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Volumn 33, Issue 12, 2014, Pages 604-608

Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cells

Author keywords

CpG methylation; DNA methyltransferase; Epstein Barr virus; Gastric cancer; Nasopharyngeal carcinoma; Tumor suppressor gene

Indexed keywords

VIRAL PROTEIN;

EID: 84909967043     PISSN: None     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.014.10191     Document Type: Review
Times cited : (22)

References (57)
  • 1
    • 4944266319 scopus 로고    scopus 로고
    • Epstein-Barr virus: 40 years on
    • [1] Young LS, Rickinson AB. Epstein-Barr virus: 40 years on. Nat Rev Cancer, 2004,4:757-768.
    • (2004) Nat Rev Cancer , vol.4 , pp. 757-768
    • Young, L.S.1    Rickinson, A.B.2
  • 2
    • 0031616004 scopus 로고    scopus 로고
    • Current perspectives on the molecular pathogenesis of virus-induced cancers in human immunodeficiency virus infection and acquired immunodeficiency syndrome
    • [2] Kieff E. Current perspectives on the molecular pathogenesis of virus-induced cancers in human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst Monogr, 1998,23:7-14.
    • (1998) J Natl Cancer Inst Monogr , vol.23 , pp. 7-14
    • Kieff, E.1
  • 3
    • 0036435166 scopus 로고    scopus 로고
    • Epstein-Barr virus in the pathogenesis of NPC
    • [3] Raab-Traub N. Epstein-Barr virus in the pathogenesis of NPC. Semin Cancer Biol, 2002,12:431-441.
    • (2002) Semin Cancer Biol , vol.12 , pp. 431-441
    • Raab-Traub, N.1
  • 4
    • 33744484523 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV) and its associated human cancers—genetics, epigenetics, pathobiology and novel therapeutics
    • [4] Tao Q, Young LS, Woodman CB, et al. Epstein-Barr virus (EBV) and its associated human cancers—genetics, epigenetics, pathobiology and novel therapeutics. Front Biosci, 2006,11:2672-2713.
    • (2006) Front Biosci , vol.11 , pp. 2672-2713
    • Tao, Q.1    Young, L.S.2    Woodman, C.B.3
  • 5
    • 34548631786 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments
    • [5] Tao Q, Chan AT. Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments. Expert Rev Mol Med, 2007,9:1-24.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-24
    • Tao, Q.1    Chan, A.T.2
  • 6
    • 2442540470 scopus 로고    scopus 로고
    • Focus on nasopharyngeal carcinoma
    • [6] Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma. Cancer Cell, 2004,5:423-428.
    • (2004) Cancer Cell , vol.5 , pp. 423-428
    • Lo, K.W.1    To, K.F.2    Huang, D.P.3
  • 8
    • 0030221507 scopus 로고    scopus 로고
    • Epstein-Barr virus and gastric carcinoma
    • [8] Osato T, Imai S. Epstein-Barr virus and gastric carcinoma. Semin Cancer Biol, 1996,7:175-182.
    • (1996) Semin Cancer Biol , vol.7 , pp. 175-182
    • Osato, T.1    Imai, S.2
  • 9
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • [9] Jones PA, Baylin SB. The epigenomics of cancer. Cell, 2007,128:683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 10
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • [10] Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet, 2002,3:415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • [11] Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell, 2011,144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer—a mechanism for early oncogenic pathway addiction?
    • [12] Baylin SB, Ohm JE. Epigenetic gene silencing in cancer—a mechanism for early oncogenic pathway addiction? Nat Rev Cancer, 2006,6:107-116.
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 13
    • 84907011938 scopus 로고    scopus 로고
    • Targeted p16ink4a epimutation causes tumorigenesis and reduces survival in mice
    • [13] Yu DH, Waterland RA, Zhang P, et al. Targeted p16ink4a epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest, 2014,124:3708-3712.
