메뉴 건너뛰기




Volumn 16, Issue 4, 2014, Pages

UPA and PAI-1 as biomarkers in breast cancer: Validated for clinical use in level-of-evidence-1 studies

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; PLASMINOGEN ACTIVATOR INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE; ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 84910070390     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/s13058-014-0428-4     Document Type: Review
Times cited : (220)

References (99)
  • 3
    • 33745102306 scopus 로고    scopus 로고
    • Estrogen receptors: role in breast cancer
    • Duffy MJ. Estrogen receptors: role in breast cancer. Crit Rev Clin Lab Sci 2006, 43:325-347. 10.1080/10408360600739218, 16769596.
    • (2006) Crit Rev Clin Lab Sci , vol.43 , pp. 325-347
    • Duffy, M.J.1
  • 4
    • 84873993908 scopus 로고    scopus 로고
    • Current approaches and future directions in the treatment of HER2-positive breast cancer
    • Hurvitz SA, Hu Y, O'Brien N, Finn RS. Current approaches and future directions in the treatment of HER2-positive breast cancer. Cancer Treat Rev 2013, 39:219-229. 10.1016/j.ctrv.2012.04.008, 3835685, 22658319.
    • (2013) Cancer Treat Rev , vol.39 , pp. 219-229
    • Hurvitz, S.A.1    Hu, Y.2    O'Brien, N.3    Finn, R.S.4
  • 6
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • Simon RM, Paik S, Hayes DF. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 2009, 101:1446-1452. 10.1093/jnci/djp335, 2782246, 19815849.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 7
    • 0035918882 scopus 로고    scopus 로고
    • Randomized adjuvant chemotherapy trial in high-risk node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1
    • Jänicke F, Prechtl A, Thomssen C, Harbeck N, Meisner C, Untch M, Sweep CG, Selbmann HK, Graeff H, Schmitt M. Randomized adjuvant chemotherapy trial in high-risk node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1. J Natl Cancer Inst 2001, 93:913-992. 10.1093/jnci/93.12.913, 11416112.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 913-992
    • Jänicke, F.1    Prechtl, A.2    Thomssen, C.3    Harbeck, N.4    Meisner, C.5    Untch, M.6    Sweep, C.G.7    Selbmann, H.K.8    Graeff, H.9    Schmitt, M.10
  • 9
    • 84876691969 scopus 로고    scopus 로고
    • Ten-year analysis of the prospective multicenter Chemo-N0 trial validates American Society of Clinical Oncology (ASCO)-recommended biomarkers uPA and PAI-1 for therapy decision making in node-negative breast cancer patients
    • Harbeck N, Schmitt M, Meisner C, Friedel C, Untch M, Schmidt M, Sweep CG, Lisboa BW, Lux MP, Beck T, Hasmüller S, Kiechle M, Jänicke F, Thomssen C. Ten-year analysis of the prospective multicenter Chemo-N0 trial validates American Society of Clinical Oncology (ASCO)-recommended biomarkers uPA and PAI-1 for therapy decision making in node-negative breast cancer patients. Eur J Cancer 2013, 49:1825-1835. 10.1016/j.ejca.2013.01.007, 23490655.
    • (2013) Eur J Cancer , vol.49 , pp. 1825-1835
    • Harbeck, N.1    Schmitt, M.2    Meisner, C.3    Friedel, C.4    Untch, M.5    Schmidt, M.6    Sweep, C.G.7    Lisboa, B.W.8    Lux, M.P.9    Beck, T.10    Hasmüller, S.11    Kiechle, M.12    Jänicke, F.13    Thomssen, C.14
  • 10
    • 0347917028 scopus 로고    scopus 로고
    • The urokinase plasminogen activation system: role in malignancy
    • Duffy MJ. The urokinase plasminogen activation system: role in malignancy. Curr Pharm Des 2004, 10:39-49. 10.2174/1381612043453559, 14754404.
    • (2004) Curr Pharm Des , vol.10 , pp. 39-49
    • Duffy, M.J.1
  • 12
    • 80051691520 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator and the generation of inhibitors of urokinase activity and signaling
    • Carriero MV, Stoppelli MP. The urokinase-type plasminogen activator and the generation of inhibitors of urokinase activity and signaling. Curr Pharm Des 2011, 17:1944-1961. 10.2174/138161211796718143, 21711235.
    • (2011) Curr Pharm Des , vol.17 , pp. 1944-1961
    • Carriero, M.V.1    Stoppelli, M.P.2
  • 14
    • 84910103160 scopus 로고    scopus 로고
    • the Peptidase Database
    • MEROPS - the Peptidase Database. http://merops.sanger.ac.uk/cgi-bin/speccards?sp=sp001823;type=peptidase
  • 16
    • 84869069142 scopus 로고    scopus 로고
    • Cell surface remodeling by plasmin: a new function for an old enzyme
    • Deryugina EI, Quigley JP. Cell surface remodeling by plasmin: a new function for an old enzyme. J Biomed Biotechnol 2012, 5:64259.
