Affinity-based drug delivery systems for tissue repair and regeneration

Biomacromolecules

Volumn 15, Issue 11, 2014, Pages 3867-3880

  Vulic, Katarina ^a   Shoichet, Molly S ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG DELIVERY; ENDOTHELIAL CELLS; FUNCTIONAL POLYMERS; MATHEMATICAL MODELS; POLYSACCHARIDES; PROTEINS; REPAIR; SCAFFOLDS (BIOLOGY); TISSUE;

AFFINITY INTERACTIONS; AFFINITY-BASED DRUG DELIVERY SYSTEMS; DNA-PROTEIN INTERACTION; FIBROBLAST GROWTH FACTOR-2; HEPARIN-BINDING PROTEINS; POLYMERIC MATRICES; TRANSIENT INTERACTIONS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

TISSUE REGENERATION;

APTAMER; CYCLODEXTRIN; DNA; HEPARIN; HEPARIN BINDING PROTEIN; MOLECULARLY IMPRINTED POLYMER; NANOPARTICLE; POLYMER; PROTEIN BINDING; SIGNAL PEPTIDE;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CHEMICAL REACTION KINETICS; DEGRADATION; DIELS ALDER REACTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; EXTRACELLULAR MATRIX; HUMAN; HYDROPHOBICITY; IMMUNE RESPONSE; MATHEMATICAL MODEL; NONHUMAN; POLYMERIZATION; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; STATIC ELECTRICITY; SUSTAINED DRUG RELEASE; TISSUE REGENERATION; TISSUE REPAIR; ANIMAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; PROCEDURES; REGENERATION; TISSUE ENGINEERING; TISSUE SCAFFOLD;

ANIMALS; DRUG DELIVERY SYSTEMS; HEPARIN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; REGENERATION; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84910028342     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm501084u     Document Type: Article

References (103)

1. Langer, R. Drug delivery and targeting Nature 1998, 392 (6679) 5-10
2. Biondi, M.; Ungaro, F.; Quaglia, F.; Netti, P. A. Controlled drug delivery in tissue engineering Adv. Drug Delivery Rev. 2008, 60 (2) 229-242
3. Chen, R.; Mooney, D. Polymeric growth factor delivery strategies for tissue engineering Pharm. Res. 2003, 20 (8) 1103-1112
4. Babensee, J. E.; McIntire, L. V.; Mikos, A. G. Growth factor delivery for tissue engineering Pharm. Res. 2000, 17 (5) 497-504
5. Jain, J. P.; Yenet Ayen, W.; Domb, A. J.; Kumar, N. Biodegradable Polymers in Drug Delivery. In Biodegrad. Polym. Clin. Use Clin. Dev.; John Wiley & Sons, Inc.: New York, 2011; pp 1-58.
6. Siepmann, J.; Siepmann, F. Swelling Controlled Drug Delivery Systems. In Fundamentals and Applications of Controlled Release Drug Delivery; Siepmann, J.; Siegel, R. A.; Rathbone, M. J., Eds.; Springer: New York, 2012; pp 153-170.
