Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated

Journal of Investigative Dermatology

Volumn 134, Issue 12, 2014, Pages 2890-2897

  Lin, Tzu Kai ^a,b,c   Man, Mao Qiang ^b   Santiago, Juan Luis ^c   Scharschmidt, Tiffany C ^d   Hupe, Melanie ^e   Martin Ezquerra, Gemma ^f   Youm, Jong Kyung ^a   Zhai, Yongjiao ^a   Trullas, Carles ^g   Feingold, Kenneth R ^e,h   Elias, Peter M ^a,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d HOSPITAL GENERAL UNIVERSITARIO DE CIUDAD REAL   (Spain)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^g ISDIN   (Spain)

^h SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; IMMUNOGLOBULIN E; MIFEPRISTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; DERMATITIS; EPIDERMIS; FEMALE; INFLAMMATION; IRRITANT DERMATITIS; MENTAL STRESS; MOUSE; NONHUMAN; SKIN ALLERGY; ANIMAL; BLOOD; C57BL MOUSE; CELL MEMBRANE PERMEABILITY; DISEASE MODEL; HAIRLESS MOUSE; HOMEOSTASIS; INNATE IMMUNITY; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SKIN; SKIN DISEASE; WOUND HEALING;

ANIMALS; CELL MEMBRANE PERMEABILITY; DISEASE MODELS, ANIMAL; FEMALE; GLUCOCORTICOIDS; HOMEOSTASIS; IMMUNITY, INNATE; IMMUNOGLOBULIN E; MALE; MICE; MICE, HAIRLESS; MICE, INBRED C57BL; SKIN; SKIN DISEASES; STRESS, PSYCHOLOGICAL; WOUND HEALING;

EID: 84909982967     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.265     Document Type: Article

References (53)