    • (2012) J Biomed Biotechnol , vol.5 , pp. 64259
    • Deryugina, E.I.1    Quigley, J.P.2
  • 17
    • 77951151605 scopus 로고    scopus 로고
    • Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
    • Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P. Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation. J Cell Mol Med 2009, 13:4587-4595. 10.1111/j.1582-4934.2008.00521.x, 19210287.
    • (2009) J Cell Mol Med , vol.13 , pp. 4587-4595
    • Tjwa, M.1    Moura, R.2    Moons, L.3    Plaisance, S.4    De Mol, M.5    Jansen, S.6    Dewerchin, M.7    Verfaillie, C.8    Carmeliet, P.9
  • 19
    • 84878280950 scopus 로고    scopus 로고
    • Urokinase plasminogen activator receptor: a functional integrator of extracellular proteolysis, cell adhesion, and signal transduction
    • Ferraris GM, Sidenius N. Urokinase plasminogen activator receptor: a functional integrator of extracellular proteolysis, cell adhesion, and signal transduction. Semin Thromb Hemost 2013, 39:347-355. 10.1055/s-0033-1334485, 23532573.
    • (2013) Semin Thromb Hemost , vol.39 , pp. 347-355
    • Ferraris, G.M.1    Sidenius, N.2
  • 20
    • 20444478292 scopus 로고    scopus 로고
    • Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator
    • Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem 2005, 280:17449-17457. 10.1074/jbc.M413141200, 15728176.
    • (2005) J Biol Chem , vol.280 , pp. 17449-17457
    • Jo, M.1    Thomas, K.S.2    Marozkina, N.3    Amin, T.J.4    Silva, C.M.5    Parsons, S.J.6    Gonias, S.L.7
  • 21
    • 20044363847 scopus 로고    scopus 로고
    • Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta
    • Kiyan J, Kiyan R, Haller H, Dumler I. Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta. EMBO J 2005, 24:1787-1797. 10.1038/sj.emboj.7600669, 1142599, 15889147.
    • (2005) EMBO J , vol.24 , pp. 1787-1797
    • Kiyan, J.1    Kiyan, R.2    Haller, H.3    Dumler, I.4
  • 22
    • 84873278736 scopus 로고    scopus 로고
    • UPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLF-receptors
    • Montuori N, Cosimato V, Rinaldi L, Rea VE, Alfano D, Ragno P. uPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLF-receptors. Thromb Haemost 2013, 109:309-318. 10.1160/TH12-08-0546, 23238745.
    • (2013) Thromb Haemost , vol.109 , pp. 309-318
    • Montuori, N.1    Cosimato, V.2    Rinaldi, L.3    Rea, V.E.4    Alfano, D.5    Ragno, P.6
  • 24
    • 63849278644 scopus 로고    scopus 로고
    • The urokinase receptor as an entertainer of signal transduction
    • D'Alessio S, Blasi F. The urokinase receptor as an entertainer of signal transduction. Front Biosci 2009, 14:4575-4587.
    • (2009) Front Biosci , vol.14 , pp. 4575-4587
    • D'Alessio, S.1    Blasi, F.2
  • 25
    • 0023711754 scopus 로고    scopus 로고
    • Kinetics of inhibition of tissue-type and urokinase-type plasminogen activator by plasminogen-activator inhibitor type 1 and type 2
    • Thorsen S, Philips M, Selmer J, Lecander I, Astedt B. Kinetics of inhibition of tissue-type and urokinase-type plasminogen activator by plasminogen-activator inhibitor type 1 and type 2. Eur J Biochem 2008, 175:33-39.
    • (2008) Eur J Biochem , vol.175 , pp. 33-39
    • Thorsen, S.1    Philips, M.2    Selmer, J.3    Lecander, I.4    Astedt, B.5
  • 27
    • 0030926412 scopus 로고    scopus 로고
    • Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
    • Nykjaer A, Conese M, Christensen EI, Olson D, Cremona O, Gliemann J, Blasi F. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J 1997, 16:2610-2620. 10.1093/emboj/16.10.2610, 1169872, 9184208.
    • (1997) EMBO J , vol.16 , pp. 2610-2620
    • Nykjaer, A.1    Conese, M.2    Christensen, E.I.3    Olson, D.4    Cremona, O.5    Gliemann, J.6    Blasi, F.7
  • 30
    • 0021045628 scopus 로고
    • Antibodies to plasminogen activator inhibits human tumor metastasis
    • Ossowski L. Antibodies to plasminogen activator inhibits human tumor metastasis. Cell 1983, 35:611-619. 10.1016/0092-8674(83)90093-4, 6418388.