7. Soppimath, K. S.; Aminabhavi, T. M.; Kulkarni, A. R.; Rudzinski, W. E. Biodegradable polymeric nanoparticles as drug delivery devices J. Controlled Release 2001, 70 (1-2) 1-20
8. Mohammadi-Samani, S.; Taghipour, B. PLGA micro and nanoparticles in delivery of peptides and proteins; problems and approaches Pharm. Dev. Technol. 2014, 1-9
9. Ulery, B. D.; Nair, L. S.; Laurencin, C. T. Biomedical applications of biodegradable polymers J. Polym. Sci., Part B: Polym. Phys. 2011, 49 (12) 832-864
10. Lu, J.; Liong, M.; Zink, J. I.; Tamanoi, F. Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs Small 2007, 3 (8) 1341-1346
11. Baumann, M. D.; Kang, C. E.; Stanwick, J. C.; Wang, Y.; Kim, H.; Lapitsky, Y.; Shoichet, M. S. An injectable drug delivery platform for sustained combination therapy J. Controlled Release 2009, 138 (3) 205-213
12. Danhier, F.; Ansorena, E.; Silva, J. M.; Coco, R.; Le Breton, A.; Preat, V. PLGA-based nanoparticles: An overview of biomedical applications J. Controlled Release 2012, 161 (2) 505-522
13. Fu, K.; Klibanov, A. M.; Langer, R. Protein stability in controlled-release systems Nat. Biotechnol. 2000, 18 (1) 24-25
14. van de Weert, M.; Hennink, W.; Jiskoot, W. Protein instability in poly(lactic- co -glycolic acid) microparticles Pharm. Res. 2000, 17 (10) 1159-1167
15. Vulic, K.; Shoichet, M. S. Tunable growth factor delivery from injectable hydrogels for tissue engineering J. Am. Chem. Soc. 2012, 134 (2) 882-885
16. Vulic, K.; Pakulska, M. P.; Sonthalia, R.; Ramachandran, A.; Shoichet, M. S., Mathematical model accurately predicts protein release from an affinity-based delivery system. J. Controlled Release, submitted for publication, 2014.
17. Wang, N. X.; von Recum, H. A. Affinity-based drug delivery Macromol. Biosci. 2011, 11 (3) 321-332
18. Vermonden, T.; Censi, R.; Hennink, W. E. Hydrogels for protein delivery Chem. Rev. 2012, 112 (5) 2853-2888
19. Doane, T.; Burda, C. Nanoparticle mediated non-covalent drug delivery Adv. Drug Delivery Rev. 2013, 65 (5) 607-621
20. Fan, T.-H.; Soontornworajit, B.; Karzar-Jeddi, M.; Zhang, X.; Wang, Y. An aptamer-functionalized hydrogel for controlled protein release: A modeling study Soft Matter 2011, 7 (19) 9326-9334
21. Fu, A. S.; Thatiparti, T. R.; Saidel, G. M.; von Recum, H. A. Experimental studies and modeling of drug release from a tunable affinity-based drug delivery platform Ann. Biomed. Eng. 2011, 39 (9) 2466-75
22. Koehler, K. C.; Anseth, K. S.; Bowman, C. N. Diels-Alder mediated controlled release from a poly(ethylene glycol) based hydrogel Biomacromolecules 2013, 14 (2) 538-47
23. Lin, C. C.; Metters, A. T. Enhanced protein delivery from photopolymerized hydrogels using a pseudospecific metal chelating ligand Pharm. Res. 2006, 23 (3) 614-22
24. Lin, C. C.; Metters, A. T. Metal-chelating affinity hydrogels for sustained protein release J. Biomed. Mater. Res., Part A 2007, 83 (4) 954-64
25. Maxwell, D. J.; Hicks, B. C.; Parsons, S.; Sakiyama-Elbert, S. E. Development of rationally designed affinity-based drug delivery systems Acta Biomater. 2005, 1 (1) 101-113
26. Sakiyama-Elbert, S. E.; Hubbell, J. A. Development of fibrin derivatives for controlled release of heparin-binding growth factors J. Controlled Release 2000, 65 (3) 389-402
27. Wood, M. D.; Sakiyama-Elbert, S. E. Release rate controls biological activity of nerve growth factor released from fibrin matrices containing affinity-based delivery systems J. Biomed. Mater. Res., Part A 2008, 84A (2) 300-312
