Effects of L-Carnitine and Coenzyme Q10 on Impaired Spermatogenesis Caused by Isoproterenol in Male Rats

Drug Research

Volumn 64, Issue 9, 2013, Pages 449-453

  Ghanbarzadeh, S ^a,b   Garjani, A ^b   Ziaee, M ^c   Khorrami, A ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

coenzyme Q10; isoproterenol; L carnitine; myocardial infarction; spermatogenesis

Indexed keywords

CARNITINE; FOLLITROPIN; ISOPRENALINE; LUTEINIZING HORMONE; MALONALDEHYDE; TESTOSTERONE; UBIDECARENONE; ANTIOXIDANT; SEX HORMONE; UBIQUINONE; VITAMIN B COMPLEX;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EPIDIDYMIS; FOLLITROPIN BLOOD LEVEL; FOLLITROPIN RELEASE; LIPID PEROXIDATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE INFERTILITY; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; RAT; SEMINAL VESICLE; SPERM QUALITY; SPERMATOGENESIS; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; STOMACH LAVAGE; TESTIS; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; METABOLISM; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CARNITINE; GONADAL STEROID HORMONES; ISOPROTERENOL; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR; SPERMATOGENESIS; UBIQUINONE; VITAMIN B COMPLEX;

EID: 84909624085     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0033-1361103     Document Type: Article

References (38)