    • (1983) Cell , vol.35 , pp. 611-619
    • Ossowski, L.1
  • 31
    • 80053458622 scopus 로고    scopus 로고
    • Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells
    • 3182273, 21969814
    • Bekes EM, Deryugina EI, Kupriyanova TA, Zajac E, Botkjaer KA, Andreasen PA, Quigley JP. Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells. Neoplasia 2011, 13:806-821. 3182273, 21969814.
    • (2011) Neoplasia , vol.13 , pp. 806-821
    • Bekes, E.M.1    Deryugina, E.I.2    Kupriyanova, T.A.3    Zajac, E.4    Botkjaer, K.A.5    Andreasen, P.A.6    Quigley, J.P.7
  • 32
    • 84887488313 scopus 로고    scopus 로고
    • SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis
    • Masuda T, Hattori N, Senoo T, Akita S, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N. SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol Cancer Ther 2013, 12:2378-2388. 10.1158/1535-7163.MCT-13-0041, 23990114.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2378-2388
    • Masuda, T.1    Hattori, N.2    Senoo, T.3    Akita, S.4    Ishikawa, N.5    Fujitaka, K.6    Haruta, Y.7    Murai, H.8    Kohno, N.9
  • 34
    • 4644247804 scopus 로고    scopus 로고
    • Host-derived plasminogen activator-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
    • Bajou K, Maillard C, Jost M, Lijnen RH, Gils A, Declerck P, Carmeliet P, Foidart JM, Noel A. Host-derived plasminogen activator-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. Oncogene 2004, 23:6986-6990. 10.1038/sj.onc.1207859, 15286708.
    • (2004) Oncogene , vol.23 , pp. 6986-6990
    • Bajou, K.1    Maillard, C.2    Jost, M.3    Lijnen, R.H.4    Gils, A.5    Declerck, P.6    Carmeliet, P.7    Foidart, J.M.8    Noel, A.9
  • 36
    • 0034014726 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis
    • Kwaan HC, Wang J, Svoboda K, Declerck PJ. Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis. Br J Cancer 2000, 82:1702-1708. 10.1054/bjoc.2000.1207, 2374508, 10817507.
    • (2000) Br J Cancer , vol.82 , pp. 1702-1708
    • Kwaan, H.C.1    Wang, J.2    Svoboda, K.3    Declerck, P.J.4
  • 37
    • 84867293505 scopus 로고    scopus 로고
    • Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function
    • Fang H, Placencio VR, DeClerck YA. Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function. J Natl Cancer Inst 2012, 104:1470-84. 10.1093/jnci/djs377, 3529616, 22984202.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1470-1484
    • Fang, H.1    Placencio, V.R.2    DeClerck, Y.A.3
  • 38
    • 16644362231 scopus 로고    scopus 로고
    • Identification, validation, and clinical implementation of tumor-associated biomarkers to improve therapy concepts, survival, and quality of life of cancer patients: tasks of the Receptor and Biomarker Group of the European Organization for Research and Treatment of Cancer
    • Schmitt M, Harbeck N, Daidone MG, Brynner N, Duffy MJ, Foekens JA, Sweep FC. Identification, validation, and clinical implementation of tumor-associated biomarkers to improve therapy concepts, survival, and quality of life of cancer patients: tasks of the Receptor and Biomarker Group of the European Organization for Research and Treatment of Cancer. Int J Oncol 2004, 25:1397-406.
    • (2004) Int J Oncol , vol.25 , pp. 1397-1406
    • Schmitt, M.1    Harbeck, N.2    Daidone, M.G.3    Brynner, N.4    Duffy, M.J.5    Foekens, J.A.6    Sweep, F.C.7
  • 42
    • 77953402793 scopus 로고    scopus 로고
    • ASCO-recommended prognostic factors uPA/PAI-1 in node-negative (N0) breast cancer patients (pts) compared to clinicopathological risk assessment within the NNBC 3-Europe trial NNBC-3 Trial Group
    • ASCO Annual Meeting Proceedings (Post-Meeting Edition)
    • Thomssen C, Vetter M, Schmidt M, Veyret C, Meisner C, von Minckwitz G, Martin P, Sweep CG, Paepke D, Harbeck N. ASCO-recommended prognostic factors uPA/PAI-1 in node-negative (N0) breast cancer patients (pts) compared to clinicopathological risk assessment within the NNBC 3-Europe trial NNBC-3 Trial Group. J Clin Oncol 2009, 27(Suppl):544. ASCO Annual Meeting Proceedings (Post-Meeting Edition).
