The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol

Biochemical Journal

Volumn 455, Issue 1, 2013, Pages 37-46

  Queiroz, Raphael F ^a,b   Paviani, Verônica ^a   Coelho, Fernando R ^a   Marques, Emerson F ^a   Mascio, Paolo Di ^a   Augusto, Ohara ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE ESTADUAL DO SUDOESTE DA BAHIA   (Brazil)

Author keywords

Bicarbonate dependent peroxidase activity of hSOD1; Cyclic nitroxide; HSOD1 carbonylation; HSOD1 covalent dimerization; Non native hSOD1 form; Tempol.

Indexed keywords

BICARBONATE; CARBONIC ACID; COPPER ZINC SUPEROXIDE DISMUTASE; HYDROGEN PEROXIDE; PENTETIC ACID; PEROXIDASE; TEMPOL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARBONYLATION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; IN VITRO STUDY; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; RAT; SPINAL CORD; SURVIVAL;

BICARBONATES; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ASSAYS; ESCHERICHIA COLI; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; PEPTIDES; PEROXIDASES; PROTEIN CARBONYLATION; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPIN LABELS; SUPEROXIDE DISMUTASE;

EID: 84884257701     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130180     Document Type: Article

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