Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme

Journal of Biological Chemistry

Volumn 289, Issue 44, 2014, Pages 30690-30701

  Coelho, Fernando R ^a   Iqbal, Asif ^a   Linares, Edlaine ^a   Silva, Daniel F ^a   Lima, Filipe S ^a   Cuccovia, Iolanda M ^a   Augusto, Ohara ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; GLYCOPROTEINS; OXYGEN;

ALS PATIENTS; AMYOTROPHIC LATERAL SCLEROSIS; MOST LIKELY; OXIDATION PRODUCTS; PEROXIDASE ACTIVITIES; POST-TRANSLATIONAL MODIFICATIONS; SUPER OXIDE DISMUTASE;

OXIDATION;

ALANINE; AMYLOID; BICARBONATE; COPPER ZINC SUPEROXIDE DISMUTASE; DIMER; DITRYPTOPHAN; GLYCINE; KYNURENINE; PEROXIDASE; PROTEIN TRYPTOPHAN 32; TEMPOL; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; SUPEROXIDE DISMUTASE;

ARTICLE; COVALENT BOND; ENZYME ACTIVITY; ENZYME METABOLISM; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN CROSS LINKING; PROTEIN PROCESSING; PROTEIN UNFOLDING; WILD TYPE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; PROTEIN CARBONYLATION; PROTEIN MULTIMERIZATION; PROTEINOSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BICARBONATES; HUMANS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CARBONYLATION; PROTEIN MULTIMERIZATION; SUPEROXIDE DISMUTASE; TRYPTOPHAN;

EID: 84910067736     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.586370     Document Type: Article

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