Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum

Journal of Biotechnology

Volumn 192, Issue Part A, 2014, Pages 1-10

  Fan, Yuxiang ^a   Gao, Yang ^a   Zhou, Jie ^a   Wei, Liujing ^a   Chen, Jun ^a   Hua, Qiang ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shanghai Technology Innovation Center   (China)

Author keywords

Actinosynnema pretiosum; Ansamitocin P 3; Fructose; Medium optimization; Transcription analysis

Indexed keywords

BIOSYNTHESIS; CARBON; FRUCTOSE; GLUCOSE; OPTIMIZATION; PHYSIOLOGY; PRODUCTIVITY; STARCH; TRANSCRIPTION;

ACTINOSYNNEMA PRETIOSUM; ANSAMITOCIN P-3; BIOSYNTHETIC GENE CLUSTER; BIOSYNTHETIC PRECURSORS; MEDIUM OPTIMIZATION; RESPONSE SURFACE METHOD; SINGLE-FACTOR EXPERIMENTS; TRANSCRIPTION ANALYSIS;

METABOLISM;

ANSAMITOCIN P 3; FRUCTOSE; GLUCOSE; GLYCEROL; STARCH; ANSAMITOCIN; CARBON; MAYTANSINE; MESSENGER RNA; TUBULIN MODULATOR;

ACTINOBACTERIA; ACTINOSYNNEMA PRETIOSUM; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CARBON SOURCE; DRUG SYNTHESIS; FERMENTATION; GENETIC TRANSCRIPTION; NONHUMAN; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD; SECONDARY METABOLISM; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM;

ACTINOBACTERIA; CARBON; FRUCTOSE; GENES, BACTERIAL; GLUCOSE; GLYCEROL; MAYTANSINE; RNA, MESSENGER; SECONDARY METABOLISM; TUBULIN MODULATORS;

EID: 84909944235     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.10.020     Document Type: Article

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