    • (2009) J Clin Oncol , vol.27 , Issue.Suppl , pp. 544
    • Thomssen, C.1    Vetter, M.2    Schmidt, M.3    Veyret, C.4    Meisner, C.5    von Minckwitz, G.6    Martin, P.7    Sweep, C.G.8    Paepke, D.9    Harbeck, N.10
  • 43
    • 84858169566 scopus 로고    scopus 로고
    • Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development
    • Poste G, Carbone DP, Parkinson DR, Verweij J, Hewitt SM, Jessup JM. Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development. Clin Cancer Res 2012, 18:1515-1523. 10.1158/1078-0432.CCR-11-2206, 3307147, 22422403.
    • (2012) Clin Cancer Res , vol.18 , pp. 1515-1523
    • Poste, G.1    Carbone, D.P.2    Parkinson, D.R.3    Verweij, J.4    Hewitt, S.M.5    Jessup, J.M.6
  • 44
    • 0023140631 scopus 로고
    • Do proteases play a role in cancer invasion and metastasis?
    • Duffy MJ. Do proteases play a role in cancer invasion and metastasis?. Eur J Cancer Clin Oncol 1987, 23:583-589. 10.1016/0277-5379(87)90326-9, 3308476.
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 583-589
    • Duffy, M.J.1
  • 46
    • 0024428950 scopus 로고
    • Urokinase-type plasminogen activator antigen and early relapse in breast cancer
    • Jänicke F, Schmitt M, Ulm K, Gössner W, Graeff H. Urokinase-type plasminogen activator antigen and early relapse in breast cancer. Lancet 1989, 2:1049. 10.1016/S0140-6736(89)91070-2, 2572788.
    • (1989) Lancet , vol.2 , pp. 1049
    • Jänicke, F.1    Schmitt, M.2    Ulm, K.3    Gössner, W.4    Graeff, H.5
  • 48
    • 0025995880 scopus 로고
    • Clinical relevance of the urokinase-type and tissue-type plasminogen activators and their type 1 inhibitor in breast cancer
    • Jänicke F, Schmitt M, Graeff H. Clinical relevance of the urokinase-type and tissue-type plasminogen activators and their type 1 inhibitor in breast cancer. Sem Thromb Hemostasis 1991, 17:303-312.
    • (1991) Sem Thromb Hemostasis , vol.17 , pp. 303-312
    • Jänicke, F.1    Schmitt, M.2    Graeff, H.3
  • 51
    • 43249099314 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 is the most significant of the usual tissue prognostic factors in node-negative breast ductal adenocarcinoma independent of urokinase-type plasminogen activator
    • Descotes F, Riche B, Saez S, De Laroche G, Datchary J, Roy P, Andre J, Bobin JY. Plasminogen activator inhibitor type 1 is the most significant of the usual tissue prognostic factors in node-negative breast ductal adenocarcinoma independent of urokinase-type plasminogen activator. Clin Breast Cancer 2008, 8:168-177. 10.3816/CBC.2008.n.018, 18621614.
    • (2008) Clin Breast Cancer , vol.8 , pp. 168-177
    • Descotes, F.1    Riche, B.2    Saez, S.3    De Laroche, G.4    Datchary, J.5    Roy, P.6    Andre, J.7    Bobin, J.Y.8
  • 53
    • 0027223048 scopus 로고
    • High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinoma are associated with poor prognosis
    • Grondahl-Hansen J, Christensen IJ, Rosenquist C, Brünner N, Mouridsen HT, Danø K, Blichert-Toft M. High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinoma are associated with poor prognosis. Cancer Res 1993, 53:2513-2521.
    • (1993) Cancer Res , vol.53 , pp. 2513-2521
    • Grondahl-Hansen, J.1    Christensen, I.J.2    Rosenquist, C.3    Brünner, N.4    Mouridsen, H.T.5    Danø, K.6    Blichert-Toft, M.7
  • 54
    • 0028127825 scopus 로고
    • Prognostic role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas
    • Bouchet C, Spyratos F, Martin P-M, Hacène K, Gentile A, Oglobine J. Prognostic role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas. Br J Cancer 1994, 69:398-405. 10.1038/bjc.1994.74, 1968685, 8297742.
    • (1994) Br J Cancer , vol.69 , pp. 398-405
    • Bouchet, C.1    Spyratos, F.2    Martin, P.-M.3    Hacène, K.4    Gentile, A.5    Oglobine, J.6
  • 55
    • 0008060092 scopus 로고
    • PAI-1 and PAI-2 levels as predictors in staging malignancy in breast cancer
    • CRC Press, Boca Raton, FL, Glas-Greenwalt P
    • Sumiyoshi K, Urano T, Takada Y, Takada A. PAI-1 and PAI-2 levels as predictors in staging malignancy in breast cancer. Fibrinolysis in Disease 1995, 26-30. CRC Press, Boca Raton, FL, Glas-Greenwalt P.