28. Taylor, S. J.; McDonald Iii, J. W.; Sakiyama-Elbert, S. E. Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury J. Controlled Release 2004, 98 (2) 281-294
29. Vo, T. T. N.; Meere, M. G. Minimizing the passive release of heparin-binding growth factors from an affinity-based delivery system Math. Med. Biol. 2013, 30 (4) 357-382
30. Liang, Y.; Kiick, K. L. Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications Acta Biomater. 2014, 10 (4) 1588-1600
31. Sakiyama-Elbert, S. E. Incorporation of heparin into biomaterials Acta Biomater. 2014, 10 (4) 1581-1587
32. Rabenstein, D. L. Heparin and heparan sulfate: structure and function Nat. Prod. Rep. 2002, 19 (3) 312-331
33. Edelman, E. R.; Mathiowitz, E.; Langer, R.; Klagsbrun, M. Controlled and modulated release of basic fibroblast growth factor Biomaterials 1991, 12 (7) 619-626
34. Cai, S.; Liu, Y.; Zheng Shu, X.; Prestwich, G. D. Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor Biomaterials 2005, 26 (30) 6054-6067
35. Pike, D. B.; Cai, S.; Pomraning, K. R.; Firpo, M. A.; Fisher, R. J.; Shu, X. Z.; Prestwich, G. D.; Peattie, R. A. Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF Biomaterials 2006, 27 (30) 5242-5251
36. Peattie, R. A.; Pike, D. B.; Yu, B.; Cai, S.; Shu, X. Z.; Prestwich, G. D.; Firpo, M. A.; Fisher, R. J. Effect of gelatin on heparin regulation of cytokine release from hyaluronan-based hydrogels Drug Delivery 2008, 15 (6) 389-397
37. Osmond, R. I. W.; Kett, W. C.; Skett, S. E.; Coombe, D. R. Protein-heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization Anal. Biochem. 2002, 310 (2) 199-207
38. Elia, R.; Fuegy, P. W.; VanDelden, A.; Firpo, M. A.; Prestwich, G. D.; Peattie, R. A. Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels Biomaterials 2010, 31 (17) 4630-4638
39. Chung, H.; Kim, H.; Yoon, J.; Park, T. Heparin immobilized porous PLGA microspheres for angiogenic growth factor delivery Pharm. Res. 2006, 23 (8) 1835-1841
40. Chung, Y.-I.; Tae, G.; Hong Yuk, S. A facile method to prepare heparin-functionalized nanoparticles for controlled release of growth factors Biomaterials 2006, 27 (12) 2621-2626
41. Tae, G.; Scatena, M.; Stayton, P. S.; Hoffman, A. S. PEG-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor J. Biomater. Sci., Polym. Ed. 2006, 17 (1-2) 187-197
42. Lee, J. S.; Go, D. H.; Bae, J. W.; Lee, S. J.; Park, K. D. Heparin conjugated polymeric micelle for long-term delivery of basic fibroblast growth factor J. Controlled Release 2007, 117 (2) 204-209
43. Nie, T.; Baldwin, A.; Yamaguchi, N.; Kiick, K. L. Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems J. Controlled Release 2007, 122 (3) 287-296
44. Lu, Y.; Jiang, H.; Tu, K.; Wang, L. Mild immobilization of diverse macromolecular bioactive agents onto multifunctional fibrous membranes prepared by coaxial electrospinning Acta Biomater. 2009, 5 (5) 1562-1574
45. Rajangam, K.; Behanna, H. A.; Hui, M. J.; Han, X.; Hulvat, J. F.; Lomasney, J. W.; Stupp, S. I. Heparin binding nanostructures to promote growth of blood vessels Nano Lett. 2006, 6 (9) 2086-2090
46. Ho, Y.-C.; Mi, F.-L.; Sung, H.-W.; Kuo, P.-L. Heparin-functionalized chitosan-alginate scaffolds for controlled release of growth factor Int. J. Pharm. 2009, 376 (1-2) 69-75
