697-707
21. Park, C. and Marqusee, S. (2005) Pulse proteolysis: a simple method for quantitative determination of protein stability and ligand binding. Nat. Methods 2, 207-212
22. Werz, O., Klemm, J., Samuelsson, B. and Rådmark, O. (2001) Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes. Blood 97, 2487-2495
23. Comeau, S. R., Gatchell, D. W., Vajda, S. and Camacho, C. J. (2004) ClusPro: an automated docking and discrimination method for the prediction of protein complexes. Bioinformatics 20, 45-50
24. Mandell, J. G., Roberts, V. A., Pique, M. E., Kotlovyi, V., Mitchell, J. C., Nelson, E., Tsigelny, I. and Ten Eyck, L. F. (2001) Protein docking using continuum electrostatics and geometric fit. Protein Eng. 14, 105-113
25. Ten Eyck, L. F., Mandell, J. G., Roberts, V. A. and Pique, M. E. (1995) Surveying Molecular Interactions With DOT, Proceedings of the 1995 ACM/ IEEE Supercomputing Conference, San Diego, IEEE Computer Society Press, Los Alamitos, CA
26. Werz, O., Tretiakova, I., Michel, A., Ulke-Lemee, A., Hornig, M., Franke, L., Schneider, G., Samuelsson, B., Rådmark, O. and Steinhilber, D. (2005) Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. Proc. Natl. Acad. Sci. U.S.A. 102, 13164-13169
27. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S. and Karplus, M. (1983) CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. Comp. Chem. 4, 187-217
28. Kulkarni, S., Das, S., Funk, C. D., Murray, D. and Cho, W. (2002) Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase. J. Biol. Chem. 277, 13167-13174
29. Rådmark, O. (2002) Arachidonate 5-lipoxygenase. Prostaglandins Other Lipid Mediat. 68-69, 211-234
30. Law, D. S., Ten Eyck, L. F., Katzenelson, O., Tsigelny, I., Roberts, V. A., Pique, M. E. and Mitchell, J. C. (2003) Finding needles in haystacks: reranking DOT results by using shape complementarity, cluster analysis, and biological information. Proteins 52, 33-40
31. Dai, H., Huang, W., Xu, J., Yao, B., Xiong, S., Ding, H., Tang, Y., Liu, H., Wu, J. and Shi, Y. (2006) Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. Biochim. Biophys. Acta 1764, 1688-1700
32. Denis, D., Falgueyret, J. P., Riendeau, D. and Abramovitz, M. (1991) Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors. J. Biol. Chem. 266, 5072-5079
33. Hogaboom, G. K., Cook, M., Newton, J. F., Varrichio, A., Shorr, R. G., Sarau, H. M. and Crooke, S. T. (1986) Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities. Mol. Pharmacol. 30, 510-519
34. Pande, A. H., Moe, D., Nemec, K. N., Qin, S., Tan, S. and Tatulian, S. A. (2004) Modulation of human 5-lipoxygenase activity by membrane lipids. Biochemistry 43, 14653-14666
35. Rouzer, C. A. and Samuelsson, B. (1985) On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors. Proc. Natl. Acad. Sci. U.S.A. 82, 6040-6044
36. Walther, M., Wiesner, R. and Kuhn, H. (2004) Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium. J. Biol. Chem. 279, 3717-3725
37. Pande, A. H., Qin, S. and Tatulian, S. A. (2005) Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase. Biophys. J. 88, 4084-4094
38. Okamoto, H., Hammarberg, T., Zhang, Y. Y., Persson, B., Watanabe, T., Samuelsson, B. and Rådmark, O. (2005) Mutation analysis of the human 5-lipoxygenase C-terminus: Support for a stabilizing C-terminal loop. Biochim. Biophys. Acta 1749, 123-131
39. Allard, J. B. and Brock, T. G. (2005) Structural organization of the regulatory domain of human 5-lipoxygenase. Curr. Protein Pept. Sci. 6, 125-131
40. Hammel, M., Walther, M., Prassl, R. and Kuhn, H. (2004) Structural flexibility of the N-terminal β-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding. J. Mol. Biol. 343, 917-929
41. Bindu, P. H., Sastry, G. M. and Sastry, G. N. (2004) Characterization of calcium and magnesium binding domains of human 5-lipoxygenase. Biochem. Biophys. Res. Commun. 320, 461-467
42. Heinrikson, R. L. (1977) Applications of thermolysin in protein structural analysis. Methods Enzymol. 47, 175-189
43. Sudharshan, E., Srinivasulu, S. and Rao, A. G. A. (2000) pH-induced domain interaction and conformational transitions of lipoxygenase-1. Biochim. Biophys. Acta 1480, 13-22