    • (2014) J Clin Invest , vol.124 , pp. 3708-3712
    • Yu, D.H.1    Waterland, R.A.2    Zhang, P.3
  • 14
    • 84863954527 scopus 로고    scopus 로고
    • Epstein-Barr virus infection as an epigenetic driver of tumorigenesis
    • [14] Kaneda A, Matsusaka K, Aburatani H, et al. Epstein-Barr virus infection as an epigenetic driver of tumorigenesis. Cancer Res, 2012,72:3445-3450.
    • (2012) Cancer Res , vol.72 , pp. 3445-3450
    • Kaneda, A.1    Matsusaka, K.2    Aburatani, H.3
  • 15
    • 82655181474 scopus 로고    scopus 로고
    • Classification of Epstein- Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes
    • [15] Matsusaka K, Kaneda A, Nagae G, et al. Classification of Epstein- Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res, 2011,71:7187-7197.
    • (2011) Cancer Res , vol.71 , pp. 7187-7197
    • Matsusaka, K.1    Kaneda, A.2    Nagae, G.3
  • 16
    • 79954550436 scopus 로고    scopus 로고
    • Epigenetic disruption of cell signaling in nasopharyngeal carcinoma
    • [16] Li LL, Shu XS, Wang ZH, et al. Epigenetic disruption of cell signaling in nasopharyngeal carcinoma. Chin J Cancer, 2011,30:231-239.
    • (2011) Chin J Cancer , vol.30 , pp. 231-239
    • Li, L.L.1    Shu, X.S.2    Wang, Z.H.3
  • 17
    • 24344465856 scopus 로고    scopus 로고
    • Epigenetic changes in virus-associated human cancers
    • [17] Li HP, Leu YW, Chang YS. Epigenetic changes in virus-associated human cancers. Cell Res, 2005,15:262-271.
    • (2005) Cell Res , vol.15 , pp. 262-271
    • Li, H.P.1    Leu, Y.W.2    Chang, Y.S.3
  • 18
    • 0022895276 scopus 로고
    • The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation
    • [18] Raab-Traub N, Flynn K. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell, 1986,47:883-889.
    • (1986) Cell , vol.47 , pp. 883-889
    • Raab-Traub, N.1    Flynn, K.2
  • 19
    • 84901680089 scopus 로고    scopus 로고
    • Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
    • [19] Wang K, Yuen ST, Xu J, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet, 2014,46:573-582.
    • (2014) Nat Genet , vol.46 , pp. 573-582
    • Wang, K.1    Yuen, S.T.2    Xu, J.3
  • 20
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • The Cancer Genome Atlas Research Network
    • [20] The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature, 2014,513:202-209.
    • (2014) Nature , vol.513 , pp. 202-209
  • 21
    • 84905514047 scopus 로고    scopus 로고
    • The genomic landscape of nasopharyngeal carcinoma
    • [21] Lin DC, Meng X, Hazawa M, et al. The genomic landscape of nasopharyngeal carcinoma. Nat Genet, 2014,46:866-871.
    • (2014) Nat Genet , vol.46 , pp. 866-871
    • Lin, D.C.1    Meng, X.2    Hazawa, M.3
  • 22
    • 0036121312 scopus 로고    scopus 로고
    • Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    • [22] Kang GH, Lee S, Kim WH, et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol, 2002,160:787-794.
    • (2002) Am J Pathol , vol.160 , pp. 787-794
    • Kang, G.H.1    Lee, S.2    Kim, W.H.3
  • 23
    • 50149120544 scopus 로고    scopus 로고
    • Epstein-Barr virus and gastric carcinoma: Virus-host interactions leading to carcinoma
    • [23] Fukayama M, Hino R, Uozaki H. Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma. Cancer Sci, 2008,99:1726-1733.