    • (1995) Fibrinolysis in Disease , pp. 26-30
    • Sumiyoshi, K.1    Urano, T.2    Takada, Y.3    Takada, A.4
  • 56
    • 0029950191 scopus 로고    scopus 로고
    • Urokinase plasminogen activator, a strong independent prognostic factor in breast cancer: analysed in steroid receptor cytosols with a luminometric immunoassay
    • Ferno M, Bendahl PO, Borg A, Brundell J, Hirschberg L, Olsson H, Killander D. Urokinase plasminogen activator, a strong independent prognostic factor in breast cancer: analysed in steroid receptor cytosols with a luminometric immunoassay. Eur J Cancer 1996, 32A:793-801. 10.1016/0959-8049(95)00652-4, 9081356.
    • (1996) Eur J Cancer , vol.32 A , pp. 793-801
    • Ferno, M.1    Bendahl, P.O.2    Borg, A.3    Brundell, J.4    Hirschberg, L.5    Olsson, H.6    Killander, D.7
  • 58
    • 0030703165 scopus 로고    scopus 로고
    • Cellular localisation of urokinase-type plasminogen activator, its inhibitors and their mRNA in breast cancer tissue
    • Umeda T, Eguchi Y, Okino K, Kodama M, Hattori T. Cellular localisation of urokinase-type plasminogen activator, its inhibitors and their mRNA in breast cancer tissue. J Pathol 1997, 183:388-397. 10.1002/(SICI)1096-9896(199712)183:4<388::AID-PATH943>3.0.CO;2-I, 9496254.
    • (1997) J Pathol , vol.183 , pp. 388-397
    • Umeda, T.1    Eguchi, Y.2    Okino, K.3    Kodama, M.4    Hattori, T.5
  • 59
  • 60
  • 61
    • 2642705008 scopus 로고    scopus 로고
    • Prognostic impact of urokinase-type plasminogen activator (uPA), PA inhibitor type-1 and tissue-type PA antigen levels in node-negative breast cancer: a prospective study on multicenter basis
    • Kim SJ, Shiba E, Kobayashi T, Yayoi E, Furukawa J, Takatsuka Y, Shin E, Koyama H, Inaji H, Takai S. Prognostic impact of urokinase-type plasminogen activator (uPA), PA inhibitor type-1 and tissue-type PA antigen levels in node-negative breast cancer: a prospective study on multicenter basis. Clin Cancer Res 1998, 4:177-182.
    • (1998) Clin Cancer Res , vol.4 , pp. 177-182
    • Kim, S.J.1    Shiba, E.2    Kobayashi, T.3    Yayoi, E.4    Furukawa, J.5    Takatsuka, Y.6    Shin, E.7    Koyama, H.8    Inaji, H.9    Takai, S.10
  • 62
    • 0031660713 scopus 로고    scopus 로고
    • Prognostic significance of stromelysin 3, gelatinase A and urokinase expression in breast cancer
    • Tetu B, Brisson J, Lapointe H. Prognostic significance of stromelysin 3, gelatinase A and urokinase expression in breast cancer. Human Pathol 1998, 29:979-985.
    • (1998) Human Pathol , vol.29 , pp. 979-985
    • Tetu, B.1    Brisson, J.2    Lapointe, H.3
  • 64
    • 0031974329 scopus 로고    scopus 로고
    • Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols define a group of node-negative breast cancer patients with low risk of recurrence
    • Kute TE, Grondahl-Hansen J, Shao S-M, Long R, Russell G, Brünner N. Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols define a group of node-negative breast cancer patients with low risk of recurrence. Breast Cancer Res Treat 1998, 47:9-16. 10.1023/A:1005882520982, 9493971.
    • (1998) Breast Cancer Res Treat , vol.47 , pp. 9-16
    • Kute, T.E.1    Grondahl-Hansen, J.2    Shao, S.-M.3    Long, R.4    Russell, G.5    Brünner, N.6
  • 65
    • 0032938496 scopus 로고    scopus 로고
    • Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: a multicenter study
    • Broet P, Spyratos F, Romain S, Quillien V, Daver A, Ricolleau G, Rallet A, Toulas C, Asselain B. Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: a multicenter study. Br J Cancer 1999, 80:536-545. 10.1038/sj.bjc.6690389, 2362331, 10408864.
    • (1999) Br J Cancer , vol.80 , pp. 536-545
    • Broet, P.1    Spyratos, F.2    Romain, S.3    Quillien, V.4    Daver, A.5    Ricolleau, G.6    Rallet, A.7    Toulas, C.8    Asselain, B.9
  • 67
    • 0035300764 scopus 로고    scopus 로고
    • S-phase fraction and urokinase plasminogen activator are better markers for distant recurrences than Nottingham Prognostic Index and histological grade in a prospective study of premenopausal lymph node-negative breast cancer
    • Malmstrom P, Bendahl P-O, Boiesen P, Brünner N, Idvall I, Fernö M. S-phase fraction and urokinase plasminogen activator are better markers for distant recurrences than Nottingham Prognostic Index and histological grade in a prospective study of premenopausal lymph node-negative breast cancer. J Clin Oncol 2001, 19:2010-2019.