1. Aberg K M, Radek K A, Choi E H et al. (2007) Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest 117:3339-49
2. Ahmadi N, Hajsadeghi F, Mirshkarlo HB et al. (2011) Post-traumatic stress disorder, coronary atherosclerosis, and mortality. Am J Cardiol 108:29-33
3. Altemus M, Rao B, Dhabhar FS et al. (2001) Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol 117:309-17
4. Baschant U, Tuckermann J (2010) The role of the glucocorticoid receptor in inflammation and immunity. J Steroid Biochem Mol Biol 120:69-75
5. Boonen E, Vervenne H, Meersseman P et al. (2013) Reduced cortisol metabolism during critical illness. N Engl J Med 368:1477-88
6. Buske-Kirschbaum A, Ebrecht M, Hellhammer DH (2010) Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation. Brain Behav Immun 24:1347-53
7. Buske-Kirschbaum A, Geiben A, Hellhammer D (2001) Psychobiological aspects of atopic dermatitis: an overview. Psychother Psychosom 70:6-16
8. Buske-Kirschbaum A, Geiben A, Hollig H et al. (2002) Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis. J Clin Endocrinol Metab 87:4245-51
9. Buske-Kirschbaum A, Krieger S, Wilkes C et al. (2007) Hypothalamic-pituitaryadrenal axis function and the cellular immune response in former preterm children. J Clin Endocrinol Metab 92:3429-35
10. Buske-Kirschbaum A, von Auer K, Krieger S et al. (2003) Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease? Psychosom Med 65:806-10
11. Campisi J, Leem TH, Fleshner M (2002) Acute stress decreases inflammation at the site of infection. A role for nitric oxide. Physiol Behav 77:291-9
12. Chen E, Miller GE (2007) Stress and inflammation in exacerbations of asthma. Brain Behav Immun 21:993-9
13. Chesnokova V, Melmed S (2002) Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology 143:1571-4
14. Choi EH, Brown BE, Crumrine D et al. (2005a) Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. J Invest Dermatol 124:587-95
15. Choi EH, Demerjian M, Crumrine D et al. (2006) Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. Am J Physiol Regul Integr Comp Physiol 291:R1657-62
16. Choi EH, Man MQ, Wang F et al. (2005b) Is endogenous glycerol a determinant of stratum corneum hydration in humans? J Invest Dermatol 125:288-93
17. Cork MJ, Danby SG, Vasilopoulos Y et al. (2009) Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 129:1892-908
18. Denda M, Tsuchiya T, Elias PM et al. (2000) Stress alters cutaneous permeability barrier homeostasis. Am J Physiol Regul Integr Comp Physiol 278:R367-72
19. Denda M, Tsuchiya T, Hosoi J et al. (1998) Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin. Br J Dermatol 138:780-5
20. Dhabhar FS (2013) Psychological stress and immunoprotection versus immunopathology in the skin. Clin Dermatol 31:18-30
21. Elenkov IJ, Chrousos GP (2006) Stress system-organization, physiology and immunoregulation. Neuroimmunomodulation 13:257-67
22. Elias PM, Hatano Y, Williams ML (2008) Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 121:1337-43
23. Elias PM, Steinhoff M (2008) Outside-to-inside (and now back to outside) pathogenic mechanisms in atopic dermatitis. J Invest Dermatol 128: 1067-70
24. Elias PM (2010) Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Ann Dermatol 22:245-54
25. Fantuzzi G, Ghezzi P (1993) Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases. Mediators Inflamm 2:263-70
26. Fowler AJ, Sheu MY, Schmuth M et al. (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120:246-55
27. Furlan R, Ardizzone S, Palazzolo L et al. (2006) Sympathetic overactivity in active ulcerative colitis: effects of clonidine. Am J Physiol Regul Integr Comp Physiol 290:R224-32
28. Gardner DG, Shoback D (2011) Greenspans Basic and Clinical Endocrinology. McGraw Hill: New York, 880
29. Garg A, Chren MM, Sands LP et al. (2001) Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch Dermatol 137: 53-9
30. Gomez-Sanchez CE (2013) Adrenal dysfunction in critically ill patients. N Engl J Med 368:1547-9
31. Gupta MA, Gupta AK (1996) Psychodermatology: an update. J Am Acad Dermatol 34:1030-46
32. Hamer M, ODonnell K, Lahiri A et al. (2010) Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and women. Eur Heart J 31:424-9
33. Hansel A, Hong S, Camara RJ et al. (2010) Inflammation as a psychophysiological biomarker in chronic psychosocial stress. Neurosci Biobehav Rev 35:115-21
34. Hatano Y, Elias PM, Crumrine D et al. (2011) Efficacy of combined peroxisome proliferator-activated receptor-alpha ligand and glucocorticoid therapy in a murine model of atopic dermatitis. J Invest Dermatol 131:1845-52
35. Irvine AD, McLean WH, Leung DY (2011) Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 365:1315-27
36. Kao JS, Fluhr JW, Man MQ et al. (2003) Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities. J Invest Dermatol 120:456-64
37. Kiecolt-Glaser JK, Marucha PT, Malarkey WB et al. (1995) Slowing of wound healing by psychological stress. Lancet 346:1194-6
38. Man MQ, Hatano Y, Lee SH et al. (2008) Characterization of a hapteninduced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol 128:79-86
39. Marshall GD Jr (2011) The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases. Immunol Allergy Clin North Am 31:133-40
40. McEwen BS, Kalia M (2010) The role of corticosteroids and stress in chronic pain conditions. Metabolism 59(Suppl 1):S9-15
41. Nowotny B, Cavka M, Herder C et al. (2010) Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Horm Metab Res 42:746-53
42. OSullivan RL, Lipper G, Lerner EA (1998) The neuro-immuno-cutaneousendocrine network: relationship of mind and skin. Arch Dermatol 134:1431-5
43. Pawlak CR, Witte T, Heiken H et al. (2003) Flares in patients with systemic lupus erythematosus are associated with daily psychological stress. Psychother Psychosom 72:159-65
44. Radek K, Gallo R (2007) Antimicrobial peptides: natural effectors of the innate immune system. Semin Immunopathol 29:27-43
45. Reber SO, Birkeneder L, Veenema AH et al. (2007) Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: implications and mechanisms. Endocrinology 148:670-82
46. Reber SO, Peters S, Slattery DA et al. (2011) Mucosal immunosuppression and epithelial barrier defects are key events in murine psychosocial stressinduced colitis. Brain Behav Immun 25:1153-61
47. Rostenberg A Jr (1960) The role of psychogenic factors in skin diseases. Arch Dermatol 81:81-6
48. Schleimer RP (1993) An overview of glucocorticoid anti-inflammatory actions. Eur J Clin Pharmacol 45(Suppl 1):S3-7
49. Sheu HM, Lee JY, Kuo KW et al. (1998) Permeability barrier abnormality of hairless mouse epidermis after topical corticosteroid: characterization of stratum corneum lipids by ruthenium tetroxide staining and high-performance thin-layer chromatography. J Dermatol 25:281-9
50. Tausk FA, Nousari H (2001) Stress and the skin. Arch Dermatol 137:78-82
51. Wright RJ, Cohen RT, Cohen S (2005) The impact of stress on the development and expression of atopy. Curr Opin Allergy Clin Immunol 5:23-9
52. Yehuda R, Seckl J (2011) Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis. Endocrinology 152: 4496-503
53. Youm J K, Park K, Uchida Y et al. (2013) Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen 21:715-22