메뉴 건너뛰기




Volumn 44, Issue 12, 2014, Pages 1099-1107

Pharmacokinetics and tissue distribution of ginsenoside Rh2 and Rg3 epimers after oral administration of BST204, a purified ginseng dry extract, in rats

Author keywords

A purified ginseng dry extract; And R Rg3; BST204; Pharmacokinetics; R Rh2; Rats; S Rg3; S Rh2; Tissue distribution

Indexed keywords

BST 204; GINSENG EXTRACT; GINSENOSIDE RG 3; GINSENOSIDE RH 2; UNCLASSIFIED DRUG; BST204 GINSENG EXTRACT; GINSENOSIDE; PLANT EXTRACT;

EID: 84910008896     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2014.929192     Document Type: Article
Times cited : (26)

References (34)
  • 1
    • 0036370799 scopus 로고    scopus 로고
    • Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    • Bae EA, Han MJ, Choo MK, et al. (2002). Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 25:58-63.
    • (2002) Biol Pharm Bull , vol.25 , pp. 58-63
    • Bae, E.A.1    Han, M.J.2    Choo, M.K.3
  • 2
    • 84879228639 scopus 로고    scopus 로고
    • Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: Application to a pharmacokinetic study
    • Bae SH, Zheng YF, Yoo YH, et al. (2013). Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: application to a pharmacokinetic study. J Sep Sci 36:1904 -12.
    • (2013) J Sep Sci , vol.36 , pp. 1904-1912
    • Bae, S.H.1    Zheng, Y.F.2    Yoo, Y.H.3
  • 3
    • 0036207452 scopus 로고    scopus 로고
    • Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells
    • Fei XF, Wang BX, Tashiro S, et al. (2002). Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells. Acta Pharmacol Sin 23:315-22.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 315-322
    • Fei, X.F.1    Wang, B.X.2    Tashiro, S.3
  • 4
    • 84878179067 scopus 로고    scopus 로고
    • Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways
    • Gao JL, Lv GY, He BC, et al. (2013). Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways. Oncol Rep 30:292-8.
    • (2013) Oncol Rep , vol.30 , pp. 292-298
    • Gao, J.L.1    Lv, G.Y.2    He, B.C.3
  • 5
    • 68049127779 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs
    • Gu Y, Wang GJ, Sun JG, et al. (2009). Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. Food Chem Toxicol 47:2257-68.
    • (2009) Food Chem Toxicol , vol.47 , pp. 2257-2268
    • Gu, Y.1    Wang, G.J.2    Sun, J.G.3
  • 6
    • 33751169108 scopus 로고    scopus 로고
    • Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospray ionization mass spectrometry
    • Gu Y, Wang GJ, Sun JG, et al. (2006). Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospray ionization mass spectrometry. Anal Bioanal Chem 386: 2043-53.
    • (2006) Anal Bioanal Chem , vol.386 , pp. 2043-2053
    • Gu, Y.1    Wang, G.J.2    Sun, J.G.3
  • 7
    • 77955607007 scopus 로고    scopus 로고
    • Intestinal absorption mechanisms of ginsenoside Rh2: Stereoselectivity and involvement of ABC transporters
    • Gu Y, Wang GJ, Wu XL, et al. (2010). Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters. Xenobiotica 40:602-12.
    • (2010) Xenobiotica , vol.40 , pp. 602-612
    • Gu, Y.1    Wang, G.J.2    Wu, X.L.3
  • 8
    • 4644356962 scopus 로고    scopus 로고
    • Cancer prevention and therapeutics: Panax ginseng
    • Helms S. (2004). Cancer prevention and therapeutics: panax ginseng. Altern Med Rev 9:259-74.
    • (2004) Altern Med Rev , vol.9 , pp. 259-274
    • Helms, S.1
  • 9
    • 0037293063 scopus 로고    scopus 로고
    • Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kB activation and tumor promotion
    • 75-85
    • Keum YS, Ha n SS, Chun KS, et al. (2003). Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kB activation and tumor promotion. Mutat Res 523-524: 75-85.
    • (2003) Mutat Res , pp. 523-524
    • Keum, Y.S.1    Han, S.S.2    Chun, K.S.3
  • 10
    • 16544379730 scopus 로고    scopus 로고
    • Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells
    • Kim HS, Lee EH, Ko SR, et al. (2004). Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 27: 429-35.
    • (2004) Arch Pharm Res , vol.27 , pp. 429-435
    • Kim, H.S.1    Lee, E.H.2    Ko, S.R.3
  • 11
    • 0037212768 scopus 로고    scopus 로고
    • Reversal of P-glycoproteinmediated multidrug resistance by ginsenoside Rg3
    • Kim SW, Kwon HY, Chi DW, et al. (2003). Reversal of P-glycoproteinmediated multidrug resistance by ginsenoside Rg3. Biochem Pharmacol 65:75-82.
    • (2003) Biochem Pharmacol , vol.65 , pp. 75-82