47. Chen, L.; He, Z.; Chen, B.; Yang, M.; Zhao, Y.; Sun, W.; Xiao, Z.; Zhang, J.; Dai, J. Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold J. Mater. Sci.: Mater. Med. 2010, 21 (1) 309-317
48. Sakiyama-Elbert, S. E.; Hubbell, J. A. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix J. Controlled Release 2000, 69 (1) 149-158
49. Manning, C. N.; Schwartz, A. G.; Liu, W.; Xie, J.; Havlioglu, N.; Sakiyama-Elbert, S. E.; Silva, M. J.; Xia, Y.; Gelberman, R. H.; Thomopoulos, S. Controlled delivery of mesenchymal stem cells and growth factors using a nanofiber scaffold for tendon repair Acta Biomater. 2013, 9 (6) 6905-6914
50. Willerth, S. M.; Johnson, P. J.; Maxwell, D. J.; Parsons, S. R.; Doukas, M. E.; Sakiyama-Elbert, S. E. Rationally designed peptides for controlled release of nerve growth factor from fibrin matrices J. Biomed. Mater. Res., Part A 2007, 80A (1) 13-23
51. Wood, M. D.; Borschel, G. H.; Sakiyama-Elbert, S. E. Controlled release of glial-derived neurotrophic factor from fibrin matrices containing an affinity-based delivery system J. Biomed. Mater. Res., Part A 2009, 89A (4) 909-918
52. Menajovsky, L. B. Heparin-induced thrombocytopenia: clinical manifestations and management strategies Am. J. Med. 2005, 118 (8, Supplement) 21-30
53. Willerth, S. M.; Rader, A.; Sakiyama-Elbert, S. E. The effect of controlled growth factor delivery on embryonic stem cell differentiation inside fibrin scaffolds Stem Cell Res. 2008, 1 (3) 205-218
54. Mammadov, R.; Mammadov, B.; Toksoz, S.; Aydin, B.; Yagci, R.; Tekinay, A. B.; Guler, M. O. Heparin mimetic peptide nanofibers promote angiogenesis Biomacromolecules 2011, 12 (10) 3508-3519
55. Freeman, I.; Cohen, S. The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization Biomaterials 2009, 30 (11) 2122-2131
56. Freeman, I.; Kedem, A.; Cohen, S. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins Biomaterials 2008, 29 (22) 3260-3268
57. Ritger, P. L.; Peppas, N. A. A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs J. Controlled Release 1987, 5 (1) 23-36
58. Ruvinov, E.; Leor, J.; Cohen, S. The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model Biomaterials 2010, 31 (16) 4573-4582
59. Wang, N. X.; Sieg, S. F.; Lederman, M. M.; Offord, R. E.; Hartley, O.; von Recum, H. A. Using glycosaminoglycan/chemokine interactions for the long-term delivery of 5P12-RANTES in HIV prevention Mol. Pharmaceutics 2013, 10 (10) 3564-3573
60. Purcell, B. P.; Kim, I. L.; Chuo, V.; Guenin, T.; Dorsey, S. M.; Burdick, J. A. Incorporation of sulfated hyaluronic acid macromers into degradable hydrogel scaffolds for sustained molecule delivery Biomater. Sci. 2014, 2 (5) 693-702
61. Lin, C.-C.; Metters, A. Enhanced protein delivery from photopolymerized hydrogels using a pseudospecific metal chelating ligand Pharm. Res. 2006, 23 (3) 614-622
62. Lin, C.-C.; Metters, A. T. Metal-chelating affinity hydrogels for sustained protein release J. Biomed. Mater. Res., Part A 2007, 83A (4) 954-964
63. Lin, C.-C.; Metters, A. T. Bifunctional monolithic affinity hydrogels for dual-protein delivery Biomacromolecules 2008, 9 (3) 789-795
64. Branco, M. C.; Pochan, D. J.; Wagner, N. J.; Schneider, J. P. The effect of protein structure on their controlled release from an injectable peptide hydrogel Biomaterials 2010, 31 (36) 9527-9534
65. Lee, J. S.; Suarez-Gonzalez, D.; Murphy, W. L. Mineral coatings for temporally controlled delivery of multiple proteins Adv. Mater. 2011, 23 (37) 4279-4284