    • (2008) Cancer Sci , vol.99 , pp. 1726-1733
    • Fukayama, M.1    Hino, R.2    Uozaki, H.3
  • 24
    • 33744789155 scopus 로고    scopus 로고
    • CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus
    • [24] Chang MS, Uozaki H, Chong JM, et al. CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. Clin Cancer Res, 2006,12:2995-3002.
    • (2006) Clin Cancer Res , vol.12 , pp. 2995-3002
    • Chang, M.S.1    Uozaki, H.2    Chong, J.M.3
  • 25
    • 84872087715 scopus 로고    scopus 로고
    • Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cells
    • [25] Zhao J, Liang Q, Cheung KF, et al. Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cells. Cancer, 2013,119:304-312.
    • (2013) Cancer , vol.119 , pp. 304-312
    • Zhao, J.1    Liang, Q.2    Cheung, K.F.3
  • 26
    • 34547619642 scopus 로고    scopus 로고
    • Epigenetic silencing of a Ca(2+)- regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers
    • [26] Jin H, Wang X, Ying J, et al. Epigenetic silencing of a Ca(2+)- regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A, 2007,104:12353-12358.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12353-12358
    • Jin, H.1    Wang, X.2    Ying, J.3
  • 27
    • 0035872408 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma
    • [27] Lo KW, Kwong J, Hui AB, et al. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res, 2001,61:3877-3881.
    • (2001) Cancer Res , vol.61 , pp. 3877-3881
    • Lo, K.W.1    Kwong, J.2    Hui, A.B.3
  • 28
    • 2942737278 scopus 로고    scopus 로고
    • The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma
    • [28] Qiu GH, Tan LK, Loh KS, et al. The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Oncogene, 2004,23:4793-4806.
    • (2004) Oncogene , vol.23 , pp. 4793-4806
    • Qiu, G.H.1    Tan, L.K.2    Loh, K.S.3
  • 29
    • 33244483580 scopus 로고    scopus 로고
    • Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
    • [29] Ying J, Li H, Seng TJ, et al. Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene, 2006,25:1070-1080.
    • (2006) Oncogene , vol.25 , pp. 1070-1080
    • Ying, J.1    Li, H.2    Seng, T.J.3
  • 30
    • 77955728660 scopus 로고    scopus 로고
    • KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas
    • [30] Cheng Y, Geng H, Cheng SH, et al. KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas. Cancer Res, 2010,70:6516-6526.
    • (2010) Cancer Res , vol.70 , pp. 6516-6526
    • Cheng, Y.1    Geng, H.2    Cheng, S.H.3
  • 31
    • 84906969231 scopus 로고    scopus 로고
    • Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes
    • [31] Birdwell CE, Queen KJ, Kilgore P, et al. Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes. J Virol, 2014,88:11442-11458.
    • (2014) J Virol , vol.88 , pp. 11442-11458
    • Birdwell, C.E.1    Queen, K.J.2    Kilgore, P.3
  • 32
    • 0042467687 scopus 로고    scopus 로고
    • Epstein-Barr virus and oncogenesis: From latent genes to tumours
    • [32] Young LS, Murray PG. Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene, 2003,22:5108-5121.
    • (2003) Oncogene , vol.22 , pp. 5108-5121
    • Young, L.S.1    Murray, P.G.2
  • 34
    • 39449102142 scopus 로고    scopus 로고
    • Reconstitution of nasopharyngeal carcinoma-type EBV infection induces tumorigenicity
    • [34] Seto E, Ooka T, Middeldorp J, et al. Reconstitution of nasopharyngeal carcinoma-type EBV infection induces tumorigenicity. Cancer Res, 2008,68:1030-1036.
    • (2008) Cancer Res , vol.68 , pp. 1030-1036
    • Seto, E.1    Ooka, T.2    Middeldorp, J.3
  • 35
    • 0028146198 scopus 로고
    • Epstein-Barr virusassociated gastric carcinoma and Epstein-Barr virus infection of the stomach
    • [35] Fukayama M, Hayashi Y, Iwasaki Y, et al. Epstein-Barr virusassociated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab Invest, 1994,71:73-81.