    • (2001) J Clin Oncol , vol.19 , pp. 2010-2019
    • Malmstrom, P.1    Bendahl, P.-O.2    Boiesen, P.3    Brünner, N.4    Idvall, I.5    Fernö, M.6
  • 69
    • 0032944657 scopus 로고    scopus 로고
    • Risk-group discrimination in node-negative breast cancer using invasion and proliferation markers: 6-year median follow-up
    • Harbeck N, Dettmar C, Thomssen C, Berger U, Ulm K, Kates R, Höfler H, Jänicke F, Graeff H, Schmitt M. Risk-group discrimination in node-negative breast cancer using invasion and proliferation markers: 6-year median follow-up. Br J Cancer 1999, 80:419-426. 10.1038/sj.bjc.6690373, 2362313, 10408848.
    • (1999) Br J Cancer , vol.80 , pp. 419-426
    • Harbeck, N.1    Dettmar, C.2    Thomssen, C.3    Berger, U.4    Ulm, K.5    Kates, R.6    Höfler, H.7    Jänicke, F.8    Graeff, H.9    Schmitt, M.10
  • 70
    • 0033869134 scopus 로고    scopus 로고
    • Nonlinear discriminant analysis and prognostic factor classification in node-negative primary breast cancer using probabilistic neural networks
    • Le Goff JM, Lavayssiere L, Rouesse J, Spyratos F. Nonlinear discriminant analysis and prognostic factor classification in node-negative primary breast cancer using probabilistic neural networks. Anticancer Res 2000, 20:2213-2218.
    • (2000) Anticancer Res , vol.20 , pp. 2213-2218
    • Le Goff, J.M.1    Lavayssiere, L.2    Rouesse, J.3    Spyratos, F.4
  • 72
    • 0037083657 scopus 로고    scopus 로고
    • Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualised therapy in primary breast cancer is greatest when used in combination
    • Harbeck N, Kates RE, Schmitt M. Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualised therapy in primary breast cancer is greatest when used in combination. J Clin Oncol 2002, 20:1000-1007. 10.1200/JCO.20.4.1000, 11844823.
    • (2002) J Clin Oncol , vol.20 , pp. 1000-1007
    • Harbeck, N.1    Kates, R.E.2    Schmitt, M.3
  • 73
    • 0027082979 scopus 로고
    • Urokinase plasminogen activator (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer
    • Jänicke F, Schmitt M, Pache L, Ulm K, Harbeck N, Höfler H, Graeff H. Urokinase plasminogen activator (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer. Breast Cancer Res Treat 1993, 24:195-208. 10.1007/BF01833260, 8435475.
    • (1993) Breast Cancer Res Treat , vol.24 , pp. 195-208
    • Jänicke, F.1    Schmitt, M.2    Pache, L.3    Ulm, K.4    Harbeck, N.5    Höfler, H.6    Graeff, H.7
  • 74
    • 0028114470 scopus 로고
    • Urokinase plasminogen activator as a prognostic marker in different subgroups of patients with breast cancer
    • Duffy MJ, Reilly D, McDermott EW, O'Higgins N, Fennelly JJ, Andreasen PA. Urokinase plasminogen activator as a prognostic marker in different subgroups of patients with breast cancer. Cancer 1994, 74:2276-2280. 10.1002/1097-0142(19941015)74:8<2276::AID-CNCR2820740811>3.0.CO;2-7, 7922979.
    • (1994) Cancer , vol.74 , pp. 2276-2280
    • Duffy, M.J.1    Reilly, D.2    McDermott, E.W.3    O'Higgins, N.4    Fennelly, J.J.5    Andreasen, P.A.6
  • 78
    • 0033945556 scopus 로고    scopus 로고
    • The role of cathepsin D and PAI-1 in primary invasive breast cancer as prognosticators and predictors of treatment with adjuvant tamoxifen
    • Billgren AM, Ritqvist LE, Johansson H, Hägerström T, Skoog L. The role of cathepsin D and PAI-1 in primary invasive breast cancer as prognosticators and predictors of treatment with adjuvant tamoxifen. Eur J Cancer 2000, 36:1374-1380. 10.1016/S0959-8049(00)00114-3, 10899650.
    • (2000) Eur J Cancer , vol.36 , pp. 1374-1380
    • Billgren, A.M.1    Ritqvist, L.E.2    Johansson, H.3    Hägerström, T.4    Skoog, L.5
  • 79
    • 0037102368 scopus 로고    scopus 로고
    • Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424)
    • Harbeck N, Kates RE, Look MP, Meijer-Van Gelder ME, Klijn JG, Krüger A, Kiechle M, Jänicke F, Schmitt M, Foekens JA. Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424). Cancer Res 2002, 62:4617-4622.