66. Yu, X.; Khalil, A.; Dang, P. N.; Alsberg, E.; Murphy, W. L. Multilayered inorganic microparticles for tunable dual growth factor delivery Adv. Funct. Mater. 2014, 24 (20) 3082-3093
67. Thatiparti, T. R.; Shoffstall, A. J.; von Recum, H. A. Cyclodextrin-based device coatings for affinity-based release of antibiotics Biomaterials 2010, 31 (8) 2335-2347
68. Thatiparti, T. R.; von Recum, H. A. Cyclodextrin complexation for affinity-based antibiotic delivery Macromol. Biosci. 2010, 10 (1) 82-90
69. Halpern, J. M.; Gormley, C. A.; Keech, M. A.; von Recum, H. A. Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system J. Mater. Chem. B 2014, 2 (18) 2764-2772
70. Challa, R.; Ahuja, A.; Ali, J.; Khar, R. K. Cyclodextrins in drug delivery: an updated review AAPS PharmSciTech 2005, 6 (2) E329-57
71. Vyas, A.; Saraf, S.; Saraf, S. Cyclodextrin based novel drug delivery systems J. Inclusion Phenom. Macrocyclic Chem. 2008, 62 (1-2) 23-42
72. Schreiber, G. Kinetic studies of protein-protein interactions Curr. Opin. Struct. Biol. 2002, 12 (1) 41-47
73. Stollar, E. J.; Garcia, B.; Chong, P. A.; Rath, A.; Lin, H.; Forman-Kay, J. D.; Davidson, A. R. Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p J. Biol. Chem. 2009, 284 (39) 26918-26927
74. Deyev, S. M.; Waibel, R.; Lebedenko, E. N.; Schubiger, A. P.; Pluckthun, A. Design of multivalent complexes using the barnase·barstar module Nat. Biotechnol. 2003, 21 (12) 1486-1492
75. Fan, J.; Xiao, Z.; Zhang, H.; Chen, B.; Tang, G.; Hou, X.; Ding, W.; Wang, B.; Zhang, P.; Dai, J.; Xu, R. Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promote axonal regeneration and partial functional recovery after complete spinal cord transection J. Neurotrauma 2010, 27 (9) 1671-1683
76. Lin, H.; Chen, B.; Sun, W.; Zhao, W.; Zhao, Y.; Dai, J. The effect of collagen-targeting platelet-derived growth factor on cellularization and vascularization of collagen scaffolds Biomaterials 2006, 27 (33) 5708-5714
77. Yang, Y.; Zhao, Y.; Chen, B.; Han, Q.; Sun, W.; Xiao, Z.; Dai, J. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds Tissue Eng., Part A 2009, 15 (11) 3589-3596
78. Andrades, J. A.; Han, B.; Becerra, J.; Sorgente, N.; Hall, F. L.; Nimni, M. E. A recombinant human TGF-β1 fusion protein with collagen-binding domain promotes migration, growth, and differentiation of bone marrow mesenchymal cells Exp. Cell Res. 1999, 250 (2) 485-498
79. Lin, C.-C.; Anseth, K. S. Controlling affinity binding with peptide-functionalized poly(ethylene glycol) hydrogels Adv. Funct. Mater. 2009, 19 (14) 2325-2331
80. Impellitteri, N. A.; Toepke, M. W.; Lan Levengood, S. K.; Murphy, W. L. Specific VEGF sequestering and release using peptide-functionalized hydrogel microspheres Biomaterials 2012, 33 (12) 3475-3484
81. Belair, D. G.; Khalil, A. S.; Miller, M. J.; Murphy, W. L. Serum-dependence of affinity-mediated VEGF release from biomimetic microspheres Biomacromolecules 2014, 15 (6) 2038-2048
82. Pakulska, M. M.; Vulic, K.; Shoichet, M. S. Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel J. Controlled Release 2013, 171 (1) 11-16
83. Mulyasasmita, W.; Cai, L.; Hori, Y.; Heilshorn, S. C. Avidity-controlled delivery of angiogenic peptides from injectable molecular-recognition hydrogels Tissue Eng., Part A 2014, 20 (15-16) 2102-14