    • (1994) Lab Invest , vol.71 , pp. 73-81
    • Fukayama, M.1    Hayashi, Y.2    Iwasaki, Y.3
  • 36
    • 0028577894 scopus 로고
    • Gastric carcinoma: Monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein
    • [36] Imai S, Koizumi S, Sugiura M, et al. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci U S A, 1994,91:9131-9135.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9131-9135
    • Imai, S.1    Koizumi, S.2    Sugiura, M.3
  • 37
    • 50149086269 scopus 로고    scopus 로고
    • Epstein-Barr virus and gastric carcinoma— viral carcinogenesis through epigenetic mechanisms
    • [37] Uozaki H, Fukayama M. Epstein-Barr virus and gastric carcinoma— viral carcinogenesis through epigenetic mechanisms. Int J Clin Exp Pathol, 2008,1:198-216.
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 198-216
    • Uozaki, H.1    Fukayama, M.2
  • 38
    • 84878510017 scopus 로고    scopus 로고
    • Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: Implications for possible immune adjuvant therapy
    • [38] Strong MJ, Xu G, Coco J, et al. Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. PLoS Pathog, 2013,9:e1003341.
    • (2013) Plos Pathog , vol.9
    • Strong, M.J.1    Xu, G.2    Coco, J.3
  • 39
    • 2342420041 scopus 로고    scopus 로고
    • Identification of virusencoded microRNAs
    • [39] Pfeffer S, Zavolan M, Grasser FA, et al. Identification of virusencoded microRNAs. Science, 2004,304:734-736.
    • (2004) Science , vol.304 , pp. 734-736
    • Pfeffer, S.1    Zavolan, M.2    Grasser, F.A.3
  • 40
    • 33645758064 scopus 로고    scopus 로고
    • Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
    • [40] Cai X, Schafer A, Lu S, et al. Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog, 2006,2:e23.
    • (2006) Plos Pathog , vol.2
    • Cai, X.1    Schafer, A.2    Lu, S.3
  • 41
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics: Two sides of the same coin?
    • [41] You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell, 2012,22:9-20.
    • (2012) Cancer Cell , vol.22 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 42
    • 70350149728 scopus 로고    scopus 로고
    • Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice
    • [42] Schuettengruber B, Cavalli G. Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009,136:3531-3542.
    • (2009) Development , vol.136 , pp. 3531-3542
    • Schuettengruber, B.1    Cavalli, G.2
  • 43
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • [43] Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Develop, 2011,25:1010-1022.
    • (2011) Genes Develop , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 44
    • 0037162536 scopus 로고    scopus 로고
    • The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases
    • [44] Tsai CN, Tsai CL, Tse KP, et al. The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc Natl Acad Sci U S A, 2002,99:10084-10089.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10084-10089
    • Tsai, C.N.1    Tsai, C.L.2    Tse, K.P.3
  • 45
    • 33846227472 scopus 로고    scopus 로고
    • Activation of DNA methyltransferase 1 by EBV LMP1 involves c-Jun NH(2)-terminal kinase signaling
    • [45] Tsai CL, Li HP, Lu YJ, et al. Activation of DNA methyltransferase 1 by EBV LMP1 involves c-Jun NH(2)-terminal kinase signaling. Cancer Res, 2006,66:11668-11676.
    • (2006) Cancer Res , vol.66 , pp. 11668-11676
    • Tsai, C.L.1    Li, H.P.2    Lu, Y.J.3
  • 46
    • 84901664088 scopus 로고    scopus 로고
    • Epstein-Barr virus downregulates tumor suppressor DOK1 expression
    • [46] Siouda M, Frecha C, Accardi R, et al. Epstein-Barr virus downregulates tumor suppressor DOK1 expression. PLoS Pathog, 2014,10:e1004125.