    • (2002) Cancer Res , vol.62 , pp. 4617-4622
    • Harbeck, N.1    Kates, R.E.2    Look, M.P.3    Meijer-Van Gelder, M.E.4    Klijn, J.G.5    Krüger, A.6    Kiechle, M.7    Jänicke, F.8    Schmitt, M.9    Foekens, J.A.10
  • 80
    • 1642475133 scopus 로고    scopus 로고
    • Predictive impact of urokinase-type plasminogen activator: plasminogen activator inhibitor type-1 complex on the efficacy of adjuvant systemic therapy in primary breast cancer
    • Manders P, Tjan-Heijnen VC, Span PN, Grebenchtchikov N, Foekens JA, Beex LV, Sweep CG. Predictive impact of urokinase-type plasminogen activator: plasminogen activator inhibitor type-1 complex on the efficacy of adjuvant systemic therapy in primary breast cancer. Cancer Res 2004, 64:659-664. 10.1158/0008-5472.CAN-03-1820, 14744782.
    • (2004) Cancer Res , vol.64 , pp. 659-664
    • Manders, P.1    Tjan-Heijnen, V.C.2    Span, P.N.3    Grebenchtchikov, N.4    Foekens, J.A.5    Beex, L.V.6    Sweep, C.G.7
  • 81
    • 77953120317 scopus 로고    scopus 로고
    • High levels of uPA and PAI-1 predict a good response to anthracyclines
    • Borstnar S, Sadikov A, Mozina B, Cufer T. High levels of uPA and PAI-1 predict a good response to anthracyclines. Breast Cancer Res Treat 2010, 121:615-624. 10.1007/s10549-009-0691-8, 20039121.
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 615-624
    • Borstnar, S.1    Sadikov, A.2    Mozina, B.3    Cufer, T.4
  • 82
    • 38649120281 scopus 로고    scopus 로고
    • Pooled analysis (n = 8,377) evaluates predictive impact of uPA and PAI-1 for response to adjuvant therapy in breast cancer
    • Harbeck N, Kates RE, Look MP, Foekens JA. Pooled analysis (n = 8,377) evaluates predictive impact of uPA and PAI-1 for response to adjuvant therapy in breast cancer. J Clin Oncol 2004, 23:523.
    • (2004) J Clin Oncol , vol.23 , pp. 523
    • Harbeck, N.1    Kates, R.E.2    Look, M.P.3    Foekens, J.A.4
  • 84
    • 84892865263 scopus 로고    scopus 로고
    • Molecular and protein markers for clinical decision making in breast cancer: today and tomorrow
    • Harbeck N, Sotlar K, Wuerstlein R, Doisneau-Sixou S. Molecular and protein markers for clinical decision making in breast cancer: today and tomorrow. Cancer Treat Rev 2014, 40:434-444. 10.1016/j.ctrv.2013.09.014, 24138841.
    • (2014) Cancer Treat Rev , vol.40 , pp. 434-444
    • Harbeck, N.1    Sotlar, K.2    Wuerstlein, R.3    Doisneau-Sixou, S.4
  • 85
    • 84863103557 scopus 로고    scopus 로고
    • Prospective comparison of risk assessment tools in early breast cancer (recurrence score, uPA/PAI-1, central grade, and luminal subtypes): final correlation analysis from the phase III WSG-plan B trial
    • S4-S3
    • Gluz O, Kreipe H, Degenhardt T, Christgen M, Kates R, Liedtke C, Shak S, Clemens M, Markmann S, Uleer C, Augustin D, Thomssen C, Nitz U, Harbeck N. Prospective comparison of risk assessment tools in early breast cancer (recurrence score, uPA/PAI-1, central grade, and luminal subtypes): final correlation analysis from the phase III WSG-plan B trial. Cancer Res 2011, 71(24 Suppl):S4-3.
    • (2011) Cancer Res , vol.71 , Issue.24 SUPPL
    • Gluz, O.1    Kreipe, H.2    Degenhardt, T.3    Christgen, M.4    Kates, R.5    Liedtke, C.6    Shak, S.7    Clemens, M.8    Markmann, S.9    Uleer, C.10    Augustin, D.11    Thomssen, C.12    Nitz, U.13    Harbeck, N.14
  • 86
    • 36849069347 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • Harris L, Fritsche H, Mennel R, Norton L, Ravdin P, Taube S, Somerfield MR, Hayes DF, Bast RC. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol 2007, 25:5287-5312. 10.1200/JCO.2007.14.2364, 17954709.