84. Gelain, F.; Unsworth, L. D.; Zhang, S. Slow and sustained release of active cytokines from self-assembling peptide scaffolds J. Controlled Release 2010, 145 (3) 231-239
85. Martino, M. M.; Hubbell, J. A. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain FASEB J. 2010, 24 (12) 4711-4721
86. Martino, M. M.; Briquez, P. S.; Ranga, A.; Lutolf, M. P.; Hubbell, J. A. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix Proc. Natl. Acad. Sci. U.S.A. 2013, 110 (12) 4563-4568
87. Tan, W.; Wang, H.; Chen, Y.; Zhang, X.; Zhu, H.; Yang, C.; Yang, R.; Liu, C. Molecular aptamers for drug delivery Trends Biotechnol. 2011, 29 (12) 634-640
88. Hermann, T.; Patel, D. J. Adaptive Recognition by nucleic acid aptamers Science 2000, 287 (5454) 820-825
89. Soontornworajit, B.; Zhou, J.; Shaw, M. T.; Fan, T.-H.; Wang, Y. Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release Chem. Commun. 2010, 46 (11) 1857-1859
90. Soontornworajit, B.; Zhou, J.; Wang, Y. A hybrid particle-hydrogel composite for oligonucleotide-mediated pulsatile protein release Soft Matter 2010, 6 (17) 4255-4261
91. Soontornworajit, B.; Zhou, J.; Zhang, Z. Y.; Wang, Y. Aptamer-functionalized in situ injectable hydrogel for controlled protein release Biomacromolecules 2010, 11 (10) 2724-2730
92. Battig, M. R.; Soontornworajit, B.; Wang, Y. Programmable release of multiple protein drugs from aptamer-functionalized hydrogels via nucleic acid hybridization J. Am. Chem. Soc. 2012, 134 (30) 12410-12413
93. Zhang, X. L.; Soontornworajit, B.; Zhang, Z. Y.; Chen, N. C.; Wang, Y. Enhanced loading and controlled release of antibiotics using nucleic acids as an antibiotic-binding effector in hydrogels Biomacromolecules 2012, 13 (7) 2202-2210
94. Sundaram, P.; Wower, J.; Byrne, M. E. A nanoscale drug delivery carrier using nucleic acid aptamers for extended release of therapeutic Nanomed. Nanotechnol. Biol. Med. 2012, 8 (7) 1143-1151
95. Keefe, A. D.; Pai, S.; Ellington, A. Aptamers as therapeutics Nat. Rev. Drug Discovery 2010, 9 (7) 537-550
96. Soontornworajit, B.; Zhou, J.; Snipes, M. P.; Battig, M. R.; Wang, Y. Affinity hydrogels for controlled protein release using nucleic acid aptamers and complementary oligonucleotides Biomaterials 2011, 32 (28) 6839-6849
97. Butterfield, K. C.; Conovaloff, A. W.; Panitch, A. Development of affinity-based delivery of NGF from a chondroitin sulfate biomaterial Biomatter 2011, 1 (2) 174-81
98. Zhao, Y.; Zhang, J.; Wang, X.; Chen, B.; Xiao, Z.; Shi, C.; Wei, Z.; Hou, X.; Wang, Q.; Dai, J. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies J. Controlled Release 2010, 141 (1) 30-37
99. Alvarez-Lorenzo, C.; Concheiro, A. Molecularly imprinted polymers for drug delivery J. Chromatogr. B 2004, 804 (1) 231-245
100. Cunliffe, D.; Kirby, A.; Alexander, C. Molecularly imprinted drug delivery systems Adv. Drug Delivery Rev. 2005, 57 (12) 1836-1853
101. Puoci, F.; Cirillo, G.; Curcio, M.; Parisi, O. I.; Iemma, F.; Picci, N. Molecularly imprinted polymers in drug delivery: state of art and future perspectives Expert Opin. Drug Delivery 2011, 8 (10) 1379-1393
102. Abdouss, M.; Asadi, E.; Azodi-Deilami, S.; Beik-mohammadi, N.; Aslanzadeh, S. Development and characterization of molecularly imprinted polymers for controlled release of citalopram J. Mater. Sci.: Mater. Med. 2011, 22 (10) 2273-2281
103. Lulinski, P. Molecularly imprinted polymers as the future drug delivery devices Acta Polym. Pharm. 2013, 70 (4) 601-609