1. Charlagorla P., Liu J., Patel M. et al. Loss of plasma membrane integrity, complement response and formation of reactive oxygen species during early myocardial ischemia/reperfusion. Mol Immunol: 2013; 56 507 512
2. Law S. K., Leung CS-L, Yau K. L. et al. Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J Cardiol: 2013; In Press
3. Pagel P. S., Krolikowski J. G., Pratt P. F. Jr et al. Reactive Oxygen Species and Mitochondrial Adenosine Triphosphate - Regulated Potassium Channels Mediate Helium-Induced Preconditioning Against Myocardial Infarction In Vivo. J Cardiothorac Vasc Anesth: 2008; 22 554 559
4. Sugamura K., Keaney JJ F. Reactive oxygen species in cardiovascular disease. Free Radical Biol Med: 2011; 51 978 992
5. Aziz N., Saleh R. A., Sharma R. K. et al. Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index. Fertil Steril: 2004; 81 349 354
6. Henkel R., Kierspel E., Stalf T. et al. Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients. Fertil Steril: 2005; 83 635 642
7. Hsu P-C, Liu M-Y, Hsu C-C et al. Effects of vitamin E and/or C on reactive oxygen species-related lead toxicity in the rat sperm. Toxicology: 1998; 128 169 179
8. Hsu P-C, Liu M-Y, Hsu C-C et al. Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm. Toxicology: 1997; 122 133 143
9. Williams A. C., Ford WC L. Relationship between reactive oxygen species production and lipid peroxidation in human sperm suspensions and their association with sperm function. Fertil Steril: 2005; 83 929 936
10. Al-Gubory K. H., Fowler P. A., Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol: 2010; 42 1634 1650
11. Michael A., Alexopoulos C., Pontiki E. et al. Effect of antioxidant supplementation on semen quality and reactive oxygen species of frozen-thawed canine spermatozoa. Theriogenology: 2007; 68 204 212
12. Michael A. J., Alexopoulos C., Pontiki E. A. et al. Effect of antioxidant supplementation in semen extenders on semen quality and reactive oxygen species of chilled canine spermatozoa. Anim Reprod Sci: 2009; 112 119 135
13. Seifried H. E., Anderson D. E., Fisher E. I. et al. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem: 2007; 18 567 579
14. Taylor C. T. Antioxidants and reactive oxygen species in human fertility. Environ Toxicol Pharmacol: 2001; 10 189 198
15. Imhof M., Lackner J., Lipovac M. et al. Improvement of sperm quality after micronutrient supplementation. e-SPEN Journal: 2012; 7 e50 e53
16. Lewin A., Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Asp Med: 1997; 18 Supplement 1 213 219
17. Littarru G. P., Tiano L. Clinical aspects of coenzyme Q10: An update. Nutrition: 2010; 26 250 254
18. Mancini A., Conte B., De Marinis L. et al. Coenzyme Q10 levels in human seminal fluid: Diagnostic and clinical implications. Mol Asp Med: 1994; 15 Supplement 1 s249 s255
19. Abd El-baset S. A., Abd El-Wahab S. M., Mansour AM A. et al. Light and electron microscopic study of the effect of L-carnitine on the sperm morphology among sub fertile men. Middle East Fertil Soc J: 2010; 15 95 105
20. Duru N. K., Morshedi M., Schuffner A. et al. Semen treatment with progesterone and/or acetyl-L-carnitine does not improve sperm motility or membrane damage after cryopreservation-thawing. Fertil Steril: 2000; 74 715 720
21. Garolla A., Maiorino M., Roverato A. et al. Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels. Fertil Steril: 2005; 83 355 361
22. Xuan W., Lamhonwah A-M, Librach C. et al. Characterization of organic cation/carnitine transporter family in human sperm. Biochem Biophys Res Commun: 2003; 306 121 128
23. Yeste M., Sancho S., Briz M. et al. A diet supplemented with l-carnitine improves the sperm quality of Piétrain but not of Duroc and Large White boars when photoperiod and temperature increase. Theriogenology: 2010; 73 577 586
24. Foresta C., Selice R., Ferlin A. et al. Hormonal treatment of male infertility: FSH. Reprod Biomed Online: 2007; 15 666 672
25. He X., Chian R., Zhang Z. et al. The process of spermatogenesis plays an important role in the pregnancy outcome of ICSI treatment for patients with azoospermic infertility. Fertil Steril: 2009; 92 S75 S76
26. Okabe M., Ikawa M., Ashkenas J. Male Infertility and the Genetics of Spermatogenesis. Am J Hum Genet: 1998; 62 1274 1281
27. Ko E. Y., Sabanegh E. S. The Role of Nutraceuticals in Male Fertility. Urol Clin N Am: 2013; In Press
28. Kumar R., Gautam G., Gupta N. P. Drug Therapy for Idiopathic Male Infertility: Rationale Versus Evidence. J Urol: 2006; 176 1307 1312
29. Lanzafame F. M., La Vignera S., Vicari E. et al. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online: 2009; 19 638 659
30. Ramadan L. A., Abd-Allah AR A., Aly HA A. et al. Testicular Toxicity Effects of Magnetic Field Exposure and Prophylactic Role of Coenzyme Q10 And L-Carnitine in Mice. Pharmacol Res: 2002; 46 363 370
31. Safarinejad M. R., Safarinejad S., Shafiei N. et al. Effects of the Reduced Form of Coenzyme Q10 (Ubiquinol) on Semen Parameters in Men with Idiopathic Infertility: a Double-Blind, Placebo Controlled, Randomized Study. J Urol: 2012; 188 526 531
32. Ziyatdinova G. K., Budnikov H. C., Pogorel'tzev V. I. et al. The application of coulometry for total antioxidant capacity determination of human blood. Talanta: 2006; 68 800 805
33. Al-Rubiey F. K. Effect of L-carnitine and meloxicam treatment on testicular leydig cell numbers of varicocelized rats. Middle East Fertil Soc J: 2012; 17 47 53
34. Patel S. R., Sigman M. Antioxidant Therapy in Male Infertility. Urol Clin N Am: 2008; 35 319 330
35. Mahfouz R., Sharma R., Thiyagarajan A. et al. Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species. Fertil Steril: 2010; 94 2141 2146
36. Mata-Campuzano M., Álvarez-Rodríguez M., del Olmo E. et al. Quality, oxidative markers and DNA damage (DNA) fragmentation of red deer thawed spermatozoa after incubation at 37°C in presence of several antioxidants. Theriogenology: 2012; 78 1005 1019
37. Wang C., Chan V., Tse T. F. et al. Effect of acute myocardial infarction on pituitary-testicular function. Clin Endocrinol: 1978; 9 249 253
38. Marouani N., Tebourbi O., Mahjoub S. et al. Effects of hexavalent chromium on reproductive functions of male adult rats. Reprod Biol: 2012; 12 119 133