    • Kim, S.W.1    Kwon, H.Y.2    Chi, D.W.3
  • 12
    • 0020550397 scopus 로고
    • Chemical studies on crude drug precession: 1 the constituents of ginseng radix rubra
    • Kitagawa I, Yoshikawa M, Yoshihara M, et al. (1983). Chemical studies on crude drug precession: 1. The constituents of ginseng radix rubra. Yakugaku Zasshi 103:612-22.
    • (1983) Yakugaku Zasshi , vol.103 , pp. 612-622
    • Kitagawa, I.1    Yoshikawa, M.2    Yoshihara, M.3
  • 13
    • 48649105424 scopus 로고    scopus 로고
    • The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing
    • Lee YJ, Kim HY, Kang KS, et al. (2008). The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing. Bioorg Med Chem Lett 18:4515-20.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 4515-4520
    • Lee, Y.J.1    Kim, H.Y.2    Kang, K.S.3
  • 14
    • 71049183577 scopus 로고    scopus 로고
    • Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
    • Liu H, Yang J, Du F, et al. (2009). Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metab Dispos 37:2290-8.
    • (2009) Drug Metab Dispos , vol.37 , pp. 2290-2298
    • Liu, H.1    Yang, J.2    Du, F.3
  • 15
    • 77956680962 scopus 로고    scopus 로고
    • Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells
    • Liu J, Shimizu K, Yu H, et al. (2010). Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells. Fitoterapia 81:902-5.
    • (2010) Fitoterapia , vol.81 , pp. 902-905
    • Liu, J.1    Shimizu, K.2    Yu, H.3
  • 16
    • 65749114119 scopus 로고    scopus 로고
    • 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgene sis inhibitor without any cytotoxicity
    • Liu J, Shiono J, Shimizu K, et al. (2009). 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgene sis inhibitor without any cytotoxicity. Bioorg Med Chem Lett 19:3320-3.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 3320-3323
    • Liu, J.1    Shiono, J.2    Shimizu, K.3
  • 17
    • 0030777703 scopus 로고    scopus 로고
    • Activation of caspase-3 protease via aBcl-2-insensitive pathway during the process of ginse noside Rh2-induced apoptosis
    • Park JA, Lee KY, Oh YJ, et al. (1997). Activation of caspase-3 protease via aBcl-2-insensitive pathway during the process of ginse noside Rh2-induced apoptosis. Cancer Lett 121:73-81.
    • (1997) Cancer Lett , vol.121 , pp. 73-81
    • Park, J.A.1    Lee, K.Y.2    Oh, Y.J.3
  • 18
    • 0036403187 scopus 로고    scopus 로고
    • Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leu kemia (THP-1) cell line
    • Popovich DG, Kitts DD. (2002). Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leu kemia (THP-1) cell line. Arch Biochem Biophys 406:1-8.
    • (2002) Arch Biochem Biophys , vol.406 , pp. 1-8
    • Popovich, D.G.1    Kitts, D.D.2
  • 19
    • 77955663174 scopus 로고    scopus 로고
    • American ginseng: Potential structure-function relationship in cancer chemoprevention
    • Qi LW, Wang CZ, Yuan CS. (2010). American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol 80:947-54.
    • (2010) Biochem Pharmacol , vol.80 , pp. 947-954
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 20
    • 79954627696 scopus 로고    scopus 로고
    • Ginsenosides from American ginseng: Chemical and pharmacological diversity
    • Qi LW,Wang CZ,Yuan CS., 2011, Ginsenosides from American ginseng: chemical and pharmacological diversity, Phytochemistry, 72, 689-99.
    • (2011) Phytochemistry , vol.72 , pp. 689-699
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 21
    • 12444277341 scopus 로고    scopus 로고
    • In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3
    • Qian T, Cai Z, Wong RN, et al. (2005). In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3. J Chromatogr B Analyt Technol Biomed Life Sci 816:223-32.
    • (2005) J Chromatogr B Analyt Technol Biomed Life Sci , vol.816 , pp. 223-232
    • Qian, T.1    Cai, Z.2    Wong, R.N.3
  • 22
    • 20144366833 scopus 로고    scopus 로고
    • Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages
    • Seo JY, Lee JH, Kim NW, et al. (2005a ). Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages. Int Immunopharmacol 5:929-36.
    • (2005) Int Immunopharmacol , vol.5 , pp. 929-936
    • Seo, J.Y.1    Lee, J.H.2    Kim, N.W.3
  • 23
    • 21044451729 scopus 로고    scopus 로고
    • Inhibitory effects of a fermented ginseng extract, BST204, on the expression of inducible nitric oxide synthase and nitric oxide production in lipopolysaccharide-activated murine macrophages
