Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 9, 2013, Pages 2152-2163

  Mello Vieira, João ^a   Sousa, Tânia ^a   Coutinho, Ana ^a,b   Fedorov, Aleksander ^a   Lucas, Susana D ^c   Moreira, Rui ^c   Castro, Rui E ^c   Rodrigues, Cecília M P ^c   Prieto, Manuel ^a   Fernandes, Fábio ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Apoptosis; Fluorescence spectroscopy; Lipid rafts; Model membrane systems

Indexed keywords

BILE ACID; CHOLESTEROL; DEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; 1,2-DIPALMITOYL-3-PHOSPHATIDYLETHANOLAMINE; 1,6 DIPHENYL 1,3,5 HEXATRIENE; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; 4 CHLORO 7 NITROBENZOFURAZAN; 7 FLUORO 4 NITROBENZOFURAZAN; 7-FLUORO-4-NITROBENZO-2-OXA-1,3-DIAZOLE; CHENODEOXYCHOLIC ACID; DEHYDROERGOSTEROL; DEOXYCORTICOSTERONE ACETATE; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; DRUG DERIVATIVE; FLUORESCENT DYE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PROTEIN BAX; TAUROCHENODEOXYCHOLIC ACID;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL PROTECTION; CHEMICAL INTERACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIPID MEMBRANE; MEMBRANE BINDING; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; RIGIDITY; 1,2-DIOLEOYL-SN-GLICERO-3-PHOSPHOETHANOLAMINE-N-(LISSAMINE RHODAMINE B SULFONYL); 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(NITRO-2-1,3-BENZOXADIAZOL-4YL); 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-BIOTINYL; 1,6-DIPHENYL-1,3,5-HEXATRIENE; 1-(4-TRIMETHYLAMMONIUMPHENYL)-6-PHENYL-1,3,5-HEXATRIENE P-TOLUENESULFONATE; 1-[2-HYDROXY-3-(N,N-DI-METHYL-N-HYDROXYETHYL)AMMONIOPROPYL]-4-[Β-[2-(DI-N-BUTYLAMINO)-6-NAPTHYL] VINYL]PYRIDINIUM DIBROMIDE; 1-PALMITOYL-2-OLEOYL-SN-GLICERO-3-PHOSPHORYLCHOLINE; BA(S); BAX; BILE ACID(S); CDCA; CHEMISTRY; CHOL; DHE; DI-4-ANEPPDHQ; DOPE-RHO; DPH; DPPE-BIOTIN; DPPE-NBD; FLUORESCENCE SPECTROSCOPY; FÖRSTER RESONANCE ENERGY TRANSFER; FRET; GIANT UNILAMELLAR VESICLES; GUV; L(D); L(O); LARGE UNILAMELLAR VESICLES; LIPID BILAYER; LIPID RAFTS; LIQUID DISORDERED; LIQUID ORDERED; LUV; MODEL MEMBRANE SYSTEMS; N-PALMITOYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE; NBD; NITRO-2-1,3-BENZOXADIAZOL-4YL; POPC; PSM; STAINING; TMA-DPH; TUDCA; UDCA;

1,2-DIOLEOYL-SN-GLICERO-3-PHOSPHOETHANOLAMINE-N-(LISSAMINE RHODAMINE B SULFONYL); 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(NITRO-2-1,3-BENZOXADIAZOL-4YL); 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-BIOTINYL; 1,6-DIPHENYL-1,3,5-HEXATRIENE; 1-(4-TRIMETHYLAMMONIUMPHENYL)-6-PHENYL-1,3,5-HEXATRIENE P-TOLUENESULFONATE; 1-[2-HYDROXY-3-(N,N-DI-METHYL-N-HYDROXYETHYL)AMMONIOPROPYL]-4-[Β-[2-(DI-N-BUTYLAMINO)-6-NAPTHYL] VINYL]PYRIDINIUM DIBROMIDE; 1-PALMITOYL-2-OLEOYL-SN-GLICERO-3-PHOSPHORYLCHOLINE; APOPTOSIS; BA(S); BAX; BCL-2-ASSOCIATED X PROTEIN; BILE ACID(S); CDCA; CHENODEOXYCHOLIC ACID; CHOL; CHOLESTEROL; DCA; DEHYDROERGOSTEROL; DEOXYCHOLIC ACID; DHE; DI-4-ANEPPDHQ; DOPE-RHO; DPH; DPPE-BIOTIN; DPPE-NBD; FLUORESCENCE SPECTROSCOPY; FÖRSTER RESONANCE ENERGY TRANSFER; FRET; GIANT UNILAMELLAR VESICLES; GUV; L(D); L(O); LARGE UNILAMELLAR VESICLES; LIPID RAFTS; LIQUID DISORDERED; LIQUID ORDERED; LUV; MODEL MEMBRANE SYSTEMS; N-PALMITOYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE; NBD; NITRO-2-1,3-BENZOXADIAZOL-4YL; POPC; PSM; TAUROURSODEOXYCHOLIC ACID; TMA-DPH; TUDCA; UDCA; URSODEOXYCHOLIC ACID;

4-CHLORO-7-NITROBENZOFURAZAN; CHOLESTEROL; DEOXYCHOLIC ACID; DIPHENYLHEXATRIENE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; LIPID BILAYERS; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; STAINING AND LABELING; TAUROCHENODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

EID: 84879241584     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.05.021     Document Type: Article

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