Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: Application to a pharmacokinetic study

Journal of Separation Science

Volumn 36, Issue 12, 2013, Pages 1904-1912

  Bae, Soo Hyeon ^a   Zheng, Yu Fen ^b   Yoo, Young Hyo ^c   Kim, Jeom Yong ^c   Kim, Sun Ok ^c   Jang, Min Jung ^c   Seo, Jae Hong ^a   Bae, Soo Kyung ^a  

^a The Catholic University of Korea   (South Korea)

^b Seoul National University   (South Korea)

^c Green Cross Herb and Pharmaceutical Co Ltd   (South Korea)

Author keywords

Epimers; Ginsenosides; LC MS MS; Pharmacokinetics; Rat plasma

Indexed keywords

CHROMATOGRAPHIC SEPARATIONS; DETECTION AND QUANTIFICATIONS; EPIMERS; GINSENOSIDES; LC-MS/MS; LOWER LIMIT OF QUANTIFICATIONS; NEGATIVE ELECTROSPRAY IONIZATIONS; RAT PLASMA;

ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; PHARMACODYNAMICS; PHARMACOKINETICS;

BODY FLUIDS;

ACETONITRILE; FORMIC ACID; GINSENOSIDE RG 3; GINSENOSIDE RH 2;

ACCURACY; ARTICLE; CHEMICAL STRUCTURE; ELECTROSPRAY; EPIMER; FLOW RATE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETER; MASS SPECTROMETRY; MOLECULAR STABILITY; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; STEREOCHEMISTRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

PANAX GINSENG; RATTUS;

EID: 84879228639     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201300107     Document Type: Article

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