    • Seo JY, Lee JH, Kim NW, et al. (2005b ). Inhibitory effects of a fermented ginseng extract, BST204, on the expression of inducible nitric oxide synthase and nitric oxide production in lipopolysaccharide-activated murine macrophages. J Pharm Pharmacol 57:911-18.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 911-918
    • Seo, J.Y.1    Lee, J.H.2    Kim, N.W.3
  • 24
    • 0042526129 scopus 로고    scopus 로고
    • Degradation of ginsenosides in humans after oral administration
    • Tawab MA, Bahr U, Karas M, et al. (2003). Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 31:1065-71.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1065-1071
    • Tawab, M.A.1    Bahr, U.2    Karas, M.3
  • 25
    • 33645702638 scopus 로고    scopus 로고
    • Ginsenoside Rh2 enhances antitumour activity and decreases genotoxic effect of cyclophosphamide
    • Wang Z, Zheng Q, Liu K, et al. (2006). Ginsenoside Rh2 enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. Basic Clin Pharmacol Toxicol 98:411-15.
    • (2006) Basic Clin Pharmacol Toxicol , vol.98 , pp. 411-415
    • Wang, Z.1    Zheng, Q.2    Liu, K.3
  • 26
    • 84864005465 scopus 로고    scopus 로고
    • Stereospecificity of ginsenoside Rg3 in promotion of the immune response to ovalbumin in mice
    • Wei X, Chen J, Su F, et al. (2012a). Stereospecificity of ginsenoside Rg3 in promotion of the immune response to ovalbumin in mice. Int Immunol 24:465-71.
    • (2012) Int Immunol , vol.24 , pp. 465-471
    • Wei, X.1    Chen, J.2    Su, F.3
  • 27
    • 84861680914 scopus 로고    scopus 로고
    • Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice
    • Wei X, Su F, Su X, et al. (2012b). Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice. Fitoterapia 83:636-42.
    • (2012) Fitoterapia , vol.83 , pp. 636-642
    • Wei, X.1    Su, F.2    Su, X.3
  • 28
    • 0030308288 scopus 로고    scopus 로고
    • Differentiation of B16 melanoma cells induced by ginsenoside Rh2
    • Xia LJ, Han R. (1996). Differentiation of B16 melanoma cells induced by ginsenoside Rh2. Acta Pharm Sin 31:742-5.
    • (1996) Acta Pharm Sin , vol.31 , pp. 742-745
    • Xia, L.J.1    Han, R.2
  • 29
    • 84870383328 scopus 로고    scopus 로고
    • Implication of the stereoisomers of ginsenoside derivatives in the antiproliferative effect of HSC-T6 cells
    • Yang H, Yoo G, Kim HS, et al. (2012). Implication of the stereoisomers of ginsenoside derivatives in the antiproliferative effect of HSC-T6 cells. J Agric Food Chem 60:11759-64.
    • (2012) J Agric Food Chem , vol.60 , pp. 11759-11764
    • Yang, H.1    Yoo, G.2    Kim, H.S.3
  • 30
    • 28744443958 scopus 로고    scopus 로고
    • Effect of telomerase on ginsenoside Rh2-induced differentiation of hepatocarcinoma cell line SMMC-7721
    • Zeng XL, Tu ZG. (2004). Effect of telomerase on ginsenoside Rh2-induced differentiation of hepatocarcinoma cell line SMMC-7721. Chin J Cancer 23:1655-9.
    • (2004) Chin J Cancer , vol.23 , pp. 1655-1659
    • Zeng, X.L.1    Tu, Z.G.2
  • 31
    • 80052492263 scopus 로고    scopus 로고
    • Effects of 20 (S)-ginsenoside Rh2 and 20 (R)-ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cell
    • Zhang C, Yu H, Hou J. (2011). Effects of 20 (S)-ginsenoside Rh2 and 20 (R)-ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cell. Zhongguo Zhong Yao Za Zhi 36:1670-4.
    • (2011) Zhongguo Zhong Yao Za Zhi , vol.36 , pp. 1670-1674
    • Zhang, C.1    Yu, H.2    Hou, J.3
  • 32
    • 84860014033 scopus 로고    scopus 로고
    • Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics
    • Zhang J, Zhou F, Niu F, et al. (2012). Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. PLoS One 7:e35768.
    • (2012) PLoS One , vol.7 , pp. e35768
    • Zhang, J.1    Zhou, F.2    Niu, F.3
  • 33
    • 78649580065 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: A case for herb-drug interactions
    • Zhang J, Zhou F, Wu X, et al. (2010). 20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions. Drug Metab Dispos 38:2179-87.
    • (2010) Drug Metab Dispos , vol.38 , pp. 2179-2187
    • Zhang, J.1    Zhou, F.2    Wu, X.3
  • 34
    • 84910013142 scopus 로고    scopus 로고
    • Study on anti-tumor activity of Ginsenoside Rh2
    • Zhao Y, Su S. (2003). Study on anti-tumor activity of Ginsenoside Rh2. Chin J Microbiol 23:61-3.
    • (2003) Chin J Microbiol , vol.23 , pp. 61-63
    • Zhao, Y.1    Su, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.