The Bile Acid-Sensitive Ion Channel (BASIC) Is activated by alterations of its membrane environment

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Schmidt, Axel ^a   Lenzig, Pia ^a   Oslender Bujotzek, Adrienne ^a   Kusch, Jana ^b   Lucas, Susana Dias ^c   Gründer, Stefan ^a   Wiemuth, Dominik ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; BILE ACID; BILE ACID SENSITIVE ION CHANNEL; CHLORPROMAZINE; GADOLINIUM; ION CHANNEL; PICRIC ACID; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; ACID SENSING ION CHANNEL; CHOLESTEROL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL MEMBRANE; CHIMERA; CONTROLLED STUDY; FEMALE; MEMBRANE BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SENSITIVITY ANALYSIS; ANIMAL; CHANNEL GATING; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOUSE; PROTEIN TERTIARY STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ACID SENSING ION CHANNELS; ANIMALS; BILE ACIDS AND SALTS; CELL MEMBRANE; CHLORPROMAZINE; CHOLESTEROL; GADOLINIUM; ION CHANNEL GATING; MICE; PICRATES; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; URSODEOXYCHOLIC ACID; XENOPUS LAEVIS;

EID: 84909993096     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111549     Document Type: Article

References (45)

1. Wiemuth D, Assmann M, Gründer S (2013) The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC. Channels (Austin) 8: 29-34.
2. Kellenberger S, Schild L (2002) Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 82: 735-767.
3. Jasti J, Furukawa H, Gonzales EB, Gouaux E (2007) Structure of acid-sensing ion channel 1 at 1.9 s resolution and low pH. Nature 449: 316-323.
4. +channel gene in mammals. J Physiol 519 Pt 2: 323-333.
5. Wiemuth D, Sahin H, Falkenburger BH, Lefevre CM, Wasmuth HE, et al. (2012) BASIC - A bile acid-sensitive ion channel highly expressed in bile ducts. FASEB J 26: 4122-4130.
6. Boiko N, Kucher V, Wang B, Stockand JD (2014) Restrictive expression of Acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. PLoS One 9: e91326.
7. + channel from human small intestine. FEBS Lett 471: 205-210.
8. + channel (BLINaC). J Biol Chem 285: 30404-30410.
9. + channel: inhibition by diarylamidines and activation by fenamates. Mol Pharmacol 80: 911-919.
10. Hofmann AF, Hagey LR (2008) Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 65: 2461-2483.
11. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, et al. (1999) Identification of a nuclear receptor for bile acids. Science 284: 1362-1365.
12. Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, et al. (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284: 1365-1368.
13. Schaap FG, Trauner M, Jansen PL (2014) Bile acid receptors as targets for drug development. Nat Rev Gastroenterol Hepatol 11: 55-67.
14. Wiemuth D, Sahin H, Lefevre CM, Wasmuth HE, Gründer S (2012) Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid. Channels (Austin) 7: 38-42.
15. Bassler EL, Ngo-Anh TJ, Geisler HS, Ruppersberg JP, Gründer S (2001) Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. J Biol Chem 276: 33782-33787.
16. Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein TW, et al. (2007) A peptide-gated ion channel from the freshwater polyp Hydra. J Biol Chem 282: 35098-35103.
17. Chen X, Paukert M, Kadurin I, Pusch M, Gründer S (2006) Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium. Neuropharmacology 50: 964-974.
18. Mello-Vieira J, Sousa T, Coutinho A, Fedorov A, Lucas SD, et al. (2013) Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations. Biochim Biophys Acta 1828: 2152-2163.
19. Biskup C, Kusch J, Schulz E, Nache V, Schwede F, et al. (2007) Relating ligand binding to activation gating in CNGA2 channels. Nature 446: 440-443.
20. Maingret F, Patel AJ, Lesage F, Lazdunski M, Honore E (2000) Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem 275: 10128-10133.
21. Lundbaek JA, Koeppe RE 2nd, Andersen OS (2010) Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proc Natl Acad Sci U S A 107: 15427-15430.
22. Martinac B, Adler J, Kung C (1990) Mechanosensitive ion channels of E. coli activated by amphipaths. Nature 348: 261-263.
23. Deuticke B (1968) Transformation and restoration of biconcave shape of human erythrocytes induced by amphiphilic agents and changes of ionic environment. Biochim Biophys Acta 163: 494-500.
24. Sheetz MP, Painter RG, Singer SJ (1976) Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes. J Cell Biol 70: 193-203.
25. Sheetz MP, Singer SJ (1974) Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc Natl Acad Sci U S A 71: 4457-4461.
26. Yang XC, Sachs F (1989) Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science 243: 1068-1071.
27. Hamill OP, McBride DW Jr (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol Rev 48: 231-252.
28. Hofmann AF (1994) Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand J Gastroenterol Suppl 204: 1-15.
29. Zheng J, Zagotta WN (2003) Patch-clamp fluorometry recording of conformational rearrangements of ion channels. Sci STKE 2003: PL7.
30. Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, et al. (2012) Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Sci Signal 5: ra48.
31. Wu S, Vysotskaya ZV, Xu X, Xie C, Liu Q, et al. (2011) State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry. Biophys J 100: 1226-1232.
32. Kusch J, Biskup C, Thon S, Schulz E, Nache V, et al. (2010) Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels. Neuron 67: 75-85.
33. Dürrnagel S, Kuhn A, Tsiairis CD, Williamson M, Kalbacher H, et al. (2010) Three homologous subunits form a high affinity peptide-gated ion channel in Hydra. J Biol Chem 285: 11958-11965.
34. Krueger B, Haerteis S, Yang L, Hartner A, Rauh R, et al. (2009) Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1. Cell Physiol Biochem 24: 605-618.
35. Macchiarulo A, Gioiello A, Thomas C, Pols TWH, Nuti R, et al. (2013) Probing the Binding Site of Bile Acids in TGR5. Acs Medicinal Chemistry Letters 4: 1158-1162.
36. Perozo E, Kloda A, Cortes DM, Martinac B (2002) Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nat Struct Biol 9: 696-703.
37. Hill K, Schaefer M (2007) TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem 282: 7145-7153.
38. Brohawn SG, Su Z, Mackinnon R (2014) Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. Proc Natl Acad Sci U S A 111: 3614-3619.
39. Dart C (2010) Lipid microdomains and the regulation of ion channel function. J Physiol 588: 3169-3178.
40. Wang XL, Ye D, Peterson TE, Cao S, Shah VH, et al. (2005) Caveolae targeting and regulation of large conductance Ca(2+)-activated K+ channels in vascular endothelial cells. J Biol Chem 280: 11656-11664.
41. Akare S, Martinez JD (2005) Bile acid induces hydrophobicity-dependent membrane alterations. Biochim Biophys Acta 1735: 59-67.
42. Zhou Y, Maxwell KN, Sezgin E, Lu M, Liang H, et al. (2013) Bile acids modulate signaling by functional perturbation of plasma membrane domains. J Biol Chem 288: 35660-35670.
43. Wiemuth D, Lefevre CM, Heidtmann H, Gründer S (2014) Bile acids increase the activity of the epithelial Na(+) channel. Pflugers Arch 466: 1725-1733.
44. Caldwell RA, Boucher RC, Stutts MJ (2004) Serine protease activation of near-silent epithelial Na+ channels. Am J Physiol Cell Physiol 286: C190-194.
45. Lefevre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, et al. (2013) Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC). Pflugers Arch 466: 256-263.