    • (2014) Plos Pathog , vol.10
    • Siouda, M.1    Frecha, C.2    Accardi, R.3
  • 47
    • 66149101689 scopus 로고    scopus 로고
    • Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma
    • [47] Hino R, Uozaki H, Murakami N, et al. Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Cancer Res, 2009,69:2766-2774.
    • (2009) Cancer Res , vol.69 , pp. 2766-2774
    • Hino, R.1    Uozaki, H.2    Murakami, N.3
  • 48
    • 77954687468 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma
    • [48] Kong QL, Hu LJ, Cao JY, et al. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog, 2010,6:e1000940.
    • (2010) Plos Pathog , vol.6
    • Kong, Q.L.1    Hu, L.J.2    Cao, J.Y.3
  • 49
    • 0034103269 scopus 로고    scopus 로고
    • EBNA-1: A protein pivotal to latent infection by Epstein-Barr virus
    • [49] Leight ER, Sugden B. EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus. Rev Med Virol, 2000,10:83-100.
    • (2000) Rev Med Virol , vol.10 , pp. 83-100
    • Leight, E.R.1    Sugden, B.2
  • 50
    • 0024474724 scopus 로고
    • A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA- 1, a viral protein required for viral DNA replication during latent infection
    • [50] Sugden B, Warren N. A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA- 1, a viral protein required for viral DNA replication during latent infection. J Virol, 1989,63:2644-2649.
    • (1989) J Virol , vol.63 , pp. 2644-2649
    • Sugden, B.1    Warren, N.2
  • 51
    • 84882302748 scopus 로고    scopus 로고
    • Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance
    • [51] Kanda T, Horikoshi N, Murata T, et al. Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance. J Biol Chem, 2013,288:24189-24199.
    • (2013) J Biol Chem , vol.288 , pp. 24189-24199
    • Kanda, T.1    Horikoshi, N.2    Murata, T.3
  • 52
    • 77957371838 scopus 로고    scopus 로고
    • Genome-wide analysis of host-chromosome binding sites for Epstein-Barr virus nuclear  antigen 1 (EBNA1)
    • [52] Lu F, Wikramasinghe P, Norseen J, et al. Genome-wide analysis of host-chromosome binding sites for Epstein-Barr virus nuclear  antigen 1 (EBNA1). Virol J, 2010,7:262.
    • (2010) Virol J , vol.7 , pp. 262
    • Lu, F.1    Wikramasinghe, P.2    Norseen, J.3
  • 53
    • 76049087454 scopus 로고    scopus 로고
    • EBNA1 regulates cellular gene expression by binding cellular promoters
    • [53] Canaan A, Haviv I, Urban AE, et al. EBNA1 regulates cellular gene expression by binding cellular promoters. Proc Natl Acad Sci U S A, 2009,106:22421-22426.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 22421-22426
    • Canaan, A.1    Haviv, I.2    Urban, A.E.3
  • 54
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • [54] Esteller M. Epigenetics in cancer. N Engl J Med, 2008, 358:1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 55
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome—biological and translational implications
    • [55] Baylin SB, Jones PA. A decade of exploring the cancer epigenome—biological and translational implications. Nat Rev Cancer, 2011,11:726-734.
    • (2011) Nat Rev Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 56
    • 2342570310 scopus 로고    scopus 로고
    • Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors
    • [56] Chan AT, Tao Q, Robertson KD, et al. Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. J Clin Oncol, 2004,22:1373-1381.
    • (2004) J Clin Oncol , vol.22 , pp. 1373-1381
    • Chan, A.T.1    Tao, Q.2    Robertson, K.D.3
  • 57
    • 84655163371 scopus 로고    scopus 로고
    • Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
    • [57] Juergens RA, Wrangle J, Vendetti FP, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov, 2011,1:598-607.
    • (2011) Cancer Discov , vol.1 , pp. 598-607
    • Juergens, R.A.1    Wrangle, J.2    Vendetti, F.P.3


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