    • (2007) J Clin Oncol , vol.25 , pp. 5287-5312
    • Harris, L.1    Fritsche, H.2    Mennel, R.3    Norton, L.4    Ravdin, P.5    Taube, S.6    Somerfield, M.R.7    Hayes, D.F.8    Bast, R.C.9
  • 90
    • 84910061248 scopus 로고    scopus 로고
    • TRANSIT-Informationsseite
    • TRANSIT-Informationsseite. http://www.agoonline.de/fileadmin/downloads/leitlinien/mamma/march2012/06_2012E_Prognostic_and_Predictive_Factors.pdf
  • 92
    • 84884157423 scopus 로고    scopus 로고
    • Optimized immunohistochemistry in combination with image analysis: a reliable alternative to quantitative ELISA determination of uPA and PAI-1 for routine risk group discrimination in breast cancer
    • Lang DS, Heilenkötter U, Schumm W, Behrens O, Simon R, Vollmer E, Goldmann T. Optimized immunohistochemistry in combination with image analysis: a reliable alternative to quantitative ELISA determination of uPA and PAI-1 for routine risk group discrimination in breast cancer. Breast 2013, 22:736-743. 10.1016/j.breast.2012.12.011, 23332148.
    • (2013) Breast , vol.22 , pp. 736-743
    • Lang, D.S.1    Heilenkötter, U.2    Schumm, W.3    Behrens, O.4    Simon, R.5    Vollmer, E.6    Goldmann, T.7
  • 95
    • 0035884636 scopus 로고    scopus 로고
    • Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer
    • Goldhirsch A, Glick JH, Gelber RD, Coates AS, Senn HJ. Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer. J Clin Oncol 2001, 19:3817-3827.
    • (2001) J Clin Oncol , vol.19 , pp. 3817-3827
    • Goldhirsch, A.1    Glick, J.H.2    Gelber, R.D.3    Coates, A.S.4    Senn, H.J.5
  • 96
    • 84910061247 scopus 로고    scopus 로고
    • Evaluating efficacy of anthracycline-free chemotherapy in primary HER2-negative breast cancer after molecular-based risk assessment according to Oncotype DX and uPA/PAI-1
    • Degenhardt T, Gluz O, Kreipe H, Henschen S, Clemens MR, Salem M, Thomssen C, Kreipe H, Harbeck N, Nitz U. Evaluating efficacy of anthracycline-free chemotherapy in primary HER2-negative breast cancer after molecular-based risk assessment according to Oncotype DX and uPA/PAI-1. J Clin Oncol 2011, 29(Suppl):10594.
    • (2011) J Clin Oncol , vol.29 , Issue.Suppl , pp. 10594
    • Degenhardt, T.1    Gluz, O.2    Kreipe, H.3    Henschen, S.4    Clemens, M.R.5    Salem, M.6    Thomssen, C.7    Kreipe, H.8    Harbeck, N.9    Nitz, U.10
  • 97
    • 56249141809 scopus 로고    scopus 로고
    • Experience in phase I trials and an upcoming phase II study with upa inhibitors in metastatic breast cancer
    • Goldstein LJ. Experience in phase I trials and an upcoming phase II study with upa inhibitors in metastatic breast cancer. Breast Care (Basel) 2008, 3:25-28. 10.1159/000151733, 2930999, 20824011.
    • (2008) Breast Care (Basel) , vol.3 , pp. 25-28
    • Goldstein, L.J.1
  • 98
    • 84910090446 scopus 로고    scopus 로고
    • A randomized double-blind phase II study of the combination of oral WX-671 plus capecitabine versus capecitabine monotherapy in first-line HER2-negative metastatic breast cancer (MBC)
    • Goldstein LJ, Oliveira CT, Heinrich B, Stemmer SM, Mala C, Selder S, Bevan P, Harbeck N. A randomized double-blind phase II study of the combination of oral WX-671 plus capecitabine versus capecitabine monotherapy in first-line HER2-negative metastatic breast cancer (MBC). J Clin Oncol 2013, 31(Suppl):508.
    • (2013) J Clin Oncol , vol.31 , Issue.Suppl , pp. 508
    • Goldstein, L.J.1    Oliveira, C.T.2    Heinrich, B.3    Stemmer, S.M.4    Mala, C.5    Selder, S.6    Bevan, P.7    Harbeck, N.8
  • 99
    • 84875215526 scopus 로고    scopus 로고
    • Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer
    • Heinemann V, Ebert MP, Laubender RP, Bevan P, Mala C, Boeck S. Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer. Br J Cancer 2013, 108:766-770. 10.1038/bjc.2013.62, 3590684, 23412098.
    • (2013) Br J Cancer , vol.108 , pp. 766-770
    • Heinemann, V.1    Ebert, M.P.2    Laubender, R.P.3    Bevan, P.4    Mala, C.5    Boeck, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.