Enhanced production of ansamitocin P-3 by addition of Mg 2+ in fermentation of Actinosynnema pretiosum

Bioresource Technology

Volumn 102, Issue 21, 2011, Pages 10147-10150

  Jia, Yongliang ^a   Zhong, Jian Jiang ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shanghai Jiao Tong University   (China)

Author keywords

Actinosynnema pretiosum; Enzyme activity; Mg 2+ addition; Secondary metabolite production; Submerged fermentation

Indexed keywords

ACTINOSYNNEMA PRETIOSUM; AGRO-INDUSTRIAL RESIDUE; DIVALENT METAL ION; EFFICIENT PRODUCTION; MALONYL-COA; METHYLMALONYL-COA MUTASE; OPTIMAL CONDITIONS; REGULATION OF ENZYME ACTIVITY; SECONDARY METABOLITE PRODUCTION; SUBMERGED CULTURES; SUBMERGED FERMENTATION;

COPPER; FERMENTATION; LAKES; MANGANESE; MANGANESE COMPOUNDS; METABOLITES; METAL IONS;

ENZYME ACTIVITY;

ANSAMITOCIN P 3; COBALT; COPPER ION; MAGNESIUM ION; MANGANESE; METHYLMALONYL COENZYME A CARBOXYLTRANSFERASE; METHYLMALONYL COENZYME A MUTASE; ZINC ION;

AGROINDUSTRY; BACTERIUM; ENZYME ACTIVITY; FERMENTATION; ION; MAGNESIUM; MANGANESE; SECONDARY METABOLITE; ZINC;

ACTINOBACTERIA; ACTINOSYNNEMA PRETIOSUM; ARTICLE; BIOSYNTHESIS; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG MANUFACTURE; ENZYME ACTIVITY; FERMENTATION; NONHUMAN; PRIORITY JOURNAL;

ACTINOMYCETALES; ACYL COENZYME A; EXTRACELLULAR SPACE; FERMENTATION; INTRACELLULAR SPACE; IONS; MAGNESIUM; MALONYL COENZYME A; MAYTANSINE; METALS; TIME FACTORS;

ACTINOSYNNEMA PRETIOSUM;

EID: 80053103145     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2011.08.031     Document Type: Article

References (16)

1. Bandi S., Kim Y.J., Chang Y.K., Shang G.D., Yu T.W., Floss H.G. Construction of asm2 deletion mutant of Actinosynnema pretiosum and medium optimization for ansamitocin P-3 production using statistical approach. J. Microbiol. Biotechnol. 2006, 16:1338-1346.
2. Behal V. Enzymes of secondary metabolism: regulation of their expression and activity. Regulation of Secondary Metabolite Formation. Proceedings of the 16th Workshop Conference Hoescht, Gracht Castle (1985) 1986, 265-281. VCH Verlagsgerelleshaft mbH, Weinheim, Germany. H. Kleinkauf, H. von Dohren, H. Dornaner, G. Nesemann (Eds.).
3. Choi D.B., Park Y., Okabe M. Effects of rapessed oil on activity of methylmalonyl-CoA carboxyltransferase in culture of Streptomyces fradiae. Biosci. Biotechnol. Biochem. 1998, 62:902-906.
4. 2+ on erythromycin biosynthesis. Front. Chem. Eng. China 2007, 1:246-250.
5. 2+ on the morphological development of Streptomyces hygroscopicus var. Geldaus. Appl. Microbiol. Biotechnol. 2008, 81:119-126.
6. Hunaiti A.A., Kolattukudy O.E. Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus. Antimicrob. Agents. Chem. 1984, 25:173-178.
7. Kim H.O., Lim J.M., Joo J.H., Kim S.K., Hwang H.J., Choi J.W., Yun J.W. Optimization of submerged culture condition for the production of mycelial biomass and exopolyaccharides by Agrocybe cylindracea. Bioresour. Technol. 2005, 96:1175-1182.
8. Lin J.X., Bai L.Q., Deng Z.X., Zhong J.J. Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum. Bioresour. Technol. 2011, 102:1863-1868.
9. Milner J.L., Raffel S.J., Lethbridge B.J., Handelsman J. Culture conditions that influence accumulation of zwittermicin A by Bacillus cereus UW85. Appl. Microbiol. Biotechnol. 1995, 43:685-691.
10. Mo S.J., Ban Y.H., Park J.W., Yoo Y.J., Yoon Y.J. Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor. J. Ind. Microbiol. Biotechnol. 2009, 36:1473-1482.
11. Ng D., Chin H.K., Wong V.V.T. Constitutive overexpression of asm2 and asm39 increases AP-3 production in the actinomycete Actinosynnema pretiosum. J. Ind. Microbiol. Biotechnol. 2009, 36:1345-1351.
12. 2+ on submerged mycelial growth of Streptomyces azureus. J. Ferment. Bioeng. 1998, 86:28-33.
13. 2+) effect on production of fusaricidin-type antifungal compounds by Paenibacillus polymyxa SQR-2. Bioresour. Technol. 2010, 101:9264-9271.
14. Reeves A.R., Brikum I.A., Cernota W.H., Leach B.I., Gonzalez M.C., Weber J.M. Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production. Metab. Eng. 2007, 7:297-303.
15. Wang Z.W., Liu X.L. Medium optimization for antifungal active substances production from a newly isolated Paenibacillus sp. using response surface methodology. Bioresour. Technol. 2008, 99:8245-8251.
16. Weinberg E.D. Role of trace metals in transcriptional control of microbial secondary metabolism. Biol. Metals 1990, 2:191-196.