Improvement of sperm quality after micronutrient supplementation

e-SPEN Journal

Volumn 7, Issue 1, 2012, Pages

  Imhof, Martin ^a,b   Lackner, Jakob ^a,c   Lipovac, Markus ^a,b   Chedraui, Peter ^d   Riedl, Claus ^e  

^a Fertility Clinic IMI   (Austria)

^b General Public Teaching Hospital Korneuburg   (Austria)

^c General Public Hospital Hietzing   (Austria)

^d UNIVERSIDAD CATÓLICA DE SANTIAGO DE GUAYAQUIL   (Ecuador)

^e General Public Hospital Baden   (Austria)

Author keywords

Idiopathic male infertility; Oligoasthenoteratozoospermia; Sperm quality; Sub fertility

Indexed keywords

ALPHA TOCOPHEROL; ARGININE; CARNITINE; CLOMIFENE CITRATE; FOLIC ACID; GLUTATHIONE; NON PRESCRIPTION DRUG; NUTRACEUTICAL; SELENIUM; UBIDECARENONE; ZINC;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; AUSTRIA; CONTROLLED STUDY; DRUG CAPSULE; EJACULATION; HUMAN; IDIOPATHIC MALE SUBFERTILITY; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; MORPHOLOGY; NUTRIENT SUPPLY; PILOT STUDY; PREGNANCY; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 84865623390     PISSN: None     EISSN: 22128263     Source Type: Journal    
DOI: 10.1016/j.eclnm.2011.11.002     Document Type: Article

References (55)

1. Mosher W.D., Pratt W.F. Fecundity and infertility in the United States, 1965-1988. advanced data from vital and health statistics 1990, National Centre for Health Statistics, Hyattsville.
2. Templeton A. Infertility - epidemiology, aetiology and effective management. Health Bull 1995, 53:294-298.
3. Buckett W., Bentick B. The epidemiology of infertility in a rural population. Acta Obstet Gynecol Scand 1997, 76:233-237.
4. Snick H.K., Snick T.S., Evers J.L., Collins J.A. The spontaneous pregnancy prognosis in untreated subfertile couples: the Walcheren primary care study. Hum Reprod 1997, 12:1582-1588.
5. Downey J., Yingling S., McKinney M., Husami N., Jewelewicz R., Maidman J. Mood disorders, psychiatric symptoms, and distress in women presenting for infertility evaluation. Fertil Steril 1989, 52:425-432.
6. Whiteford L.M., Gonzalez L. Stigma: the hidden burden of infertility. Soc Sci Med 1995, 40:27-36.
7. Isidori A.M., Pozza C., Gianfrilli D., Isidori A. Medical treatment to improve sperm quality. Reprod Biomed Online 2006, 12:704-714.
8. Bonde J.P.E., Ernst E., Jensen T.K., Hjollund N.H.I., Kolstad H., Henriksen T.B., et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 1998, 352:1172-1177.
9. Zinaman M.J., Brown C.C., Selevan S.G., Clegg E. Semen quality and human fertility: a prospective study with healthy couples. J Androl 2000, 21:145-153.
10. McLachlan R.I., Baker H.W., Clarke G.N., Harrison K.L., Matson P.L., Holden C.A., et al. Semen analysis: its place in modern reproductive medical practice. Pathology 2003, 35:25-33.
11. Baker H.W. Management of male infertility. Baillieres Best Pract Res Clin Endocrinol Metab 2000, 14:409-422.
12. Kumar R., Gautam G., Gupta N.P. Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol 2006, 176:1307-1312.
13. Wong W.Y., Thomas C.M., Merkus J.M., Zielhuis G.A., Steegers-Theunissen R.P. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril 2000, 73:435-442.
14. Ebisch I.M., Thomas C.M., Peters W.H., Braat D.D., Steegers-Theunissen R.P. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007, 13:163-174.
15. Showell M.G., Brown Julie, Yazdani A., Stankiewicz M.T., Hart R.J. Antioxidants for male subfertility. Cochrane Database Syst Rev 2011, (1):CD007411.
16. World Health Organization WHO laboratory manual for the examination of human semen and sperm-cervical mucus interactions 1999, Cambridge University Press, Cambridge, United Kingdom. 4th ed.
17. Menchini-Fabris G.F., Canale D., Izzo P.L., Olivieri L., Bartelloni M. Free L-carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril 1984, 42:263-267.
18. Lenzi A., Lombardo F., Sgro P., Salacone P., Caponecchia L., Dondero F., et al. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertil Steril 2003, 79:292-300.
19. Lenzi A., Sgro P., Salacone P., Paoli D., Gilio B., Lombardo F., et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004, 81:1578-1584.
20. Balercia G., Regoli F., Armeni T., Koverech A., Mantero F., Boscaro M. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril 2005, 84:662-671.
21. Sigman M., Glass S., Campagnone J., Pryor J.L. Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial. Fertil Steril 2006, 85:1409-1414.
22. Zhang H., Zheng R.L. Possible role of nitric oxide on fertile and asthenozoospermic infertile human sperm functions. Free Rad Res 1996, 25:347-354.
23. Scibona M., Meschini P., Capparelli S., Pecori C., Rossi P., Menchini Fabris G.F. L-arginine and male infertility. Minerva Urol Nefrol 1994, 46:251-253.
24. Morales M.E., Rico G., Bravo C., Tapia R., Alvarez C., Mendez J.D. Progressive motility increase caused by L-arginine and polyamines in sperm from patients with idiopathic and diabetic asthenozoospermia. Ginecol Obstet Mex 2003, 71:297-303.
25. Suleiman S.A., Ali M.E., Zaki Z.M., el-Malik E.M., Nasr M.A. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl 1996, 17:530-537.
26. Kessopoulou E., Powers H.J., Sharma K.K., Pearson M.J., Russell J.M., Cooke I.D., et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril 1995, 64:825-831.
27. Vezina D., Mauffette F., Roberts K.D., Bleau G. Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res 1996, 53:65-83.
28. Keskes-Ammar L., Feki-Chakroun N., Rebai T., Sahnoun Z., Ghozzi H., Hammami S., et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 2003, 49:83-94.
29. Oldereid N.B., Thomassen Y., Purvis K. Selenium in human male reproductive organs. Hum Reprod 1998, 13:2172-2176.
30. Foresta C., Flohe L., Garolla A., Roveri A., Ursini F., Maiorino M. Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase. Biol Reprod 2002, 67:967-971.
31. Scott R., MacPherson A., Yates R.W., Hussain B., Dixon J. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998, 82:76-80.
32. Iwanier K., Zachara B.A. Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men. J Androl 1995, 16:441-447.
33. Hawkes W.C., Turek P.J. Effects of dietary selenium on sperm motility in healthy men. J Androl 2001, 22:764-772.
34. Bedwal R.S., Bahuguna A. Zinc, copper and selenium in reproduction. Experientia 1994, 50:626-640.
35. Kvist U., Kjellberg S., Bjorndahl L., Soufir J.C., Arver S. Seminal fluid from men with agenesis of the Wolffian ducts: zinc-binding properties and effects on sperm chromatin stability. Int J Androl 1990, 13:245-252.
36. Caldamone A.A., Freytag M.K., Cockett A.T. Seminal zinc and male infertility. Urology 1979, 13:280-281.
37. Netter A., Hartoma R., Nahoul K. Effect of zinc administration on plasma testosterone, dihydrosterosterone, and sperm count. Arch Androl 1981, 7:69-73.
38. Tikkiwal M., Ajmera R.L., Mathur N.K. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol 1987, 31:30-34.
39. Omu A.E., Dashti H., Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. Eur J Obstet Gynecol 1998, 79:179-184.
40. Wong W.Y., Merkus H.M., Thomas C.M., Menkveld R., Zielhuis G.A., Steegers-Theunissen R.P. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril 2002, 77:491-498.
41. Ebisch I.M., Pierik F.H., DE Jong F.H., Thomas C.M., Steegers-Theunissen R.P. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?. Int J Androl 2006, 29:339-345.
42. Eskenazi B., Kidd S.A., Marks A.R., Sloter E., Block G., Wyrobek A.J. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 2005, 20:1006-1012.
43. Kamen B. Folate and antifolate pharmacology. Semin Oncol 1997, 24:S18-S39.
44. Landau B., Singer R., Klein T., Segenreich E. Folic acid levels in blood and seminal plasma of normo- and oligospermic patients prior and following folic acid treatment. Experientia 1978, 34:1301-1302.
45. Raijmakers M.T., Roelofs H.M., Steegers E.A., Steegers-Theunissen R.R.P., Mulder T.P., Knapen M.F., et al. Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa. Fertil Steril 2003, 79:169-172.
46. Lenzi A., Lombardo F., Gandini L., Culasso F., Dondero F. Glutathione therapy for male infertility. Arch Androl 1992, 29:65-68.
47. Lenzi A., Culasso F., Gandini L., Lombardo F., Dondero F. Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod 1993, 8:1657-1662.
48. Lenzi A., Picardo M., Gandini L., Lombardo F., Terminali O., Passi S., et al. Glutathione treatment of dyspermia: effect on the lipoperoxidation process. Hum Reprod 1994, 9:2044-2050.
49. Ernster L., Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1995, 1271:195-204.
50. Mancini A., De Marinis L., Littarru G.P., Balercia G. An update of coenzyme Q10. Implications in male infertility: biochemical and therapeutic aspects. Biofactors 2005, 25:165-174.
51. Lewin A., Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997, 18:S213-S219.
52. Balercia G., Mosca F., Mantero F., Boscaro M., Mancini A., Ricciardo-Lamonica G., et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004, 81:93-98.
53. Sheweita S.A., Tilmisany A.M., Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab 2005, 6:495-501.
54. De Lamirande E., Gagnon C. Reactive oxygen species (ROS) and reproduction. Adv Exp Med Biol 1994, 366:185-197.
55. Agarwal A., Nallella K.P., Allamaneni S.S., Said T.M. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online 2004, 8:616-627.